Bioactive Small Molecules
Cayman Chemical ANTIBODY RO5166017 10mg
A TAAR1 agonist; binds to TAAR1 (Kis = 31, 24, 1.9, and 2.7 nM in HEK293 cells expressing the recombinant human, cynomolgus monkey, mouse, or rat enzyme, respectively) and is >15-fold selective for TAAR1 over a panel of 123 receptors, ion channels, and transporters at 10 µM; induces cAMP production in HEK293 cells expressing human, cynomolgus monkey, mouse, or rat TAAR1 (EC50s = 55, 97, 3.3, and 14 nM, respectively); reduces the frequency of neuronal firing in mouse VTA and DRN slices (IC50s = 1.73 and 2.99 nM, respectively); inhibits stress-induced hyperthermia, as well as reduces cocaine-induced hyperlocomotion, in mice; impairs expression of cocaine-induced place preference in rats
Cayman Chemical ANTIBODY GSK2636771 25mg
An orally bioavailable inhibitor of PI3K p110β that decreases cell viability and Akt phosphorylation in p100β-dependent PTEN-deficient PC-3 prostate and BT549 and HCC70 breast cancer cell lines
Apexbio Technology LLC FPH1 (BRD-6125) 708219-39-0 25mg
FPH1 (BRD-6125 CAS nan) is a synthetic small-molecule compound identified to stimulate functional proliferation of primary human hepatocytes FPH1 modulates hepatocyte proliferation independent of individual donor variability promoting expansion in hepatocytes from diverse genetic backgrounds FPH1 exerts its biological activity by enhancing hepatic functions notably increasing albumin secretion during the differentiation of induced pluripotent stem (iPS) cells to hepatocyte-like cells and elevating CYP3A4 expression while suppressing alpha-fetoprotein (AFP) production In cell-based studies FPH1 demonstrates proliferative and maturation-promoting activity in primary human hepatocytes and iPS-derived hepatocyte-like cells Based on these pharmacological properties FPH1 holds research potential in hepatocyte expansion hepatic maturation and applications in biomedical and regenerative medicine research
Medchemexpress LLC Veliparib (ABT-888) | 912444-00-9 | 99.8% | 244.29 | 100 MG
Veliparib (ABT-888) is a potent PARP inhibitor that targets PARP1 and PARP2 with high specificity. It demonstrates good oral bioavailability and the ability to cross the blood-brain barrier in various tumor models, making it suitable for a range of research applications.
- Potent PARP inhibitor
- Inhibits PARP1 and PARP2 with Ki values of 5.2 nM and 2.9 nM, respectively
- Good oral bioavailability
- Can cross the blood-brain barrier
- Targets autophagy
Abcam (S)-Timolol maleate, non-selective beta adrenoceptor antagonist, 100MG
MW 432.49 g/mol, Purity >99%. Potent non-selective β adrenoceptor antagonist (Ki values are 1.97 and 2.0 nM for β₁ and β₂ receptor subtypes, respectively). 50% bioavailability following oral administration. Does not cross the blood-brain barrier.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Rr-11a analog | 685543-66-2 | 99.1% | 491.49 | 25 MG
RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. It is an aza-Asn derivative and an aza-peptide Michael acceptor.
- Potent and irreversible inhibitor of Schistosoma mansoni legumain
- IC50 of 31 nM against Schistosoma mansoni legumain
- Aza-Asn derivative
- Aza-peptide Michael acceptor
- Available for research use only
Cayman Chemical HydroxetamIn 5mg
An analytical reference standard categorized as an arylcyclohexylamine; a metabolite of methoxetamine; intended for research and forensic applications
Medchemexpress LLC Pyridoxylamine dihydrochloride | 524-36-7 | MFCD00012808 | 99.1% | 25 MG
Pyridoxylamine dihydrochloride (Standard) is an analytical standard used for research and analytical applications. It functions as an inhibitor of advanced glycation end products (AGEs) and lipoxidation end products (ALEs), providing protection against diabetes-induced retinal vascular lesions.
- Intended for research and analytical applications
- Inhibits AGEs and ALEs
- Protects against diabetes-induced retinal vascular lesions
- Used as a reference standard in HPLC, GC, and MS experiments
Medchemexpress LLC Aldastotug 25mg | 25mg
Aldastotug (PYX-106 BSI-060T) is a human monoclonal antibody (mAb) targeting Siglec-15/CD33L3 Aldastotug reverses Siglec-15-mediated immunosuppression and enhances T-cell proliferation Aldastotug induces significantly increased levels of IFN and TNF in T cells Aldastotug can be used in cancer immunity research Recommended isotype control Human IgG1 kappa Isotype Control (HY-P99001)[1]
Medchemexpress LLC GM-CSF Huma 500ug | 500ug
GM-CSF R alpha is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2 GM-CSF R alpha binds to the cytokine with high specificity and low affinity[1] GM-CSF R alpha binds to GM-CSF and induces cell differentiation[2] GM-CSF R alpha monoclonal antibody decreases GM-CSFR expression on GM-CSF-responsive cells and shows anti-inflammatory activity in rheumatoid arthritis (RA)[3] GM-CSF R alpha Protein Human (HEK293 His) is a recombinant protein with a C-Terminal His label It consists of 298 amino acids (E23-G320) and is produced in HEK293 cells
![Medchemexpress LLC 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-1H-indole-2-carboxylic | 2349374-37-2 | 98.8% | 412.87 g·mol⁻¹ | C22H21ClN2O4 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000223318.png-250.jpg)
Medchemexpress LLC 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-1H-indole-2-carboxylic | 2349374-37-2 | 98.8% | 412.87 g·mol⁻¹ | C22H21ClN2O4 | 5 MG
15-LOX-1 inhibitor 1 is a small-molecule research reagent that selectively inhibits 15-lipoxygenase-1 (15-LOX-1) with an IC50 of 0.19 μM. It has been reported to protect macrophages from lipopolysaccharide-induced cytotoxicity and to inhibit nitric oxide formation and lipid peroxidation. The compound is supplied as a solid and as a DMSO solution in multiple sizes for laboratory use.
- Inhibits 15-lipoxygenase-1 (IC50 = 0.19 μM).
- Protects macrophages from LPS-induced cytotoxicity.
- Reduces nitric oxide formation and lipid peroxidation.
- High purity suitable for research (98.8%).
- Available as solid and as a DMSO solution in multiple sizes.
Enzo Life Sciences Ac-muramyl-Ala-D-Glu-amide (5mg). CAS: 53678-77-6
NALP3 ligand. Specific ligand for NALP3. For inactive control compound see MDP-DD (ALX-151-036). Alternative name: MDP-LD, N-Acetylmuramyl-L-alanyl-D-isoglutamine, Adjuvant peptide. Formula: C19H32N4O11. MW: 492.5. Purity: ≥95% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in water (50mg/ml). Long Term Storage: -20°C. Handling: After reconstitution, prepare aliquots and store at -20°C.
Cayman Chemical ANTIBODY DabIgatrn 5mg
A thrombin inhibitor (Ki = 0.0045 µM); an active metabolite dabigatran etexilate; an inhibitor of trypsin (Ki = 0.0503 µM); selective for thrombin and trypsin over plasmin, Factor Xa, activated protein C, and tissue plasminogen activator (tPA; Kis = 1.695, 3.76, 20.93, and 45.36 µM, respectively)
Medchemexpress LLC H2-003 | 1060438-30-3 | >99.5% | 446.50 | 1 MG
H2-003 is a selective human DGAT2 inhibitor that effectively inhibits triglyceride (TG) biosynthesis and lipid droplet formation in 3T3-L1 cells. It is suitable for research on DGAT2 and TG-related metabolic diseases.
- Selective human DGAT2 inhibitor
- Inhibits triglyceride (TG) biosynthesis
- Effectively inhibits lipid droplet formation
- Useful for research on DGAT2 and TG-related metabolic diseases
![Medchemexpress LLC 4-[(5,5-dimethyl-8-quinolin-3-yl-6H-naphthalene-2-carbonyl)amino]benzoic acid | 182135-66-6 | MFCD00952209 | 99.5% | 448.5 g/mol | C29H24N2O3 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000212494.png-250.jpg)
Medchemexpress LLC 4-[(5,5-dimethyl-8-quinolin-3-yl-6H-naphthalene-2-carbonyl)amino]benzoic acid | 182135-66-6 | MFCD00952209 | 99.5% | 448.5 g/mol | C29H24N2O3 | 1 MG
This compound is a small-molecule neutral antagonist selective for retinoic acid receptor alpha (RARα) used in research to modulate retinoid signaling. It exhibits high affinity for RARα and has reported effects on inflammatory signaling, angiogenesis, cell migration, and blue-light-induced phototoxicity.
- High affinity for RARα (Ki ≈ 2.5 nM).
- High purity (>99%).
- Molecular formula C29H24N2O3 and molecular weight 448.5 g/mol.
- Suitable for in vitro and in vivo studies of inflammation, angiogenesis, and cell migration.
- Reported to reduce blue-light-induced phototoxicity.