Bioactive Small Molecules
Medchemexpress LLC BMS-986187 | 684238-37-7 | 5 MG
BMS-986187 is a small-molecule positive allosteric modulator selective for the δ-opioid receptor, characterized for potentiation of receptor signaling and used in studies of signaling bias.
- Potent δ-opioid receptor PAM with reported EC50 ≈ 0.03 μM.
- High purity solid, supplied as white to off-white powder.
- Available in research quantities such as 5 mg and as a 10 mM solution in DMSO.
- Molecular weight 470.6 g/mol; chemical formula C31H34O4.
- Suitable for in vitro pharmacology and receptor mechanism studies.
Medchemexpress LLC Gentiopicroside | 20831-76-9 | 356.32 | 25 MG
Gentiopicroside is a naturally occurring iridoid glycoside that inhibits P450 activity and exhibits anti-inflammatory and antioxidative effects.
- Naturally occurring iridoid glycoside
- Inhibits P450 activity
- Has anti-inflammatory effects
- Has antioxidative effects
- Inhibits RANKL-induced osteoclast formation
- Blocks expression of osteoclast-related proteins
- Prevents RANKL-triggered JNK and NF-κB activation
- Inhibits RANKL-induced bone resorption
- Reduces gastric ulcer index (in vivo)
Medchemexpress LLC Leritrelvir (RAY1216) | 2923310-64-7 | C31H44F3N5O6 | 5 MG
Leritrelvir (RAY1216) is an orally active SARS-CoV-2 main protease slow-tight inhibitor with a Ki of 8.6 nM. It is for research use only and not sold to patients.
- Orally active SARS-CoV-2 main protease slow-tight inhibitor
- Potent inhibitor with a Ki of 8.6 nM
- Covalently attaches to the catalytic Cys145
- Demonstrates antiviral activities against SARS-CoV-2 wild type ancestral strain and variants
- Effectively prolongs survival in SARS-CoV-2 infected mice models
- Reduces virus-induced pathology in animal models
- Exhibits a promising human pharmacokinetics profile
Cayman Chemical (±)5-epi CP 55,940, Purity: ≥97%, CAS: 2365471-91-4, 5 mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; a potential byproduct in the synthesis of (±)-CP 55,940 based on the published synthesis of (−)-CP 47,497; intended for research and forensic applications
Cayman Chemical BCP-T.A., Purity: ≥98%, CAS: 2786829-70-5, 5 mg
A ferroptosis inducer; induces ferroptosis in NCI H522 cells an effect that can be blocked by liproxstatin-1; binds to GPX4 and increases the accumulation of lipid peroxides in NCI H522 cells at 0.5 µM; cytotoxic to WI38 cells and MEFs (IC50s = 22 and 10 nM, respectively), as well as NCI H522, HT-1080, MDA-MB-468, MDA-MB-231, and HeLa cancer cells(IC50s = 17, 19, 84, 21, and 242 nM, respectively)
Medchemexpress LLC JMJD1C-IN-1 | 861224-48-8 | 100.0% | 317.36 | 100 MG
This product is an orally active and selective inhibitor that targets JMJD1C, preventing its binding to H3K9me2 peptide substrate. It improves antitumor immunity by disrupting intratumoral regulatory T cell fitness, promoting H3K9me2 accumulation to downregulate PD1 expression, and enhancing STAT3 activation. It has shown dose-dependent antitumor efficacy in multiple mouse tumor models and is valuable for tumor immunotherapy research.
- Orally active and selective inhibition of target.
- Inhibits target binding to H3K9me2 peptide substrate.
- Disrupts intratumoral regulatory T cell fitness for improved antitumor immunity.
- Promotes H3K9me2 accumulation, downregulating PD1 expression.
- Enhances STAT3 activation by reducing demethylation.
- Demonstrates dose-dependent antitumor efficacy across various mouse tumor models.
- Exhibited no significant toxicity in animal models.
Cayman Chemical SKF 82958 (hydrobromide), Purity: ≥95%, CAS: 74115-01-8, 5 mg
A dopamine D1 receptor agonist (K0.5 = 4 nM in a radioligand binding assay); selective for dopamine D1 over D2 receptors (K0.5 = 73 nM); induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50 = 491 nM); prevents and reverses fentanyl-induced respiratory depression in cats at 3 mg/kg; increases locomotion and rearing in rats
Medchemexpress LLC N-Acetylprocainamide (Standard) | 32795-44-1 | MFCD00009052 | 99.8% | 5 MG
N-Acetylprocainamide is a class III antiarrhythmic that blocks K+ channels.
- Blocks K+ channels.
- Inhibits TEA uptake in OCT2-expressing MDCK cells with an IC50 of 5 μM.
- Inhibits TEA uptake in OCT1-expressing MDCK cells with an IC50 of 8.8 μM.
- Decreases tensions induced by K+ and methacholine.
- Relaxant effect is inhibited by K+ channel blockers.
- Shows no effect on Na+ absorption or Cl- secretion.
Medchemexpress LLC HY-135401 5mg Medchemexpress, VU6015929 CAS: Purity:>98%
Medchemexpress, HY-135401 5mg VU6015929 CAS: VU6015929 is a potent, selective and orally active dual discoidin domain receptor 1/2 (DDR1/2) inhibitor with IC50s of 4.67 nM and 7.39 nM, respectively. VU6015929 potently blocks collagen-induced DDR1 activation and collagen-IV production. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 6-Methoxy-7-(3-(pyrrolidin-1-yl)propoxy)-4-(tetrahydro-2H-pyran-4-yl)quinolin-2-amine | 99.4% | 385.50 | 25 MG
MS152 is an orally bioactive inhibitor of EHMT2/G9a. It reactivates maternally silenced Prader-Willi syndrome (PWS) genes in brain and liver tissues of PWS mouse models. This product is for research use only.
- Oral bioactive inhibitor of EHMT2/G9a.
- Reactivates maternally silenced Prader-Willi syndrome (PWS) genes.
- Suitable for research applications.
Cayman Chemical 1,2-Dioleoyl-sn-glycero-3-PA (ammonium salt), Purity: ≥95%, 5 mg
A phospholipid; has been used in the generation of micelles, liposomes, and other artificial membranes
Apexbio Technology LLC Vitamin D2 (Ergocalciferol) 50mg
A8543 is a small molecule compound employed in biomedical research to investigate cellular signaling pathways Although detailed structural and potency data are not currently available A8543 is recognized for its utility in mechanistic studies enabling researchers to probe specific molecular interactions and pathway modulation in various experimental contexts Its application supports the exploration of cellular processes and potential therapeutic targets within preclinical research models
Cayman Chemical NAP-1, Purity: ≥98%, CAS: 131721-28-3, 5 mg
A compound with anesthetic activity; increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices at 100 μM; induces loss of righting reflex in tadpoles (EC50 = 0.53 μM)
Medchemexpress LLC Raffinose (Standard) | 512-69-6 | 10 MG
Raffinose (Standard) is an analytical standard intended for research and analytical applications. It regulates intestinal flora, inhibits the TLR4-MyD88-NF-κB signaling pathway, and activates the Nrf2 signaling pathway. Raffinose exhibits anti-inflammatory, antioxidant, and immunomodulatory activities, and is orally active. This analytical standard is commonly used in qualitative, quantitative, and methodological research experiments.
- Analytical standard of Raffinose
- Intended for research and analytical applications
- Regulates intestinal flora
- Inhibits the TLR4-MyD88-NF-κB signaling pathway
- Activates the Nrf2 signaling pathway
- Exhibits anti-inflammatory activity
- Exhibits antioxidant activity
- Exhibits immunomodulatory activities
- Orally active
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
