Hydrochlorides
Medchemexpress LLC Benzamil hydrochloride | 161804-20-2 | 99.7% | 100 MG
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). It is also a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.
- Na+/Ca2+ exchanger (NCX) inhibitor
- Non-selective Deg/epithelial sodium channels (ENaC) blocker
- Can potentiate myogenic vasoconstriction
- Inhibits TRPP3-mediated Ca2+-activated currents
Medchemexpress LLC Eniporide hydrochlor 25mg | 211813-86-4 | 25MG
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na /H exchange inhibitor
Medchemexpress LLC (±)-Bepridil hydrochloride hydrate | 74764-40-2 | 99.9% | 421.02 | 25 MG
Bepridil hydrochloride hydrate is a non-selective, long-acting calcium channel antagonist and sodium, potassium channel inhibitor. It exhibits antianginal and type I antiarrhythmic effects, and also functions as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. This product is intended for research on cardiovascular disorders.
- Non-selective calcium channel antagonist
- Long-acting
- Sodium channel inhibitor
- Potassium channel inhibitor
- Antianginal effects
- Type I antiarrhythmic effects
- Cardiac Na+/Ca2+ exchange (NCX1) inhibitor
- Blockades of Ca2+-dependent action potentials in vascular smooth muscle
- Blocks Ca currents and Na currents
- Decreases IKs under blockade of IKr
- Exhibits a half-life of averages 33±15 hours after single-dose administration
Medchemexpress LLC Bepridil hydrochloride hydrate | 74764-40-2 | 99.9% | 421.02 | 1 ML
Bepridil hydrochloride hydrate is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor. It possesses antianginal and type I antiarrhythmic effects and functions as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. It can be used for the research of cardiovascular disorders.
- Blocks Ca2+-dependent action potentials in vascular smooth muscle.
- Inhibits Ca currents and Na currents in cultured ventricular cells.
- Decreases IKs under blockade of IKr.
- Suitable for research into cardiovascular disorders.
Medchemexpress LLC Nisoxetine hydrochloride | 57754-86-6 | 99.9% | 25 MG
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. It is an antidepressant and local anesthetic, capable of blocking voltage-gated sodium channels.
- Potent and selective inhibitor of noradrenaline transporter (NET)
- Functions as an antidepressant
- Acts as a local anesthetic
- Blocks voltage-gated sodium channels
Medchemexpress LLC Nisoxetine hydrochloride | 57754-86-6 | MFCD00078426 | 99.92% | 5 MG
Nisoxetine hydrochloride is a potent and selective inhibitor of the noradrenaline transporter (NET), with a Kd of 0.76 nM. It functions as an antidepressant and local anesthetic by blocking voltage-gated sodium channels.
- Potent and selective inhibitor of noradrenaline transporter (NET)
- Acts as an antidepressant
- Functions as a local anesthetic
- Blocks voltage-gated sodium channels
Selleck Chemical LLC N-Acetyl-5-hydroxytryptamine S2985-5mg
N-Acetyl-5-hydroxytryptamine (NAS N-Acetylserotonin Normelatonin O-Demethylmelatonin) a precursor of melatonin is a potent and selective agonist of TrkB receptor
Medchemexpress LLC Amiloride hydrochloride dihydrate | 17440-83-4 | MFCD00211292 | 99.9% | 1 ML
Amiloride hydrochloride dihydrate is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). It also acts as a blocker of polycystin-2 (PC2; TRPP2) channel.
- Inhibits epithelial sodium channel (ENaC)
- Inhibits urokinase-type plasminogen activator receptor (uTPA)
- Blocks polycystin-2 (PC2; TRPP2) channel
Medchemexpress LLC Benzenepropanamine, gamma-(2-methoxyphenoxy)-N-methyl-, hydrochloride | 57754-86-6 | 99.9% | 307.82 | C17H22ClNO2 | 10 MG
Nisoxetine hydrochloride is a research-grade small molecule that potently and selectively inhibits the noradrenaline (norepinephrine) transporter (NET) and can block voltage-gated sodium channels. It is supplied as a solid powder for use in transporter pharmacology, neurotransmitter uptake assays, and sodium channel studies.
- Potent, selective noradrenaline transporter (NET) inhibitor (reported Kd ≈ 0.76 nM).
- Acts as an antidepressant-class compound and local anesthetic via sodium channel blockade.
- High purity suitable for biochemical assays and pharmacology studies.
- Available in small-scale powder sizes and DMSO solution formats for ready use.
- Stable when stored under recommended conditions (powder and in solvent).
Medchemexpress LLC Benzenepropanamine, γ-(2-methoxyphenoxy)-N-methyl- | 53179-07-0 | 98.56% | 50 MG
Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. It is an antidepressant and local anesthetic, capable of blocking voltage-gated sodium channels. It is suitable for laboratory research and experimentation in various biological activities.
- Potent and selective inhibitor of noradrenaline transporter (NET)
- Kd of 0.76 nM (NET)
- Antidepressant properties
- Local anesthetic properties
- Blocks voltage-gated sodium channels
Medchemexpress LLC Benzamil hydrochloride | 161804-20-2 | 99.7% | 50 MG
Benzamil hydrochloride is an Amiloride analogue that acts as a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). It also functions as a non-selective Deg/epithelial sodium channels (ENaC) blocker and can enhance myogenic vasoconstriction. This product inhibits TRPP3-mediated Ca2+-activated currents with an IC50 of 1.1 μM.
- Inhibits neuronal and heterologously expressed small conductance Ca2+-activated K+ channels.
- Shown to improve survival in stroke-prone spontaneously hypertensive rats (SHRSP) when treated at 0.7 mg/kg/day (s.c.).
Medchemexpress LLC Benzamil hydrochloride | 161804-20-2 | 99.7% | 5 MG
Benzamil hydrochloride, an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor with an IC50 of approximately 100 nM. It also functions as a non-selective blocker of Deg/epithelial sodium channels (ENaC) and can enhance myogenic vasoconstriction. It inhibits TRPP3-mediated Ca2+-activated currents with an IC50 of 1.1 μM.
- Inhibits neuronal and heterologously expressed small conductance Ca2+-activated K-channels.
- Treatment with the compound (0.7 mg/kg/day; s.c.) resulted in an average survival until 16.1 weeks of age in stroke-prone spontaneously hypertensive rats (SHRSP).
Medchemexpress LLC Nisoxetine | 53179-07-0 | 98.6% | 100 MG
Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. It functions as an antidepressant and local anesthetic, capable of blocking voltage-gated sodium channels. This product is intended for research use only.
- Potently and selectively inhibits the noradrenaline transporter (NET) with a Kd of 0.76 nM.
- Acts as both an antidepressant and a local anesthetic.
- Can block voltage-gated sodium channels.
- Available in multiple quantities.
- Comes with a data sheet, COA, SDS, and handling instructions.
- Detailed solubility information provided for in vitro use.
Medchemexpress LLC Eniporide hydrochloride | 211813-86-4 | MFCD31560490 | 99.5% | 356.83 g/mol | C14H17ClN4O3S | 1 ML
Eniporide hydrochloride is a potent Na+/H+ (NHE) exchange inhibitor supplied for research use. It is commonly used in cellular and biochemical studies of NHE activity and cardiovascular research, and is offered as both solid material and as a ready-to-use DMSO solution.
- Potent Na+/H+ exchange inhibitor for NHE studies.
- Available as a 10 mM solution in DMSO or as a solid.
- Approximately 99.5% purity suitable for analytical and biological assays.
- Molecular weight 356.83 g/mol; formula C14H17ClN4O3S.
- CAS number 211813-86-4 for unambiguous identification.
- For research use only; not for human or clinical use.
Medchemexpress LLC Benzamide, N-(aminoiminomethyl)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl) hydrochloride | 211813-86-4 | MFCD31560490 | 99.5% | 356.83 | C14H17ClN4O3S | 50 MG
Eniporide hydrochloride is a research-grade Na+/H+ exchange inhibitor provided as the hydrochloride salt for in vitro and in vivo studies of cellular pH regulation and myocardial ischemia/reperfusion. The reagent is characterized by high purity, defined solubility in common solvents, and recommended storage conditions to preserve stability for research use.
- High purity suitable for research applications.
- Available as solid and as solution in DMSO for experimental flexibility.
- Soluble in DMSO and water with documented concentrations and handling notes.
- Stable when stored under recommended sealed, low-temperature conditions.
- Selective inhibition of Na+/H+ exchanger for mechanistic studies.
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