Bioactive Small Molecules
Selleck Chemical LLC Torkinib (PP242) 50mg 1092351-67-1
Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3K? or PI3K?/?/?, respectively. Torkinib (PP242) induces mitophagy and apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Melittin | 20449-79-0 | 99.7% | 2846.46 | 10 MG
Melittin | 20449-79-0 | 99.7% | 2846.46 | 10 MG
Medchemexpress LLC Abc99 | 2331255-53-7 | 98.5% | 1 MG
ABC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50 13 nM) and preserves Wnt3A signaling in the presence of NOTUM.
- Selective NOTUM inhibitor with IC50 of 13 nM.
- Preserves Wnt3A signaling in the presence of NOTUM.
- Molecular formula C22H21ClN4O5; molecular weight 456.88.
- Purity 98.5% with supporting analytical documentation (COA, H NMR, LCMS, SDS).
- Available as a 1 mg solid and as a 10 mM solution in DMSO.
Medchemexpress LLC Dithranol (Anthralin) | 1143-38-0 | 95.3% | 50 MG
Dithranol (Anthralin) is an anthraquinone derivative with potent anti-psoriatic effects. It can inhibit DNA replication and repair.
- Potent anti-psoriatic effects
- Inhibits DNA replication and repair
- Active against HEK293, HaCaT, PMNL, THP-1, U-937 cell lines
- Used in clinical trials for Psoriasis Vulgaris
Cayman Chemical Bilaid A, Purity: ≥95%, CAS: 2393865-97-7, 5 mg
A tetrapeptide μ-opioid receptor agonist (Ki = 3.1 μM using HEK293 cell membranes expressing the human receptor); inhibits forskolin-induced cAMP accumulation in HEK293cells expressing the human μ-opioid receptor by 21% at 10 μM
Medchemexpress LLC H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Pro-Ile-Leu-Thr-Arg-Ile-Thr-Leu-Glu-OH | 99.32% | 2617.13 | 10 MG
ReACp53 is a potent activator of p53, a critical tumor suppressor. It inhibits p53 amyloid formation and restores its function in cancer cells. It penetrates high-grade serous ovarian cancer (HGSOC) cells, converting mutant p53 into a soluble, wild-type-like form. ReACp53 induces cancer cell death, cell cycle arrest, and promotes p53 degradation, specifically targeting cancer cells with mutant p53 while sparing wild-type cells. This makes ReACp53 a promising therapeutic agent for p53-driven cancers.
- Inhibits p53 amyloid formation.
- Rescues p53 function in cancer cell lines.
- Converts mutant p53 to soluble WT-like p53 in HGSOC cells.
- Induces cancer cell death and cell cycle arrest.
- Promotes p53 degradation.
- Targets mutant p53 cancer cells, sparing wild type.
- Reduces tumor proliferation in animal models.
- Increases p21 and MDM2 transcription in OVCAR3 xenografts.
Medchemexpress LLC HY-141659 5mg , USP30 inhibitor 18 CAS:2242582-40-5 Purity:>98%
HY-141659 5mg USP30 inhibitor 18 CAS: 2242582-40-5 USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical GSK547, Purity: ≥98%, CAS: 2226735-55-1, 25 mg
A RIPK1 inhibitor (IC50 = 31 nM); selective for RIPK1 over a panel of 371 kinases at 10 µM; increases survival and reduces tumor volume and the number of liver metastases in a P48Cre KrasG12D orthotopic mouse model of progressive PDA at 100 mg/kg; adoptive transfer of tumor-infiltrating T cells isolated from GSK547-treated mice protects against orthotopic PDA tumor growth in mice; reduces plasma levels of TNF-α and IL-1β and decreases macrophage infiltration in aortic sinus lesions in an ApoESA/SA mouse model of early-phase atherogenesis
Medchemexpress LLC 2,5-Dihydroxyacetophenone | 490-78-8 | 152.15 | 1 ML
2,5-Dihydroxyacetophenone, isolated from *Rehmannia glutinosa*, acts as an inhibitor of inflammatory mediators. It blocks the ERK1/2 and NF-κB signaling pathways.
- Derived from natural source (*Rehmannia glutinosa*).
- Targets multiple inflammatory pathways (ERK1/2 and NF-κB).
- Effective in suppressing inflammatory responses in activated macrophages.
Medchemexpress LLC α-Hydroxylinoleic acid | 57818-44-7 | MFCD31544382 | 296.44 | 50 MG
ABTL-0812 (α-Hydroxylinoleic acid) is a first-in-class small molecule that induces endoplasmic reticulum (ER) stress-mediated autophagy, demonstrating anti-cancer activity. It has been observed to inhibit cell viability in squamous NSCLC H157 cells and induce ER stress in human lung and pancreatic xenografts during in vivo studies.
- Induces ER stress-mediated autophagy
- Exhibits anti-cancer activity against squamous NSCLC H157 cells
- Induces ER stress in human lung and pancreatic xenografts
- First-in-class small molecule
- Liquid appearance, colorless to off-white
- Derived from Bombacaceae Pachira aquatica Aublet plants
- Potential anti-cancer therapeutic
Medchemexpress LLC Milbemycin A3 | 51596-10-2 | MFCD04972569 | 99.5% | 528.68 g/mol | C31H44O7 | 5 MG
Milbemycin A3 is an insecticidal antibiotic exhibiting acaricidal and nematocidal activity, supplied as a solid for research use. It is used in laboratory studies of parasitic control and insecticidal effects.
- Has acaricidal and nematocidal activity.
- Supplied as a solid, white to light yellow powder.
- Chemical formula C31H44O7; molecular weight 528.68 g/mol.
- CAS number 51596-10-2.
- Reported purity varies by supplier (reported ranges include ≥85% to ≈99.5%).
- Intended for research use only.
Medchemexpress LLC 2H,2H,3H,3H-perfluorooctanoic acid | 914637-49-3 | MFCD08460490 | 99.8% | 342.11 g/mol | C8H5F11O2 | 50 MG
2H,2H,3H,3H-perfluorooctanoic acid is a fluorinated carboxylic acid used as an analytical reference standard and intermediate in environmental and fluorochemical research.
- High purity 99.8% (GC)
- Cas number 914637-49-3
- Molecular formula C8H5F11O2
- Molecular weight 342.11 g/mol
- Suitable as an analytical reference standard for PFAS and environmental testing
- Available in 50 MG quantity with accompanying COA
Medchemexpress LLC HY-136256 5mg Medchemexpress, DCC-3014 CAS:1628606-05-2 Purity:>98%
Medchemexpress, HY-136256 5mg DCC-3014 CAS:1628606-05-2 DCC-3014 is a c-FMS (CSF-IR) and c-Kit dual inhibitor extracted from patent WO2014145025A2, Compound Example 10, has IC50s of <0.01 μM and 0.1-1 μM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical Torasemide, Purity: ≥98%, CAS: 56211-40-6, 5 mg
An analytical reference standard categorized as a diuretic; has been abused as a performance-enhancing drug and masking agent in doping in sports; intended for research and forensic applications