Dimethyl Sulfoxide
Apexbio Technology LLC Cathepsin S inhibitor 1373215-15-6 10mM (in 1mL DMSO)
Cathepsin S inhibitor (CAS 1373215-15-6) is a small-molecule inhibitor targeting the lysosomal cysteine protease Cathepsin S an enzyme critically involved in antigen processing and presentation By reversibly and selectively inhibiting Cathepsin S demonstrating notably less affinity for Cathepsin B this molecule impairs MHC class II-mediated antigen presentation resulting in selective immunosuppressive effects on T cells Consequently Cathepsin S inhibitor holds therapeutic potential for autoimmune and inflammatory conditions such as rheumatoid arthritis psoriasis and multiple sclerosis
Apexbio Technology LLC Flucytosine 2022-85-7 10mM (in 1mL DMSO)
Flucytosine also known as 5-Fluorocytosine (5-FC) is a fluorinated pyrimidine analogue with antifungal properties It exerts its biological activity by penetrating fungal cells and undergoing intracellular conversion into 5-fluorouracil (5-FU) via cytosine deaminase Subsequently 5-FU metabolites inhibit nucleic acid synthesis interfering with fungal RNA and DNA synthesis pathways thus blocking cellular proliferation In laboratory experiments Flucytosine is commonly utilized for antifungal susceptibility assays fungal growth inhibition studies as well as research into antifungal resistance mechanisms The typical reported in vitro antifungal activity displays IC50 values ranging from approximately 0 12 to 8 g/mL depending on fungal species and experimental conditions
Apexbio Technology LLC HTH-01-015(Synonyms: HTH01015, WZ4003, NUAK1 inhibitor WZ4003, NUAK1-IN-1, NUAK1 inhibitor, WZ-4003), 10mM (in 1mL DMSO), CAS: 1613724-42-7.
HTH-01-015 (CAS 1613724-42-7) is a highly selective inhibitor targeting the NUAK1 kinase exhibiting potent inhibitory activity with an IC50 of approximately 100 nM It specifically blocks NUAK1-mediated phosphorylation of MYPT1 at Ser445 with negligible off-target effects among a comprehensive panel of 139 other kinases Cellular studies demonstrate that treatment with HTH-01-015 reduces migration of mouse embryonic fibroblasts (MEFs) suppresses proliferation in U2OS and MEF cell lines at concentrations around 10 M and significantly inhibits invasion of U2OS cells within 3D Matrigel transwell assays This compound serves as a useful research tool for investigating NUAK1-related signaling pathways in cancer biology and cellular dynamics
Apexbio Technology LLC Taxifolin 480-18-2 10mM (in 1mL DMSO)
Taxifolin (CAS number 480-18-2) a bioactive flavonoid isolated primarily from coniferous species of the Pinaceae family exhibits notable antioxidant anti-inflammatory and chemopreventive properties It functions primarily through free radical scavenging and modulation of oxidative stress pathways reducing cellular damage associated with reactive oxygen species (ROS) Taxifolin further influences various signaling cascades involved in inflammation and apoptosis regulation Due to these pharmacological attributes it is widely utilized in biomedical research exploring oxidative stress-related diseases inflammatory conditions and potential cancer therapeutic avenues For optimal stability maintain storage conditions sealed dry and cool
Apexbio Technology LLC Sotrastaurin (AEB071)(Synonyms: AEB071, Sotrastaurin, PKC inhibitor AEB071, PKC inhibitor Sotrastaurin, Sotrastaurin base, AEB-071), 10mM (in 1mL DMSO), CAS: 425637-18-9.
Sotrastaurin (AEB071 CAS 425637-18-9) is a small-molecule inhibitor targeting protein kinase C (PKC) with inhibitory activity against classical and novel PKC isoforms PKC plays an integral role in immune cell signaling influencing T-cell activation proliferation and cytokine synthesis Sotrastaurin blocks PKC-mediated pathways thereby suppressing T-cell activation proliferation IL-2 mRNA expression and NK-cell function as demonstrated in ex vivo lymphocyte assays Due to its immunoregulatory properties Sotrastaurin has potential therapeutic applications in autoimmune conditions including psoriasis
Apexbio Technology LLC (-)-MK 801 121917-57-5 10mM (in 1mL DMSO)
(-)-MK 801 (CAS 121917-57-5) is a small molecule serving as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor It crosses the blood-brain barrier binding reversibly and with high affinity to cortical membranes in a saturable regionally specific manner notably within the hippocampus (-)-MK 801 selectively inhibits depolarization responses to NMDA receptor activation leading to suppression of seizure-like neuronal activity induced by neurotoxins such as tetrodotoxin Due to these properties it has widespread use as a research tool in neuroscience particularly in investigating excitotoxicity epilepsy and neurological disorders associated with NMDA receptor dysfunction
Apexbio Technology LLC Rucaparib (free base) 283173-50-2 10mM (in 1mL DMSO)
Rucaparib (free base) (CAS 283173-50-2) also known as AG014699 or PF-01367338 is a pharmacological inhibitor targeting poly(ADP-ribose) polymerase (PARP) a nuclear enzyme centrally involved in DNA damage signaling and base excision repair pathways By impeding PARP activity Rucaparib compromises DNA repair capacity leading to persistent DNA strand breaks as evidenced by increased gamma-H2AX and p53BP1 foci It has demonstrated radiosensitizing properties in prostate cancer cells notably those harboring PTEN deficiency or expressing ETS gene fusion proteins due partly to inhibition of non-homologous end-joining (NHEJ) DNA repair Rucaparib serves as a tool compound in oncology research to study chemosensitization and radiosensitization strategies
Apexbio Technology LLC Vardenafil 224785-90-4 10mM (in 1mL DMSO)
Vardenafil (CAS 224785-90-4) is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5) It inhibits PDE5 enzyme activity with an IC50 of approximately 0 7 nM in vitro Compared with other PDE isoforms (PDE1-4 and PDE6) vardenafil demonstrates superior selectivity toward PDE5 though moderate inhibition of PDE6 (IC50 11 nM) is observed Vardenafil enhances cGMP accumulation in human corpus cavernosum and significantly potentiates nitric oxide (SNP)- acetylcholine- and electrical field stimulation-induced relaxation in human trabecular smooth muscle Its vasodilatory effects render it suitable for research in erectile function and related vascular physiology
Apexbio Technology LLC Chlorocresol 10mM (in 1mL DMSO)
B1696 is a small molecule compound utilized in biomedical research primarily due to its modulatory effects on specific cellular signaling pathways Although the explicit molecular target is currently unpublished available evidence indicates that B1696 influences cellular processes implicated in inflammation immune response and cell proliferation Researchers employ this compound to investigate disease mechanisms and signaling networks within in vitro or ex vivo experimental systems contributing valuable information on therapeutic intervention strategies and drug development efforts
Apexbio Technology LLC SRT1720 HCl 1001645-58-4 10mM (in 1mL DMSO)
SRT1720 HCl is a small molecule activator of SIRT1 exerting more potent activation than resveratrol It functions through a SIRT1- and PGC-1 -dependent mechanism modulating mitochondrial oxidative metabolism and insulin sensitivity The compound has demonstrated activity in regulating cell growth and apoptosis in multiple myeloma (MM) cells without notably affecting normal cell viability Its antitumor properties relate to activation of caspase-8 caspase-9 caspase-3 and PARP enhancement of reactive oxygen species generation induction of ATM/CHK2 signaling suppression of NF- B signaling and reduction of VEGF-induced migration SRT1720 is utilized in biomedical research to investigate metabolic pathways tumor biology and potential sensitization effects to chemotherapy agents
Apexbio Technology LLC Orlistat(Synonyms: Xenical, Alli, tetrahydrolipstatin, THL, Roche Xenical, lipase inhibitor, (-)-tetrahydrolipstatin), 10mM (in 1mL DMSO), CAS: 96829-58-2.
Orlistat (CAS 96829-58-2) also referred to as tetrahydrolipstatin is a synthetic derivative of lipstatin originally isolated from Streptomyces toxytricini This small molecule specifically inhibits gastrointestinal lipases particularly pancreatic lipase impeding enzymatic hydrolysis of dietary triglycerides and consequently decreasing intestinal absorption of fat Due to its targeted lipase inhibition Orlistat is widely studied in obesity-related metabolic research and lipid metabolism investigations providing a valuable experimental tool for evaluating effects of reduced dietary fat uptake and downstream physiological responses
Apexbio Technology LLC Q-VD(OMe)-OPh 10mM (in 1mL DMSO)
Q-VD(OMe)-OPh is a pan-caspase inhibitor structurally identified as quinolyl-valyl-O-methylaspartyl-[2 6-difluorophenoxy]-methyl ketone As a broad-spectrum inhibitor Q-VD(OMe)-OPh reversibly targets multiple caspases involved in apoptotic signaling including initiator caspases (such as caspases 8 9 10 and 12) and executioner caspases (such as caspase 3) thereby blocking intrinsic extrinsic and endoplasmic reticulum-mediated apoptotic pathways In recombinant enzyme assays this inhibitor displays nanomolar-range IC values against caspases 1 3 8 and 9 Due to minimal cytotoxicity at tested concentrations Q-VD(OMe)-OPh serves as a tool compound in apoptosis-related biomedical research applied broadly for dissecting caspase-dependent apoptotic mechanisms and evaluating cytoprotective strategies