Bioactive Small Molecules
Cayman Chemical ANTIBODY BAMEA-O16B 5mg
An ionizable cationic lipid; has been used in the generation of LNPs for the delivery of CRISPR complementary sgRNA and Cas9 mRNA for genome editing in vitro and in vivo; LNPs containing BAMEA-O16B encapsulating Cas9 mRNA and sgRNAs targeting PCSK9 accumulate in the liver and decrease serum PCSK9 levels in mice
Cayman Chemical ANTIBODY AZ 3146 25mg
A selective Mps1 inhibitor (IC50 = 35 nM); inhibits the recruitment of Mad1, Mad2, and CENP-E to kinetochores
Medchemexpress LLC Rage antagonist peptide TFA | 1092460-91-7 | 99.41% | 1386.58 | 25 MG
RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. It prevents RAGE from binding with several of its key ligands, including HMGB-1, S100P, and S100A4. This product has demonstrated anti-tumor and anti-inflammatory activities.
- Functions as an advanced glycation end products (RAGE) antagonist
- Prevents RAGE from binding with key ligands (HMGB-1, S100P, S100A4)
- Demonstrates anti-tumor activities
- Demonstrates anti-inflammatory activities
Selleck Chemical LLC Eleutherol E8270-5MG
Eleutherol (Allium A) is a naphthalene extracted from the bulb of E americana and a potent inhibitor of -glucosidase with an IC50 of 1 00 M It also exhibits significant antifungal activity with MIC values between 7 8 g/mL and 250 g/mL It can be used in research on antimicrobial infections and diabetes treatment
Medchemexpress LLC HY-13064 100mg , Cobimetinib CAS:934660-93-2 Purity:>98%
HY-13064 100mg Cobimetinib CAS: 934660-93-2 Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK1 inhibitor with an IC50 of 4.2 nM for MEK1. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY RheIn 100mg
An anthraquinone derivative; induces cell cycle arrest at the S phase and inhibits the proliferation of HepG2 cells at 40 and 100 µM, respectively; inhibits proliferation of MCF-7 and MDA-MB-435s breast cancer cells under normoxic and hypoxic conditions at 100 and 200 µM; reduces controlled cortical impact-induced decreases in catalase and SOD activity and MDA, glutathione, and glutathione disulfide levels in the brain in a rat model of traumatic brain injury at 12 mg/kg; reduces cerulein-induced increases in serum TNF-α, IL-1β, and amylase levels, as well as reduces pancreatic glandular atrophy and fibrosis, in a mouse model of chronic pancreatitis at 50 mg/kg per day
Selleck Chemical LLC L-Sulforaphane E4007-25MG
L-Sulforaphane ((R)-Sulforaphane) is a highly potent inducer of the Keap1/Nrf2/ARE pathway It is a more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer
Cayman Chemical ANTIBODY PRN-1371 10mg
An irreversible pan-FGFR inhibitor (IC50s = 0.7, 1.3, 4.4, and 19.3 nM for FGFR-1, -2, -3, and -4, respectively); selective for FGFR over VEGFR2 (IC50 = 705 nM) and a panel of 250 kinases (IC50s = >1 µM for all) but does inhibit CSF1R activity by >90% at 1 µM; inhibits proliferation in a panel of ten cancer cell lines containing various FGFR mutants (IC50s = 2-231 nM) and induces apoptosis in SNU-16 gastric and RT4 bladder cancer cells (EC50s = 15.9 and 11.8 nM, respectively); reduces tumor growth in an SNU-16 mouse xenograft model and a PDX mouse model of liver cancer at 15 mg/kg twice per day
Cayman Chemical ANTIBODY CK-636 25mg
A cell-permeable inhibitor of Arp2/3 complex action that inhibits actin polymerization in vitro, using human, bovine and fission yeast proteins (IC50s = 4, 32, and 24 µM, respectively); prevents the formation of actin filament comet tails by Listeria in infected SKOV3 cells (IC50 = 22 µM)
Cayman Chemical ANTIBODY CyprodInIl 100mg
An anilinopyrimidine fungicide; inhibits the biosynthesis of methionine in phytopathogenic fungi; inhibits mycelial cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media (IC50s = 0.44, 4.8, and 0.03 µM, respectively); an estrogen receptor agonist (EC20 = 1.91 µM); inhibits the androgenic effect of DHT (IC20 = 15.1 µM); increases proliferation of estrogen receptor-expressing BG-1 ovarian cancer cells at low micromolar concentrations in combination with 17β-estradiol; increases tumor mass in a BG-1 ovariectomized mouse xenograft model after 70 days at 3 mg/kg every three days
Medchemexpress LLC Lyso-PAF C-18 | 74430-89-0 | MFCD00065889 | 98.0% | 509.70 g·mol⁻¹ | C26H56NO6P | 5 MG
Lyso-PAF C-18 is a research intermediate used for the synthesis of C18-PAF and related platelet-activating factor derivatives. It is supplied as a purified lipid for organic synthesis and biological research and is intended for research use only.
- High purity (98.0%) for consistent experimental results.
- Molecular formula C26H56NO6P; molecular weight 509.70 g·mol⁻¹.
- Available in small laboratory quantities suitable for synthesis and screening.
- Powder stable at -20°C for long-term storage; in solvent stability limited over shorter periods.
- Certificate of analysis and safety data sheet available to support use.
- Useful intermediate for preparation of platelet-activating factor analogs.
Cayman Chemical C17 SphngomyelInd18 117 0 5mg
A synthetic derivative of sphingomyelin; has been used as an internal standard for the quantification of sphingomyelin
Cayman Chemical ANTIBODY MS023 10mg
An inhibitor of type I PRMTs (IC50s = 30, 119, 83, 4, and 5 nM for PRMT1, -3, -4, -6, and -8, respectively); selective for these type I PRMTs over PRMT5, -7, and -9, as well as a panel of 25 PKMTs and DNMTs at 10 µM; inhibits methylation of H4R3 in MCF-7 cells and H3R2 in HEK293 cells (IC50s = 9 and 56 nM, respectively); inhibits methylation of the SARS-CoV-2 nucleocapsid protein and the replication of SARS-CoV-2 in Vero E6 cells at 20 µM; reduces tumor growth in a Huh7 mouse xenograft model at 160 mg/kg
Medchemexpress LLC HY-131318 100mg Medchemexpress, Lenalidomide-I CAS:2207541-30-6 Purity:>98%
Medchemexpress, HY-131318 100mg Lenalidomide-I CAS:2207541-30-6 Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 (HY-112609). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC (S,R,S)-AHPC-C10-NH2 dihydrochloride | 2341796-75-4 | 96.7% | 686.78 g·mol⁻¹ | C33H53Cl2N5O4S | 5 MG
(S,R,S)-AHPC-C10-NH2 dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates a VHL ligand and a ten-carbon alkyl linker for use in PROTAC synthesis and chemical biology applications. It is supplied as the dihydrochloride salt and is characterized by formula C33H53Cl2N5O4S and a molecular weight of 686.78 g·mol⁻¹.
- Designed as an E3 ligase ligand-linker conjugate for PROTAC development.
- Provides a ten-carbon alkyl linker terminating in a primary amine for conjugation.
- Supplied as a dihydrochloride salt for improved stability and handling.
- Available in small research quantities suitable for assay development.
- Characterized with specified purity for chemical biology use.