Bioactive Small Molecules
Apexbio Technology LLC Zileuton, 100mg. Cas: 111406-87-2 MFCD: MFCD00866097. 5-lipoxygenase (5-LOX) inhibitor, orally active
IC50: Zileuton inhibited 5-hydroxyeicosatetraenoic aicd synthesis in rat basophilic leukemia cell and polymorphonuclear leukocytes (IC50 = 0.5 and 0.3 M), respectively [1]. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC XL-888, 5mg. Cas: 1149705-71-4 MFCD: MFCD22124888. Hsp90 inhibitor
XL-888 is a novel and orally-bioavailable inhibitor of heat shock protein 90 (HSP90) that selectively inhibits HSP90 and HSP90 with values of 50% inhibition concentration IC50 of 22 nM and 44 nM respectively. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC Tolcapone, 10mg. Cas: 134308-13-7 MFCD: MFCD00866569. COMT inhibitor
Tolcapone is a novel, reversible and orally-bioavailable small-molecule catechol-O-methyltransferase (COMT) inhibitor used for as an adjunct to levodopa therapy for the treatment of Parkinsons disease (PD). Other sizes are available. Please inqury us for quote.
Medchemexpress LLC HY-N1382 5mg Medchemexpress, Asperuloside CAS:14259-45-1 Purity:>98%
Medchemexpress, HY-N1382 5mg Asperuloside CAS:14259-45-1 Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ARCYRIAFLAVIN A 5MG
A CDK4 and CaMKII inhibitor (IC50s = 140 and 25 nM, respectively); selective for CDK4 and CaMKII over PKA and PKC (IC50s = >2 and >100 µM, respectively); inhibits replication of HCMV in vitro (IC50 = 200 nM); inhibits proliferation of HCT116 and NCI H460 carcinoma cells in vitro (IC50s = 850 and 590 nM, respectively); inhibits proliferation and induces apoptosis of ECSCs
Apexbio Technology LLC RN486, 5mg. Cas: 1242156-23-5 MFCD: MFCD24682729. Btk inhibitor,potent and selective
RN486 is a reversible inhibitor of Btk with IC50 value of 4.0 nM [1].Bruton's tyrosine kinase (Btk) is a type of kinase protein which is expressed by immune system-related cells and plays a pivotal role in cell differentiation and proliferation at the transition from pre-B to later B cell stages. Other sizes are available. Please inqury us for quote.
Cayman Chemical ANTIBODY EtravIrIn 50mg
An NNRTI; active against the wild-type HIV-1 strains LAI, SF2, and Ba-L (EC50s = 1.4-4.8 nM) but not the HIV-2 strain ROD (EC50 = 3,479 nM); active against 18 HIV-1 strains carrying NNRTI resistance-associated mutations (EC50s = <5 nM for all); increases intracellular processing of the viral polyproteins Gag and Gag-Pol and decreases viral particle production in HEK293T cells transfected with a plasmid encoding the NL4.3 infectious molecular clone of HIV-1 at 5 μM
Selleck Chemical LLC ISRIB (trans-isomer) 10mg 1597403-47-8
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM and does not have global effects on translation, transcription, or mRNA stability in non-stressed cells. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical Aralosde A 5mg
A triterpenoid saponin with anti-inflammatory and gastroprotective activities; increases apoptosis of and decreases production of IL-1β and IL-6 in human MH7A rheumatoid arthritis fibroblast-like synoviocytes from 4-16 µM; reduces gastric acid secretion and lesion size in rat models of hydrochloric acid and ethanol-, aspirin-, water immersion stress-, or pyloric ligation-induced ulcer formation at 50 and 100 mg/kg
Cayman Chemical ANTIBODY VR23 5mg
A trypsin-like proteasome inhibitor (IC50 = 1 nM) that deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells
Cayman Chemical ANTIBODY DL-TBOA 5mg
An EAAT inhibitor (IC50s = 67 and 5.5 μM for glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, respectively); inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 4.4 μM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 3.2 μM) voltage-clamped at -60 mV; increases extracellular aspartate, glutamate, and alanine levels in rat hippocampus at 500 μM; increases lesion volume in the rat hippocampal CA1 region when administereed intrahippocampally; induces hyperexcitability, wet-dog shakes, salivation, forelimb myoclonus, limbic seizures, and epileptic EEG discharges in rats at 25 nmol; induces antinociception in the second phase of the formalin test in rats at 5 and 10 μg when administered 10 minutes prior to formalin
AdipoGen Martinomycin (1 mg)
Chemical. CAS: 160791-16-2. Formula: C49H84O17. MW: 945.2. Isolated from Actinoallamurus yoronensis. Antibiotic. Active against Gram-positive bacteria. Active against Spodoptera eridania.
Cayman Chemical ANTIBODY WZB117 25mg
An irreversible inhibitor of Glut1 that blocks glucose transport in diverse cancer cells (IC50 = ~0.6 µM) and cancer cell proliferation (IC50s= 5-10 µM); reduces tumor size in mice, with only small reductions in body weight and leukocyte count
Abcam RSL3, 25MG
MW 440.9 Da, Purity >=98%. RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor and an inducer of ferroptosis. RSL3 increases lipid peroxidase levels in vitro and inhibits tumor formation and progression in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical ANTIBODY 3BDO 1mg
A butyrolactone derivative and autophagy inhibitor; increases phosphorylation of EIF4EBP1 and RPS6KB1/p70S6K1 in HUVECs at 60 μM; prevents rapamycin-induced MAP1LC3B puncta formation in HUVECs at 60 μM; inhibits apoptosis, senescence, and increases in integrin β4 levels induced by serum- and FGF2-deprivation in at 40 μg/ml; reduces cortical and hippocampal amyloid plaque burden, inhibits autophagy in the brain, and rescues learning and memory deficits in the AβPP/PS1 transgenic mouse model of Alzheimer’s disease at 80 mg/kg per day