Lipids and Lipid Derivatives
Medchemexpress LLC Hydrocortisone cypionate | 508-99-6 | MFCD00083363 | 486.64 | 20 MG
Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester, intended for research use only. It demonstrates diverse biological activities in vitro.
- Shows dose-dependent down-regulation of GR transcript in hCMEC/D3 cells and significantly increases TER across the hCMEC/D3 monolayer.
- Decreases expression of MHC II molecules, costimulatory molecule CD86, and DC-specific marker CD83 in treated dendritic cells, along with strongly reduced IL-12 secretion.
- Inhibits IFN-γ production but induces increased IL-4 release in dendritic cells.
- Reduces postischemic oxidative stress, perfusion pressure, transudate formation.
- Inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan, as well as histamine release from mast cells.
Medchemexpress LLC Hydrocortisone acepo 5mg | 74050-20-7 | 460.56 g·mol⁻¹ | C26H36O7 | 5 MG
Hydrocortisone aceponate is supplied as an analytical standard of hydrocortisone 17-propionate 21-acetate for research and analytical applications, commonly used as a reference in assay development and dermatoses studies.
- Analytical standard of hydrocortisone aceponate for research and assays.
- Declared purity suitable for HPLC analysis (97%).
- Molecular formula C26H36O7 and molecular weight 460.56 g·mol⁻¹.
- Supplied in a small 5 mg quantity for analytical use.
- Suitable as a reference standard in topical glucocorticoid research.
Medchemexpress LLC 17-hydroxy-11-dehydrocorticosterone | 53-06-5 | 99.3% | 360.44 | 5 G
Cortisone (17-Hydroxy-11-dehydrocorticosterone) is an oxidized metabolite of Cortisol, a Glucocorticoid. It functions as an immunosuppressant and anti-inflammatory agent. At high concentrations, Cortisone can partially interfere with the binding of Glucocorticoid to the Glucocorticoid-receptor. This product is intended for research use only.
- Oxidized metabolite of Cortisol
- Functions as an immunosuppressant
- Acts as an anti-inflammatory agent
- Partially interferes with Glucocorticoid-receptor binding
- For research use only
Medchemexpress LLC Dexamethasone phosphate disodium | 2392-39-4 | 99.9% | 1 ML
Dexamethasone phosphate disodium is an orally active Glucocorticoid receptor agonist. It regulates several transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, leading to the activation and repression of key genes involved in the inflammatory response.
- Potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM.
- Induces transcription of the β2-receptor (EC50=36 nM).
- Inhibits 3xκB (NF-κB, IκBα, and I-κBβ) with IC50=0.5 nM.
- Effectively inhibits lipopolysaccharide (LPS)-induced inflammation.
- Decreases recruitment of granulocytes and spontaneous production of oxygen radicals.
Medchemexpress LLC Dexamethasone impuri 10mg | 37927-01-8 | 10 MG
Dexamethasone impurity 3 (CAS 37927-01-8) is an analytical impurity of dexamethasone supplied for research and analytical use. It is intended for impurity profiling, method development, and analytical testing; consult the certificate of analysis for storage and purity details.
- Analytical impurity for dexamethasone quality control.
- Intended for impurity profiling and method development.
- Provided in a small analytical pack suitable for laboratory use.
- Molecular formula C21H27FO5, molecular weight 378.43 g/mol.
- Store under conditions specified in the certificate of analysis.
Medchemexpress LLC Hydrocortisone acepo 100mg | 74050-20-7 | 460.56 g/mol | C26H36O7 | 100 MG
Hydrocortisone aceponate (hydrocortisone 17-propionate 21-acetate) is an analytical reference standard used for research, method development, and assay calibration in chromatographic and mass spectrometric workflows.
- Analytical reference standard for HPLC, GC, and MS applications.
- Suitable for qualitative and quantitative method development and validation.
- Available in a 100 mg packaged standard for laboratory use.
- Molecular formula C26H36O7 and molecular weight about 460.56 g/mol.
- High-purity material intended for accurate calibration and assay performance.
Medchemexpress LLC Cortisone acetate | 50-04-4 | 99.9% | 402.48 | 5 G
Cortisone acetate is an oxidized metabolite of Cortisol. It acts as an immunosuppressant and anti-inflammatory agent. At high concentrations, it can partially intervene in the binding of Glucocorticoid to the Glucocorticoid-receptor.
- Appearance: Solid
- Color: White to off-white
- Structure classification: Steroids
- Initial source: Endogenous metabolite
Apexbio Technology LLC Cortisone acetate 50-04-4 1g
Cortisone acetate (50-04-4) is a glucocorticoid receptor agonist targeting the glucocorticoid receptor It is designed to modulate glucocorticoid signaling thereby regulating gene transcription and downstream immune and inflammatory responses Cortisone acetate exerts its biological activity primarily through enzymatic conversion to cortisol which subsequently activates glucocorticoid receptors to influence cellular stress and inflammatory pathways Based on these pharmacological properties cortisone acetate holds research potential in the investigation of glucocorticoid signaling pathways receptor-mediated transcriptional regulation cellular stress responses and inflammatory condition models
Apexbio Technology LLC Cortisone acetate 50-04-4 100mg
Cortisone acetate (50-04-4) is a glucocorticoid receptor agonist targeting the glucocorticoid receptor It is designed to modulate glucocorticoid signaling thereby regulating gene transcription and downstream immune and inflammatory responses Cortisone acetate exerts its biological activity primarily through enzymatic conversion to cortisol which subsequently activates glucocorticoid receptors to influence cellular stress and inflammatory pathways Based on these pharmacological properties cortisone acetate holds research potential in the investigation of glucocorticoid signaling pathways receptor-mediated transcriptional regulation cellular stress responses and inflammatory condition models
Medchemexpress LLC Hydrocortisone acepo 10mM 1mL | 74050-20-7 | 460.56 g/mol | C26H36O7 | 1 ML
Hydrocortisone aceponate (hydrocortisone 17-propionate 21-acetate) is a synthetic topical glucocorticoid supplied as an analytical standard for research applications. It is offered as solid material and as a ready-to-use 10 mM solution in DMSO (1 mL). The compound is used in dermatoses and glucocorticoid receptor studies; supplier guidance lists purity and storage conditions.
Medchemexpress LLC Hydrocortisone acepo 10mg | 74050-20-7 | 460.56 g/mol | C26H36O7 | 10 MG
Hydrocortisone aceponate (hydrocortisone 17-propionate 21-acetate) is a potent topical glucocorticoid supplied for research use in studies of dermatoses and glucocorticoid receptor biology.
- Potent topical glucocorticoid for dermatoses research.
- White to off-white powder appearance.
- Purity approximately 99.4% as stated by supplier.
- Chemical formula C26H36O7; molecular weight 460.56 g/mol.
- Available as solids (5 mg, 10 mg, 25 mg, 50 mg) and as a 10 mM solution in DMSO (1 mL).
- Soluble in DMSO (~100 mg/mL); ultrasonic treatment recommended.
- Storage: powder -20°C (stable ~3 years) or 4°C (stable ~2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Intended for research use only; not for human or veterinary use.
Sigma Aldrich Fine Chemicals Biosciences Fluocinonide >=98% (HPLC) | 356-12-7 | MFCD00079302 | 50MG
Fluocinonide >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 494.52 | 356-12-7 | MFCD00079302 | 50MG
Sigma Aldrich Fine Chemicals Biosciences Cortisone >=98% | 53-06-5 | MFCD00003610 | 250MG
Cortisone >=98% | Purity: >=98% | Mol Wt: 360.44 | 53-06-5 | MFCD00003610 | 250MG
Sigma Aldrich Fine Chemicals Biosciences Methylprednisolone acetate | 53-36-1 |
Methylprednisolone acetate | Mol Wt: 416.51 | 53-36-1 |