Bioactive Small Molecules
Cayman Chemical SynthetIc PImodIvIr 5mg
An inhibitor of influenza virus PB2 (KD = ~1.6 µM) and inhibits the activity of Axl and CaMKIIβ by >50% in a panel of 65 human and rat kinases; decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC50s = 50s = 0.58, 0.64, and 0.89, respectively, in a cell-based assay); increases survival in a mouse model of intranasal influenza A infection at 1, 3, and 10 mg/kg twice per day
Cayman Chemical ANTIBODY AZD 8797 1mg
A CX3CR1 antagonist (Ki = 3.9 nM); selective for CX3CR1 over CX3CR2 (Ki = 2,800 nM); inhibits CX3CL1-induced [35S]GTPγS accumulation in CHO cell membranes expressing human CX3CR1 from 0.1-10 µM; inhibits adhesion of RBMI-8226 cells to CX3CL1 (IC50 = 5.8 nM); reduces spinal cord inflammation and demyelination, as well as the incidence of disease relapse, in a rat model of myelin oligodendrocyte glycoprotein-induced EAE at 39 and 78 µmol/kg per day
Medchemexpress LLC Isosakuranin | 491-69-0 | MFCD29049499 | 100.0% | 448.42 g·mol⁻¹ | C22H24O10 | 10 MG
Isosakuranin is a naturally occurring flavonoid (flavanone glycoside) isolated from the fruits of Paliurus ramosissimus. It is supplied as a high-purity research reagent for in vitro studies and should be stored protected from light.
- High purity: 99.97%.
- Molecular formula C22H24O10 and molecular weight 448.42 g·mol⁻¹.
- Suitable for in vitro research applications and biochemical studies.
- Store protected from light at 4°C; in solvent: -80°C (6 months) or -20°C (1 month).
- Available in mg-scale quantities for laboratory research.
ABclonal Technology CTP synthase / CTPS Rabbit mAb
This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate) This reaction is an important step in the biosynthesis of phospholipids and nucleic acids Activity of this proten is important in the immune system and loss of function of this gene has been associated with immunodeficiency Alternative splicing results in multiple transcript variants
Cayman Chemical ANTIBODY VU0238429 50mg
A muscarinic M5 receptor positive allosteric modulator (EC50 = 1.16 µM in a calcium mobilization assay); selective for M5 mAChRs over M1, M2, M3, and M4 mAChRs in CHO cells expressing the human receptors (EC50s = >30 µM for all in calcium mobilization assays); reduces DOI-induced head-twitch behavior in mice at 10 mg/kg; reverses MK-801-induced memory deficits in the novel object recognition test in mice when administered alone or in combination with GS-39783
QA Bio Inc Ludger Glucose Ladder - Procainamide
The procainamide glucose homopolymer (GHP) ladder derived from digested wheat starch used as a standard for sizing of glycans. Amount supplied sufficient for 30 HPLC runs. • The GHP ladder is also available labeled with 2-AB (CAB-GHP-30), 2-AA(CAA-GHP-30) and procainamide(PROC-GHP-30 . • Sources: Derived from wheat starch • Form: Dry. Dried by centrifugal evaporation from an aqueous solution. • Amount: 100 picomoles • Purity: > 90% pure as assessed by a combination of HPLC
Apexbio Technology LLC CX-6258 1202916-90-2 10mg
CX-6258 (CAS 1202916-90-2) is a potent selective and orally bioavailable inhibitor targeting all three Pim kinase isoforms (PIM-1 PIM-2 and PIM-3) serine/threonine kinases implicated in cell survival regulation In cellular assays CX-6258 suppressed proliferation across a diverse panel of human solid tumor and hematologic malignancy cell lines and demonstrated synergistic effects with chemotherapeutic agents In vivo CX-6258 produced dose-dependent tumor growth inhibition in MV-4-11 acute myeloid leukemia and PC3 prostate cancer xenograft models These properties make CX-6258 a valuable research tool for investigating Pim kinase biology and oncogenic mechanisms
Cayman Chemical ANTIBODY MacItentn 100mg
A dual ETA/ETB receptor antagonist (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively); inhibits ET-1-induced intracellular Ca2+ increase in HPASMCs (IC50 = 0.9 nM) and contractions of isolated rat aortic rings (pA2 = 7.6 for ETA) and sarafotoxin S6c-induced contractions of isolated rat tracheal rings (pA2 = 5.9 for ETB); decreases mean arterial blood pressure in DOCA-salt hypertensive rats (ED50 = 1 mg/kg); prevents development of pulmonary hypertension and right ventricle hypertrophy in a rat model of hypertension; decreases the number of vascular and tubule-interstitial lesions and amount of glomerular damage in a rat model of diabetes
Medchemexpress LLC Tak-901 | 934541-31-8 | 99.8% | 50 MG
TAK-901 is a multi-targeted Aurora kinase inhibitor used in research to inhibit Aurora A and Aurora B, with reported IC50 values of 21 nM and 15 nM, respectively. It is supplied as a high-purity powder suitable for in vitro and preclinical studies.
- Inhibits Aurora A (IC50 = 21 nM) and Aurora B (IC50 = 15 nM).
- High purity for reliable assay and screening results.
- Powder form allows flexible preparation and dosing.
- Recommended storage preserves stability for extended use.