Drug Standards
Sigma Aldrich Fine Chemicals Biosciences Dipyridamole Related Compound F United States Pharmacopeia (USP) Reference Standard | 60286-30-8 | 25MG
Dipyridamole Related Compound F United States Pharmacopeia (USP) Reference Standard | Mol Wt: 480.56 | 60286-30-8 | 25MG
Medchemexpress LLC Itacitinib | 1334298-90-6 | 100.0% | 553.51 | 5 MG
Itacitinib (INCB039110) is an orally active and selective inhibitor of JAK1, exhibiting significant selectivity over JAK2, JAK3, and TYK2. It is primarily used in the research of myelofibrosis. This product is for research purposes only and has not been fully validated for medical applications.
- Orally active and selective JAK1 inhibitor
- IC50 of 2 nM for human JAK1
- Over 20-fold selectivity for JAK1 over JAK2
- Over 100-fold selectivity over JAK3 and TYK2
- Used in myelofibrosis research
- For research purposes only
Medchemexpress LLC Keto-itraconazole | 112560-33-5 | MFCD08063772 | 98.4% | 719.62 g·mol^-1 | C35H36Cl2N8O5 | 5 MG
Keto-itraconazole is the primary human metabolite of itraconazole used in research as a potent cytochrome P450 3A (CYP3A) inhibitor. It is supplied as a high-purity solid for in vitro pharmacology, metabolism, and drug-drug interaction studies. Typical small pack sizes are provided for lab-scale experiments.
- Potent CYP3A inhibitor (unbound IC50 ≈ 4.6 nM in human liver microsomes with midazolam).
- High purity solid suitable for in vitro assays (reported purity 98.4%).
- Molecular formula C35H36Cl2N8O5 and molecular weight 719.62 g·mol^-1.
- Suitable for liver microsome incubations and drug-drug interaction studies.
- Available in small quantities for research use.
Sigma Aldrich Fine Chemicals Biosciences Adrenaline European Pharmacopoeia (EP) Reference Standard | 51-43-4 | MFCD00002204 |
Adrenaline European Pharmacopoeia (EP) Reference Standard | Mol Wt: 183.2 | 51-43-4 | MFCD00002204 |
Selleck Chemical LLC Liraglutide 1mg 204656-20-2 Victoza, Liraglutida, Liraglutidum, NN2211, NN-2211
Liraglutide (Victoza, Liraglutida, Liraglutidum, NN2211) is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Atazanavir (sulfate) | 229975-97-7 | 99.7% | 802.93 | 50 MG
Atazanavir sulfate is a highly selective and orally active HIV-1 protease inhibitor with blood-brain barrier permeability. It functions as both a substrate and inhibitor of CYP3A4, and also inhibits P-glycoprotein (P-gp). Additionally, it is a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. This compound has demonstrated the ability to inhibit cardiac fibrosis and hyperlipidemia, and induce malignant glioma cell death.
- Highly selective and orally active
- HIV-1 protease inhibitor
- Crosses the blood-brain barrier
- Inhibitor and substrate of CYP3A4
- Inhibits P-glycoprotein (P-gp)
- SARS-CoV 3CLpro inhibitor (IC50 of 3.49 μM)
- Inhibits cardiac fibrosis
- Inhibits hyperlipidemia
- Induces malignant glioma cell death
Medchemexpress LLC Mitotane | 53-19-0 | 320.04 | 1 ML
Mitotane (2,4′-DDD) is an isomer of DDD and a derivative of dichlorodiphenyltrichloroethane (DDT). It acts as an antineoplastic agent primarily used in adrenocortical carcinoma research. Its adrenocorticolytic effect is exerted, in part, through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can also influence corticotroph cells in the pituitary and activate CYP3A4 gene expression via steroid and xenobiotic receptor (SXR).
- Used as an antineoplastic agent in adrenocortical carcinoma research
- Exerts adrenocorticolytic effect through lipotoxicity
- Induces CYP3A4 gene expression via SXR activation
- Can have direct pituitary effects on corticotroph cells
Medchemexpress LLC Tenofovir Disoproxil fumarate | 202138-50-9 | 99.65% | 635.51 | 200 MG
Tenofovir Disoproxil fumarate is a nucleotide reverse transcriptase inhibitor used to treat HIV and chronic Hepatitis B. It is intended for research use only and not for patient administration. The product is available as a solid, appearing as a white to off-white substance.
- Exhibited an IC50 of 4.7 μM against HIV-1 in HeLa cells.
- Showed an IC50 of 5.1 μM against Hepatitis B virus in HepG2 cells.
- Demonstrated dose-dependent activity during vaginal HIV challenge in BLT mice.
- Indicated safety and effectiveness in an HBV infection model in woodchucks.
Medchemexpress LLC Tenofovir Disoproxil | 201341-05-1 | 99.5% | 519.44 | 50 MG
Tenofovir Disoproxil is a nucleotide reverse transcriptase inhibitor primarily used in the treatment of HIV and chronic Hepatitis B. This product is intended for research use only and is not sold to patients, providing a valuable tool for scientific studies.
- Nucleotide reverse transcriptase inhibitor
- Aids in the treatment of HIV and chronic Hepatitis B
- High purity of 99.5%
- Provides in vitro and in vivo solubility data
- Stable in powder form for up to 3 years at -20°C
- Stable in solvent for up to 2 years at -80°C
Medchemexpress LLC Lenalidomide-4-aminomethyl hydrochloride | 444289-05-8 | 90.9% | 309.75 | 100 MG
Lenalidomide-4-aminomethyl hydrochloride is a lenalidomide-based cereblon (CRBN) ligand utilized for the recruitment of CRBN protein. It can be linked to a ligand for protein via a linker to form PROTAC.
- Lenalidomide-based cereblon (CRBN) ligand
- Used in the recruitment of CRBN protein
- Can be connected to a ligand for protein by a linker to form PROTAC
Medchemexpress LLC Clevudine | 163252-36-6 | 99.84% | 260.22 | 100 MG
Clevudine (L-FMAU) is a nucleoside analog of the unnatural L-configuration, exhibiting potent anti-HBV activity with a long half-life and low toxicity. It acts as a non-competitive inhibitor by binding to the polymerase rather than being incorporated into the viral DNA. This compound is also effective against cowpox virus respiratory infection in mice and shows activity against Epstein-Barr virus.
- Nucleoside analog with L-configuration
- Potent anti-HBV activity
- Long half-life and low toxicity
- Non-competitive inhibitor; binds to polymerase
- Effective against cowpox virus respiratory infection
- Shows activity against Epstein-Barr virus
- White to off-white solid appearance
Medchemexpress LLC Agouti-related Protein (AGRP) (83-132) Amide (human) TFA | 97.0% | 5676.57 (free base) | 1 MG
Agouti-related Protein (AGRP) (83-132) Amide (human) TFA is a fragment of agouti-related protein (AGRP) found in abundance in the arcuate nucleus of the hypothalamus. It primarily functions as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake.
- Fragment of agouti-related protein (AGRP)
- Acts as an inverse agonist for the melanocortin-4 receptor (MC4R)
- Increases food intake and decreases spontaneous locomotor activity in rats
- Solid, white to off-white appearance
- Soluble in DMSO up to 100 mg/mL with ultrasonic assistance
- Features a specific amino acid sequence with identified disulfide bridges
Medchemexpress LLC Citalopram (hydrobromide) | 59729-32-7 | 99.9% | 50 MG
Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI) that can cross the blood-brain barrier. It inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM and inhibits 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM, demonstrating an antidepressant effect.
- It is a selective serotonin reuptake inhibitor.
- It exhibits blood-brain barrier permeability.
- It inhibits 5-HT uptake into synaptosomes.
- It inhibits 5-HT uptake in rabbit blood platelets.
- It has an antidepressant effect.
Medchemexpress LLC Promazine hydrochloride | 53-60-1 | 99.9% | 100 MG
Promazine hydrochloride is an antipsychotic and a dopamine receptor D2 antagonist that inhibits dopaminergic neurotransmission.
- IC50 & Target: D2 Receptor
- Shows KDs of 25, 190, and 8400 nM at the human norepinephrine transporter, serotonin transporter, and dopamine transporter respectively in vitro
- Molecular weight: 320.88
- Formula: C17H21ClN2S
- CAS number: 53-60-1
- Appearance: Solid
- Color: White to off-white
Sigma Aldrich Fine Chemicals Biosciences Timolol Related Compound B United States Pharmacopeia (USP) Reference Standard | 59697-06-2 | 20MG
Timolol Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 316.42 | 59697-06-2 | 20MG