Dimethyl Sulfoxide
Apexbio Technology LLC Org 27569 868273-06-7 10mM (in 1mL DMSO)
Org 27569 (CAS 868273-06-7) is an allosteric modulator targeting the cannabinoid CB1 receptor It enhances the binding of the agonist CP55940 to purified CB1 receptors while simultaneously inhibiting receptor functionality In electrically-stimulated mouse vas deferens assays Org 27569 reduced WIN55212-induced contractions exhibiting a pEC50 of 8 24 0 12 and a maximal response (Emax) of approximately 45 4% Binding studies suggest its interaction at a putative allosteric site on CB1 receptors reflected by parameters such as a pKB of 5 67 0 23 and a Log of 1 14 0 17 Org 27569 serves as a tool compound for studying CB1 receptor allosteric modulation
Apexbio Technology LLC Pomalidomide (CC-4047) 19171-19-8 10mM (in 1mL DMSO)
Pomalidomide (CC-4047) an immunomodulatory derivative structurally related to Thalidomide exhibits anti-tumor and anti-angiogenic properties Chemically the molecule is distinguished by additional amino substituent at the fourth position of the phthalimide ring and two extra oxy groups Its mechanism of action includes modulation of specific cytokines within the tumor microenvironment (TNF- IL-6 IL-8 VEGF) suppression of tumor cell proliferation and modification of host immune cell activity Pomalidomide is widely studied in biomedical research particularly in therapeutic exploration for hematologic malignancies such as multiple myeloma including relapsed or refractory disease states
Apexbio Technology LLC Resveratrol 501-36-0 10mM (in 1mL DMSO)
Resveratrol is a naturally occurring polyphenolic phytoalexin known to function as an activator of the NAD-dependent protein deacetylase SIRT1 Through SIRT1 activation resveratrol modulates downstream pathways implicated in cellular metabolism inflammation aging and tumorigenesis Commonly employed in biomedical research settings resveratrol serves as a molecular tool to explore the regulatory roles and signaling mechanisms involving sirtuin-mediated pathways Cellular assays have demonstrated resveratrol s inhibitory activity against multiple targets with reported IC50 values typically ranging from 20 to 50 M depending on cell type and experimental conditions Therefore resveratrol is widely utilized in vitro and in vivo to elucidate its roles in metabolic regulation inflammation responses cardiovascular function and cancer biology
Apexbio Technology LLC Ornidazole 16773-42-5 10mM (in 1mL DMSO)
Ornidazole a 5-nitroimidazole derivative exhibits antibacterial and antiprotozoal activities by interfering with DNA synthesis in anaerobic microorganisms through the reduction of its nitro group forming cytotoxic intermediates In experimental assays Ornidazole demonstrates inhibitory activity against diverse anaerobic bacterial strains including Bacteroides and Clostridium species and protozoan pathogens such as Giardia lamblia and Trichomonas vaginalis typically showing IC50 values ranging from micromolar to low millimolar concentrations This compound is widely utilized in microbiology and infectious disease research to elucidate anaerobic microbial drug sensitivity pathogen resistance mechanisms and protozoan infection biology
Apexbio Technology LLC SCR7 1533426-72-0 10mM (in 1mL DMSO)
SCR7 (CAS 1533426-72-0) is a small-molecule inhibitor targeting DNA ligase IV and to a lesser extent DNA ligase III It interacts with the DNA-binding domain of DNA ligase IV thereby diminishing its affinity for double-strand breaks (DSBs) and effectively blocking nonhomologous end-joining (NHEJ)-mediated DNA repair In cell culture models expressing inducible Cas9 SCR7-mediated transient inhibition of NHEJ promotes increased homologous-directed repair (HDR) by facilitating accumulation in the S/G2 phase SCR7 treatment in mice transiently impairs lymphocyte development due to the reversible inhibition of DNA ligase IV activity during V(D)J recombination Thus SCR7 serves as a useful tool in genome editing research to enhance precise gene editing efficiency
Apexbio Technology LLC ABT-737 852808-04-9 10mM (in 1mL DMSO)
ABT-737 (CAS 852808-04-9) is a small molecule inhibitor targeting the BCL-2 protein family exhibiting high binding affinity toward the anti-apoptotic proteins BCL-2 BCL-X L and BCL-w ABT-737 disrupts BCL-2/BAX protein interactions leading to apoptosis primarily via the BAK-mediated intrinsic pathway independent of BIM In preclinical studies ABT-737 demonstrated single-agent antitumor activity in lymphoma multiple myeloma and small-cell lung cancer models Additionally research indicates activity against acute myeloid leukemia (AML) cells progenitor cells and leukemia stem cells while sparing normal hematopoietic populations highlighting its potential for therapeutic research in hematologic malignancies
Apexbio Technology LLC PD 151746 179461-52-0 10mM (in 1mL DMSO)
PD 151746 is a cell-permeable inhibitor that selectively targets calpain a calcium-dependent cysteine protease involved in various cellular processes With a Ki value of 0 26 M against -calpain it prevents the proteolytic cleavage of substrates like neuronal nitric oxide synthase (nNOS) and calmodulin-dependent protein kinase II-alpha (CaMPK-II) particularly under stress In neuronal models PD 151746 inhibits apoptosis induced by serum/potassium withdrawal reduces MEF2 phosphorylation suppresses cdk5/p25 complex formation and decreases caspase-3 activation In HepG2 hepatoma cells it disrupts insulin-stimulated glycogen synthesis and affects protein tyrosine phosphatase-2 (PTP2) expression PD 151746 is used in research to study calpain-related signaling pathways apoptosis cell motility and metabolism
Apexbio Technology LLC R428 1037624-75-1 10mM (in 1mL DMSO)
R428 (CAS 1037624-75-1) is a potent selective inhibitor of the receptor tyrosine kinase Axl demonstrating an IC50 of 14 nM In comparison to related kinases such as Abl Mer Tyro3 InsR EGFR HER2 and PDGFR R428 displays greater than 50-fold selectivity for Axl By inhibiting Axl catalytic function R428 disrupts downstream intracellular signaling pathways including Akt phosphorylation cellular invasion pro-inflammatory cytokine production angiogenesis and epithelial-mesenchymal transition mediator expression (e g Snail) Preclinical studies utilizing animal xenograft tumor models indicate its capacity to reduce metastatic tumor burden and extend survival both alone and combined with cisplatin R428 is orally bioavailable and represents a valuable tool for cancer research targeting Axl-driven pathogenesis
Medchemexpress LLC Cimetidine sulfoxide | 54237-72-8 | 97.0% | C10H16N6OS | 10MG
Cimetidine sulfoxide is the sulfoxide metabolite of cimetidine provided for research and analytical applications (CAS 54237-72-8). Supplied as a research-grade solid, it is used as a reference standard in studies of histamine H2-receptor antagonists, drug metabolism, and analytical method development.
- High-purity reference standard suitable for analytical assays.
- Useful for metabolic and pharmacokinetic studies.
- Available in small milligram pack sizes for research use.
- Documentation available: COA, SDS, and handling instructions.
- Stable solid form for storage and long-term use.
Apexbio Technology LLC Entecavir Hydrate 209216-23-9 10mM (in 1mL DMSO)
Entecavir hydrate is an antiviral compound that acts as a reverse transcriptase (RT) inhibitor specifically targeting hepatitis B virus (HBV) infection It inhibits HBV DNA replication by interacting with the viral reverse transcriptase enzyme thus preventing the synthesis of complementary DNA from the viral RNA template Entecavir hydrate is frequently employed in antiviral studies and clinical research related to hepatitis B treatment regimens In studies involving chronic HBV-infected patients entecavir hydrate combined with peginterferon alpha-2b therapy has shown significant suppression of viral DNA levels and reduced covalently closed circular DNA (cccDNA) within hepatocytes The reported IC50 value of entecavir hydrate against HBV DNA polymerase activity typically ranges below 10 nM in cellular assay systems enabling its utility in both preclinical and clinical antiviral investigations
Apexbio Technology LLC Pioglitazone(Synonyms: Actos, Pioglitazone Hydrochloride, AD-4833, U-72107, Glustin, Zactos, Piozone), 10mM (in 1mL DMSO), CAS: 111025-46-8.
Pioglitazone (CAS 111025-46-8) is a small-molecule agonist selectively targeting peroxisome proliferator-activated receptor gamma (PPAR ) By activating this nuclear receptor pioglitazone influences gene expression pathways involved primarily in glucose and lipid metabolism insulin sensitivity and adipocyte differentiation It is widely employed in biomedical research focusing on metabolic disorders including type 2 diabetes mellitus insulin resistance mechanisms and associated inflammatory processes
Apexbio Technology LLC CH5138303 959763-06-5 10mM (in 1mL DMSO)
CH5138303 (CAS 959763-06-5) is a potent inhibitor targeting Heat Shock Protein 90 (HSP90) exhibiting strong binding affinity with a Kd of 0 48 nM HSP90 a molecular chaperone regulates protein folding stability and degradation and maintains oncogenic proteins crucial to tumor cell proliferation CH5138303 effectively reduces protein levels and phosphorylation of HSP90 client proteins including Raf1 AKT EGFR and HER2 in NCI-N87 cancer cells In animal studies using human gastric cancer NCI-N87 xenografts oral administration of CH5138303 demonstrates significant antitumor activity achieving a tumor growth inhibition (TGI) rate of 136% at an ED of 3 9 mg/kg
Apexbio Technology LLC KU 55933 587871-26-9 10mM (in 1mL DMSO)
KU 55933 (CAS 587871-26-9) is a selective inhibitor of ATM kinase with an IC50 of 13 nM ATM kinase promotes insulin-induced Akt activation via phosphorylation of Akt at Ser473 KU 55933 inhibition of ATM significantly reduces Akt Ser473 phosphorylation in insulin- or IGF-I-treated MDA-MB-453 and PC-3 cells resulting in suppressed proliferation cell cycle arrest at G1 phase and decreased cyclin D1 levels KU 55933 serves as a tool for studying ATM-related signaling and Akt-driven cancer cell growth regulation
Apexbio Technology LLC Lonafarnib 193275-84-2 10mM (in 1mL DMSO)
Lonafarnib (CAS 193275-84-2) also known as SCH66336 or Sarasar is a tricyclic orally bioavailable inhibitor of farnesyltransferase (FTase) functioning without peptide or sulfhydryl groups FTase mediates post-translational farnesylation of Ras proteins a modification required for their membrane localization and activation of downstream signaling pathways involved in cellular growth proliferation and survival By inhibiting this enzymatic activity Lonafarnib disrupts Ras translocation to the plasma membrane limiting Ras-mediated signaling Currently Lonafarnib is widely evaluated in preclinical and clinical investigations particularly in oncology contexts
Apexbio Technology LLC Laquinimod (ABR-215062) 248281-84-7 10mM (in 1mL DMSO)
Laquinimod (ABR-215062 CAS 248281-84-7) is an orally bioavailable immunomodulatory small molecule Research studies demonstrate that in experimental autoimmune encephalomyelitis (EAE) a widely utilized rodent model for studying human multiple sclerosis (MS) laquinimod treatment suppresses disease progression in a dose-dependent manner Mechanistically the compound reduces inflammatory infiltration of CD4 T lymphocytes and macrophages into the central nervous system thereby modulating the Th1/Th2 immune response and inducing regulatory cytokines such as TGF- Clinical investigations into relapsing MS indicate that laquinimod administration correlates with reduced disease activity clinical relapse rate MRI-measured lesions and brain volume loss