Bioactive Small Molecules
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Filtered Search Results
Selleck Chemical LLC Pelabresib CPI-0610-5mg
Pelabresib (CPI-0610) is a potent and selective benzoisoxazoloazepine BET bromodomain inhibitor with an IC50 of 39 nM for BRD4-BD1 in TR-FRET assay and currently undergoing human clinical trials for hematological malignancies. CPI-0610 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.
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Medchemexpress LLC Miglustat hydrochloride | 210110-90-0 | MFCD00269940 | 98.0% | 255.74 g/mol | C10H22ClNO4 | 10 MG
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Miglustat hydrochloride is the hydrochloride salt of miglustat, a reversible ceramide glucosyltransferase inhibitor used as a research standard in studies such as type I Gaucher disease. It is provided as an analytical/research reagent with defined purity and storage instructions.
- Orally active reversible inhibitor of ceramide glucosyltransferase.
- Intended for research and analytical use, including Gaucher disease studies.
- Purity 98.0% as supplied.
- Molecular formula C10H22ClNO4; molecular weight 255.74 g/mol.
- Store at -20°C under nitrogen; in solvent, store at -80°C up to 6 months.
- Pack size 10 MG.
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Cayman Chemical 6-PPD-Q, Purity: ≥95%, CAS: 2754428-18-5, 1 mg
An oxidized transformation product of 6-PPD; has been detected as a contaminant in atmospheric particles, various aquatic sources, including surface water, stormwater, and wastewater, and road dust, among other media; highly toxic to aquatic organisms, including salmon and zebrafish; induces oxidative stress, DNA damage, inflammation, and reproductive dysfunction in a variety of model organisms
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Cayman Chemical C18 Sphingomyelin (d18:1/18:0), Purity: ≥98%, CAS: 54336-69-5, 5 mg
A bioactive sphingolipid; naturally occurring form of sphingomyelin; increased by approximately 35-fold in CCD-112 colon fibroblasts compared with HCT116 human colorectal carcinoma cells; has been used as an internal standard for the quantification of sphingolipid metabolites; a mixture of the D-erythro and L-threo isomers of C18 sphingomyelin
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Medchemexpress LLC Lfhp-1c | 2102347-47-5 | 98.0% | 873.13 | 100 MG
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LFHP-1c is a PGAM5 inhibitor with neuroprotective activity in brain ischemic stroke. It protects blood-brain barrier integrity from ischemia-induced injury. LFHP-1c binds to endothelial PGAM5 to inhibit the activity of PGAM5 phosphatase and its interaction with NRF2. It exhibits in vitro and in vivo protection.
- PGAM5 inhibitor
- Offers neuroprotective activity in brain ischemic stroke
- Protects blood-brain barrier integrity from ischemia-induced injury
- Binds to endothelial PGAM5 to inhibit the activity of PGAM5 phosphatase
- Inhibits the interaction of PGAM5 with NRF2
- Exhibits in vitro and in vivo protection
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Medchemexpress LLC USP5-IN-1 | 2851040-81-6 | 99.7% | 437.90 | 1 MG
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USP5-IN-1 is a selective competitive inhibitor of the USP5 zinc finger ubiquitin binding domain (ZnF-UBD) with a KD of 2.8 μM. It functions by blocking the binding of ubiquitin to ZnF-UBD, which inhibits the catalytic activity of USP5 and hinders the hydrolysis of ubiquitin chains. This compound can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is considered a potential USP5 chemical probe and inhibitor for USP5-related cancers.
- Selectively inhibits USP5 zinc finger ubiquitin binding domain (ZnF-UBD)
- Shows ≥30-fold selectivity over 9 homologous ZnF-UBD proteins
- Inhibits USP5 cleavage of Lys48-linked diubiquitin substrates in vitro
- Potential chemical probe for USP5 research
- Potential inhibitor for cancers related to USP5 activity
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Medchemexpress LLC Recombinant human CD299 (CLEC4M) Fc-fusion protein | 90.1% | 50 UG
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Recombinant human CD299 extracellular domain fused to human Fc, expressed in HEK293 cells and supplied as a lyophilized powder. Designed for binding assays, immunoassays, and protein-protein interaction studies, the product has low endotoxin and is supplied in a PBS-based formulation for reliable reconstitution and downstream functional assays.
- Expressed in HEK293 cells for proper mammalian glycosylation
- Human Fc fusion enhances stability and facilitates detection
- Lyophilized powder formulated in PBS, pH 7.4, for storage stability
- Low endotoxin level (<1 EU/μg) suitable for sensitive assays
- Recommended reconstitution ≥100 μg/mL for functional use
- Contains extracellular sequence S78-E399 of the human protein
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000293099 ADAM8 HUMAN HEK293 100UG
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Medchemexpress LLC PKUMDL-LC-101-D04 10mM 1mL | 2143896-83-5 | 1 ML
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PKUMDL-LC-101-D04 is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) used in research to inhibit ferroptosis and modulate inflammatory responses. The compound is provided as a 10 mM solution in DMSO (1 ML) and has reported in vitro and cellular activity at micromolar concentrations.
- Allosteric activator of GPX4 with reported pEC50 4.7.
- Increases GPX4 enzymatic activity up to ~150% in cell-free assays.
- Shows cellular activity and protects against cholesterol peroxide toxicity.
- High reported purity (99.94%) suitable for research use.
- Supplied as a 10 mM solution in DMSO, ready for in vitro applications.
- Storage and solubility data provided for experimental planning.
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Medchemexpress LLC Zolucatetide 5Mg | HY-P10925-5MG
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Zolucatetide 5Mg
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Medchemexpress LLC Aur1545-5Mg | HY-173158-5MG
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Aur1545-5Mg
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Apexbio Technology LLC Sitagliptin phosphate monohydrate, 200mg
Sitagliptin phosphate monohydrate is the phosphate salt of its active component, sitagliptin, with one molecule of water. Sitagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4), an enzyme catalyzing the cleavage of peptides with an N-terminal alanine or proline amino acid residue Other sizes are available. Please inqury us for quote.
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Selleck Chemical LLC ATN-161 Ac-PHSCN-NH2-5mg
ATN-161 (Ac-PHSCN-NH2) is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.
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Selleck Chemical LLC SHP099-5mg
SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 71 nM and shows no activity against SHP1.
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Medchemexpress LLC Rig012 | 2642218-43-5 | ≥99.0% | C23H21NO3 | 10MG
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RIG012 is a small-molecule antagonist of the RIG-I innate immune receptor. It inhibits RIG-I ATPase activity (IC50 = 0.71 μM, NADH-coupled ATPase assay) and suppresses downstream signaling, including interferon-β and ISG expression. Supplied as a research-grade solid for in vitro studies; not for human or diagnostic use.
- Potent RIG-I inhibition (IC50 0.71 μM).
- Activity measured by NADH-coupled ATPase assay.
- Suppresses IFN-β and ISG expression in cellular assays.
- Supplied as a purified small-molecule for research use.
- Product datasheet and safety data sheet available for handling information.
- Useful for studying innate immune signaling and antiviral responses.
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