Bioactive Small Molecules
AdipoGen Purvalanol A (5 mg)
Chemical. CAS: 212844-53-6. Formula: C19H25ClN6O. MW: 388.9. Synthetic. Potent, cell permeable cyclin-dependent protein kinase (cdk) inhibitor. Inhibits human CDK1 (IC50=4nM), CDK2/cyclin A (IC50=70nM), Cdc2/cyclin B, CDK2/cyclin E (IC50=35nM), CDK4/cyclin D1 (IC50=850nM) as well as CDK5/p35 (IC50=75nM). DYRK1A inhibitor (IC50=300nM). Anticancer agent. Strong apoptotic and autophagy inducer which causes cell cycle arrest in the G1 and G2 phase in various cancer cell lines. More membrane permeable than purvalanol B. Shown to inhibit ABCB1 and ABCB2 transporters and useful in co-treatment with selected anticancer drugs.
Cayman Chemical NIH 12848, Purity: ≥95%, CAS: 959551-10-1, 25 mg
An inhibitor of PI5P4K (IC50 = ~1 µM); selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >100 µM); inhibits translocation of the Na+/K+-ATPase to the plasma membrane in mpkCCD cells; an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 7.9 µM); increases accumulation of monoubiquitinated PCNA in H1299 NSCLC cells at 20 µM
Medchemexpress LLC HY-Y0106 500mg Medchemexpress, 2,6-Dihydroxyacetophenone CAS:699-83-2 Purity:>98%
Medchemexpress, HY-Y0106 500mg 2,6-Dihydroxyacetophenone CAS:699-83-2 2,6-Dihydroxyacetophenone is an endogenous metabolite. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-W008634 10mg Medchemexpress, Bropirimine CAS:56741-95-8 Purity:>98%
Medchemexpress, HY-W008634 10mg Bropirimine CAS:56741-95-8 Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7). Bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β. Bropirimine is an orally active immunomodulator that has demonstrated anticancer activity in transitional cell carcinoma in situ (CIS) in both the bladder and upper urinary tract. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-137315 5mg Medchemexpress, TML-6 CAS:1462868-88-7 Purity:>98%
Medchemexpress, HY-137315 5mg TML-6 CAS:1462868-88-7 TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![Medchemexpress LLC Benzoic acid, 3-(1,3,3a,4,9,9a-hexahydro-4-nitro-1,3-dioxo-4,9[1',2']-benzeno-2H-isoindol-2-yl) | 690991-06-1 | 99.7% | 440.40 g·mol⁻1 | C25H16N2O6 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000223088.png-250.jpg)
Medchemexpress LLC Benzoic acid, 3-(1,3,3a,4,9,9a-hexahydro-4-nitro-1,3-dioxo-4,9[1',2']-benzeno-2H-isoindol-2-yl) | 690991-06-1 | 99.7% | 440.40 g·mol⁻1 | C25H16N2O6 | 5 MG
S100P-IN-1 is a small-molecule inhibitor of S100P that blocks S100P-RAGE binding and reduces invasive behavior in S100P-expressing pancreatic cancer cells. It is intended for in vitro research of S100P-related signaling and invasion assays.
- Potent S100P inhibition with reported IC50 22.7 nM.
- Anti-metastatic activity in pancreatic cancer cell invasion assays at 10 μM without obvious cytotoxicity.
- Molecular formula C25H16N2O6 and molecular weight 440.40 g·mol⁻1.
- High purity (99.74%).
- Available as solid and as 10 mM solution in DMSO in multiple package sizes.
- Storage: solid at 4°C; in solvent at -80°C (6 months) or -20°C (1 month).
- Suitable for in vitro studies of S100P-related pathways and invasion assays.
Medchemexpress LLC HY-117626 5mg Medchemexpress, LP-935509 CAS:1454555-29-3 Purity:>98%
Medchemexpress, HY-117626 5mg LP-935509 CAS:1454555-29-3 LP-935509 is a selective, ATP-competitive and brain-penetrant inhibitor of adapter protein-2 associated kinase 1 (AAK1) with an IC50 and a Ki of 3.3 nM and 0.9 nM, respectively. LP-935509 is also a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
TARGETMOL CHEMICALS INC AGNUSIDE 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Agnuside (chasteberry oil) inhibits COX-2 (IC50 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3 66.8 and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5 25 and 100 uM respectively. purity: 99%
TARGETMOL CHEMICALS INC ALPINETIN 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeutic agent CDDP. Alpinetin has strong anti-hepatoma and pancreatic cancer cells effects by inhibiting proliferation regulating of the Bcl-2 family and XIAP expression releasing of cytochrome c and activating caspases. purity: 99%
Medchemexpress LLC Thioperamide maleate | 148440-81-7 | >98.0% | 10 MG
Thioperamide maleate is the maleate salt of thioperamide, a selective histamine H3 receptor antagonist used as a pharmacological tool to study histaminergic signaling. It is brain-penetrant and orally active, with a reported Ki of approximately 4.3 nM for H3 receptor inhibition.
- Selective H3 receptor antagonist with Ki ≈ 4.3 nM.
- Brain-penetrant and orally active, suitable for in vivo studies.
- Provided as a solid, commonly supplied in 10 mg vials for research use.
- High purity (>98%) as determined by vendor quality control.
Cayman Chemical Ertugliflozin, Purity: ≥98%, CAS: 1210344-57-2, 5 mg
An SGLT2 inhibitor (IC50 = 0.927 nM for the human enzyme); selective for SGLT2 over SGLT1 (IC50 = 2,050 nM for the human enzyme); increases urinary glucose excretion in rats in a dose-dependent manner
Cayman Chemical S-72, Purity: ≥98%, CAS: 2446799-14-8, 50 mg
An inhibitor of microtubule polymerization; inhibits microtubule polymerization in a cell-free assay at 1, 3, and 10 µM; reduces viability in MCF-7 and paclitaxel-resistant MCF-7/T cells (IC50s = 15.64 and 26.32 nM, respectively); inhibits migration and invasion, as well as the percentage of wound closure in a scratch assay in MCF-7 and MCF-7/T cells at 50 nM; induces cell cycle arrest at the G2/M phase in MCF-7/T cells and induces apoptosis in those same cells at 100 nM; inhibits STING activation in MCF-7/T cells at 100 nM; inhibits tumor growth in MCF-7/T and MX-1/T mouse xenograft models of paclitaxel-resistant breast cancer at 15 mg/kg per day
Cayman Chemical Darusentan, Purity: ≥98%, CAS: 171714-84-4, 1 mg
An ETA receptor antagonist (Ki = 13 nM in rat aortic vascular smooth muscle cells); inhibits ET-1-induced contractions in isolated rat aortic rings and mesenteric microvessels (pA2s = 8.1 and 7.97, respectively); decreases systolic blood pressure in DOCA-salt hypertensive rats at 50 mg/kg; decreases MAP and LVDP in normotensive pigs at 1 and 5 mg/kg; reduces myocardial infarct size as a percentage of the area at risk in a porcine model of LAD coronary artery ligation-induced ischemia-reperfusion injury