Bioactive Small Molecules
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Filtered Search Results
Selleck Chemical LLC MK-2206 2HCl 5mg 1032350-13-2
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM in cell-free assays, respectively; no inhibitory activities against 250 other protein kinases observed. MK-2206 2HCl induces autophagy and apoptosis in cancer cells. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Selleck Chemical LLC Trametinib (GSK1120212) 10mg 871700-17-3 JTP-74057, Mekinist
Trametinib (GSK1120212, JTP-74057, Mekinist) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Selleck Chemical LLC TSA (Trichostatin A) S1045-5mg
TSA (Trichostatin A) is an HDAC inhibitor with IC50 of 1 8 nM in cell-free assays
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Selleck Chemical LLC SB431542 S1067-200mg
SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay 100-fold more selective for ALK5 than p38 MAPK and other kinases
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Cayman Chemical Lanifibranor, Purity: ≥98%, CAS: 927961-18-0, 5 mg
A PPAR agonist (EC50s = 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively); increases β-oxidation in Huh-7 and C2C12 cells at 1 and 3 µM, respectively; reduces plasma glucose and triglyceride levels in a db/db mouse model of type 2 diabetes at 10 and 30 mg/kg for five days; increases plasma adiponectin levels and decreases collagen deposition in a carbon tetrachloride-induced mouse model of NASH
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Medchemexpress LLC BUTYROLACTONE 3 5MG
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Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases.
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CHEMIETEK ABT-199 10MG
NC2004888 ABT-199 10MG
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Selleck Chemical LLC CISPLATIN 200 MG
CISPLATIN 200 mg *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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BIOGEMS INTERNATIONAL INC (Z)-4-Hydroxytamoxifen 25mg
Tamoxifen is a modulator of the of the estrogen receptor, with tissue specific agonistic and antagonistic effects. (Z)-4-Hydroxytamoxifen is a Tamoxifen metabolite with increased potency and a 100x higher affinity for the estrogen receptors. It is also reported to inhibit lipid peroxidation and can be used to activate intein-linked or estrogen receptor ERT2 domain fused Cas9 to reduce off target effects in CRISPR-mediated gene editing.
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BIOGEMS INTERNATIONAL INC All-Trans Retinoic Acid 1g
Retinoic Acid is vitamin A derivative that is an agonist for the retinoic acid receptors, which act as transcription factors that regulate the growth and differentiation of normal and malignant cells. It is reported to promote the differentiation of embryonic cells into motor neurons, pancreatic progenitors and cardiomyocytes.
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Medchemexpress LLC CAN10 1mg | 1mg
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CAN10 is a humanized monoclonal antibody inhibitor targeting interleukin 1RAP (IL1RAP) CAN10 is promising for research of immune system diseases[1]
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Medchemexpress LLC hT84.66-M5A 1mg | 1mg
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hT84 66-M5A is a humanized IgG1 antibody that targets carcinoembryonic antigen (CEA) The isotype control for hT84 66-M5A can refer to Human IgG1 kappa Isotype Control (HY-P99001)[1]
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Medchemexpress LLC Anti-Mouse PD-1 Anti 50mg | 50mg
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Anti-Mouse PD-1 Antibody (RMP1-14) is an anti-mouse PD-1 IgG2a antibody Anti-Mouse PD-1 Antibody (RMP1-14) can be used for the study of colon carcinoma[1]
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Medchemexpress LLC Eculizumab 10mg | 10mg
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Eculizumab (Anti-Human C5 Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5 Eculizumab inhibits the cleavage of C5 into C5a and C5b and inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC) Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in mice Eculizumab can be used in hemolysis studies[1][2]
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Cayman Chemical cKK-E12, Purity: ≥95%, CAS: 1432494-65-9, 25 mg
An ionizable lipomer; has been used in combination with other lipids in the formation of LNPs for the delivery of mRNA; LNPs containing cKK-E12 and L-319 and encapsulating VZV mRNA encoding gE increase the lymph node and spleen levels of CD11c+CD80+ and CD11c+CD86+ cells and total serum IgG titers in mice, as well as decrease the number of VZV-induced rashes and the epithelial levels of VZV DNA in a guinea pig model of VZV-induced shingles
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