Lipids and Lipid Derivatives
Sigma Aldrich Fine Chemicals Biosciences beta Estradiol 17 beta D g25MG
beta Estradiol 17 beta D g25MG
Cayman Chemical Ethynyl Estradiol
An estrogen receptor agonist (EC50 = 8.5 pM in a reporter assay using T47D cells); reduces serum cholesterol levels and femur bone mass and increases uterine mass in an OVX rat model of postmenopause at 0.1 mg/kg per day; has been found in wastewater effluent; prevents secondary sexual development in male fathead minnows and increases the numbers of intersex fish at 4 ng/l
Apexbio Technology LLC α-Estradiol 57-91-0 10mM (in 1mL Ethanol)
alpha-Estradiol (57-91-0) is a small-molecule inhibitor targeting 5 -reductase the enzyme responsible for converting testosterone to dihydrotestosterone (DHT) It is designed to inhibit 5 -reductase activity thereby modulating androgen metabolism and androgen-related signaling pathways alpha-Estradiol exerts its biological activity primarily through enzyme inhibition In reported experimental studies alpha-Estradiol demonstrates inhibitory activity against 5 -reductase with an IC50 value ranging from approximately 1 to 10 M though the precise value may depend on assay conditions Based on these pharmacological properties alpha-Estradiol holds research potential in the treatment and study of androgenetic alopecia
Medchemexpress LLC Alpha-estradiol | 57-91-0 | MFCD00064144 | 99.9% | 272.39 | C18H24O2 | 10 MG
Alpha-estradiol (analytical standard) is a reference material intended for analytical testing and method development. It is a weak estrogen and a 5α-reductase inhibitor supplied as a high-purity solid suitable for calibration, qualitative analyses, and quantitative assays in research and laboratory workflows.
- Analytical reference standard for research and method validation.
- High stated purity for accurate calibration (99.93%).
- Supplied as a solid for convenient handling and storage.
- Available in small pack sizes appropriate for analytical use (10 mg).
- Applicable to studies of estrogenic activity and 5α-reductase inhibition.
Cambridge Isotope Laboratories Estradiol (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
Estradiol (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
Cayman Chemical Ethynyl Estradiol
An estrogen receptor agonist (EC50 = 8.5 pM in a reporter assay using T47D cells); reduces serum cholesterol levels and femur bone mass and increases uterine mass in an OVX rat model of postmenopause at 0.1 mg/kg per day; has been found in wastewater effluent; prevents secondary sexual development in male fathead minnows and increases the numbers of intersex fish at 4 ng/l
Cayman Chemical 17-EstradIol-d3 1mg
An internal standard for the quantification of 17β-estradiol by GC- or LC-MS
Medchemexpress LLC Estradiol (Standard) | 50-28-2 | 99.9% | 1 ML
Estradiol (β-Estradiol) is a steroid hormone and the primary female sex hormone. It can increase the expression of neural markers in human endometrial stem cells (hEnSCs) and promote their neural differentiation. This product is intended for research use only and is utilized in studies concerning cancers, neurodegenerative diseases, and neural tissue engineering.
- Increases expression of neural markers in human endometrial stem cells.
- Promotes neural differentiation of human endometrial stem cells.
- Utilized in research for cancers, neurodegenerative diseases, and neural tissue engineering.
- Increases SIRT1 protein levels in C2C12 cells.
- Increases FoxL2 and pFoxL2 protein expression levels in ZF4 cells.
- Promotes proliferation of sheep myoblasts.
- Enhances expression of ERRα and VLDL-related genes in primary hepatocytes.
- Induces mRNA expression of pS2 and NRF1 genes in MCF-7 cells.
Medchemexpress LLC Estradiol 3-methyl ether | 1035-77-4 | 99.9% | 286.41 | 10 MG
Estradiol 3-methyl ether is a synthetic estrogen that can disrupt microtubule networks in V79 cells with an EC50 of 9 μM and inhibit cell proliferation. Additionally, it decreases serum cholesterol levels and increases body weight loss, showing feminizing activity in an HFD murine model.
- Synthetic estrogen
- Disrupts microtubule networks
- Inhibits cell proliferation
- Decreases serum cholesterol levels
- Increases body weight loss
- Useful for biochemical assays
- Potential for research into microtubule modulation and cell proliferation
- Applicable in studies related to cholesterol regulation and weight management in relevant models
Medchemexpress LLC Estradiol dipropionate | 113-38-2 | 99.5% | 50 MG
Estradiol dipropionate is a combined estrogen-progesterone that acts as an estrogen and progesterone agonist. It is for research use only and not sold to patients.
- Acts as an estrogen and progesterone agonist.
- Suitable for in vivo studies.
- Used in research for metabolic or endocrine disease.
Sigma Aldrich Fine Chemicals Biosciences beta-Estradiol 6-O-carboxy5MG
BETA beta-Estradiol 6-O-carboxy5MG
Medchemexpress LLC Estradiol-d3 | 79037-37-9 | 98.6% | 5 MG
Estradiol-d3 is a deuterium-labeled form of Estradiol, a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. It upregulates IL-6 expression via the estrogen receptor β (ERβ) pathway and is intended for research use only. This compound serves as a tracer and internal standard for quantitative analysis, leveraging the potential of deuteration to influence pharmacokinetic and metabolic profiles.
- Used as a tracer
- Used as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Deuteration influences drug pharmacokinetic and metabolic profiles
- Appears as a white to off-white solid
- Molecular weight: 275.40
- Chemical formula: C18H21D3O2
- Powder storage: -20°C for 3 years or 4°C for 2 years
- Solvent storage: -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO (50 mg/mL) and ethanol (20 mg/mL)
Medchemexpress LLC Estradiol 3-glucuronide sodium | 14982-12-8 | 1 MG
Estradiol 3-glucuronide sodium is an estrogen metabolite, a glucuronide conjugate formed in tissues like the liver from Estradiol. It is a potent substrate of Mrp2, achieving hepatobiliary transport in hepatocytes via basolateral uptake through OATP1B1, OATP1B3, and OATP2B1, and apical efflux via MRP2 and BCRP. For research use only.
- Substrate for OATP1B1, OATP1B3, and OATP2B1 in HEK293T cells.
- Uptake inhibited by OATP substrates and inhibitors.
- Inhibits OATP1B3- and OATP2B1-mediated estrone-3-sulfate uptake.
- Inhibits OATP1B1-, OATP1B3-, OATP2B1-mediated Rosuvastatin uptake.
- Substrate of rat Mrp2 in Sf9 cell membrane vesicles.
- Competitively inhibits rat Mrp2-mediated Estradiol 17-glucuronide transport.
- Used to produce high-affinity antiserum for radioimmunoassay in urine samples.