Dimethyl Sulfoxide
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 500mL
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1] br/ Low endotoxin can be used in various biochemical experiments such as drug dissolution
Supply Solutions Dimethyl sulfoxide | 67-68-5 | 78.14 g/mol | 50ML
Dimethyl sulfoxide | 67-68-5 | 78.14 g/mol | 50ML
Supply Solutions Dextran sulfate sodium salt from Leuconostoc spp., average mol wt ~40,000
A research chemical with the chemical formula C6H5CH2CH2NH2. It is supplied as a colorless to pale yellow liquid with a molecular weight of 121.18 g/mol. This aromatic amine has a density of 0.964 g/mL at 25C and a boiling point of 184-185C. It can be used as a precursor to make other organic compounds. D2650 is sold in a variety of sizes ranging from 5g to 500g. It should be handled carefully as it is harmful if swallowed, inhaled or absorbed through the skin. Proper PPE like gloves and goggles should be worn.
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 99.9% | 78.13 g/mol | C2H6OS | 50mL
Dimethyl sulfoxide cryoprotectant vitrification agent (DMSO cryoprotectant vitrification agent) is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1] This product has been sterilized and has no endotoxin It can be used for long-term cell cryopreservation and will not affect the normal growth of cells
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide
Dimethyl sulfoxide | Purity: 99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 1L
Apexbio Technology LLC (-)-JQ1 1268524-71-5 10mM (in 1mL DMSO)
(-)-JQ1 (CAS 1268524-71-5) is a stereoisomer of ( )-JQ1 designed as a negative control in bromodomain inhibition studies Unlike ( )-JQ1 a competitive BET bromodomain inhibitor known to displace BRD4 fusion oncoproteins from chromatin the (-)-enantiomer shows negligible interaction with tested bromodomains It exhibits minimal inhibitory activity against BRD4(1) with an IC50 of 10 000 nM Due to the lack of significant bromodomain binding (-)-JQ1 serves widely as an appropriate negative control compound in experiments investigating BET protein functions and related signaling
Apexbio Technology LLC GSK 650394 890842-28-1 10mM (in 1mL DMSO)
GSK 650394 is a small-molecule inhibitor selectively targeting serum- and glucocorticoid-regulated kinase 1 (SGK1) showing inhibition through competitive binding mechanism with an IC50 of approximately 13 nM in fluorescence polarization assays SGK1 functions as an androgen-regulated kinase inhibition of this signaling reduces androgen-driven growth in prostate cancer cell lines Experimental studies demonstrate that GSK 650394 blocks SGK1 and SGK2 kinase activity with IC50 values of 62 nM and 103 nM respectively assessed by scintillation proximity assays Additionally GSK 650394 reduces androgen-induced phosphorylation of SGK substrate Nedd4-2 and suppresses androgen-stimulated proliferation of prostate cancer LNCaP cells (IC50 1 M) suggesting its use in prostate cancer research as a potential therapeutic strategy
Apexbio Technology LLC Didanosine 69655-05-6 10mM (in 1mL DMSO)
Didanosine is a nucleoside analogue known to inhibit reverse transcriptase enzymes by acting as a competitive inhibitor and terminator of viral DNA elongation Mechanistically didanosine is phosphorylated intracellularly to its active metabolite dideoxyadenosine triphosphate (ddATP) an analog of dATP Incorporation of ddATP into viral DNA by viral reverse transcriptase causes premature termination of DNA synthesis thereby inhibiting retroviral replication Didanosine is frequently employed as an experimental tool in studies examining antiviral activity and resistance mechanisms in retroviral infection models particularly HIV research In vitro assays commonly report IC50 values for didanosine against HIV reverse transcriptase in the range of approximately 0 5 to 10 M varying according to experimental conditions and viral strain sensitivity evaluated
Medchemexpress LLC XMU-MP-9 ,10 mM 1 mL in DMSO Solution
XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used in cancer research.
Apexbio Technology LLC IWR-1-endo 1127442-82-3 10mM (in 1mL DMSO)
IWR-1-endo (CAS 1127442-82-3) is a synthetic small-molecule antagonist of the Wnt/ -catenin signaling pathway It inhibits the activity of WNT1 2 and 3 ligands preventing downstream -catenin accumulation by stabilizing Axin-based degradation complexes and disrupting signaling events mediated via LRP6 and DVL2 Experimentally IWR-1-endo suppresses processes dependent on Wnt/ -catenin activity such as tissue regeneration and epithelial stem cell self-renewal demonstrated notably in zebrafish tailfin regeneration models Additionally it reduces abnormal proliferation induced by APC loss in cancer cell lines highlighting its relevance in oncogenesis research
Apexbio Technology LLC LY2584702 1082949-67-4 10mM (in 1mL DMSO)
LY2584702 (CAS 1082949-67-4) is an orally bioavailable ATP-competitive inhibitor selectively targeting p70 S6 kinase (p70S6K) a serine/threonine kinase downstream of the PI3K/Akt/mTOR signaling cascade By inhibiting p70S6K activity LY2584702 effectively suppresses phosphorylation of ribosomal protein S6 (S6) thereby modulating protein translation LY2584702 exhibits potent inhibition of p70S6K (IC50 4 nM) and effectively reduces phosphorylated S6 levels in HCT116 colorectal cancer cells (IC50 between 0 1-0 24 M) Notably LY2584702 demonstrated anticancer activity in preclinical xenograft models supporting its role in targeted cancer research and therapeutic development