Bioactive Small Molecules
![Medchemexpress LLC (βS)-β-amino-4-[(3,4-dichlorophenyl)methoxy]-β-methyl-benzenebutanol | 2748196-63-4 | 97.0% | 354.27 g/mol | C18H21Cl2NO2 | 25MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000236451.png-250.jpg)
Medchemexpress LLC (βS)-β-amino-4-[(3,4-dichlorophenyl)methoxy]-β-methyl-benzenebutanol | 2748196-63-4 | 97.0% | 354.27 g/mol | C18H21Cl2NO2 | 25MG
P053 is a potent, selective, non-competitive inhibitor of ceramide synthase 1 (CerS1) (IC50 ≈ 0.5 μM), intended for use as a research reagent to study CerS1 function, mitochondrial fatty-acid oxidation in muscle, and adiposity regulation. For research use only.
- Potent CerS1 inhibition with IC50 ≈ 0.5 μM.
- Selective for CerS1 over other ceramide synthase isoforms.
- High purity (97.0%) suitable for biochemical assays.
- Available in small milligram pack sizes for research flexibility.
- Suitable for biochemical and cellular studies of lipid metabolism.
Cayman Chemical ANTIBODY BB-Cl-Yn 1mg
A cell-permeable derivative of BB-Cl-amidine that contains an alkyne moiety for use in click chemistry reactions; inhibits PAD1-4 (kinact/KI values of 6,400, 3,600, 10,800, and 4,900 M-1min-1, respectively); has been used for labeling PADs in cell-free and cell-based assays, followed by click reactions with azide-modified TAMRA reporters or biotin capture reagents.
Medchemexpress LLC BMS-986238 | 2919596-13-5 | 99.9% | 2979.52 | 5 MG
BMS-986238 is an orally active macrocyclic peptide PD-L1 inhibitor. It can be used in the research of tumors such as solid tumors and lymphomas. PD-L1 is a key immune checkpoint protein that primarily regulates immune responses by inhibiting T-cell activity, serving as a core target for tumor immune escape and immunotherapy.
- Orally active macrocyclic peptide PD-L1 inhibitor.
- Applicable in the research of tumors including solid tumors and lymphomas.
- Targets PD-L1, a key immune checkpoint protein, to inhibit T-cell activity.
Cayman Chemical DIhydroartemIsInIc AcId 5mg
A biosynthetic precursor to artemisinin; an intermediate in the synthesis of artemisinin from artemisinic acid
Cayman Chemical ANTIBODY TafamIdIs 25mg
A TTR kinetic stabilizer; binds to TTR with negative cooperativity (Kd1 = 3 nM; Kd2 = 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dissociation; stabilizes wild-type and clinically significant V30M and V122I mutant TTR amyloidogenic homotetramers (EC50s = 2.7-3.2 μM) under fibril-promoting, denaturing, and physiological conditions in vitro; stabilizes TTR heterotetramers containing wild-type and mutant subunits ex vivo in human plasma derived from patients carrying V30M or V1221 mutations when used at a concentration of 7.2 μM
![Medchemexpress LLC N-[4-[[8-[(3S)-3,4-dimethyl-1-piperazinyl]-1,5-dihydro-7-methyl-5-oxo-2H-benzopyrano[3,4-c]pyridin-3 | 2227149-22-4 | 99.9% | C28H31F3N4O6S | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259769.png-250.jpg)
Medchemexpress LLC N-[4-[[8-[(3S)-3,4-dimethyl-1-piperazinyl]-1,5-dihydro-7-methyl-5-oxo-2H-benzopyrano[3,4-c]pyridin-3 | 2227149-22-4 | 99.9% | C28H31F3N4O6S | 10MG
DS18561882 is a potent, selective small-molecule inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) used as a biochemical and cellular probe to study mitochondrial one-carbon metabolism. It shows low-nanomolar potency and selectivity, and is supplied as a characterized compound for in vitro and in vivo research applications.
- Low-nanomolar potency against MTHFD2 (IC50 0.0063 μM).
- Selective over MTHFD1 (IC50 0.57 μM), supporting target discrimination.
- Suitable for biochemical and cellular assays as a research probe.
- Characterized with analytical data and high purity for reproducible results.
- Available in multiple pack sizes and formats for experimental flexibility.
Cayman Chemical ANTIBODY IXA4 10mg
An activator of IRE1; induces the expression of the Ire1 target Xpb1s in primary mouse hepatocytes; decreases hepatic expression of the Xbp1 target gene Dnajb9 in wild-type mice and a mouse model of high-fat diet-induced obesity at 50 mg/kg; increases glucose tolerance and suppresses hepatic gluconeogenesis and steatosis in a mouse model of high-fat diet-induced obesity
Medchemexpress LLC 4-ibp | 155798-08-6 | 98.9% | 420.29 g/mol | C19H21IN2O | 10 MG
4-IBP is a selective σ1 receptor agonist with high affinity (Ki ≈ 1.7 nM) and moderate σ2 affinity. It is used as a research reagent in studies of sigma receptor biology and cancer models, where it has been reported to reduce cell migration and sensitize cells to pro-apoptotic agents. Supplied as a high-purity solid and as a DMSO solution for in vitro research.
- Selective σ1 receptor agonist (Ki ≈ 1.7 nM).
- Moderate affinity for σ2 receptor.
- Reported to reduce cancer cell migration and sensitize cells to apoptotic agents.
- High purity suitable for research use.
- Available as powder and DMSO solution for in vitro studies.
- Stable under recommended storage conditions for laboratory reagents.
Medchemexpress LLC Izuforant | 1429374-83-3 | C12H12BrN7 | 10MG
Izuforant is a small-molecule research compound that acts as a selective histamine H4 receptor antagonist. It is orally active and has demonstrated potent activity versus human H4R (IC50 = 36 nM), with reported anti-pruritic and anti-inflammatory effects; the compound also shows weaker binding to the 5-HT3 receptor (IC50 ≈ 9.1 μM). Izuforant is provided as a research standard for laboratory and preclinical studies.
- Potent H4R antagonist activity (IC50 = 36 nM).
- Demonstrates anti-pruritic and anti-inflammatory effects.
- Orally active small-molecule suitable for in vivo studies.
- Secondary 5-HT3 receptor binding at micromolar potency.
- Molecular formula C12H12BrN7; molecular weight 334.17.
- Supplied as a high-purity research standard for laboratory use.
Cayman Chemical ANTIBODY CALX8 250mg
A calixarene detergent; has been used to solubilize membrane proteins; CMC = 2.2 mM
Cayman Chemical ANTIBODY CIM0216 1mg
A TRMP5 activator; induces inward and outward rectifying currents in TRPM3-expressing HEK293 cells voltage-clamped at ±80 mV at 1 µM; selective for TRMP3 over TRPM1, TRPM4, TRPM6, and TRMP7 in HEK293 cells expressing the human channels, but does activate TRPA1 by 15% in CHO cells expressing mouse TRPA1 at 10 µM; inhibits ADP-ribose-induced TRPM2, calcium-induced TRMP5, and methanol-induced TRPM8 activation by 17, 34, and 61%, respectively, in HEK293 cells expressing the human channels at 10 µM; stimulates insulin and CGRP release in isolated mouse pancreatic islets and skin nerve terminals, respectively, from 5-100 µM; induces activation of AP-1, c-Jun, and c-fos in HEK293 cell reporter assays at 20 µM
Medchemexpress LLC SVMP Crotalus adama 10ug
Recombinant snake venom metalloproteinase (SVMP) derived from Crotalus adamanteus, supplied lyophilized with an N-terminal 6xHis tag. Expressed in Escherichia coli and provided in small research quantities, the protein is suitable for biochemical assays investigating metalloproteinase activity and serpin interactions; molecular sequence and storage recommendations are supplied by the manufacturer.
- Recombinant protein expressed in E. coli with an N-terminal 6xHis tag.
- Purity greater than 90% by reducing SDS-PAGE.
- Lyophilized formulation from 10 mM Tris-HCl, 1 mM EDTA, 6% trehalose, pH 8.0.
- Molecular weight approximately 27.1 kDa.
- Sequence provided for verification and experimental design.
- Store at -20°C; after reconstitution, stable at 4°C for one week or frozen for long-term storage.
- Supplied in small research sizes suitable for biochemical assays and interaction studies.
AdipoGen PyTC2
Chemical. CAS 3224-36-0. Formula C19H9Cl2N3. MW 350.2. Synthetic. Fluorescent probe with high quantum efficiency, exhibiting single exponential decay kinetics. The radiative fluorescence lifetime is almost constant and independent on molecular surroundings allowing this probe to be utilized in a range of microsurroundings with exciting radiation at a constant wavelength in the blue spectral range. Its fluorescence emission demonstrates a large solvatochromic shift which changes with solvent polarity. For example, the maximum shifts from 435 nm in low polarity n-heptane to 492 nm in high polarity acetonitrile. This product is only sparingly soluble in water
Medchemexpress LLC PD 407824 | 622864-54-4 | 99.0% | 328.32 | 5 MG
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. It is also a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4.
- Inhibits Chk1 with an IC50 of 47 nM.
- Inhibits WEE1 with an IC50 of 97 nM.
- Blocks CHK1, leading to down-regulation of p21, activation of CDK8/9, and subsequent depletion of SMAD2/3.
- Selective for Chk1 and WEE1 over PKC and Cdk4.