Chromatography Standards
Apexbio Technology LLC Haloperidol hydrochloride 1511-16-6 200mg
Haloperidol hydrochloride is a small-molecule antagonist targeting dopamine D2 receptors It is designed to modulate dopaminergic neurotransmission thereby regulating neural pathways implicated in psychosis Haloperidol hydrochloride exerts its biological activity primarily through inverse agonist and antagonist effects on dopamine D2 receptors particularly within the mesocortical limbic and nigrostriatal pathways Based on these pharmacological properties haloperidol hydrochloride holds research potential in studying dopamine receptor functions dopamine-mediated neural circuits and the pathophysiological mechanisms underlying psychiatric disorders
Medchemexpress LLC Pinaverium impurity 1 | 54370-00-2 | MFCD02093896 | 247.09 | C9H11BrO3 | 5 G
Pinaverium impurity 1 is a characterized impurity of the L-type calcium channel blocker pinaverium, supplied for research and analytical use as a drug intermediate and reference material. It is intended for laboratory method development and impurity profiling and is not for human or clinical use.
- Chemical identification: CAS 54370-00-2.
- Chemical formula: C9H11BrO3.
- Molecular weight: 247.09.
- Intended use: research and analytical applications.
- Pack quantity: 5 G.
- Storage: follow conditions in the certificate of analysis.
Medchemexpress LLC Pantoprazole sodium | 138786-67-1 | 99.8% | 405.35 | 500 MG
Pantoprazole sodium is an orally active and potent proton pump inhibitor (PPI) that improves pH stability and exhibits anti-secretory and anti-ulcer activities. It acts as a potent H+/K+-ATPase inhibitor, also shown to significantly increase tumor growth delay when combined with Doxorubicin.
- Orally active and potent proton pump inhibitor
- Potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM
- Improves pH stability
- Exhibits anti-secretory and anti-ulcer activities
- Increases tumor growth delay when combined with Doxorubicin
- Blocks exosome release
- Inhibits V-H+-ATPase activity
![Medchemexpress LLC Hexanoic acid, 6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]amino]- | 2338824-30-7 | 96.4% | 373.40 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC Hexanoic acid, 6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]amino]- | 2338824-30-7 | 96.4% | 373.40 | 5 MG
Lenalidomide-C5-acid is a Lenalidomide-based E3 ligase ligand-linker conjugate. It is used in the recruitment of CRBN protein and can be utilized to synthesize PROTACs. This product is for research use only and is not intended for human use.
- E3 ligase ligand-linker conjugate based on Lenalidomide.
- Used in the recruitment of CRBN protein.
- Can be used to synthesize PROTACs.
Apexbio Technology LLC Nitisinone 104206-65-7 10mM (in 1mL DMSO)
Nitisinone (CAS 104206-65-7) is a synthetic small molecule that selectively inhibits 4-hydroxyphenylpyruvate dioxygenase an enzyme involved in the catabolic pathway of tyrosine By blocking this enzyme nitisinone disrupts the conversion of 4-hydroxyphenylpyruvate to homogentisic acid leading to reduced production of toxic tyrosine metabolites This mechanism is utilized in studies of hereditary tyrosinemia type 1 where nitisinone serves as a pharmacological tool to investigate metabolic regulation and therapeutic intervention in tyrosine degradation disorders
Medchemexpress LLC Lenalidomide-5-Br | 1010100-26-1 | 99.9% | 323.15 g·mol⁻¹ | C13H11BrN2O3 | 1 G
Lenalidomide-5-Br is a lenalidomide-derived cereblon (CRBN) ligand used to recruit the CRBN E3 ubiquitin ligase for chemical biology applications. It is supplied as a research-grade building block for PROTAC design, where it can be conjugated to a protein-targeting ligand via a linker.
- Lenalidomide-derived CRBN ligand for recruitment of cereblon
- Suitable for PROTAC design and linker conjugation
- High purity appropriate for research use
- Available in multiple pack sizes (1 g-100 g)
- Molecular formula C13H11BrN2O3, molecular weight 323.15 g·mol⁻¹
Apexbio Technology LLC Tenofovir 147127-20-6 10mM (in 1mL DMSO)
Tenofovir is an antiviral compound acting as an inhibitor of HIV reverse transcriptase specifically targeting RNA-dependent DNA polymerase to impede the replication cycle of HIV It interferes with the transcription process by competitively binding to the enzyme thereby preventing viral RNA from being transcribed into complementary DNA In vitro investigations indicate that Tenofovir inhibits viral replication as evidenced by an IC50 value of approximately 1 5 M in SIV-infected C-8166 cell assays Due to this inhibitory mechanism and antiviral activity against HIV Tenofovir is widely employed in biomedical and pharmacological research focused on HIV infection antiviral drug development and related studies involving reverse transcriptase enzymatic activity
Medchemexpress LLC Niclosamide (olamine) | 1420-04-8 | 98.7% | 1 G
Niclosamide olamine is an orally active antihelminthic agent used in parasitic infection research. It functions as a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells. This compound also exhibits biological activities against cancer and inhibits DNA replication in Vero E6 cells.
- Inhibits adrenocortical carcinoma cellular proliferation.
- Inhibits STAT3-mediated luciferase reporter activity in HeLa cells.
- Inhibits virus replication in Vero E6 cells.
- Inhibits adrenocortical carcinoma tumor growth in vivo.
Medchemexpress LLC Berberine hemisulfate | 316-41-6 | 384.40 | 5 G
Berberine hemisulfate is the hemisulfate form of Berberine. It is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective, and neuroprotective activity.
- Exhibits antimicrobial activity by inhibiting cell division protein FtsZ, or through DNA/RNA binding causing DNA/RNA damage.
- Exhibits anti-inflammatory activity by inhibiting TNF-α and the activation of its downstream pathway AP-1 and NF-kB.
- Exhibits neuroprotective efficacy by inhibiting reactive oxygen species (ROS) production and caspase activation, and activating the PI3K/Akt signaling pathway and heme oxygenase-1 (HO-1) expression.
- Attenuates metabolic diseases through regulations of lipid composition and inhibition of insulin resistance.
Medchemexpress LLC (S)-Ketorolac | 66635-92-5 | 99.3% | 25 MG
(S)-Ketorolac is a nonsteroidal anti-inflammatory agent that exhibits potent COX1 and COX2 enzyme inhibition.
- Target: COX1 and COX2
- Molecular formula: C15H13NO3
- Molecular weight: 255.27
- Appearance: White to off-white solid
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 2 years, -20°C for 1 year
- Solubility in DMSO: 200 mg/mL
Apexbio Technology LLC R788 disodium 1025687-58-4 5mg
R788 disodium (CAS 1025687-58-4) is a prodrug of the active metabolite R406 a selective inhibitor of spleen tyrosine kinase (Syk) Syk mediates signaling downstream of activated Fc and B-cell receptors (BCR) In vitro R406 suppresses constitutive and ligand-stimulated BCR signaling in diffuse large B-cell lymphoma (DLBCL) lines by inhibiting Syk autophosphorylation (SYK525/526) and associated phosphorylation of BLNK inducing apoptosis In vivo R788 reduces malignant B-cell proliferation and tumor progression in E -TCL1 mice Clinically R788 has shown utility in rheumatoid arthritis improving therapeutic response rates in phase II trials
Sigma Aldrich Fine Chemicals Biosciences Mycophenolate mofetil United States Pharmacopeia (USP) Reference Standard | 128794-94-5 | MFCD00867568 | 200MG
Mycophenolate mofetil United States Pharmacopeia (USP) Reference Standard | Mol Wt: 433.49 | 128794-94-5 | MFCD00867568 | 200MG
Medchemexpress LLC Benzoic-1,2,3,4,5,6-13C6 acid, 4-hydroxy-, butyl ester | 1416711-53-9 | 99.8% | 500 UG
Butylparaben-13C6 is the 13C labeled Butylparaben. Butylparaben is an organic compound that has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food. This compound is for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Apexbio Technology LLC Racecadotril 81110-73-8 1g
Racecadotril (CAS 81110-73-8) also known as acetorphan is a small molecule inhibitor of enkephalinase an enzyme responsible for the degradation of endogenous enkephalins By inhibiting enkephalinase with an IC50 of 4 5 M racecadotril increases the availability of enkephalins thereby modulating the activity of enkephalinergic pathways This mechanism is of interest in studies investigating the regulation of opioid-mediated physiological processes including analgesia and intestinal secretion Racecadotril is widely utilized in biomedical research focused on peptide degradation and the pharmacological modulation of endogenous opioid systems
Sigma Aldrich Fine Chemicals Biosciences Sultamicillin tosilate European Pharmacopoeia (EP) Reference Standard | 83105-70-8 |
Sultamicillin tosilate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 766.86 | 83105-70-8 |