Bioactive Small Molecules
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Filtered Search Results
Medchemexpress LLC Z-D-DAB BOC -OH DIC 500MG
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5000208708 Z-D-DAB BOC -OH DIC 500MG
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Medchemexpress LLC R -2- THIAZOL-2-YL 1G
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5000208959 R -2- THIAZOL-2-YL 1G
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Cayman Chemical AB-BICA, Purity: ≥98%, CAS: 1969264-37-6, 1 mg
A synthetic cannabinoid whose physiological and toxicological properties are not known
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Apexbio Technology LLC Ki8751 228559-41-9 5mg
Ki8751 (CAS 228559-41-9) is a small molecule inhibitor that selectively targets vascular endothelial growth factor receptor 2 (VEGFR-2) a key mediator of angiogenesis In biochemical assays Ki8751 demonstrates high potency against VEGFR-2 with an IC50 of 0 9 nM and also exhibits inhibitory activity against c-Kit (IC50 40 nM) PDGFR (IC50 67 nM) and FGFR-2 (IC50 170 nM) In human umbilical vein endothelial cells (HUVECs) Ki8751 suppresses cell proliferation in a dose-dependent manner with complete inhibition observed at 1 nM Additionally in metastatic colorectal cancer cell lines Ki8751 induces cellular senescence In vivo it impedes tumor growth in mouse xenograft models of several human cancers This compound is widely used to investigate VEGFR-2-mediated signaling and tumor angiogenesis
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Medchemexpress LLC O-acetyl-L-serine | 5147-00-2 | MFCD00037771 | 98.0% | 147.13 g/mol | C5H9NO4 | 5 G
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O-Acetylserine (O-acetyl-L-serine) is an alpha-amino acid intermediate involved in the biosynthesis of cysteine in bacteria and plants. Supplied for research and analytical use, it is used in metabolic pathway studies, enzymology, and as an analytical reference. The substance is a crystalline solid with defined storage recommendations for long-term stability.
- Intermediate in cysteine biosynthesis.
- Suitable as an analytical and research standard.
- Molecular weight 147.13 g/mol.
- Chemical formula C5H9NO4.
- Typical purity 98.0%.
- Available in laboratory solid pack sizes, including 5 g.
- Store powder at -20°C for long-term stability.
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AdipoGen 7-DCCA ethyl ester
Chemical. CAS 28705-46-6. Formula C16H19NO4. MW 289.3. Synthetic. Intermediate for the preparation of fluroescent reagents. Laser and scintillation dye. Fluoride chemosensor. Spectral properties lambdaex=418nm lambdaem=461nm, in ethanol. Inhibitor of human monoamine oxidase B hMAO-B.
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BIOGEMS INTERNATIONAL INC IBMX 100mg
IBMX is a general inhibitor of cyclic nucleotide phosphodiesterases, increasing the level of intracellular cAMP. It is used to increase cell differentiation, decrease proliferation, and induce apoptosis. IBMX is reported to inhibit TNF-alpha, reduce inflammation, and activate PKA.
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Cayman Chemical Paquinimod, Purity: ≥98%, CAS: 248282-01-1, 10 mg
An immunomodulator; reduces splenic counts of Ly6ChiCD115+ inflammatory monocytes and CD11b+CD11c+ dendritic cells in a mouse model of EAE; reduces hepatic fibrosis and accumulation of inflammatory monocytes and neutrophils in the N-IF mouse model of liver fibrosis at 25 mg/kg per day; delays disease onset and decreases insulitis in NOD mice; reduces skin thickness, the number of myofibroblasts, and autoantibody production in the tight skin 1 mouse model of systemic sclerosis at 5 and 25 mg/kg
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Medchemexpress LLC Dalidnetug 10mg | 10mg
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Dalidnetug is a humanized monoclonal antibody targeting human amyloid-beta precursor protein (APP) Dalidnetug specifically binds to APP to reduce the production of amyloid-beta (A ) thus exerting the activity of clearing amyloid-beta Dalidnetug is promising for research of Alzheimer s disease[1]
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TARGETMOL CHEMICALS INC WNT PATHWAY INHIBITOR 3 5MG
Also available in 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis. purity: 99%
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Medchemexpress LLC Meropenem-vaborbactam | 2031124-72-6 | 97.9% | 680.60 | 25 MG
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Meropenem-vaborbactam is a Carbapenem antibiotic and boronic acid-based beta-lactamase inhibitor. This fixed-dose combination product shows potent in vitro activity against Enterobacteriaceae, including Klebsiella pneumoniae carbapenemase producers. It also demonstrates activity against Pseudomonas aeruginosa isolates.
- Potently inhibits Enterobacteriaceae isolates.
- Exhibits activity against Pseudomonas aeruginosa isolates.
- Demonstrates potent in vitro activity against 991 KPC-producing Enterobacterales strains.
- Achieves bacteriostasis at an fAUC:MIC ratio of 9 in a murine model.
- Achieves a 1-log10 bacterial kill at an fAUC:MIC ratio of 38 in a murine model.
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Medchemexpress LLC 8-chloro-2-((2,4-dichlorophenyl)amino)-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one | 1361227-90-8 | 99.9% | 468.72 | C20H16Cl3N3O4 | 25MG
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JH-RE-06 is a small-molecule inhibitor that disrupts the REV1-REV7 interface, preventing recruitment of mutagenic POLζ and enhancing tumor cell sensitivity to DNA-damaging agents. It is provided for research use with reported activity data and analytical documentation available.
- Targets the REV1-REV7 interface to disrupt mutagenic translesion synthesis.
- Reported IC50 0.78 μM and Kd 0.42 μM for activity characterization.
- Chemical formula C20H16Cl3N3O4 and molecular weight 468.72 g·mol⁻¹.
- High purity: 99.87% (reported).
- Available in multiple solid sizes including 25 mg and as 10 mM solution in DMSO.
- Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Analytical documentation includes datasheet, COA, SDS, and LCMS.
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Medchemexpress LLC Aceclofenac | 89796-99-6 | 99.8% | 5 G
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Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID) with analgesic and anti-inflammatory properties. It is utilized in research for conditions such as osteoarthritis, ankylosing spondylitis, and rheumatoid arthritis.
- Orally active nonsteroidal anti-inflammatory agent (NSAID)
- Possesses analgesic and anti-inflammatory properties
- Molecular formula: C16H13Cl2NO4
- Molecular weight: 354.18
- Appearance: white to off-white solid
- Soluble in DMSO (100 mg/mL)
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Cayman Chemical PQ-10, Purity: ≥98%, CAS: 927691-21-2, 1 mg
A potent and selective inhibitor of phosphodiesterase type 10 (PDE10; Ki = 4 nM); has >38-fold selectivity for PDE10 over a panel of 60 CNS-associated receptors, enzymes, and ion channels in vitro; increases striatal cGMP and CREB phosphorylation in vivo; reduces scopolamine- and MK-801-induced memory deficits in rats; inhibits tumor cell growth with IC50 values of 0.29 and 0.22 mM for HCT116 and SW480 colon cancer cells, respectively
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Selleck Chemical LLC Apoptosis Compound Library L3300-2X100UL/WELL
A unique collection of 1223 small molecules used for apoptosis research targeting Bcl-2 Caspase p53 TNF-alpha Mdm2 survivin etc
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