Lipids and Lipid Derivatives
Sigma Aldrich Fine Chemicals Biosciences Cortisone 21-Acetate | 50-04-4 | MFCD00003609 | 10g
Cortisone 21-Acetate | Purity: 99% | Mol Wt: 402.48 | 50-04-4 | MFCD00003609 | 10g
Medchemexpress LLC Z-guggulsterone | 39025-23-5 | MFCD01310757 | 99.4% | 312.45 g/mol | C21H28O2 | 5 MG
(Z)-Guggulsterone is a plant-derived sterol (CAS 39025-23-5) isolated from Commiphora mukul. It acts as a farnesoid X receptor (FXR) antagonist with reported activities including induction of apoptosis, inhibition of angiogenesis, and modulation of ACE2 expression, and is used in biochemical and cell-signaling research.
- Potent farnesoid X receptor (FXR) antagonist.
- Induces apoptosis in multiple cancer cell lines.
- Inhibits angiogenesis via the VEGF-VEGFR2-Akt pathway.
- Reported to reduce ACE2 expression and SARS-CoV-2 infection in studies.
- Suitable for biochemical and signaling pathway research applications.
Sigma Aldrich Fine Chemicals Biosciences Escin United States Pharmacopeia (USP) Reference Standard | 11072-93-8 | 350MG
Escin United States Pharmacopeia (USP) Reference Standard | 11072-93-8 | 350MG
Medchemexpress LLC Estrone sulfate (potassium) | 1240-04-6 | 99.9% | 388.52 | 1 ML
Estrone sulfate potassium is an inactive endogenous estrogen that can be converted into Estrone and Estradiol. It is also a substrate of the OATP1B3 transporter. This compound is applicable to breast cancer-related research, as it stimulates the growth of nitrosomethylurea-induced mammary tumors and promotes colony formation of dispersed nitrosomethylurea mammary cells through its conversion to Estrone and Estradiol.
- Taken up at a low rate by normal breast parenchymal cells.
- Converted to estrone by normal breast parenchymal cells.
- Stimulates colony formation in dispersed nitrosomethylurea mammary cells.
- Exerts dose-related stimulatory effects on nitrosomethylurea-induced hormone-responsive mammary tumor growth in castrate rats.
- Reduces glucose-6-phosphatase activity and protein levels, and lowers blood glucose in ob/ob mice.
- Modulates glucose-6-phosphatase kinetic parameters in control mice.
Medchemexpress LLC Estrone O-sulfamate | 148672-09-7 | 100.0% | C18H23NO4S | 10MG
Estrone O-sulfamate is a research-grade steroid sulfatase inhibitor supplied as a high-purity solid for biochemical and pharmacological studies. It is intended for use in assays of steroid metabolism and enzyme inhibition, with recommended refrigerated storage and solvent stability guidelines for long-term experiments.
- Potent steroid sulfatase (STS) inhibitor suitable for in vitro studies.
- High purity solid for reliable analytical and biological assays.
- White to off-white powder, convenient for weighing and formulation.
- Stable under recommended storage conditions and protected from light.
- Available in small research pack sizes to minimize waste and enable pilot studies.
Cayman Chemical Estrone, Purity: ≥95%, CAS: 53-16-7, 1 g
A primary, naturally-occurring estrogen; serum concentrations in premenopausal women fluctuate according to the menstrual cycle; becomes the most predominant estrogen in postmenopausal women; binding affinities to ERα and ERβ are ~60% and ~37% relative to estradiol
Medchemexpress LLC Estradiol enanthate (E2EN) | 4956-37-0 | 98.1% | 500 MG
Estradiol enanthate (E2EN) is a shorter-acting estrogen. It is an injectable contraceptive when combined with Dihydroxyprogesterone acetophenide. It promotes withdrawal bleeding similar to menstruation and is intended for research use only.
- Molecular weight: 384.55
- Formula: C25H36O3
- Appearance: Solid
- Color: White to off-white
- Solubility in DMSO: 125 mg/mL (325.06 mM; requires ultrasonic)
- Solubility in ethanol: ≥ 100 mg/mL (260.04 mM)
- Shipping: Room temperature in continental US
- Storage: 4°C, sealed storage, away from moisture and light. In solvent: -80°C for 6 months; -20°C for 1 month (sealed storage, away from moisture and light).
Medchemexpress LLC Estradiol 3-methyl ether | 1035-77-4 | 99.9% | 286.41 | 25 MG
Estradiol 3-methyl ether is a synthetic estrogen. It can disrupt microtubule networks in V79 cells with an EC50 of 9 μM and inhibits cell proliferation. Estradiol 3-methyl ether has also been shown to decrease serum cholesterol levels and increase body weight loss, indicating feminizing activity in an HFD murine model.
- Synthetic estrogen
- Disrupts microtubule networks in V79 cells (EC50 of 9 μM)
- Inhibits cell proliferation
- Decreases serum cholesterol levels
- Increases body weight loss in HFD murine models
Medchemexpress LLC Estradiol 3-sulfamate | 172377-52-5 | 351.46 | 50 MG
Estradiol 3-sulfamate is a potent, long-acting, and orally active steroid sulfatase inhibitor. It inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. The compound is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, demonstrating potent and long-acting STS inhibition.
- Potent, long-acting, and orally active steroid sulfatase inhibitor.
- Inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.
- Increased estrone sulfatase inhibitory activity with specific halogen moieties.
- Readily absorbed and transformed in the gut into its oxidative metabolite, EMATE.
- Both compounds demonstrate potent and long-acting STS inhibition.
Alkali Scientific Digitonin, Water Soluble, 500 Milligrams
Digitonin is a water-soluble compound used primarily in membrane permeabilization for research applications. Available in a 500mg format, Digitonin is widely used in cell biology to permeabilize cell membranes, allowing researchers to study intracellular components or deliver compounds directly into cells. It is particularly useful in protein extraction, cellular signaling studies, and in assays that require the breakdown of membrane integrity without damaging the cells entirely. This high-purity product facilitates effective permeabilization while maintaining cellular viability, making it essential for research on cellular processes, membrane proteins, and intracellular interactions.
Apexbio Technology LLC Ethinyl Estradiol 57-63-6 500mg
Ethinyl Estradiol (57-63-6) is a small-molecule estrogen receptor agonist targeting intracellular estrogen receptors It is designed to activate these receptors thereby regulating transcription of estrogen-responsive genes and influencing reproductive biology and cell proliferation pathways Ethinyl Estradiol exerts its biological activity primarily through direct binding to estrogen receptors leading to the modulation of endocrine-regulated mechanisms Based on these pharmacological properties Ethinyl Estradiol holds research potential in studies of receptor-mediated responses endocrine regulation mechanisms synthetic hormone interactions drug interactions contraceptive mechanisms and hormone-dependent physiological processes
Apexbio Technology LLC Estradiol Cypionate 313-06-4 10mM (in 1mL DMSO)
Estradiol cypionate (313-06-4) is a small-molecule agonist targeting estrogen receptors (ER) It is designed to activate ER thereby modulating downstream ER-mediated gene transcription and signaling pathways and regulating processes such as vascular homeostasis Estradiol cypionate exerts its biological activity primarily through ER agonism influencing gene expression and inhibiting endothelin-1 (ET-1) synthesis via ER-dependent mechanisms Based on these pharmacological properties estradiol cypionate holds research potential in elucidating estrogen receptor mechanisms and studying estrogen-associated vascular and endocrine systems and disorders
Medchemexpress LLC Estradiol (Standard) | 50-28-2 | MFCD00003693 | 100.0% | 25 MG
Estradiol (Standard) is an analytical standard of Estradiol, a major female sex hormone and steroid hormone. Intended for research and analytical applications, it can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. This compound is useful for research in cancers, neurodegenerative diseases, and neural tissue engineering.
- Analytical standard grade
- Reference standard for assays
- Utilized in qualitative, quantitative, and methodological research experiments
- Applicable in techniques such as HPLC, GC, and MS
- Supports research in cancers, neurodegenerative diseases, and neural tissue engineering
- Up-regulates neural markers of human endometrial stem cells
- Promotes neural differentiation
Medchemexpress LLC β-Estradiol 17-acetate | 1743-60-8 | 99.9% | 1 ML
β-Estradiol 17-acetate is a metabolite of estradiol, designed for research use only in laboratory settings. It is provided for chemical synthesis and intended for use by experienced personnel in appropriately equipped facilities.
- Available in powder and pre-dissolved solution formats.
- Stable under recommended storage conditions, with specific guidance for powder and solvent forms.
- Highly soluble in DMSO for in vitro applications.
- Features established protocols for in vivo solubility using various solvent systems.
- Molecular formula C20H26O3 and molecular weight of 314.42.
- Typically appears as a white to off-white solid with a melting point of 119°C.