Protein Modification Reagents

Medchemexpress LLC Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-(PEG4-alkyne)oxy]phenyl ethyl ester | 1802907-98-7 | 95.0% | 653.63 g/mol | C29H39N3O14 | 100 MG

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PC Alkyne-PEG4-NHS ester is a cleavable PEG4 linker bearing an alkyne functional group and an N-hydroxysuccinimide (NHS) ester. It is used to attach payloads to amine-containing biomolecules via NHS chemistry and to enable azide-alkyne click reactions for bioconjugation and linker assembly.

• Contains an alkyne handle for copper-catalyzed azide-alkyne cycloaddition.
• Features an NHS ester for efficient amine conjugation.
• PEG4 spacer provides solubility and flexibility for linker design.
• Typical applications include antibody-drug conjugate and PROTAC linker synthesis.
• Provided with analytical purity suitable for research use.

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eMolecules​ SPDP-PEG-24-NHS ester | BroadpharmMFCD13185007 | 1440.710 | C63H113N3O29S2 | 95.000 | O=C(CCSSc1ccccn1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 100mg | 229582551

SPDP-PEG-24-NHS ester | BroadpharmMFCD13185007 | 1440.710 | C63H113N3O29S2 | 95.000 | O=C(CCSSc1ccccn1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 100mg | 229582551

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Advanced Biomatrix Extralink-Lite PEGDA Version 2.0 Thiol-reactive crosslinker for HyStem, 10 units x 0.5 mL

Extralink-Lite PEGDA is a thiol-reactive crosslinker designed for use in HyStem kits. Pack comes with Buffer B for reconstitution. HyStem V2.0 kit components are reconstituted with a buffered 1X PBS. The resulting components will also result in a pH neutral isotonic salt hydrogel. The ending pH, osmo, and rheological properties are the same from Version 1.0 to Version 2.0. Extralink is polyethylene diacrylate (PEGDA) with a molecular weight of 3500 Da. It is a thiol-reactive crosslinker that covalently reacts with the thiol groups in Glycosil, Heprasil and Gelin-S to form viscoelastic hydrogels. Extralink Lite vials are >80% acrylated and supplied as the crosslinking component in the HyStem kits. Extralink Lite is used to chemically crosslink Glycosil. Extralink Lite is used in place of Extralink for applications where Gelin-S is not included. The higher relative concentration of Glycosil requires less crosslinker to emulate the gelation time and stiffness of HyStem-C and Hy

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Medchemexpress LLC DSPE-PEG 2000 | 892144-24-0 | 99.37% | (C2H4O)nC42H82NO10P | 50 MG

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DSPE-PEG 2000 is a PEG polymer that contains DSPE and amine end groups. It can be utilized to create micelles that function as nanoparticles for drug delivery.

• PEG polymer containing DSPE and amine end groups.
• Can be used to form micelles.
• Suitable for nanoparticle drug delivery.

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Medchemexpress LLC DSPE-PEG-Amine | 95.0% | 500 MG

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DSPE-PEG-Amine, MW 5000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• PEG-based PROTAC linker
• Used in the synthesis of PROTACs
• PROTACs contain two different ligands connected by a linker
• Ligand for an E3 ubiquitin ligase
• Ligand for the target protein
• Exploits the intracellular ubiquitin-proteasome system
• Selectively degrades target proteins

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Medchemexpress LLC DSPE-PEG-NHS | 1445723-73-8 | MFCD03098978 | 80.0% | 5000 (average) | C49H89N2O15P | 25 MG

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DSPE-PEG-NHS (average MW 5000) is an NHS-activated PEGylated phospholipid used to functionalize liposomes and nanoparticle platforms. The NHS ester allows covalent attachment to primary amines, while the PEG chain provides steric stabilization and extended circulation, making it useful for targeted and stealth formulations.

• Enables covalent conjugation to amine-containing ligands via NHS-amine chemistry.
• Provides steric stabilization and reduced protein adsorption through PEGylation.
• Amphiphilic structure supports incorporation into lipid bilayers and micelles.
• Available as a solid for convenient handling and storage.
• Typical purity around 80% suitable for formulation development.

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Medchemexpress LLC PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 40:60) | 95.0% | 20kDA to 5.0kDA | 50 MG

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PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 40:60) is a type of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. It has a molecular weight range of 20kDA to 5.0kDA and contains a 40:60 ratio of lactic acid (LA) to glycolic acid (GA) molecules.

• It is a nanoparticle.
• For research use only.
• Appearance: solid
• Color: white to off-white

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eMolecules​ Biotin-PEG4-STP Ester | Broadpharm |719.720 | C27H37F4N3O11S2 | 0.000 | OS(=O)(=O)c1c(F)c(F)c(OC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)c(F)c1F | 5mg | 795362059

Biotin-PEG4-STP Ester | Broadpharm |719.720 | C27H37F4N3O11S2 | 0.000 | OS(=O)(=O)c1c(F)c(F)c(OC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)c(F)c1F | 5mg | 795362059

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eMolecules​ 1374666-32-6 | Mal-PEG2-acid | Broadpharm | MFCD23726620 | 257.242 | C11H15NO6 | 98.000 | OC(=O)CCOCCOCCN1C(=O)C=CC1=O | 1g | 335341196

Mal-PEG2-acid | Broadpharm | 1374666-32-6 | MFCD23726620 | 257.242 | C11H15NO6 | 98.000 | OC(=O)CCOCCOCCN1C(=O)C=CC1=O | 1g | 335341196

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eMolecules​ t-BuO2C-PEG3-SS-PEG3-CO2tBu | BroadpharmMFCD28950759 | 586.800 | C26H50O10S2 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCSSCCOCCOCCOCCC(=O)OC(C)(C)C | 250mg | 282987757

t-BuO2C-PEG3-SS-PEG3-CO2tBu | BroadpharmMFCD28950759 | 586.800 | C26H50O10S2 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCSSCCOCCOCCOCCC(=O)OC(C)(C)C | 250mg | 282987757

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eMolecules​ 1367918-21-5 | Methylamino-PEG1-acid HCl salt | Broadpharm | MFCD26783686 | 147.174 | C6H13NO3 | 98.000 | CNCCOCCC(O)=O | 1g | 266683159

Methylamino-PEG1-acid HCl salt | Broadpharm | 1367918-21-5 | MFCD26783686 | 147.174 | C6H13NO3 | 98.000 | CNCCOCCC(O)=O | 1g | 266683159

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eMolecules​ 2204246-03-5 | Pomalidomide-PEG3-NH-Boc | Broadpharm548.593 | C26H36N4O9 | 0.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 500mg | 533795541

Pomalidomide-PEG3-NH-Boc | Broadpharm | 2204246-03-5548.593 | C26H36N4O9 | 0.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 | 500mg | 533795541

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eMolecules​ 2183440-72-2 | N-(Azido-PEG3)-NH-PEG3-acid HCl salt | Broadpharm422.479 | C17H34N4O8 | 95.000 | OC(=O)CCOCCOCCOCCNCCOCCOCCOCCN=[N+]=[N-] | 250mg | 550804447

N-(Azido-PEG3)-NH-PEG3-acid HCl salt | Broadpharm | 2183440-72-2422.479 | C17H34N4O8 | 95.000 | OC(=O)CCOCCOCCOCCNCCOCCOCCOCCN=[N+]=[N-] | 250mg | 550804447

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Medchemexpress LLC Tos-PEG4-acid | 1453117-42-4 | 97.2% | 50 MG

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Tos-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound facilitates the degradation of target proteins by exploiting the intracellular ubiquitin-proteasome system.

• Peg-based PROTAC linker
• Utilized in PROTAC synthesis
• Facilitates protein degradation
• Selectively targets proteins via ubiquitin-proteasome system

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eMolecules​ (S, R, S)-AHPC-PEG8-NHS ester | Broadpharm |980.140 | C46H69N5O16S | 98.000 | Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(C)(C)C)cc1 | 250mg | 573896592

(S, R, S)-AHPC-PEG8-NHS ester | Broadpharm |980.140 | C46H69N5O16S | 98.000 | Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(C)(C)C)cc1 | 250mg | 573896592

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