Bioactive Small Molecules
Medchemexpress LLC HY-133045 100mg Medchemexpress, VHL Ligand 8 CAS: Purity:>98%
Medchemexpress, HY-133045 100mg VHL Ligand 8 CAS: VHL Ligand 8 is a VHL ligand. VHL Ligand 8 can be used to synthesize ARD-266 (HY-133020), a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![Medchemexpress LLC 1H-indol-2-yl-[4-[2-(4-methoxyphenoxy)ethyl]piperazin-1-yl]methanone | 1386162-69-1 | MFCD32174273 | 99.5% | 379.45 g/mol | C22H25N3O3 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000222368.png-250.jpg)
Medchemexpress LLC 1H-indol-2-yl-[4-[2-(4-methoxyphenoxy)ethyl]piperazin-1-yl]methanone | 1386162-69-1 | MFCD32174273 | 99.5% | 379.45 g/mol | C22H25N3O3 | 5 MG
ML417 is a selective, brain-penetrant D3 dopamine receptor agonist supplied as a high-purity research compound for in vitro and in vivo pharmacology. It is suitable for receptor pharmacology studies and can be prepared in solution or used as a solid for dosing, with solubility and storage guidance provided.
Cayman Chemical Deferitazole, Purity: ≥95%, CAS: 945635-15-4, 5 mg
An iron chelator; decreases the levels of iron in iron-citrate complexes at 50 µM; reduces the number of P. falciparum oocytes, an effect that can be prevented by the addition of ferric chloride, and the percent of flagellated P. falciparum male gametocytes in vitro at 25 µM; decreases the urine and fecal levels of iron excreted from iron-loaded C. apella monkeys at 150 µmol/kg
Cayman Chemical N-Benzylmethcathinone (hydrochloride), Purity: ≥98%, CAS: 16735-26-5, 5 mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Cayman Chemical 1-O-Acetylbritannilactone, Purity: ≥98%, CAS: 33627-41-7, 5 mg
A sesquiterpene lactone with diverse biological activities; inhibits LPS-induced production of PGE2 and nuclear translocation of NF-κB in primary rat aorta VSMCs; inhibits VEGF-induced capillary tube formation in HUVECs at 5 and 10 µM; reduces tumor growth in an A549 mouse xenograft model at 12 mg/kg per day
Medchemexpress LLC Endo-BCN-PEG2-C2-NHS ester | 2243565-12-8 | MFCD19705420 | 95.0% | 450.48 g/mol | C22H30N2O8 | 5 MG
endo-BCN-PEG2-C2-NHS ester is a BCN-containing PEG-based N-hydroxysuccinimide (NHS) ester linker for bioconjugation and PROTAC synthesis. The NHS ester enables efficient coupling to primary amines, while the BCN moiety provides a strained alkyne handle for copper-free click reactions, supporting linker installation in small molecules and selective protein labeling workflows.
- Reacts with primary amines via NHS ester chemistry.
- Provides strained alkyne (BCN) for copper-free click chemistry.
- Suitable for PROTAC linker installation and protein labeling.
- High purity for consistent coupling performance.
- Available in small-scale packages for research use.
Cayman Chemical Reparixin, Purity: ≥95%, CAS: 266359-83-5, 10 mg
An allosteric antagonist of CXCR1 and CXCR2 (IC50s = 1 and 100 nM, respectively); reduces ischemia and reperfusion-induced hepatic PMN recruitment, hepatic MPO levels, and serum ALT levels in a rat model of hepatic ischemia at 3, 15, and 30 mg/kg; decreases systolic blood pressure in spontaneously hypertensive rats at 5 mg/kg; reduces tumor volume and the number of intratumor cancer stem cells in a SUM159 mouse xenograft model when administered in combination with docetaxel
Medchemexpress LLC 2-((2S,6S)-2-phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone | 1009583-20-3 | 99.9% | 341.4 g·mol^-1 | C21H27NO3 | 1 ML
BMS-816336 is a potent, orally bioavailable inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with a reported IC50 of ≈3.0 nM. It is supplied for research use in solution (10 mM in DMSO, 1 mL) and in solid forms to support enzymatic and cellular assay development.
- Potent 11β-HSD1 inhibition with low nanomolar IC50.
- Suitable for enzymatic and cellular assays.
- Available as a 10 mM solution in DMSO for ready-to-use assays.
- Provided in solid quantities for formulation or dose-response studies.
- High purity suitable for research applications.
Selleck Chemical LLC OPB-171775 E4695-25MG
OPB-171775 functions as a molecular glue promoting the formation of a complex between phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12) This interaction triggers multiple cellular stresses ultimately leading to cell death It also demonstrates significant anticancer activity in patient-derived xenograft (PDX) models of Gastrointestinal stromal tumor (GIST)
Cayman Chemical BTB-1, Purity: ≥98%, CAS: 86030-08-2, 250 mg
A reversible Kif18A inhibitor (IC50 = 1.69 μM); selective for Kif18A over a panel of seven kinesins at 100 μM; inhibits Kif18A-dependent microtubule motility in a microtubule gliding assay at 100 μM; induces mitotic accumulation of HeLa cells
Medchemexpress LLC Eosin Y | 15086-94-9 | 99.47% | 25 G
Eosin Y (Acid Red 87 free base) is a soluble acid red dye molecule with wide application in organic synthesis as a photoredox catalyst. It is also used in cell staining, as a pH indicator, an indicator in analytical halide determination by Fajans, and as a dye pigment. It is the most widely used counterstain in routine staining of histological tissue sections (erythrocytes, collagen, epithelial cells, etc.).
- Soluble acid red dye molecule
- Applicable as a photoredox catalyst in organic synthesis
- Used in cell staining, as a pH indicator, and in analytical halide determination
- Commonly used counterstain in histological tissue sections
- Versatile for various applications including organic synthesis and biological staining
- Effective as a photoredox catalyst
- Reliable for routine staining of histological tissue sections
Medchemexpress LLC Hnpmi | 1980848-48-3 | 99.6% | 360.41 | 50 MG
HNPMI is an EGFR inhibitor that exhibits cytotoxic effects on tumor cells. It downregulates protein levels of osteopontin, survivin, and cathepsin S, inducing apoptosis. Additionally, HNPMI modulates BCL-2/BAX and p53 in CRC cell lines to hinder tumorigenesis.
- Inhibitor of EGFR.
- Cytotoxic effects on tumor cells.
- Downregulates osteopontin, survivin, and cathepsin S.
- Induces apoptosis.
- Regulates BCL-2/BAX and p53 in CRC cell lines.
Cayman Chemical JNJ-38158471, Purity: ≥98%, CAS: 951151-97-6, 5 mg
A VEGFR2 inhibitor (IC50 = 42 nM); selective for VEGFR2 over FMS, PDGFRα, FLT3, and KIT (IC50s = 624, 1,109 nM, 4,810, and 511 nM, respectively) and VEGFR1 and VEGFR3 (IC50s = 4,451 and 1,112 nM, respectively) but does inhibit RET (IC50 = 183 nM); decreases VEGF-induced phosphorylation of VEGFR2 in serum-starved HUVECs at 10, 100, or 500 nM; inhibits VEGF-induced migration in HUVECs at 1 µM; reduces Vegf-induced corneal neovascularization in mice at 100 mg/kg; decreases tumor size in an HCT116 mouse xenograft model at 10-200 mg/kg per day; reduces polyp number in an Apc+/Min-FCCC mouse model of spontaneous colorectal adenoma at 100 mg/kg per day
Medchemexpress LLC 4-(3-carboxyphenyl)-2,5-pyridinedicarboxylic acid | 29553-70-6 | 99.6% | 287.22 | C14H9NO6 | 5MG
4-CPPC is a small-molecule research reagent that acts as a potent, reversible, and selective inhibitor of macrophage migration inhibitory factor 2 (MIF-2). It shows Ki values of 431 μM for MIF-1 and 33 μM for MIF-2 and is supplied as a solid with reported high purity.
Cayman Chemical p,p'-DDT, Purity: ≥98%, CAS: 50-29-3, 1 mg
An organochlorine pesticide; induces 94.2% mortality of malaria mosquito (A. quadrimaculatus) fourth-instar larvae and 100% mortality of A. aegypti larvae at 0.01 and 0.05 ppm, respectively; increases secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles at ≥4 ng/ml; increases apoptosis in isolated human PBMCs from 80-150 µg/ml; increases tumor growth in a DLD1 colorectal adenocarcinoma nude mouse xenograft model at 5 nmol/kg; induces 100% mortality of C. auratus (goldfish) at 0.25 ppm; lethal to rats but not hamsters (LD50s = 120 and ~5,000 mg/kg, respectively); is a POP and is elevated in the sera of pregnant women in malaria-endemic regions of South Africa