Bioactive Small Molecules
Medchemexpress LLC (S)-GSK-3685032 | 2170142-58-0 | 420.53 | 50 MG
(S)-GSK-3685032 is a chemical compound primarily intended for research use only, suitable for laboratory applications and the manufacture of substances. It is stable under recommended storage conditions.
- Solid appearance
- Harmful if swallowed
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation
- Stable under recommended storage conditions
- For research use only
Cayman Chemical ANTIBODY SAINT C-18 1mg
A cationic lipid; has been used in the formation of liposomes for the delivery of plasmid DNA, proteins, siRNA, and small molecules; complexes of SAINT C-18 with plasmid DNA encoding PEDF inhibit corneal neovascularization induced by complexes of SAINT C-18 with plasmid DNA encoding FGF2 in rats
Selleck Chemical LLC Cefadroxil E4906-100MG
Cefadroxil(BL-S 578) is a first-generation cephalosporin antibiotic with broad spectrum of anti-bacterial activity It can be used in the management of infections in the respiratory tract urinary tract skin and soft tissues and bones and joints
Medchemexpress LLC Signal recognition particle 54 (SRP54) protein | 10 UG
SRP54 is a recombinant human signal recognition particle 54 kDa protein produced in Sf9 insect cells and provided with a histidine purification tag. The protein is supplied as a filtered, buffered solution formulated for research applications, with recommended frozen storage to preserve biochemical integrity and low endotoxin to minimize assay interference.
- Recombinant human protein expressed in Sf9 insect cells.
- C-terminal His tag for affinity purification.
- Formulated in 20 mM Tris, pH 7.5, 300 mM NaCl, 10% glycerol; 0.22 μm filtered.
- Approximate molecular weight ~58 kDa (residues M1-M504, accession P61011).
- Low endotoxin level: <1 EU/μg as measured by LAL.
- Store at -80 °C; stable short-term at -20 °C; avoid repeated freeze-thaw.
- Intended for research use only.
Cayman Chemical ANTIBODY ABX-1431 5mg
An inhibitor of MAGL (IC50s = 14 and 27 nM for human and rat enzyme, respectively); selective for MAGL over ABHD6 and PLA2G7 (IC50s = 2.7 and >10 μM, respectively), as well as a panel of 33 serine hydrolases and a panel of 95 enzymes, receptors, transporters, and ion channels at 10 μM; selective for MAGL over CYP1A2, CYP2C9, CYP2C19, and CYP3A4/5 (IC50s = >50 μM); inhibits MAGL activity in mouse and rat brain ex vivo (ED50s = 1.4 and 0.5 mg/kg, respectively); decreases brain levels of 2-AG in mice and rats; reduces formalin-induced paw-licking time in rats
Cayman Chemical ANTIBODY ARS853 500ug
An inhibitor of K-RASG12C; decreases the level of active GTP-bound K-RAS by 95% (10 µM); inhibits proliferation preferentially in lung cancer cell lines containing the K-RASG12C mutation, including H358 cells (IC50 = 2.5 µM)
Cayman Chemical A11trIfluoroacetate salt 5mg
A cell-penetrating peptide; decreases annexin A1 binding to EphA2 and increases EphA2 ubiquitination in HK1 NPC cells; inhibits HK1 and 5-8F NPC cell proliferation, migration, and invasion; reduces tumor volume in 5-8F and HK1 NPC mouse xenograft models
TARGETMOL CHEMICALS INC ST-1535 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ST 1535 is a potent and orally active antagonist of A2A adenosine receptor with antiparkinsonian activity and antitremorigenic effects. ST 1535 exhibits the potential for the research of Parkinson’s disease. purity: 99%
AdipoGen TDZD-8 (5 mg)
Chemical. CAS: 327036-89-5. Formula: C10H10N2O2S. MW: 222.3. TDZD-8 is a non-ATP competitive selective inhibitor of the serine/threonine kinase glycogen synthase kinase 3beta (GSK3beta; IC50 = 2µM), binding to the active site of GSK3beta. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase or protein kinase C (IC50s = >100 µM), but inhibits PKC and Flt-3 activities (IC50 = 1.4-5.5µM and 673nM, respectively). TDZD-8 is a potent anti-proliferative and pro-apoptotic agent of glioma cells in vitro and in vivo. These effects are associated with an early activation of extracellular signal-regulated kinase (ERK), which is followed by an increased expression of the early growth response-1 (EGR-1) and p21. TDZD-8 potentially inhibits the 33.8-kDa Main protease (Mpro)/3C-like protease of SARS-CoV-2, consequently inhibiting viral transcription and replication and possibly inhibiting spread of COVID-19.
Medchemexpress LLC HY-111844 1mg Medchemexpress, PROTAC RAR Degrader-1 CAS:1351169-27-1 Purity:>98%
Medchemexpress, HY-111844 1mg PROTAC RAR Degrader-1 CAS:1351169-27-1 PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC NAP-2/CXCL7 Rat CH 10ug
CXCL7 (also known as neutrophil activating peptide 2 NAP-2) is a platelet-derived growth factor that belongs to the ELR CXC chemokine family functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2[1] NAP-2/CXCL7 Protein Rat (CHO) is produced in CHO cells and consists of 62 amino acids (I46-I107)
Cayman Chemical ANTIBODY ThIoLox 10mg
A 15-LO-1 inhibitor (Ki = 3.3 µM); a P. falciparum aspartate carbamoyltransferase inhibitor (IC50 = 3.32 µM); reduces LPS-induced expression of the mRNAs encoding TNF-α, iNos, Il-1β, Il-6, Il-8, and Il-12b in mouse lung slices at 50 µM; inhibits glutamate-induced increases in lipid peroxidation and mitochondrial superoxide formation, as well as cell death, in mouse HT22 cells at 10 µM
Medchemexpress LLC HY-107661 10mg Medchemexpress, Arundic Acid CAS:185517-21-9 Purity:>98%
Medchemexpress, HY-107661 10mg Arundic Acid CAS:185517-21-9 Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid has the potential for stroke and Alzheimer’s disease research. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY PIK-III 1mg
A selective inhibitor of Vps34 (PI3K type 3; IC50 = 18 nM); acutely inhibits autophagy and de novo lipidation of LC3, leading to stabilization of autophagy substrates
Cayman Chemical ANTIBODY NSC 5844 25mg
A bis-quinoline with diverse biological activities; inhibits the growth of P. falciparum D-6 and W-2 strains in vitro (IC50s = 17 and 27 nM, respectively); inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells (GI50s = 7.35 and 14.80 μM, respectively); inhibits 24% of BoNT/A LC metalloprotease activity at a concentration of 20 μM