Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,436 – 6,450 of 60,541 results

6,436

Selleck Chemical LLC Biotin-azide E7114-5MG

Biotin-azide (N-(3-Azidopropyl)biotinamide) is a form of biotin with a terminal azide group Biotin-azide can be used to prepare various biotinylated conjugates via Click Chemistry Biotin-azide is a click chemistry reagent it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups

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6,437

Cayman Chemical GMQ (hydrochloride), Purity: ≥95%, CAS: 5361-15-9, 5 mg

An ASIC3 activator (EC50 = 67 µM for evoking rapid inward currents in ASIC3-expressing CHO cells at neutral pH); an inhibitor of the GABAA receptor (IC50 = 0.39 µM in primary rat hippocampal neurons); increases paw licking time in Asic3+/+ and, to a lesser extent, Asic3-/- mice at 100 µM

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6,438

Cayman Chemical PF-04995274, Purity: ≥98%, CAS: 1331782-27-4, 10 mg

A partial agonist of the 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay); increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors); decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats at 0.032 mg/kg

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6,439

Cayman Chemical DG-051, Purity: ≥98%, CAS: 929915-58-2, 1 mg

A potent LTA4H inhibitor (Kd = 25 nM; IC50 = 47 nM); also inhibits the aminopeptidase activity of LTA4H (IC50s = 72 -150 nM); does not show inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG

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6,440

TARGETMOL CHEMICALS INC BAY 11-7082 50MG

Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BAY 11-7082 a NF-(kappa)B inhibitor inhibits TNF(alpha)-induced I(kappa)B(alpha) phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21. purity: 99%

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6,441

Apexbio Technology LLC HSP990 (NVP-HSP990) 934343-74-5 25mg

HSP990 (NVP-HSP990 CAS 934343-74-5) is a small molecule inhibitor targeting heat shock protein 90 (HSP90) specifically binding the N-terminal ATP-binding domain of Hsp90 Hsp90 and Grp94 with IC50 values of 0 6 0 8 and 8 5 nM respectively HSP990 inhibits TRAP1 ATPase activity (IC50 320 nM) and destabilizes the Hsp90-p23 complex in GTL-16 cells in a concentration- and time-dependent manner The compound reduces c-Met levels induces Hsp70 (EC50 37 nM and 20 nM respectively) and inhibits phosphorylation of ERK and AKT (EC50 11 and 6 nM) leading to suppression of cell proliferation in multiple tumor cell lines (GI50 4 40 nM) In vivo HSP990 has demonstrated antitumor activity in murine gastric cancer models

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6,442

Medchemexpress LLC Lasalocid | 25999-31-9 | ≥98.0% | 25 MG

Lasalocid (Lasalocid-A) is an antibacterial and anticoccidial agent used as a feed additive. It also exhibits antitumor activity and is orally active.

Antibacterial agent
Anticoccidial agent
Can be used as feed additives
Exhibits antitumor activity
Orally active

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6,443

Cayman Chemical KDU691, Purity: ≥98%, CAS: 1513879-19-0, 10 mg

An antimalarial compound; inhibits the activity of recombinant P. vivax PI4K (IC50 = 1.5 nM); selective for P. vivax PI4K over recombinant human PI4KβIII and PI3Kα, -β, -ɣ, and -δ (IC50s = 7.9, 8.8, 2.4, 8, and 3.4 µM, respectively), as well as VPS34 (IC50 = >9.7 µM) and 36 additional kinases in a panel of lipid and protein kinases (IC50s = >10 µM); active against P. falciparum and P. yoelii schizonts (IC50s = 0.06 and 0.04 µM, respectively), as well as P. cynomolgi schizonts and hypnozoites (IC50s = 0.11 and 0.2 µM, respectively); completely prevents, but does not eradicate established, P. cynomolgi infection in rhesus monkeys at 20 mg/kg

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6,444

Medchemexpress LLC HY-101131 5mg Medchemexpress, Dansyl glutathione CAS:75017-02-6 Purity:>98%

Medchemexpress, HY-101131 5mg Dansyl glutathione CAS:75017-02-6 Dansyl glutathione is a trapping agent for the quantitative estimation and identification of reactive metabolites. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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6,445

Cayman Chemical CYM 5478, Purity: ≥98%, CAS: 870762-83-7, 1 mg

An S1P2 agonist (EC50 = 0.78 μM in a reporter assay); selective for S1P2 over S1P1 and S1P3-5 in a TGFα-shedding assay (EC50s = 119, 1,690, 1,950, >10,000, and >10,000 nM, respectively); reduces serum starvation-induced decreases in C6 rat glioma cell viability from 0.1-10 μM; reduces cisplatin-induced accumulation of ROS and apoptosis in C6 cells at 10 μM

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6,446

TARGETMOL CHEMICALS INC CPI203 25MG

Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50 37 nM for BRD4). purity: 99%

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6,447

Cayman Chemical Roslin-2, Purity: ≥98%, CAS: 29574-21-8, 1 mg

A reactivator of p53; impairs the interaction between FAK and p53 and restores p53 transcriptional activity at 111, 333, and 1000 µM; reverses FAK-mediated suppression of the expression of p53-dependent p21, MDM2, and Bax in wild-type p53 HCT116 colon and MCF-7 breast cancer cells, but not in p53 mutant SW620 colon cancer cells at 1-50 µM; potentiates the pro-apoptotic effect of doxorubicin and 5-fluorouracil in p53+/+, but not p53-/-, HCT116 cells at 10 µM; reduces tumor growth and activates p21 in p53+/+, but not p53-/- tumors, in HCT116 mouse xenograft models at 60 mg/kg

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6,448

Medchemexpress LLC PDE9-in-1 | 2305087-92-5 | 99.7% | 362.40 g·mol^-1 | C17H23FN6O2 | 25MG

PDE9-IN-1 is a potent, selective, and orally bioavailable inhibitor of phosphodiesterase-9A (PDE9A) with an IC50 of 8.7 nM. It is provided as a high-purity research chemical intended for biochemical and cellular assays, and for preclinical pharmacology studies investigating cGMP signaling and PDE9A-related pathways. Supporting documentation such as a datasheet, certificate of analysis, and safety data sheet are available from the manufacturer.

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6,449

Medchemexpress LLC HY-122727 5mg Medchemexpress, STL127705 CAS:1326852-06-5 Purity:>98%

Medchemexpress, HY-122727 5mg STL127705 CAS:1326852-06-5 STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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6,450

Cayman Chemical Dofequidar, Purity: ≥98%, CAS: 129716-58-1, 1 mg

A quinoline derivative and inhibitor of multidrug resistance; inhibits P-glycoprotein in a photolabeling assay at 100 μM; increases intracellular accumulation of [3H]-vincristine in HL-60R cells endogenously expressing the gene encoding MRP at 10 μM; restores susceptibility to vincristine- or doxorubicin-induced cytotoxicity in vincristine-resistant P388, vincristine-resistant K562, and doxorubicin-resistant K562 cells; increases survival in a vincristine-resistant P388 murine leukemia model compared with untreated controls at 80 mg/kg twice per day when administered in combination with vincristine

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Bioactive Small Molecules

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Medchemexpress LLC Lasalocid | 25999-31-9 | ≥98.0% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-101131 5mg Medchemexpress, Dansyl glutathione CAS:75017-02-6 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PDE9-in-1 | 2305087-92-5 | 99.7% | 362.40 g·mol^-1 | C17H23FN6O2 | 25MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-122727 5mg Medchemexpress, STL127705 CAS:1326852-06-5 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Lasalocid | 25999-31-9 | ≥98.0% | 25 MG

Medchemexpress LLC HY-101131 5mg Medchemexpress, Dansyl glutathione CAS:75017-02-6 Purity:>98%

Medchemexpress LLC PDE9-in-1 | 2305087-92-5 | 99.7% | 362.40 g·mol^-1 | C17H23FN6O2 | 25MG

Medchemexpress LLC HY-122727 5mg Medchemexpress, STL127705 CAS:1326852-06-5 Purity:>98%