Dimethyl Sulfoxide
Apexbio Technology LLC Atomoxetine HCl 82248-59-7 10mM (in 1mL DMSO)
Atomoxetine HCl (CAS 82248-59-7) is a selective inhibitor of the norepinephrine transporter (NET) a membrane protein responsible for norepinephrine reuptake and synaptic homeostasis Atomoxetine shows high selectivity towards human NET (Ki 5 nM) with substantially lower affinity for serotonin (Ki 77 nM) and dopamine transporters (Ki 1451 nM) In preclinical studies using rat models atomoxetine elevated extracellular norepinephrine and dopamine specifically in the prefrontal cortex region without affecting dopamine levels in the striatum or nucleus accumbens These traits render it useful in research on neurotransmitter regulation related to cognition and attention disorders
Apexbio Technology LLC Hydroxyurea 127-07-1 10mM (in 1mL DMSO)
Hydroxyurea is a potent inhibitor of ribonucleoside diphosphate reductase a rate-limiting enzyme converting ribonucleotides to deoxyribonucleotides thereby interrupting DNA synthesis and arresting cells in the S-phase of the cell cycle Its reported IC50 values approximate 1 5 mM Hydroxyurea has demonstrated potential in biomedical research settings including inhibition of HIV-1 replication in activated peripheral blood mononuclear cells (PBMCs) with an IC90 of around 0 4 mM induction of fetal hemoglobin (HbF) in erythroid cells from -thalassemia/hemoglobin E patients and tumor growth suppression in various tumor xenograft animal models when used in combination therapy regimens
Apexbio Technology LLC Axitinib (AG 013736) 319460-85-0 10mM (in 1mL DMSO)
Axitinib (CAS 319460-85-0) also known as AG 013736 is an orally bioavailable selective inhibitor targeting vascular endothelial growth factor receptor (VEGFR) tyrosine kinases 1 2 and 3 It inhibits VEGFR phosphorylation with IC50 values of approximately 0 1 nM (VEGFR-1) 0 2 nM (VEGFR-2) and 0 1 0 3 nM (VEGFR-3) and demonstrates significantly higher selectivity relative to FGFR-1 Axitinib reduces phosphorylation of VEGF-mediated intracellular signaling proteins Akt eNOS and ERK1/2 and exhibits in vivo suppression of VEGFR-2 activation (EC50 0 49 nM) Its antiangiogenic action results in tumor growth delay in human xenograft models (e g HCT-116 SN12C) highlighting its utility in cancer research
Apexbio Technology LLC TWS119 601514-19-6 10mM (in 1mL DMSO)
TWS119 (CAS 601514-19-6) is a selective inhibitor of glycogen synthase kinase-3 (GSK-3 ) exhibiting an IC50 of approximately 30 nM Originally identified from a library of pyrrolopyrimidine-based compounds TWS119 binds GSK-3 with a Kd value around 126 nM By inhibiting GSK-3 activity TWS119 modulates downstream transcriptional events promoting neuronal differentiation in murine embryonic carcinoma (P19) and mouse embryonic stem cells through mechanisms distinct from classical Wnt signaling Due to this property TWS119 serves as a useful tool for research in neural differentiation and regenerative medicine
Apexbio Technology LLC Azaguanine-8 134-58-7 10mM (in 1mL DMSO)
Azaguanine-8 (CAS 134-58-7) is a synthetic purine analog utilized in biomedical research due to its antineoplastic properties Structurally similar to guanine Azaguanine-8 exerts its biological activity by competitively interfering with guanine metabolism subsequently disrupting nucleic acid synthesis and cellular replication pathways Through this mechanism the compound demonstrates inhibitory effects on cell proliferation making it a valuable tool in investigating nucleic acid metabolism and cancer biology in preclinical studies
Apexbio Technology LLC AZD2461 1174043-16-3 10mM (in 1mL DMSO)
AZD2461 (CAS 1174043-16-3) is a novel small-molecule inhibitor of poly(ADP-ribose) polymerase (PARP) exhibiting potency with an IC50 of 5 nM PARP enzymes are pivotal regulators of DNA repair and apoptosis-associated processes In breast cancer cell lines such as SKBR-3 and MCF-7 AZD2461 reduces cell viability in a concentration- and time-dependent manner arresting cells predominantly in the G2 phase In BRCA1-deficient mouse KB1P tumors AZD2461 disrupts PARP activity regardless of P-glycoprotein-mediated resistance to other inhibitors like olaparib highlighting its utility in overcoming drug resistance and elucidating DNA repair pathways in cancer research
Apexbio Technology LLC Cathepsin S inhibitor 1373215-15-6 10mM (in 1mL DMSO)
Cathepsin S inhibitor (CAS 1373215-15-6) is a small-molecule inhibitor targeting the lysosomal cysteine protease Cathepsin S an enzyme critically involved in antigen processing and presentation By reversibly and selectively inhibiting Cathepsin S demonstrating notably less affinity for Cathepsin B this molecule impairs MHC class II-mediated antigen presentation resulting in selective immunosuppressive effects on T cells Consequently Cathepsin S inhibitor holds therapeutic potential for autoimmune and inflammatory conditions such as rheumatoid arthritis psoriasis and multiple sclerosis
Apexbio Technology LLC Rucaparib (free base) 283173-50-2 10mM (in 1mL DMSO)
Rucaparib (free base) (CAS 283173-50-2) also known as AG014699 or PF-01367338 is a pharmacological inhibitor targeting poly(ADP-ribose) polymerase (PARP) a nuclear enzyme centrally involved in DNA damage signaling and base excision repair pathways By impeding PARP activity Rucaparib compromises DNA repair capacity leading to persistent DNA strand breaks as evidenced by increased gamma-H2AX and p53BP1 foci It has demonstrated radiosensitizing properties in prostate cancer cells notably those harboring PTEN deficiency or expressing ETS gene fusion proteins due partly to inhibition of non-homologous end-joining (NHEJ) DNA repair Rucaparib serves as a tool compound in oncology research to study chemosensitization and radiosensitization strategies
Apexbio Technology LLC Vardenafil 224785-90-4 10mM (in 1mL DMSO)
Vardenafil (CAS 224785-90-4) is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5) It inhibits PDE5 enzyme activity with an IC50 of approximately 0 7 nM in vitro Compared with other PDE isoforms (PDE1-4 and PDE6) vardenafil demonstrates superior selectivity toward PDE5 though moderate inhibition of PDE6 (IC50 11 nM) is observed Vardenafil enhances cGMP accumulation in human corpus cavernosum and significantly potentiates nitric oxide (SNP)- acetylcholine- and electrical field stimulation-induced relaxation in human trabecular smooth muscle Its vasodilatory effects render it suitable for research in erectile function and related vascular physiology
Apexbio Technology LLC Chlorocresol 10mM (in 1mL DMSO)
B1696 is a small molecule compound utilized in biomedical research primarily due to its modulatory effects on specific cellular signaling pathways Although the explicit molecular target is currently unpublished available evidence indicates that B1696 influences cellular processes implicated in inflammation immune response and cell proliferation Researchers employ this compound to investigate disease mechanisms and signaling networks within in vitro or ex vivo experimental systems contributing valuable information on therapeutic intervention strategies and drug development efforts