Bioactive Small Molecules
Cayman Chemical PentaNacetylchItopentaose 5mg
A pentameric chito-oligosaccharide involved in root nodulation; produced by NodC, a chito-oligosaccharide synthase, and serves as a substrate for NodL, an O-acetyltransferase; binds plant root lectins, an interaction that may be important in the promotion of cell division in the root cortex
Cayman Chemical ANTIBODY LED209 5mg
A potent QseC inhibitor that blocks both norepinephrine- and epinephrine-triggered QseC-dependent virulence gene expression at 5 pM in vitro
Cayman Chemical ANTIBODY OTS514 5mg
An inhibitor of TOPK (IC50 = 2.6 nM); selectively inhibits growth of patient-derived AML cells over normal CD34+ cells; inhibits growth of small cell lung, kidney, and ovarian cancer cell lines (IC50s = 0.4-42.6 nM); increases survival in a peritoneal mouse dissemination model of ovarian cancer at 25 and 50 mg/kg; dose-dependently inhibits tumor growth in an A549 mouse xenograft model at 1, 2.5, and 5 mg/kg
Medchemexpress LLC SPOP-IN-6b dihydrochloride | 99.7% | 573.51 | 10 MG
SPOP-IN-6b dihydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM. It is intended for research use only and not for sale to patients.
- Potent SPOP inhibitor with an IC50 of 3.58 μM.
- Suppresses SPOP activity, leading to an increase in suppression cancer substrate proteins PTEN and DUSP7 content in vitro (IC50s of 2-10.2 μM for A498, Caki-2, Ketr-3, 769-P, 0S-RC-2, and 786-0 cells).
- Slows down tumor growth in nude mice by suppressing SPOP (40-80 mg/kg; intraperitoneal injection; daily; for 25 days).
Medchemexpress LLC GPR15 antagonist-1 | 252280-67-4 | 99.7% | 593.75 g/mol | C34H47N3O6 | 10 MG
GPR15 antagonist-1 is a small-molecule antagonist of the G protein-coupled receptor GPR15 supplied as a white to off-white powder for research use. It is designed for biochemical and cell-based studies of GPR15-related processes, including investigations related to HIV entry and inflammatory pathways. Store the powder at low temperature and prepare aliquots for solution storage.
Cayman Chemical ANTIBODY GSK2292767 25mg
A potent and selective inhibitor of PI3Kδ (Ki = 79 pM); has >1,000-fold selectivity for PI3Kδ over isoforms PI3Kα, PI3Kβ, and PI3Kγ (Kis = 501, 630, and 501 nM, respectively); >100-fold selective for PI3Kδ over a panel of 250 kinases; inhibits IFNγ and IL-2 production (IC50s = 1.9 and 3.16 nM, respectively) in a human lung parenchyma assay; protects against eosinophil recruitment (ED50 = 35 μg/kg) in the brown Norway rat acute ovalbumin model of Th2-driven lung inflammation
Medchemexpress LLC HY-112786 1mg Medchemexpress, MC-Val-Cit-PAB-MMAF CAS:863971-17-9 Purity:>98%
Medchemexpress, HY-112786 1mg MC-Val-Cit-PAB-MMAF CAS:863971-17-9 MC-Val-Cit-PAB-MMAF is a drug-linker conjugate for ADC with antitumor activity by using the tubulin inhibitor, MMAF, linked via cathepsin cleavable MC-Val-Cit-PAB. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical GSK-J4hydrochlorIde 50mg
An ethyl ester prodrug of the JMJD3 selective histone demethylase inhibitor GSK-J1; reduces LPS-induced proinflammatory cytokine production, including that of TNFα (IC50 = 9 µM) in human primary macrophages
Cayman Chemical ANTIBODY K-TMZ 5mg
A DNA alkylating agent; increases the concentration of O6-methylated deoxyguanosine in U87 GBM cells in a concentration-dependent manner; reduces cell viability in GBM cell lines lacking (IC50s = 18-44 μM) or expressing MGMT (IC50s = 115-240 μM); can cross the blood-brain barrier; increases survival in a Br23c mouse xenograft model of GBM at 14.9 mg/kg
Cayman Chemical ANTIBODY MLS-573151 1mg
A specific, cell permeable inhibitor of Cdc42 (IC50 = 2 μM); has no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2
Medchemexpress LLC Sauchinone | 177931-17-8 | 356.37 | 5 MG
Sauchinone is a diastereomeric lignan isolated from *Saururus chinensis* (Saururaceae). It inhibits LPS-inducible iNOS, TNF-α, and COX-2 expression by suppressing I-κBα phosphorylation and p65 nuclear translocation. Sauchinone demonstrates anti-inflammatory and antioxidant activities.
- Anti-inflammatory activity
- Antioxidant activity
Cayman Chemical ANTIBODY CYM 5442 1mg
A selective SIP1 agonist (EC50 = 1.35 nM); activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 (EC50 = 46 nM); induces S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 and 85%, respectively, at 50 nM
Cayman Chemical TLR7 AgonIst 2 5mg
A TLR7 agonist (LEC = 0.4 μM in a cell-based reporter assay); selective for TLR7 over TLR8 (LEC = >100 μM); increases IFN-α levels and the ISG response, increasing the expression of Oas1b, Isg15, and Mx1, in mouse liver and plasma at 0.3-10 mg/kg; increases plasma levels of IFN-α, CCL2, IL-6, IL-1Ra, G-CSF, and IL-10 in cynomolgus monkeys at 10 mg/kg; reduces serum and liver viral load in the HDI-HBV mouse model at 0.3-5 mg/kg
Cayman Chemical Aceclofenac ethyl ester 5mg
A potential impurity in commercial preparations of aceclofenac
Medchemexpress LLC Canertinib | 267243-28-7 | MFCD09837878 | 99.0% | 485.94 g/mol | C24H25ClFN5O3 | 200 MG
Canertinib is an irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor used as a research compound to probe EGFR/ErbB signaling. It inhibits cellular EGFR and ErbB2 autophosphorylation at low nanomolar concentrations and is provided as a solid for laboratory use.
- Irreversible EGFR/ErbB inhibitor with reported IC50s ~7.4 nM (EGFR) and ~9 nM (ErbB2).
- Suitable for in vitro and in vivo research on EGFR-driven signaling pathways.
- Provided as a solid, soluble in DMSO for preparation of stock solutions.
- Molecular formula C24H25ClFN5O3 and molecular weight ~485.94 g/mol.
- Intended for research use only; not for human or clinical applications.