Drug Standards
Apexbio Technology LLC Lenalidomide hydrochloride 1243329-97-6 100mg
Lenalidomide hydrochloride is a small-molecule immunomodulator that inhibits TNF- secretion It is designed to modulate immune signaling pathways thereby regulating T cell activation and cytokine production Lenalidomide hydrochloride exerts its biological activity primarily by inhibiting TNF- secretion (IC50 13 nM) enhancing IL-2 and soluble IL-2 receptor (sIL-2R) production and inducing CD28 tyrosine phosphorylation followed by NF- B activation in T cells It also impairs autoubiquitination of cereblon (CRBN) a substrate receptor of the E3 ligase complex affecting downstream protein expression including c-Myc IRF4 and p21(WAF-1) Based on these pharmacological properties lenalidomide hydrochloride holds research potential in oncology and inflammation studies focusing on immune modulation
Medchemexpress LLC Pyridine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-2-nitro- | 877397-70-1 | 99.9% | C13H9Cl2FN2O3 | 1 G
This product is Crizotinib impurity 1, also known as Pyridine, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-2-nitro-. It features a high purity of 99.94% as determined by HPLC.
- High purity (99.94% HPLC)
- Powder storage conditions: -20°C for 3 years or 4°C for 2 years
- In solvent storage conditions: -80°C for 6 months or -20°C for 1 month
- Appearance: Off-white to light yellow solid
Apexbio Technology LLC Amoxicillin Sodium 34642-77-8 5g
Amoxicillin Sodium (CAS 34642-77-8) is a small-molecule inhibitor targeting bacterial cell wall biosynthesis It is designed to disrupt peptidoglycan formation thereby compromising bacterial cell wall integrity Amoxicillin Sodium exerts its biological activity primarily through inhibition of peptidoglycan biosynthesis leading to bacterial lysis and cell death In in vitro studies Amoxicillin Sodium demonstrates broad-spectrum antibacterial inhibitory activity with IC50 values ranging from 0 1 g/mL to 10 g/mL depending on bacterial strain variability and experimental conditions Based on these pharmacological properties Amoxicillin Sodium holds research potential in bacterial physiology characterization antibiotic resistance evaluations and in vitro infection modeling studies
Apexbio Technology LLC Ciprofloxacin hydrochloride hydrate 86393-32-0 5g
Ciprofloxacin hydrochloride hydrate (CAS 86393-32-0) is a small-molecule inhibitor targeting bacterial DNA topoisomerase IV It is designed to inhibit topoisomerase IV-mediated DNA processes thereby impairing DNA replication and promoting DNA damage Ciprofloxacin hydrochloride hydrate exerts its biological activity primarily through inhibition of bacterial DNA topoisomerase IV leading to disruption of nuclear and mitochondrial DNA integrity mitochondrial dysfunction and increased intracellular reactive oxygen species (ROS) In cellular assays ciprofloxacin hydrochloride hydrate demonstrates inhibitory activity with IC50 values typically ranging between 5 50 M depending on the cell type and experimental conditions Based on these pharmacological properties ciprofloxacin hydrochloride hydrate holds research potential in elucidating fluoroquinolone-induced topoisomerase inhibition apoptotic pathways DNA damage responses and antiproliferative effects
Apexbio Technology LLC Haloperidol 52-86-8 500mg
Haloperidol is a small-molecule antagonist targeting dopamine receptors It is designed to block dopamine signaling thereby modulating neurotransmission within cortical limbic and nigrostriatal pathways Haloperidol exerts its biological activity primarily through inverse agonism at dopamine receptors Based on these pharmacological properties Haloperidol holds research potential in psychiatric and neuropsychological applications including studies of delirium delusions hallucinations and characterization of dopamine-mediated neuronal circuits and behavioral models in psychiatric disorders
Apexbio Technology LLC Gabapentin HCl 60142-95-2 100mg
Gabapentin HCl (CAS 60142-95-2) is a structurally related analog of gamma-aminobutyric acid (GABA) though it does not bind directly to GABA receptors Its primary mechanism involves binding to the 2 subunit of voltage-gated calcium channels in neuronal tissues resulting in decreased neurotransmitter release Originally investigated for antiepileptic properties gabapentin has been widely utilized in research exploring neuropathic pain modulation and neuronal excitability This molecule serves as a tool compound for studying calcium channel modulation and the pathophysiology of neurological disorders
Apexbio Technology LLC Econazole nitrate 24169-02-6 10mM (in 1mL DMSO)
Econazole nitrate (24169-02-6) is a small-molecule inhibitor targeting the enzyme 14 -demethylase It is designed to disrupt ergosterol synthesis in fungal membrane sterol biosynthesis thereby decreasing membrane integrity altering permeability and attenuating fungal cellular growth Econazole nitrate exerts its biological activity primarily through inhibition of 14 -demethylase In vitro studies demonstrate antifungal activity with reported IC50 values against various fungal isolates typically ranging from approximately 0 05 to 1 g/mL depending on experimental parameters and organism specificity Based on these pharmacological properties econazole nitrate holds research potential in antifungal susceptibility testing exploration of drug resistance mechanisms in fungal strains characterization of dermatopathogenic microorganisms and drug target identification studies
Selleck Chemical LLC Ketorolac tromethamine salt
Ketorolac tromethamine is a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory analgesic and antipyretic properties It is a non-selective COX inhibitor with IC50s of 20 nM for both COX-1 and COX-2
Apexbio Technology LLC Larotrectinib 1223403-58-4 5mg
Larotrectinib (CAS 1223403-58-4) is a selective orally bioavailable inhibitor of tropomyosin receptor kinases (Trk) which are receptor tyrosine kinases implicated in oncogenic signaling upon neurotrophin activation By binding to Trk proteins larotrectinib disrupts neurotrophin-mediated phosphorylation and downstream signaling leading to growth inhibition and induction of apoptosis in tumor models with Trk gene fusions or overexpression It has gained regulatory approval for use in the study and treatment of solid tumors harboring Trk alterations supporting its application in preclinical and clinical oncology research focused on Trk-driven malignancies
Sigma Aldrich Fine Chemicals Biosciences Econazole Related Compound A United States Pharmacopeia (USP) Reference Standard | 24155-42-8 | 15MG
Econazole Related Compound A United States Pharmacopeia (USP) Reference Standard | Mol Wt: 257.12 | 24155-42-8 | 15MG
Sigma Aldrich Fine Chemicals Biosciences Acebutolol Related Compound B United States Pharmacopeia (USP) Reference Standard | 22568-64-5 | 20MG
Acebutolol Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 308.37 | 22568-64-5 | 20MG
Selleck Chemical LLC crizotinib
(S)-crizotinib the (S)-enantiomer of crizotinib is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay