Dimethyl Sulfoxide
Apexbio Technology LLC Erythritol 149-32-6 10mM (in 1mL DMSO)
Erythritol (CAS 149-32-6) is a four-carbon polyol commonly studied for applications as a low-calorie sweetener Structurally related to other sugar alcohols it exhibits minimal caloric contribution due to limited systemic metabolism and absorption Mechanistically erythritol provides sweetness by interacting with taste receptors on the tongue but it does not significantly elevate blood glucose or insulin levels making it a relevant compound for diabetes and metabolic research Emerging evidence also suggests potential effects on gut microbiota and vascular health warranting exploration in biomedical studies focused on metabolism and cardiovascular function
Apexbio Technology LLC Tie2 kinase inhibitor 948557-43-5 10mM (in 1mL DMSO)
Tie2 kinase inhibitor (CAS 948557-43-5) is a selective and reversible small-molecule inhibitor targeting the Tie2 receptor tyrosine kinase a critical modulator of endothelial cell survival angiogenesis and vascular integrity By inhibiting Tie2 autophosphorylation this compound disrupts subsequent signaling pathways involved in endothelial maturation and tumor-associated angiogenesis In vitro studies demonstrate potent inhibition of Tie2 kinase activity (IC50 0 25 M) with substantial selectivity over other kinases including p38 In vivo treatment reduces angiogenesis and tumor progression in murine xenograft tumor models This inhibitor is thus relevant for research examining angiogenic mechanisms and cancer progression
Apexbio Technology LLC INCB28060 1029712-80-8 10mM (in 1mL DMSO)
INCB28060 (CAS 1029712-80-8) also known as Capmatinib or INC280 is an ATP-competitive inhibitor of the receptor tyrosine kinase c-Met (HGFR) This receptor plays essential roles in cellular processes including embryogenesis healing proliferation invasion and angiogenesis and is frequently overexpressed or mutated in cancers INCB28060 blocks c-Met phosphorylation and downstream signaling exhibiting an IC50 of 0 13 nM In preclinical studies it suppresses proliferation in cancer cell lines (e g SNU-5 S114) and inhibits migration in U-87MG and H441 cells In mouse tumor models oral administration reduces c-Met activation and tumor progression INCB28060 serves as a tool compound for investigating c-Met function in cancer research
Apexbio Technology LLC AdipoRon 924416-43-3 10mM (in 1mL DMSO)
AdipoRon (CAS 924416-43-3) is an agonist of adiponectin receptors AdipoR1 and AdipoR2 displaying binding affinities (Kd) of 1 8 M and 3 1 M respectively Upon receptor activation it promotes phosphorylation of AMPK via AdipoR1 and upregulates expression of PGC-1 improving mitochondrial biogenesis in muscle cell models In vivo studies show that AdipoRon administration stimulates AMPK and PPAR- signaling in liver and muscle tissues subsequently reducing circulating glucose insulin triglycerides and inflammatory cytokines This compound is employed in metabolic and cardiovascular disease research especially regarding insulin resistance dyslipidemia obesity-related inflammation and ischemia-induced myocardial damage
Apexbio Technology LLC JIB-04 199596-05-9 10mM (in 1mL DMSO)
JIB-04 (CAS 199596-05-9) is a selective small-molecule inhibitor targeting Jumonji histone demethylases specifically suppressing enzymes including JARID1A JMJD2 family members (JMJD2A-E) and JMJD3 Structurally categorized as a pyridine hydrazone derivative JIB-04 inhibits demethylase activity independently of competitive binding with -ketoglutarate In vitro assays revealed IC50 values ranging from 230 nM to 1100 nM across various Jumonji enzymes Additionally JIB-04 demonstrates preferential inhibition of cancer cell proliferation versus normal cells notably in lung and prostate cancer cell lines and effectively reduces tumor growth in mouse xenograft models highlighting its relevance for cancer research
Apexbio Technology LLC Prednisolone 50-24-8 10mM (in 1mL DMSO)
Prednisolone is a synthetic glucocorticoid structurally derived from cortisol characterized by anti-inflammatory and immunosuppressive properties Through binding to intracellular glucocorticoid receptors prednisolone modulates gene expression leading to inhibition of pro-inflammatory cytokine production suppression of immune cell proliferation and attenuation of inflammatory mediators In biomedical research prednisolone is commonly employed to investigate inflammatory pathways autoimmune responses and immune regulation mechanisms Additionally it serves as a reference compound in the screening and evaluation of novel anti-inflammatory and immunomodulatory therapeutics
Apexbio Technology LLC BIX 02565 1311367-27-7 10mM (in 1mL DMSO)
BIX 02565 (CAS 1311367-27-7) is a potent inhibitor of ribosomal S6 kinase 2 (RSK2) showing an IC50 of approximately 1 nM RSK activation typically stimulates Na /H exchanger (NHE) crucial for early cellular stress responses involving intracellular pH regulation calcium handling and potential induction of cardiac hypertrophy BIX 02565 also inhibits adrenergic ( 1A 1B 1D 2A 2) imidazoline I2 LRRK2 and PKD1 receptors at varying potencies (IC50 0 052 1 820 M 16 nM and 35 nM respectively) In vivo studies in rats demonstrated dose-dependent decreases in heart rate and mean arterial pressure This compound aids research into signaling pathways relevant to cardiovascular disorders and kinase biology
Apexbio Technology LLC Gemfibrozil 25812-30-0 10mM (in 1mL DMSO)
Gemfibrozil is a small-molecule pharmacological agent that functions primarily through activation of the nuclear receptor peroxisome proliferator-activated receptor-alpha (PPAR ) By modulating PPAR signaling pathways gemfibrozil regulates lipid metabolism influencing the transcription of genes associated with fatty acid oxidation and lipoprotein synthesis resulting in reduced triglyceride levels and altered lipoprotein profiles In biomedical research contexts gemfibrozil is utilized to explore molecular mechanisms underlying lipid metabolic processes atherosclerosis progression and related metabolic disorders Furthermore gemfibrozil serves as a useful experimental tool to dissect PPAR -dependent pathways and to investigate therapeutic potentials targeting lipid abnormalities and cardiovascular disease
Apexbio Technology LLC AM966 1228690-19-4 10mM (in 1mL DMSO)
AM966 (CAS 1228690-19-4) is an orally bioavailable small-molecule antagonist that selectively targets Lysophosphatidic acid type 1 receptor (LPA1) AM966 exhibits potent inhibitory activity against LPA1 receptors from humans and mice with IC50 values of approximately 17 nM and 19 nM respectively demonstrating selectivity over other LPA receptor subtypes (LPA2 5) In vitro AM966 blocks LPA-mediated chemotactic responses in IMR-90 human lung fibroblasts A2058 human melanoma cells and CHO cell lines In vivo AM966 effectively attenuates lung fibrosis inflammation and associated weight loss in bleomycin-induced murine pulmonary fibrosis models highlighting its utility in research on fibrotic diseases
Apexbio Technology LLC Lafutidine 118288-08-7 10mM (in 1mL DMSO)
Lafutidine (CAS 118288-08-7) is a histamine H2 receptor antagonist that functions by inhibiting histamine-induced gastric acid secretion Through selective blockade of H2 receptors on gastric parietal cells it reduces basal and stimulated levels of gastric acid production Lafutidine is utilized in biomedical research exploring gastric physiology receptor signaling pathways and gastrointestinal pharmacology particularly in contexts related to acid-related disorders
Crescent Chemical Co Inc DIMETHYL SULFOXIDE
Dimethyl sulfoxide research grade Highly active solvent and pharmaceutical vehicle; for freezing cells. For gradient centrifugation (1). Determination of cysteine and cystine in proteins (2). Size - 250ML Storage Conditions - +15 °C TO +30 °C Catalog
Apexbio Technology LLC Rifapentine 61379-65-5 10mM (in 1mL DMSO)
Rifapentine is an antibiotic compound employed in the treatment of pulmonary tuberculosis an infectious disease primarily caused by Mycobacterium tuberculosis Rifapentine inhibits bacterial RNA polymerase thereby preventing RNA synthesis essential for bacterial replication and survival In vitro studies demonstrate that rifapentine possesses potent activity against intracellular M tuberculosis residing within human macrophages with reported MIC values ranging from 0 015 to 0 06 mg/ml Preclinical research indicates rifapentine accumulates extensively in host cells achieving higher intracellular concentrations than structurally related rifampin Clinically rifapentine administration schedules involve twice-weekly doses during the intensive phase of tuberculosis therapy followed by weekly dosing in the continuation phase Rifapentine is commonly investigated in pharmacological studies to assess efficacy and optimize dosing regimens in pulmonary tuberculosis treatment
Apexbio Technology LLC N6022(Synonyms: N6022, GSNOR inhibitor N6022, N-6022, N 6022, GSNOR Inhibitor N-6022, CAS 1208315-24-5, GSNORi N6022), 10mM (in 1mL DMSO), CAS: 1208315-24-5.
N6022 (CAS 1208315-24-5) is a selective reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) an enzyme involved in regulating the levels of S-nitrosoglutathione (GSNO) Inhibition of GSNOR leads to elevated GSNO concentrations promoting vasodilatory and anti-inflammatory effects In biochemical assays N6022 exhibits IC50 values of 8 nM (GSNO reduction assay) and 32 nM (HMGSH oxidation assay) with corresponding Ki values of 2 5 nM and 3 1 nM respectively Due to its selectivity profile and potency N6022 has entered clinical evaluation for inflammatory pulmonary conditions
Apexbio Technology LLC UMI-77(Synonyms: UMI 77, UMI77, UMI-77 Mcl-1 inhibitor, Mcl-1 inhibitor UMI-77, 518303-20-3), 10mM (in 1mL DMSO), CAS: 518303-20-3.
UMI-77 (CAS 518303-20-3) is a small-molecule inhibitor targeting the anti-apoptotic protein Myeloid cell leukemia-1 (Mcl-1) a member of the Bcl-2 protein family implicated in apoptotic regulation and cell survival signaling Biochemical assays demonstrate that UMI-77 binds selectively to the BH3-binding groove of Mcl-1 protein competing effectively against pro-apoptotic BH3 peptides (Ki 0 49 M) Additionally UMI-77 disrupts the interaction of Mcl-1 with pro-apoptotic factors such as Bax (IC50 1 43 M) promoting apoptosis in cancer cells Preclinical studies on pancreatic cancer cell lines and BxPC-3 xenograft mouse models show that UMI-77 suppresses tumor growth and induces apoptotic cell death highlighting its value as a research tool for studying apoptosis-related oncogenic pathways
Apexbio Technology LLC BMS-777607 1025720-94-8 10mM (in 1mL DMSO)
BMS-777607 (CAS 1025720-94-8) is an orally bioavailable ATP-competitive inhibitor targeting MET kinase and related receptor tyrosine kinases It selectively inhibits members of the MET family including RON MET Tyro-3 and Axl with IC50 values of 1 8 nmol/L 3 9 nmol/L 4 3 nmol/L and 1 1 nmol/L respectively At higher doses it also inhibits additional tyrosine kinases such as Mer Flt-3 Aurora B Lck and VEGFR2 BMS-777607 has been shown to suppress c-Met autophosphorylation (IC50 20 nmol/L) thereby impairing tumor xenograft growth and metastatic phenotypes supporting its utility in oncological research models exploring MET-driven tumorigenesis and cancer progression