Dimethyl Sulfoxide
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 500mL
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1] br/ Low endotoxin can be used in various biochemical experiments such as drug dissolution
Apexbio Technology LLC Y-27632 146986-50-7 10mM (in 1mL DMSO)
Y-27632 (CAS 146986-50-7) is a selective inhibitor of Rho-associated protein kinases (ROCK) specifically targeting ROCK1 and ROCK2 isoforms It competitively binds to the ATP-binding site inhibiting ROCK1 and ROCK2 with Ki values of 0 22 M and 0 30 M respectively Compared to other kinases such as citron kinase PKN and PKC Y-27632 exhibits significantly higher selectivity toward ROCK isoforms In cellular assays Y-27632 at 10 M concentration effectively disrupts stress fiber formation in Swiss 3T3 fibroblast cells It is widely used in cell biology research to study ROCK signaling pathways and cytoskeletal dynamics
Apexbio Technology LLC Carbadox 6804-07-5 10mM (in 1mL DMSO)
Carbadox is an antibiotic compound employed in bacterial infection research primarily targeting pathogenic organisms associated with gastrointestinal infections in swine including swine dysentery Its antibacterial mechanism involves inhibition of bacterial DNA synthesis and disruption of nucleic acid metabolism thereby interfering with pathogen replication Carbadox is frequently utilized in microbiology studies investigating therapeutic interventions against enteric bacterial pathogens under controlled laboratory conditions In vitro studies report Carbadox demonstrating bacteriostatic activity with IC50 values typically ranging between 0 5 2 g/mL for common susceptible bacterial strains serving as a reference substance in microbial sensitivity assays
Apexbio Technology LLC Empagliflozin (BI 10773) 864070-44-0 10mM (in 1mL DMSO)
Empagliflozin (BI 10773 CAS 864070-44-0) is a potent selective inhibitor targeting sodium-glucose cotransporter 2 (SGLT-2) a transmembrane protein primarily expressed in the kidneys and responsible for glucose reabsorption Empagliflozin inhibits SGLT-2 with an IC50 of 3 1 nM demonstrating high selectivity relative to related transporters (SGLT-1 4 5 and 6) In vitro studies using HK2 human proximal tubular cells showed that empagliflozin suppresses high glucose-induced pro-inflammatory signaling pathways including TLR4 NF- B AP-1 and IL-6 secretion Empagliflozin has been widely studied in diabetic animal models such as Zucker diabetic obese rats effectively reducing blood glucose and increasing urinary glucose excretion supporting its application in diabetes research
Apexbio Technology LLC Piceatannol 10083-24-6 10mM (in 1mL DMSO)
Piceatannol (CAS 10083-24-6) is a naturally occurring small molecule exhibiting anti-inflammatory immunomodulatory and antiproliferative activities It functions primarily by inhibiting protein tyrosine kinases including p56lck and syk kinases and suppressing tumor necrosis factor (TNF)-induced nuclear factor-kappa B (NF- B) activation and downstream gene expression Biologically piceatannol arises as a metabolite of resveratrol through oxidation by cytochrome P450 1B1 This compound is employed in biomedical research to explore kinase signaling pathways inflammatory response regulation and potential therapeutic interventions
Apexbio Technology LLC Melatonin(Synonyms: N-acetyl-5-methoxytryptamine, MEL, Circadin, Melovine, Melatol), 10mM (in 1mL DMSO), CAS: 73-31-4.
Melatonin (CAS 73-31-4) is a naturally occurring hormone functioning primarily as an agonist at the G protein-coupled melatonin receptors MT and MT Through receptor activation melatonin regulates circadian rhythmicity and contributes significantly to sleep-wake cycle maintenance Additionally melatonin demonstrates immunomodulatory capabilities and possesses robust antioxidant properties in vivo combating oxidative stress Due to these characteristics it is frequently investigated in research related to sleep disorders circadian biology immune function and oxidative stress signaling pathways
Apexbio Technology LLC Meptazinol HCl 59263-76-2 10mM (in 1mL DMSO)
Meptazinol HCl also chemically known as WY-22811 hydrochloride is a centrally acting analgesic agent characterized as a partial agonist at the 1 opioid receptor Structurally it belongs to the synthetic opioid family and interacts selectively with opioid receptors in the central nervous system to modulate pain transmission Its partial agonist properties allow for analgesic activity with generally reduced risk of respiratory depression compared to full opioid agonists making it a useful compound in pharmacological studies examining opioid receptor activation modulation and analgesic effects In biomedical research settings Meptazinol HCl is commonly employed to investigate pain management mechanisms opioid receptor signaling pathways receptor selectivity profiles and analgesia-related side effect mitigation
Apexbio Technology LLC KPT-185 1333151-73-7 10mM (in 1mL DMSO)
KPT-185 (CAS 1333151-73-7) is an irreversible selective inhibitor of chromosome region maintenance 1 (CRM1) a nuclear export receptor essential for nuclear-cytoplasmic transport KPT-185 binds covalently at Cys528 of CRM1 thereby inhibiting CRM1-mediated nuclear export of tumor suppressor proteins Studies demonstrate that KPT-185 impairs proliferation and colony formation in acute myeloid leukemia (AML) cell lines exhibiting IC50 values ranging from 100 500 nM inducing G1 cell cycle arrest apoptosis and differentiation of AML blasts Additionally KPT-185 reduces growth and promotes apoptosis in pancreatic cancer models (Colo-357 HPAC BxPC-3) highlighting its potential in cancer research
Cayman Chemical PerphenazIn SulfoxIde 10mg
An active metabolite of perphenazine; selectively binds to dopamine D2 and α1-ARs over α2-ARs (Kis= 5.9, 24, and 683 nM, respectively) in rat brain; increases thrombin-induced increases in phosphatidylinositol levels in isolated human platelets at 5 µM
Gold Biotechnology Inc DMSO ACS Grade 100 mL
Dimethylsulfoxide (DMSO) is a very polar organic compound that is useful in organic chemistry for solubilizing organic and inorganic compounds DMSO is also used as a cryoprotectant for cell media preventing the formation of ice crystals which would otherwise damage cells DMSO can be used in PCR reactions to inhibit the self-complementation of DNA or PCR primers and increase amplification especially for DNA sequences which have GC rich sequences