Bioactive Small Molecules
Medchemexpress LLC Icg-amine | 1686147-55-6 | 98.3% | C51H64N4O4S | 10MG
ICG-amine is a near-infrared fluorescent probe derived from indocyanine green that binds to amino acid residues without the need for condensing agents. It is intended for fluorescence labeling and imaging applications that require NIR properties and includes recommended solubility and storage instructions for research use.
- Provides near-infrared fluorescence useful for deep-tissue imaging.
- Binds to amino acid residues without requiring condensing agents.
- Reported high purity supports research-grade applications.
- Soluble in DMSO and water with sonication or gentle heating as needed.
- Powder form stable at -20°C with extended shelf life when stored appropriately.
Cayman Chemical STING Agonist 12L, Purity: ≥98%, CAS: 2913152-30-2, 5 mg
A STING agonist; binds to wild-type STING (IC50 = 1.15 µM), as well as the STING R232H, AQ, and Q variants (IC50s = 1.06, 0.61, and 1.12 µM, respectively); induces reporter gene expression in THP-1 and RAW 264.7 cells (EC50s = 0.38 and 12.94 µM, respectively); induces IFNB1, CXCL10, and IL6 mRNA expression in THP-1 cells at 5 µM; increases plasma IFN-β levels and reduces tumor volume and the number of lung metastases in a B16/F10 murine melanoma model at 10 mg/kg
Cayman Chemical PF-06928215, Purity: ≥98%, CAS: 2378173-15-8, 1 mg
A cGAS inhibitor (IC50 = 4.9 µM in a fluorescence polarization assay)
Medchemexpress LLC HY-136922 5mg Medchemexpress, Orexin receptor antagonist 2 CAS:1457940-75-8 Purity:>98%
Medchemexpress, HY-136922 5mg Orexin receptor antagonist 2 CAS:1457940-75-8 Orexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pKis of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical Minoxidil Sulfate, Purity: ≥85%, CAS: 83701-22-8, 5 mg
A hair follicle stimulator and an active metabolite of minoxidil; binds to KATP channels in a biphasic manner in COS-7 cells expressing the human channel (IC50s = 0.62 and 0.96 µM); induces vasodilation in isolated rabbit mesenteric artery at 5 µM
TARGETMOL CHEMICALS INC 5-HT4 ANTAGONIST 1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. 5-HT4 antagonist 1 is an antagonist of 5-HT4 (pKi = 9.6). purity: 99%
Medchemexpress LLC HY-D0020 100mg Medchemexpress, 2,2'-Bipyridine CAS:366-18-7 Purity:>98%
Medchemexpress, HY-D0020 100mg 2,2'-Bipyridine CAS:366-18-7 2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products represented by caerulomycins (CAEs) and collismycins (COLs). 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![Medchemexpress LLC (2R)-1,1,1-trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonyl | 1361217-07-3 | >98.0% | 533.63 g·mol⁻1 | C23H30F3N3O4S2 | 50MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000239276.png-250.jpg)
Medchemexpress LLC (2R)-1,1,1-trifluoro-2-[4-[(2S)-2-[[(3S)-3-methylmorpholin-4-yl]methyl]-4-thiophen-2-ylsulfonyl | 1361217-07-3 | >98.0% | 533.63 g·mol⁻1 | C23H30F3N3O4S2 | 50MG
AMG-1694 is a potent small-molecule disruptor of the glucokinase-glucokinase regulatory protein (GK-GKRP) interaction. It promotes dissociation of the GK-GKRP complex and has been reported to normalize blood glucose in preclinical rodent models. Supplied as a powder, it is intended for research use in studies of glucokinase regulation and glucose metabolism.
- Disrupts GK-GKRP interaction to enhance glucokinase activity.
- Reported to normalize blood glucose in preclinical rodent models.
- Potent activity with reported low-nanomolar potency.
- Chemical identifiers: CAS 1361217-07-3; formula C23H30F3N3O4S2; molecular weight 533.63 g·mol⁻1.
- Purity greater than 98.0% as listed in the supplier catalog.
- Supplied as a powder with recommended cold storage for stability.
eMolecules 1370544-73-2 | AX-024 hydrochloride | Axon Medchem | 375.87 | C21H23ClFNO2 | 99 | Cl.COc1ccc2OCC(CN3CCCC3)=C(c3ccc(F)cc3)c2c1 | 25mg | 350777316
Pharmablock | tert-butyl N-(7-hydroxyheptyl)carbamate | 25mg | 731744387 | PBT4278 | 173436-02-7 | MFCD02094527 | 231.336 | C12H25NO3
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Medchemexpress LLC Khellin | 82-02-0 | 99.7% | 5 MG
Khellin is a furochromone isolated from *Ammi visnuga L.* It acts as an EGFR inhibitor with an IC50 of 0.15 μM and exhibits anti-proliferative activity *in vitro*. Additionally, Khellin possesses antispasmodic and coronary vasodilator effects.
- Acts as an EGFR inhibitor
- Exhibits anti-proliferative activity in vitro
- Possesses antispasmodic effects
- Shows coronary vasodilator effects
Cayman Chemical ML-298, Purity: ≥98%, CAS: 1426916-02-0, 5 mg
A selective inhibitor of PLD2 (IC50 = 355 nM); decreases invasive migration of U87-MG cells when used at a concentration of 10 µM
Cayman Chemical AB-928, Purity: ≥98%, CAS: 2239273-34-6, 50 mg
An adenosine A2A and A2B receptor dual antagonist; inhibits the ability of adenosine to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro; reduces tumor growth in an AT3-OVA syngeneic mouse model alone or in combination with doxorubicin; acts synergistically with an anti-PD-1 antibody to reduce tumor growth in a B16/F10 syngeneic mouse model
Medchemexpress LLC HY-112052 50mg Medchemexpress, Aminomalonic acid CAS:1068-84-4 Purity:>98%
Medchemexpress, HY-112052 50mg Aminomalonic acid CAS:1068-84-4 Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (Ki= 0.0023 M) and mouse pancreas (Ki= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis[3]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical C25-140, Purity: ≥98%, CAS: 1358099-18-9, 10 mg
An inhibitor of the TRAF6-Ubc13 protein-protein interaction (IC50 = 2.6 µM); selectively inhibits the TRAF6-Ubc13 interaction over the interactions between Ubc13- OTUB1 and Ubc13-Uev1a; selectively inhibits TRAF6-dependent ubiquitination over a panel of various E3 ligase/E2 enzymes, but does inhibit cIAP1 and E1/E2 enzymes in cell-free assays at 30 µM; reduces IL-1β-induced activation of NF-κB in MEFs at 50 µM; topical application reduces scaling and erythema in a mouse model of imiquimod-induced psoriasis; decreases disease severity in a mouse model of collagen-induced arthritis from 6-14 mg/kg twice per day; reduces alveolar septal thickening, pulmonary edema, and inflammatory cell infiltration in BALF in a mouse model of lung injury induced by mechanical ventilation with high tidal volumes
Apexbio Technology LLC Rosiglitazone HCl 302543-62-0 25mg
Rosiglitazone HCl (CAS 302543-62-0) is a small-molecule agonist targeting peroxisome proliferator-activated receptor gamma (PPAR ) It is designed to selectively activate PPAR thereby modulating gene transcription involved in glucose metabolism adipogenesis and insulin sensitivity Rosiglitazone HCl exerts its biological activity primarily through activation of PPAR receptors expressed in adipocytes Based on these pharmacological properties Rosiglitazone HCl holds research potential in diabetes mellitus metabolic syndrome obesity and associated metabolic disorders