Bioactive Small Molecules
Abcam NH 125, CaMK III inhibitor, 50MG
MW 524.6 Da, Purity >99%. Potent, selective CaMK III inhibitor (IC₅₀ = 60 nM). Histidine protein kinase inhibitor (IC₅₀ = 6.6 μM). Induces G1/S cell cycle arrest and apoptosis. Shows anticancer effects. Antibacterial agent in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical ANTIBODY ML-226 5mg
An inhibitor of ABHD11 (IC50s = 15 and 0.68 nM, respectively, in vitro and in situ); 100-fold selective for ABHD11 over approximately 20 serine hydrolases; can be used as an anti-probe for ML-211
Medchemexpress LLC Envelope glycoprotein gp64 protein, AcmNPV (HEK293, His) | >95.0% | 100 UG
Recombinant envelope glycoprotein gp64 from Autographa californica multiple nucleopolyhedrovirus (AcmNPV), expressed in HEK293 cells and supplied as a C-terminal His-tagged protein. Supplied in PBS (0.2 μm filtered, pH 7.4) with low endotoxin and high purity, the protein is intended for biochemical and immunological research applications; store frozen and avoid repeated freeze-thaw cycles.
- Recombinant expression in HEK293 cells.
- C-terminal His tag for purification and detection.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Endotoxin level <1 EU/μg (LAL method).
- Supplied in 0.2 μm filtered PBS, pH 7.4.
- Concentration approximately 2.12 mg/mL (batch dependent).
- Stable at -80 °C; aliquot and avoid repeated freeze-thaw cycles.
- For research use only; not for human or clinical applications.
Medchemexpress LLC DLK-1 Human HEK293 50ug | 50ug
The DLK-1 protein has been implicated in neuroendocrine differentiation suggesting a role in the complex processes that control neuroendocrine cell development and specialization As a monomer the single molecular form of DLK-1 helps carry out its biological activity DLK-1 Protein Human (HEK293 His) is the recombinant human-derived DLK-1 protein expressed by HEK293 with C-His labeled tag
Cayman Chemical ANTIBODY MK-7655 25mg
A β-lactamase inhibitor; inhibits hydrolysis of nitrocefin by KPC-2 β-lactamase from K. pneumoniae and AmpC β-lactamase from P. aeruginosa (IC50s = 210 and 465 nM, respectively); restores imipenem sensitivity to resistant clinical isolates of P. aeruginosa and K. pneumoniae (MIC50s = 0.25-2 and 8-16 μM in the presence and absence of MK-7655, respectively); produces a bacteriostatic effect in mouse thigh models of K. pneumoniae and P. aeruginosa infection when administered with imipenem and cilastatin (48.9 mg/kg per day)
Cayman Chemical ANTIBODY BRD3308 10mg
An HDAC3 inhibitor (Ki = 29 µM); selective for HDAC3 over HDAC1 and HDAC2 (Kis = 6,300 and 5,100 nM, respectively; reduces cytokine-induced increases in apoptosis in rat INS-1E β cells at 10 µM; reduces plasma glucose levels in rats and increases plasma insulin levels in a rat model of type 2 diabetes at 5 mg/kg
Cayman Chemical ANTIBODY PF-998425 10mg
A non-steroidal androgen receptor antagonist (IC50 = 43 nM in a cell-based assay); binds to the androgen receptor (IC50 = 37 nM in a radioligand binding assay); selective for the androgen receptor over the progesterone receptor (IC50 = >10,000 nM); topical administration increases hair growth in a mouse model of hair growth at 3% twice per day, as well as reduces EAr sebum in male Syrian golden hamsters (ED50 = 0.4% twice per day)
AdipoGen 3-Morpholinobenzanthrone (1 mg)
Chemical. CAS: 299927-47-2. Formula: C21H17NO2. MW: 315.37. Synthetic. 3-Morpholinobenzanthrone is a photostable, long-wave-length fluorescent membrane probe. This dye is excellent to be used in diagnostic applications involving the study of cell membranes such as those of immune competent lymphocytes. It is not toxic to the cell, but is sensitive to changes in the membrane structure. Spectral data: lambdaex 483nm; lambdaem 653nm (in MeOH). Has been used to characterize changes in the structural and functional properties of cell membranes and consequently the detection of immune state in patients with different pathologies.
TARGETMOL CHEMICALS INC GALOCITABINE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Galocitabine (Neofrutulon) a thymidylate synthase inhibitor is used potentially for the treatment of cancer. purity: 99%
Cayman Chemical ANTIBODY4-HDHA 25ug
An autoxidation product of DHA in vitro that can also be produced from incubation of DHA with rat liver, brain, and intestinal microsomes and enzymatic transformation of DHA by RBL-1 cells; is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA
Medchemexpress LLC VHL protein, human (His) | >90.0% | 5 UG
Recombinant human von Hippel-Lindau (VHL) protein with an N-terminal His tag, expressed in Escherichia coli and supplied lyophilized for biochemical and assay applications. The product spans amino acids M1-D213 (≈34 kDa) and is provided at high purity for binding studies, structural analysis, and assay development.
- source organism: human
- expression system: E. coli
- tag: N-6xHis
- sequence range: M1-D213
- molecular weight: ≈34 kDa
- purity: >90% by reducing SDS-PAGE
- formulation: lyophilized with 6% trehalose in Tris-HCl or PBS
- reconstitution: do not reconstitute below 100 μg/mL
- storage: store at -20°C; aliquot and store at -80°C for long term
- available size: includes 5 μg
STEMCELL Technologies IWP-3, Size: 10 mg
Inhibitor of WNT Production-3 (IWP-3) inhibits WNT signaling by inactivating Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating WNT proteins, which is essential for WNT signaling ability and secretion (Chen et al.). IWP-3 impairs WNT pathway activity in vitro with an IC₅₀ value of 40 nM (Chen et al.). DIFFERENTIATION· Promotes cardiomyocyte differentiation from human embryonic stem cells that have been induced to mesoderm by addition of BMP4 and Activin A (Willems et al.).
Cayman Chemical ANTIBODY 306-O12B-3 10mg
An ionizable cationic lipidoid; has been used in the generation of LNPs for the delivery of ASOs; intravenous administration of LNPs containing 306-O12B-3 localize to mouse liver; LNPs containing 306-O12B-3 in combination with other lipids encapsulating PCSK9-targeting ASOs decrease hepatic PCSK9 expression in mice; intravenous administration of LNPs containing 306-O12B-3 and NT1-O14B encapsulating ASOs against tau decreases tau expression and levels in mouse brain
Cayman Chemical ABFUBINACA 2Indazole Isome 5mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
Cayman Chemical Moexprlat 5mg
An ACE inhibitor and active metabolite of the prodrug moexipril (IC50 = 2.1 nM); prevents the estrone- or angiotensin II-stimulated proliferation of primary neonatal rat cardiac fibroblasts at 10 nM; reduces mean arterial blood pressure and increases the levels of atrial natriuretic peptide in ovariectomized mice at 50 mg/kg per day