Bioactive Small Molecules
Medchemexpress LLC Ono-5334 | 868273-90-9 | 99.8% | 438.58 g/mol | C21H34N4O4S | 1 MG
ONO-5334 is a small-molecule, orally active cathepsin K inhibitor used as a research compound to study bone resorption, osteoclast activity, and related biochemical pathways. It has been evaluated in preclinical and clinical settings and is commonly employed in biochemical assays and cell-based studies to probe cathepsin-mediated mechanisms.
- Potent, selective cathepsin K inhibition for target-focused studies.
- Orally active small molecule suitable for in vitro and in vivo models.
- Useful for investigating bone resorption and osteoclast function.
- Available in low-mass vials for research dosing and assay work.
- High purity compatible with analytical and biological experiments.
Cayman Chemical INDY, Purity: ≥98%, CAS: 1169755-45-6, 10 mg
A DYRK1A inhibitor (Ki = 180 nM; IC50 = 240 nM); selective for DYRK1A over MAOA and B (100 μM); inhibits DYRK1A phosphorylation of tau in COS-7 cells expressing EGFP-DYRK1A and EGFP-tau in a concentration-dependent manner; induces proliferation of human and rat β-cells and increases insulin secretion by human islets in vitro; reverses developmental deformities induced by DYRK1A overexpression in X. laevis embryos
Cayman Chemical Isoguanine, Purity: ≥95%, CAS: 3373-53-3, 250 mg
An isomer of guanine; found naturally but also formed through oxidative damage to DNA; mutagenic in mammalian and bacterial cells in vitro
Medchemexpress LLC ACTH (1-14) TFA | 96.05% | 1794.90 | 10 MG
ACTH (1-14) TFA is a fragment of adrenocorticotrophin, a tropic hormone produced by the anterior pituitary. It regulates cortisol and androgen production and is associated with conditions like Addison disease, Cushing syndrome, and Cushing disease.
- Purity of 96.05%
- Molecular weight of 1794.90
- Chemical formula: C79H110F3N21O22S
- Appears as a white to off-white solid
- Sequence: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly
- Soluble in water at 100 mg/mL (55.71 mM)
- Soluble in PBS at 25 mg/mL (13.93 mM)
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In-solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Dasotraline (hydrochloride) | 675126-08-6 | 99.04% | 1 ML
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
- Blocks dopamine, norepinephrine, and serotonin transporters.
- Exhibits high potency with IC50 values of 4 nM for dopamine, 6 nM for norepinephrine, and 11 nM for serotonin.
- Inhibits spontaneous firing rates of LC NE, VTA DA, and DR 5-HT neurons.
- Equipotently inhibits 5-HT and NE transporters.
- Used in research for neuronal signaling pathways.
- Applicable in studies on monoaminergic neurons.
- Utilized for investigations into dopamine and serotonin transporter occupancy.
Medchemexpress LLC Thyrotropin-releasing hormone (TRH), free acid | 24769-58-2 | 99.98% | 363.37 | 50 MG
Thyrotropin-releasing hormone (TRH), free acid is a highly conserved neuropeptide that plays a crucial role in the hormonal control of thyroid-stimulating hormone (TSH) levels and also exhibits neuromodulatory functions. It is an endogenous metabolite.
- Highly conserved neuropeptide.
- Exerts hormonal control of thyroid-stimulating hormone (TSH) levels.
- Possesses neuromodulatory functions.
- Agonist activity at mouse TRH-R1 and TRH-R2 receptors, assessed by Ca2+ release and IP1 formation.
- Induces a temporary, dose-dependent rise in body temperature in rats.
- Hyperthermic action may involve thyroid hormone release.
Medchemexpress LLC L-2-Aminobutyric acid | 1492-24-6 | 103.12 | 1 ML
L-2-Aminobutyric acid is a non-proteinogenic amino acid found in human tissues and body fluids, formed through the transamination of oxobutyric acid. It can act as a precursor for anticonvulsant and anti-tuberculosis agents and is a crucial intermediate in the chemical and pharmaceutical industries. Elevated levels in plasma are associated with conditions such as Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
- Non-proteinogenic amino acid
- Found in human tissues and body fluids
- Formed via transamination of oxobutyric acid
- Precursor for anticonvulsant and anti-tuberculosis agents
- Crucial intermediate in chemical and pharmaceutical industries
- Elevated levels associated with specific medical conditions
Medchemexpress LLC Genz-123346 free base | 491833-30-8 | 99.6% | 1 ML
This compound is an orally available inhibitor of glucosylceramide synthase. It functions by blocking the conversion of ceramide to glucosylceramide (GL1) and demonstrates inhibition of GM1 with an IC50 of 14 nM.
- Orally available inhibitor of glucosylceramide synthase.
- Blocks ceramide conversion to glucosylceramide.
- Inhibits GM1 with high potency.
- Enhances anti-cancer agent efficacy against tumor cells.
- Modulates drug resistance efflux pump function.
- Enhances autophagy flux in neurons.
- Lowers glucose and A1C levels, improving glucose tolerance.
- Preserves pancreatic beta-cell function and insulin secretion.
- Reduces renal glycosphingolipid levels, preventing cystic disease.
- Impacts the Akt-mTOR signaling pathway.
Medchemexpress LLC Pyr-Arg-Thr-Lys-Arg-AMC TFA | 1255501-99-5 | 99.5% | 941.95 | 10 MG
Pyr-Arg-Thr-Lys-Arg-AMC TFA is an AMC peptide. This peptide is specifically hydrolyzed by proteases such as trypsin and thrombin, making it valuable for determining protease activity and evaluating the potency of enzyme inhibitors.
- Specifically hydrolyzed by proteases such as trypsin and thrombin
- Useful for determining protease activity
- Useful for determining the potency of enzyme inhibitors
- Targets thrombin
- Involves metabolic enzyme/protease pathway
- Appearance: solid, white to off-white
- Soluble in H₂O at 100 mg/mL (106.16 mM; requires ultrasonic)
Medchemexpress LLC 5-Hydroxyindole-3-acetic acid-d2 | 56209-31-5 | 193.20 | 5 MG
5-Hydroxyindole-3-acetic acid-d2 is the deuterium labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Cayman Chemical Nicorandil N-oxide, Purity: ≥98%, CAS: 107833-98-7, 10 mg
A metabolite of nicorandil
Cayman Chemical AS1517499, Purity: ≥98%, CAS: 919486-40-1, 10 mg
A STAT6 inhibitor (IC50 = 21 nM in a reporter assay); inhibits IL-4-induced Th2 differentiation of mouse spleen T cells (IC50 = 2.3 nM); inhibits bronchial smooth muscle hyperresponsiveness and IL-13 production in ovalbumin-sensitized mice at 10 mg/kg; inhibits STAT6 phosphorylation and TEC hyperplasia and decreases serum levels of T3 and T4 in a mouse model of Graves’ disease at 10 mg/kg per day; inhibits tumor growth and liver metastasis in a murine orthotopic 4T1 mammary carcinoma model at 20 mg/kg twice weekly
![Medchemexpress LLC N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide | 1174046-72-0 | MFCD18206786 | 99.5% | 468.84 g·mol-1 | C23H15ClF2N4O3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244444.png-250.jpg)
Medchemexpress LLC N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide | 1174046-72-0 | MFCD18206786 | 99.5% | 468.84 g·mol-1 | C23H15ClF2N4O3 | 1 ML
BMS-794833 is a small-molecule kinase inhibitor active against VEGFR2 and Met, originally described in patent WO2009094417. It exhibits potent biochemical activity (VEGFR2 IC50 ≈ 15 nM; Met IC50 ≈ 1.7 nM) and is provided for research use in both solution and solid formats. Typical uses include biochemical assays, cell-based kinase studies, and preclinical pharmacology research.
- Potent dual inhibition of VEGFR2 and Met with low-nanomolar IC50s.
- High purity suitable for research applications.
- Available as concentrated solution and solid quantities for flexibility.
- Soluble in common organic solvents such as DMSO; verify before use.
- Applicable to biochemical and cellular kinase assays and preclinical studies.
Cayman Chemical Cefradine, Purity: ≥90%, CAS: 38821-53-3, 5 g
An orally bioavailable β-lactam cephalosporin antibiotic; active against S. pyogenes, E. coli, K. pneumoniae, and E. cloacae (MICs = 0.04, 9.4, 9.4, and 6.3 μg/ml, respectively); active against clinical isolates of S. aureus (MICs = 0.8-6 μg/ml) and S. pyogenes (MICs = 0.1-0.4 μg/ml), as well as H. influenzae, E. coli, and K. pneumoniae (MICs = 6.2-12.5 μg/ml); increases survival in mouse models of systemic lethal infection by S. pyogenes, E. coli, K. pneumoniae, or E. cloacae (ED50s = 5, 37, 122, and 50 mg/kg, respectively), as well as by penicillin-susceptible or -resistant strains of S. aureus (ED50s = 18 and 91 mg/kg, respectively)
Medchemexpress LLC HY-P0239 10mg , HA Peptide CAS:92000-76-5 Purity:>98%
HY-P0239 10mg HA Peptide CAS: 92000-76-5 HA Peptide (HA tag) is a nine amino acids peptide derived from the human influenza hemagglutinin (HA). HA Peptide is extensively used to isolate, purify, detect, and track the protein of interest in cell biology and biochemistry. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.