Sugar acids and derivatives
Medchemexpress LLC BET-IN-14 | 2243669-93-2 | C30H37N7O2 | 25 MG
BET-IN-14 is an orally active pan BET inhibitor with an IC50 of 5.35 nM. It exhibits anti-cancer activity. In vitro studies show that BET-IN-14 (Compound 171) has anti-tumor activity against various cancer cell lines (average IC50: 174.7 nM), particularly in MM.1S, Ty-82, MV-4-11, and KG-1 cells. In vivo, BET-IN-14 (50 and 100 mg/kg, p.o., qd) inhibits tumor growth in MV-4-11 xenograft models by 60.36%.
- Orally active pan BET inhibitor with high potency (IC50 of 5.35 nM)
- Displays anti-tumor activity against various cancer cell lines (average IC50: 174.7 nM)
- Effective in MM.1S, Ty-82, MV-4-11, and KG-1 cells
- Inhibits tumor growth in MV-4-11 xenograft models by over 60% at tested dosages
Medchemexpress LLC Integrin alpha V bet 100ug | 100ug
Integrin V beta 5 proteins specifically the -V (ITGAV) subunit are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences ITGAV ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling Integrin alpha V beta 5 Protein Human (HEK293 His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 5 protein expressed by HEK293 with C-Avi C-His labeled tag Integrin alpha V beta 5 Protein Human (HEK293 His-Avi) has molecular weight of 85-160 kDa
Medchemexpress LLC UDP-glucuronic acid trisodium | 63700-19-6 | 5 MG
UDP-glucuronic acid trisodium (Uridine-5'-diphosphoglucuronic acid trisodium salt) is a critical precursor for essential glycoconjugates across biological kingdoms, including mammalian glycosaminoglycans, plant cell wall polysaccharides, and bacterial capsule glycoglycerolipids. It promotes the migration of liver cancer cells (Huh7, SK-Hep1, and SNU449) through induction of EMT process at concentrations of 0.5-1 mM over 24 hours.
- Critical precursor for essential glycoconjugates
- Promotes migration of liver cancer cells
- Induces EMT process in liver cancer cells
- Decreases E-cadherin and increases vimentin levels in Huh7 and SNU449 cells
Medchemexpress LLC D-Glucuronic acid | 99.9% | 240.09 g·mol⁻¹ | 13C6H11NaO8 | 10 MG
13C6-labeled D-glucuronic acid sodium salt monohydrate provided as a stable-isotope internal standard for metabolomics and biochemical research. The material is the sodium salt monohydrate of D-glucuronic acid, isotopically labeled on all six carbons (13C6), and supplied as a high-purity dry solid.
- 13C6 isotopic labeling for tracer and internal standard use.
- High purity (HPLC) - 99.9%.
- Molecular weight 240.09 g·mol⁻¹ and formula 13C6H11NaO8.
- Suitable for LC-MS and metabolomics workflows as a standard or tracer.
- Supplied as a stable dry solid for controlled storage.
Medchemexpress LLC Garcinone D | 107390-08-9 | 25 MG
Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways and an inhibitor of CDK2/CyclinE1. It promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression, and by enhancing the Nrf2/HO-1 signaling pathway. Additionally, it blocks the tumor cell cycle by inhibiting CDK2/CyclinE1.
- Activates STAT3/Cyclin D1 and Nrf2/HO-1 pathways
- Inhibits CDK2/CyclinE1 (IC50 is 28.23 μM)
- Promotes neural stem cell proliferation
- Blocks tumor cell cycle
- Can inhibit prostate and breast cancer
Medchemexpress LLC 4-methylumbelliferyl α-L-arabinofuranoside | 77471-44-4 | MFCD00057308 | 99.9% | 308.28 | C15H16O7 | 5 MG
4-Methylumbelliferyl α-L-arabinofuranoside is a fluorogenic glycosidase substrate used to measure α-L-arabinofuranosidase activity. Enzymatic hydrolysis releases fluorescent 4-methylumbelliferone, enabling sensitive fluorometric assays in biochemical and enzymology workflows. For research use only.
- Fluorogenic substrate for α-L-arabinofuranosidase assays.
- Produces 4-methylumbelliferone for sensitive fluorometric detection.
- High purity (99.93%) to minimize background signal.
- Molecular weight 308.28 and formula C15H16O7.
- Soluble in DMSO at ≥ 50 mg/mL.
- White to off-white solid with recommended cold storage for stability.
- Supplied in small research pack sizes suitable for assay development.
![Alkali Scientific 4 Methylumbelliferyl β D Galactopyranoside [4 Methylumbelliferyl β D Galactoside], 5 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000659927.jpg-250.jpg)
Alkali Scientific 4 Methylumbelliferyl β D Galactopyranoside [4 Methylumbelliferyl β D Galactoside], 5 G
Methylumbelliferyl Galactopyranoside (5g) is a high-purity reagent designed for large-scale biochemical analysis, particularly in enzyme assays targeting galactosidase enzymes. This 5g size is ideal for high-throughput enzyme screening and other laboratory experiments requiring larger quantities of substrate. The reagent is widely used in studies of galactose metabolism, enzyme kinetics, and carbohydrate metabolism. It is useful for enzyme-linked assays, microbiological studies, and clinical research, particularly in applications focusing on the hydrolysis of galactose and lactose derivatives. The high purity of this reagent ensures reliable and consistent results in biochemical research.
Medchemexpress LLC 4-Methylumbelliferyl | 124223-99-0 | 10MG
4-Methylumbelliferyl 2-acetamido-2-deoxy- -D-galactopyranoside is a fluorogenic substrate for studying the enzymatic activity of -galactosidase 4-Methylumbelliferyl 2-acetamido-2-deoxy- -D-galactopyranoside is used to analyze enzyme activity in various biological samples helping scientists gain insight into the function of the enzyme in vivo 4-Methylumbelliferyl 2-acetamido-2-deoxy- -D-galactopyranoside can also be used to screen potential compounds to inhibit or activate this enzyme
Medchemexpress LLC Mac glucuronide linker-1 | 2222981-71-5 | MFCD32671554 | 96.4% | 897.90 | C42H47N3O17S | 50 MG
MAC glucuronide linker-1 is a cleavable glucuronide-based linker designed for antibody-drug conjugate (ADC) research. It enables enzymatic release of payloads from antibody-payload conjugates, facilitating controlled drug release in ADC development.
- Cleavable glucuronide linker for ADCs.
- Designed for enzymatic payload release by glucuronidase.
- Suitable for antibody-agent conjugations and linker-payload development.
- Reported purity approximately 96.4% and molecular weight 897.90.
- Available in multiple pack sizes, including 50 MG.
Medchemexpress LLC Chrysosplenol D | 14965-20-9 | MFCD01548059 | 99.9% | 360.31 | 10 MG
Chrysosplenol D is a methoxy flavonoid known for inducing ERK1/2-mediated apoptosis in triple-negative human breast cancer cells. It demonstrates anti-inflammatory properties and moderate antitrypanosomal activities.
- Inhibits cell viability in CaCo2 cells.
- Selectively inhibits viability of TNBC cell lines.
- Induces cell cycle aberrations and apoptosis in breast cancer cells.
- Shows antitrypanosomal activity against T.b. brucei.
- Inhibits tumor growth on chick chorioallantoic membranes.
- Protects against LPS-induced systemic inflammatory response syndrome in mice.
- Inhibits croton oil-induced ear edema in mice.
Selleck Chemical LLC Heparin sodium S1346-1g
Heparin sodium a sulfated polysaccharide belonging to the family of glycosaminoglycans has numerous important biological activities associated with its interaction with diverse proteins Heparin is used as an anticoagulant primarily through its interaction with AT III by enhancing AT-IIImediated inhibition of blood coagulation factors including thrombin and factor Xa Heparin prevents the induction of autophagy
Medchemexpress LLC 4-Methylumbelliferyl phosphate | 3368-04-5 | 99.8% | 256.15 | 1 ML
4-Methylumbelliferyl phosphate (4-MUP) is an anionic organophosphate and a fluorogenic substrate for both acid and alkaline phosphatase. It is also recognized as a nerve agent simulant, primarily for research use.
- Anionic organophosphate
- Fluorogenic substrate for acid and alkaline phosphatase
- Nerve agent simulant
- Used in serum acid phosphatase assays
Medchemexpress LLC Dodecanedioic acid-d4 | 97543-02-7 | 234.33 | 10 MG
Dodecanedioic acid-d4 is the deuterium labeled version of Dodecanedioic acid. Dodecanedioic acid is an orally active straight-chain dicarboxylic acid that acts as an alternative energy substrate. It can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion, and also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
- Deuterium labeled compound for quantitative tracing during drug development.
- Reduces muscle fatigue during exercise.
- Exhibits blood glucose-lowering activity.
Medchemexpress LLC Sapintoxin D | 80998-07-8 | 99.9% | 10 MG
Sapintoxin D is a fluorescent phorbol ester used to study the activation of protein kinase C (PKC). It functions as a calcium-dependent PKC activator, making it suitable for various research applications in cell biology and biochemistry.
- Fluorescent phorbol ester
- Activates protein kinase C (PKC)
- Calcium-dependent mechanism
- Appears as a white to off-white solid
- High purity of 99.91%
- Soluble in DMSO for in vitro studies
Apexbio Technology LLC Beta-Lapachone 4707-32-8 10mg
Beta-Lapachone (CAS 4707-32-8) is a small molecule inhibitor of DNA topoisomerase I In DNA unwinding assays beta-Lapachone suppresses topoisomerase I-mediated DNA relaxation at concentrations as low as 1 M without inhibiting topoisomerase II or inducing topoisomerase I-dependent DNA cleavage It exhibits broad cytotoxicity against human cancer cell lines such as AD2780s HT-29 DLD G480 and MCF-7 with IC50 values ranging from 2 to 5 M The compound induces cell death through cytochrome c release triggering both apoptosis and necrosis and affects cell cycle progression causing S-phase and G2/M arrest in different carcinoma cell models Beta-Lapachone is widely utilized in studies investigating topoisomerase I inhibition cancer cell cytotoxicity and cell cycle regulation