Bioactive Small Molecules
Medchemexpress LLC HY-128588 5mg Medchemexpress, STAT3-IN-3 CAS:2361304-26-7 Purity:>98%
Medchemexpress, HY-128588 5mg STAT3-IN-3 CAS:2361304-26-7 STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC UNC2025 S9662-100MG
UNC2025 is a potent and orally active dual inhibitor of FLT3 and MER with IC50 of 0 35 nM and 0 46 nM respectively UNC2025 also inhibits AXL TRKA TRKC QIK TYRO3 SLK NuaK1 Kit (c-Kit) and Met (c-Met) with IC50 of 1 65 nM 1 67 nM 4 38 nM 5 75 nM 5 83 nM 6 14 nM 7 97 nM 8 18 nM and 364 nM respectively
Selleck Chemical LLC Sodium pyrophosphate 10H21 E4001-250MG
Sodium pyrophosphate decahydrate acts as a buffering agent a chelator and a hydrated salt nucleating agent Sodium pyrophosphate decahydrate can also be used to a raw material for synthetic laundry scent additives
Selleck Chemical LLC Elimusertib S9864-1G
Elimusertib (BAY-1895344) is a very potent and highly selective ATR (ataxia telangiectasia and Rad3-related) inhibitor with IC50 of 7 nM Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM
Cayman Chemical PF-05190457 10mg
An inverse agonist of GHS-R; selectively binds to GHS-R (Ki = 4.37 nM) over M2 mAChRs (Ki = 1,950 nM) and 5-HT2B receptors (IC50 = 3,700 nM); increases glucose-induced insulin secretion in primary human pancreatic islets at 1 µM; potentiates GLP-1-induced intracellular calcium levels in isolated dispersed rat islets at 100 nM; increases ex vivo vagal nerve firing rate in rats when administered intragastrically (EC50 = 10.7 nM)
Cayman Chemical ANTIBODY YSK05 10mg
An ionizable cationic amino lipid (apparent pKa = ~6.5); has been used in combination with other lipids in the formation of liposomes and LNPs; administration of cyclic di-GMP in YSK05-containing liposomes increases serum levels of IFN-β, IFN-γ, IL-6, and TNF-α and activates NK cells in mice, as well as decreases lung metastasis in a B16/F10 murine melanoma model of metastasis; intravenous administration of factor VII siRNA in YSK05-containing LNPs reduces factor VII activity in isolated mouse plasma
Cayman Chemical ANTIBODY BMS 986260 10mg
An ALK5 inhibitor (IC50 = 0.0015 µM); selective for ALK over TGF-βRII (IC50 = > 15 µM) and a panel of 213 additional kinases at 1 µM; inhibits TGF-β-induced increases in the nuclear translocation of phosphorylated SMAD2/3 in Mv 1 Lu cells (IC50 = 0.35 µM); decreases tumor growth in an MC-38 murine colon carcinoma model of tumor rechallenge at 3.75 mg/kg per day in combination with an antibody against PD-1; induces hyperproliferation of chondrocytes in the femoral epiphysis, thickening of the cardiac atrioventricular valve, and inflammation in the aortic vasculature in rats at 10 mg/kg per day
Medchemexpress LLC 1-(2-(1-benzyl-2,5-dimethyl-1H-pyrrol-3-yl)-2-oxoethyl)-6-oxo-1,6-dihydropyridine-3-carbonitrile | 1449747-00-5 | MFCD28100815 | 99.5% | 345.39 g/mol | C21H19N3O2 | 100 MG
CYM-5520 is a selective allosteric agonist of the sphingosine 1-phosphate receptor 2 (S1PR2) supplied for research use. It is a white to off-white solid with reported EC50 ≈ 480 nM and high purity, commonly used in receptor pharmacology and preclinical studies.
- Selective allosteric S1PR2 agonist with reported EC50 ≈ 480 nM.
- High purity (99.48%) for reliable experimental results.
- Supplied as a white to off-white solid suitable for laboratory handling and storage.
- Available in multiple pack sizes including 100 MG to support varied study scales.
- Documentation available: data sheet, certificate of analysis, and safety data sheet.
- Appropriate for in vitro and preclinical receptor signaling studies.
Medchemexpress LLC CS-VIP 8 hydrochloride | 961.40 | 10 MG
CS-VIP 8 hydrochloride is a selective allosteric WDR5 protein inhibitor (Ki = 0.008 μM). It induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity, and regulating HOX gene expression.
- Promising for research of hematological diseases such as leukemia
Cayman Chemical 2MethylbutyrylLcarnItInd 5mg
An internal standard for the quantification of 2-methylbutyryl-L-carnitine by GC- or LC-MS
Medchemexpress LLC mUNO | 2283322-63-2 | 97.5% | 561.65 | 100 MG
mUNO is a tumor-homing peptide with the sequence "CSPGAK" that specifically binds to mouse CD206, which targets tumor-associated macrophages expressing CD206/MRC1. It can also interact with human recombinant CD206. In vitro studies showed that FAM-mUNO (3 nM; 45 min) selectively binds to IL-4-differentiated CD206+ human monocyte-derived macrophages. It is intended for research use only.
- Specifically binds to mouse CD206
- Targets tumor-associated macrophages expressing CD206/MRC1
- Interacts with human recombinant CD206
- Selectively binds to IL-4-differentiated CD206+ human monocyte-derived macrophages
- Intended for research use
Cayman Chemical DelphInIdIn3OrutInosIdec 5mg
A glycosylated anthocyanin with antioxidant activity; inhibits TBHP-induced loss of viability in isolated rat aortic SMCs, but not MH1C1 cells, at 100 µM; prevents TBHP-induced DNA damage, as well as inhibits TBHP-induced increases in MDA levels, in SMCs; displays a hydrogen peroxide-induced and pH-dependent chemiluminescence peak at pH 7
Medchemexpress LLC Cibenzoline | 53267-01-9 | MFCD00864706 | ≥95.0% | 262.35 g/mol | C18H18N2 | 50 MG
Cibenzoline is provided as an analytical standard for laboratory research. It is a class Ia antiarrhythmic (cifenline) and KATP channel inhibitor supplied as a solid reference material for qualitative and quantitative analysis, method development, and validation in chromatography and mass spectrometry.
- Intended for research use and analytical reference.
- Suitable for HPLC, GC, and MS method development and validation.
- High purity: ≥95.0% (analytical standard grade).
- Formula C18H18N2; molecular weight 262.35 g/mol.
- Provided as a solid powder in defined pack sizes for precise dosing.
Cayman Chemical 1 3DIpalmItoyl2Docosahexae 5mg
A triacylglycerol; dietary administration reduces hepatic triglyceride and cholesterol levels in mice at 30 g/kg
Sigma Aldrich Fine Chemicals Biosciences Senecionine phyproof(R) Reference Substance | 130-01-8 | MFCD00221720 | 10MG
Senecionine phyproof(R) Reference Substance | Purity: >=98.0% (HPLC) | Mol Wt: 335.39 | 130-01-8 | MFCD00221720 | 10MG
