Protein Modification Reagents
![Medchemexpress LLC 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[19-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)- | 1255942-07-4 | 99.49% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[19-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)- | 1255942-07-4 | 99.49% | 50 MG
DBCO-PEG4-Biotin is an azadibenzocyclooctyne-biotin derivative that contains a biotin group and four PEG units. It functions as a versatile biotinylation reagent, enabling the introduction of a biotin moiety to azide-labeled biomolecules. This process occurs through a copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reaction. It is a click chemistry reagent, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- Azadibenzocyclooctyne-biotin derivative
- Contains a biotin group and 4 PEGs
- Versatile biotinylation reagent
- Used for introducing a biotin moiety to azide-labeled biomolecules
- Utilizes copper-free strain-promoted alkyne-azide click chemistry (SPAAC)
- Contains a DBCO group for SPAAC with azide groups
- For research use only
Medchemexpress LLC 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44-Pentadecaoxahexatetracontan-46-amine | 2745717-94-4 | 99.9% | 691.85 | 50 MG
The m-PEG15-amine is a chemical compound with the molecular formula C31H65NO15 and a molecular weight of 691.85. It is provided as a colorless to light yellow oil with a purity of 99.91%. This product is intended for use as a laboratory chemical and in the manufacture of substances. It is classified as hazardous, causing acute oral toxicity, skin and serious eye irritation, and potential respiratory tract irritation.
- Consistent with structure based on ¹H NMR Spectrum and LCMS
- Harmful if swallowed
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation
Medchemexpress LLC Propargyl-PEG4-CH2COOH | 1429934-37-1 | >97.0% | 290.31 | 25 MG
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It acts as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide-containing molecules. PROTACs, composed of two ligands linked together, target an E3 ubiquitin ligase and a specific protein, thereby utilizing the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Features Alkyne group for CuAAc
- Enables selective protein degradation via ubiquitin-proteasome system
Medchemexpress LLC Rhodamine B PEG2-NH2 | 95.3% | 566.13 | 50 MG
Rhodamine B PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase
- Other ligand for the target protein
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Biotin-PEG4-methyltetrazine | 1962919-31-8 | 95.3% | 674.81 g·mol⁻¹ | C31H46N8O7S | 10 MG
Biotin-PEG4-MeTz is a biotinylated click-chemistry reagent containing a terminal methyltetrazine that reacts rapidly with trans-cyclooctene via inverse electron-demand Diels-Alder (iEDDA) chemistry. Supplied as a solid, it is intended for preparation of biotinylated conjugates and labeling applications in chemical biology and bioconjugation workflows.
- Contains a terminal methyltetrazine for rapid iEDDA reactions.
- Includes a PEG4 spacer to improve solubility and reduce steric hindrance.
- Facilitates preparation of biotinylated conjugates and biomolecule labeling.
- Purple to purplish red solid; high purity (~95.3%).
- Soluble in DMSO at about 250 mg/mL; ultrasonication recommended.
- Store sealed at -20 °C away from moisture and light; in solution store at -80 °C for long term.
Medchemexpress LLC Biotin-PEG4-hydrazide | 756525-97-0 | 99.9% | C21H39N5O7S | 25 MG
Biotin-PEG4-hydrazide is a biotin-labeled, PEG-based PROTAC linker. It is used in the synthesis of Proteolysis-targeting chimeras (PROTACs), which exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Pomalidomide-PEG3-azide | 2267306-15-8 | MFCD32198606 | 98.9% | 488.45 | C21H24N6O8 | 5 MG
Pomalidomide-PEG3-azide is an E3 ligase ligand-linker conjugate that combines a pomalidomide-derived cereblon ligand with a three-unit polyethylene glycol linker terminated in an azide. It is intended for use in targeted protein degradation workflows and for click-chemistry functionalization to attach pomalidomide-based ligands to alkyne- or strained-alkyne-containing molecules.
- Facilitates PROTAC construction via CRBN-mediated recruitment of E3 ligase.
- Azide terminus enables copper-catalyzed and strain-promoted azide-alkyne cycloadditions.
- PEG3 linker provides flexible spacing between ligand and cargo.
- High reported purity (≈98.9%) supports analytical and synthetic applications.
- Soluble in DMSO at high concentration; store under inert atmosphere at -20°C to preserve stability.
Medchemexpress LLC Pomalidomide-PEG4-azide | 2271036-47-4 | 99.8% | C23H30N6O8 | 250 MG
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates a Pomalidomide-based cereblon ligand and a linker used in PROTAC technology. This click chemistry reagent contains an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. Pomalidomide-PEG4-azide is intended for research use only.
- Incorporates a Pomalidomide-based cereblon ligand
- Utilizes a linker used in PROTAC technology
- Features an Azide group for click chemistry reactions
- Enables copper-catalyzed azide-alkyne cycloaddition
- Facilitates strain-promoted alkyne-azide cycloaddition
- Intended for research use only
Medchemexpress LLC Biotin-PEG6-Mal | 1808990-66-0 | MFCD28015769 | 99.0% | C31H51N5O11S | 25 MG
Biotin-PEG6-Mal is a biotin-labeled, PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting an E3 ubiquitin ligase ligand with a target protein ligand.
- Biotin-labeled, PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC N-Mal-N-bis(PEG4-NHS ester) | 2112738-60-8 | ≥95.0% | C37H54N4O19 | 100 MG
N-Mal-N-bis(PEG4-NHS ester) is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It is designed for research applications, leveraging the intracellular ubiquitin-proteasome system for targeted protein degradation.
- PEG-based PROTAC linker
- Used for PROTAC synthesis
- Connects ligands for E3 ubiquitin ligase and target proteins
- Employs ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC Azide-peg4-tos | 168640-82-2 | 99.6% | C15H23N3O6S | 100 MG
Azide-PEG4-Tos is a PEG-based PROTAC linker for PROTAC synthesis. It acts as a click chemistry reagent with an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne groups, or strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. PROTACs use two linked ligands, one targeting an E3 ubiquitin ligase and the other a protein of interest, to selectively degrade proteins via the ubiquitin-proteasome system.
- Peg-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent with azide group
- Undergoes CuAAc with alkyne groups
- Participates in SPAAC with DBCO or BCN groups
- PROTACs: two linked ligands
- Targets E3 ubiquitin ligase and protein of interest
- Utilizes ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC 5,8,11-trioxa-2-azatridecanoic acid, 13-hydroxy-, (4E)-4-cycloocten-1-yl ester | 1955497-82-1 | 99.3% | 345.43 g·mol⁻¹ | C17H31NO6
TCO-PEG3-alcohol is a PEG-based PROTAC linker and click-chemistry reagent featuring a trans-cyclooctene (TCO) moiety and a terminal alcohol. It is supplied as a viscous, colorless to light-yellow liquid with high stated purity and recommended cold storage, and is intended for use in bioconjugation, PROTAC assembly, and other chemical biology applications.
- Contains a trans-cyclooctene group for rapid iEDDA click reactions.
- PEG3 spacer provides hydrophilicity and conformational flexibility.
- Terminal alcohol enables additional derivatization and conjugation chemistry.
- High purity suitable for synthetic and bioconjugation workflows.
- Storage recommendations support long-term stability when kept cold.
Medchemexpress LLC Bromoacetamido-PEG5-DOTA | 2353410-19-0 | 98.0% | C30H55BrN6O13 | 1 MG
Bromoacetamido-PEG5-DOTA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is for research use only and not sold to patients.
- Molecular weight: 787.69
- Formula: C30H55BrN6O13
- Cas no.: 2353410-19-0
- Appearance: Oil
- Color: White to off-white
- Purity: 98.02%
Medchemexpress LLC M-PEG2-CH2CH2COOH | 209542-49-4 | 192.21 g/mol | C8H16O5 | 1 G
m-PEG2-CH2CH2COOH is a PEG-based PROTAC linker used to connect target-binding ligands and E3 ligase ligands in PROTAC molecules. It is supplied as a research reagent for chemical synthesis and proteolysis-targeting chimera development.
- PEG-based linker for PROTAC synthesis
- CAS number 209542-49-4
- Molecular weight 192.21 g/mol
- Chemical formula C8H16O5
- Available in multiple sizes, including 1 G
- For research use only, not for human or clinical use