Dimethyl Sulfoxide
Apexbio Technology LLC Sitaxentan sodium(Synonyms: TBC11251, Sitaxsentan sodium, Thelin, Sitaxentan sodium hydrate, Sitaxentan sodium salt), 10mM (in 1mL DMSO), CAS: 210421-74-2.
Sitaxentan sodium (CAS 210421-74-2) is a small molecule compound functioning as an orally bioavailable and highly selective antagonist for endothelin receptor subtype A (ETA) By specifically inhibiting ETA receptor signaling sitaxentan sodium interferes with endothelin-1 mediated vasoconstriction and cellular proliferation pathways In biomedical research contexts it serves as a valuable tool for investigating endothelin-related physiological and pathological processes with particular relevance to studies on vascular disorders and pulmonary arterial hypertension
Apexbio Technology LLC Alendronate sodium(Synonyms: Alendronate sodium hydrate, Sodium alendronate, Alendronic acid monosodium salt, Fosamax), 10mM (in 1mL DMSO), CAS: 129318-43-0.
Alendronate sodium (CAS 129318-43-0) is a small molecule inhibitor of osteoclast-driven bone resorption It acts by selectively inhibiting farnesyl diphosphate synthase (FPPS) an essential enzyme within the mevalonate (HMG-CoA reductase) pathway exhibiting an IC50 of approximately 460 nM against recombinant human FPPS Inhibition of FPPS prevents protein prenylation and sterol biosynthesis within osteoclasts subsequently inducing apoptosis in macrophage-lineage cells Alendronate sodium is commonly utilized in biomedical research focused on bone metabolism disorders osteoclast biology and evaluation of therapeutic strategies targeting bone density loss
Apexbio Technology LLC Tianeptine sodium(Synonyms: Stablon, Coaxil, Tatinol, Tianeurax, Salymbra, Tianeptine Sodium Salt), 10mM (in 1mL DMSO), CAS: 30123-17-2.
Tianeptine sodium (CAS 30123-17-2) is a small molecule known to selectively facilitate serotonin (5-HT) uptake in both in vitro and in vivo experimental models It exhibits minimal affinity toward various neurotransmitter receptors including serotonin and dopamine receptors (IC 10 M) and does not affect the uptake mechanisms of noradrenaline or dopamine Due to its distinct serotonergic modulation tianeptine sodium is extensively used in neuroscience research particularly in studies investigating the molecular basis and therapeutic potential of antidepressants
Apexbio Technology LLC Sodium Picosulfate 10040-45-6 10mM (in 1mL DMSO)
Sodium picosulfate is an organic stimulant laxative widely utilized to investigate bowel motility and electrolyte balance Its pharmacological activity involves inhibition of fluid and electrolyte absorption alongside enhancement of their secretion in the intestinal lumen thus promoting bowel evacuation In vitro studies evaluating human rat and rabbit liver cell cultures showed sodium picosulfate interaction with hepatic cells notably rabbit hepatocytes demonstrated higher sensitivity reflected by decreased cellular protein content at concentrations in the g/ml range Clinical research supports the utility of sodium picosulfate in experimental constipation models including drug-induced and chronic constipation settings allowing assessment of bowel function and symptoms such as abdominal distension and stool consistency
Apexbio Technology LLC Fluvastatin Sodium 93957-55-2 10mM (in 1mL DMSO)
Fluvastatin Sodium (CAS 93957-55-2) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase the rate-limiting enzyme in cholesterol biosynthesis By blocking HMG-CoA reductase activity fluvastatin reduces serum total cholesterol LDL-cholesterol and apolipoprotein B while increasing HDL-cholesterol and apolipoprotein A-I levels In research settings fluvastatin exhibits anti-atherosclerotic anti-thrombotic and antioxidant properties Studies have shown fluvastatin decreases platelet aggregation dose-dependently in vitro reducing platelet aggregation by approximately 10-15% at clinical doses (40 mg/day) Additionally fluvastatin inhibits inflammatory angiogenesis and NO production suggesting potential applications in inflammatory and cardiovascular research
Apexbio Technology LLC Micafungin sodium 208538-73-2 10mM (in 1mL DMSO)
Micafungin sodium is an antifungal agent that acts by inhibiting the synthesis of 1 3- -D-glucan an essential polymer for fungal cell wall integrity particularly in Candida albicans In addition to antifungal activities micafungin has been studied for its capacity to suppress biofilm formation by Pseudomonas aeruginosa via downregulation of genes encoding structural biofilm elements such as algC and pelC and the 1 3- -D-glucan-encoding gene ndvB Micafungin has demonstrated synergy with other antifungal compounds in animal models in murine models of systemic Aspergillus fumigatus infection micafungin administration resulted in increased survival rates Micafungin is utilized in biomedical research to investigate antifungal mechanisms combination therapies and inhibition of pathogen biofilms Reported inhibitory activity (IC50) for fungal glucan synthase typically falls within the nanomolar range
Supply Solutions Dextran sulfate sodium salt from Leuconostoc spp., average mol wt ~40,000
A research chemical with the chemical formula C6H5CH2CH2NH2. It is supplied as a colorless to pale yellow liquid with a molecular weight of 121.18 g/mol. This aromatic amine has a density of 0.964 g/mL at 25C and a boiling point of 184-185C. It can be used as a precursor to make other organic compounds. D2650 is sold in a variety of sizes ranging from 5g to 500g. It should be handled carefully as it is harmful if swallowed, inhaled or absorbed through the skin. Proper PPE like gloves and goggles should be worn.
Apexbio Technology LLC Simeprevir(Synonyms: Olysio, TMC435, TMC435350, Simeprevir sodium), 10mM (in 1mL DMSO), CAS: 923604-59-5.
Simeprevir (CAS 923604-59-5) is a small molecule inhibitor targeting the hepatitis C virus (HCV) NS3/4A protease a viral serine protease essential for viral polyprotein processing and replication Simeprevir inhibits NS3/4A protease with a Ki of 0 36 nM and demonstrates antiviral activity by reducing viral replication in Huh-7 replicon cells (EC50 of 7 8 nM) and Huh7-Luc HCV genotype 1b replicon cells (EC50 of 8 nM EC90 of 24 nM) Simeprevir is widely utilized in research on antiviral mechanisms and therapeutic strategies against HCV infections
Apexbio Technology LLC Proparacaine HCl 5875-06-9 10mM (in 1mL DMSO)
Proparacaine HCl (CAS 5875-06-9) is a small-molecule antagonist of voltage-gated sodium channels By inhibiting sodium ion entry through these channels Proparacaine HCl effectively suppresses action potential generation and neuronal signaling Assays demonstrate an ED50 value of approximately 3 4 mM Due to its sodium channel inhibition Proparacaine HCl is utilized in scientific research to study neuronal excitability ion channel function and related electrophysiological processes
Apexbio Technology LLC A-803467 944261-79-4 10mM (in 1mL DMSO)
A-803467 (CAS 944261-79-4) is a potent selective blocker of the voltage-gated sodium channel subtype NaV1 8 It inhibits human and rat recombinant NaV1 8 channels with IC50 values of approximately 79 nM and 45 nM respectively Its selectivity for NaV1 8 over other sodium channel subtypes (e g NaV1 2 NaV1 3 NaV1 5 and NaV1 7) is 300 1000 fold By specifically reducing activity in tetrodotoxin-resistant sodium currents of dorsal root ganglion neurons A-803467 suppresses induced and spontaneous action potential firing exhibiting analgesic properties in animal models of neuropathic and inflammatory pain
Apexbio Technology LLC Riluzole 1744-22-5 10mM (in 1mL DMSO)
Riluzole (CAS 1744-22-5) is a small molecule modulator of glutamatergic neurotransmission exhibiting multiple mechanisms of neuroprotection Its action primarily involves inhibition of voltage-gated sodium channels modulation of high-voltage-activated calcium and potassium channels and interference with protein kinase C activity collectively mitigating neuronal excitotoxicity In cultured rat cortical neurons riluzole inhibits inward sodium currents with an IC50 of 51 M At submicromolar to micromolar concentrations riluzole enhances sodium-dependent glutamate uptake mediated by the GLAST GLT1 and EAAC1 transporters Owing to these properties riluzole is commonly utilized in neuroscience research on excitotoxicity neurodegeneration and related pathologies
Apexbio Technology LLC Prilocaine 721-50-6 10mM (in 1mL DMSO)
Prilocaine (CAS 721-50-6) is a local anesthetic molecule categorized within the amino amide class Its primary pharmacological mechanism involves reversible blockade of voltage-gated sodium channels in neuronal membranes thereby inhibiting action potential propagation and sensory nerve impulse conduction Due to its sodium channel-blocking profile prilocaine is commonly investigated in biomedical research examining reversible neural inhibition pain modulation pathways and sensory signal transmission mechanisms
Apexbio Technology LLC Bupivacaine HCl 18010-40-7 10mM (in 1mL DMSO)
Bupivacaine Hydrochloride (CAS 18010-40-7) is an amino amide-type local anesthetic compound that functions primarily through blockade of voltage-gated sodium channels By preventing sodium ion influx in neuronal membranes it reduces action potential propagation resulting in reversible inhibition of nerve conduction Due to its relatively rapid onset paired with prolonged anesthetic duration bupivacaine hydrochloride is frequently utilized experimentally to investigate neuronal signaling pain mechanisms and local anesthetic pharmacology in biomedical research
Apexbio Technology LLC Chlorothiazide 58-94-6 10mM (in 1mL DMSO)
Chlorothiazide is a sulfonamide-derived diuretic compound known for its inhibitory action on carbonic anhydrase enzymes It functions by reducing sodium and chloride ion reabsorption via blockade of renal tubular transport mechanisms which subsequently promotes increased urine output Structurally Chlorothiazide contains a benzothiadiazine ring system contributing to its specific interaction with renal transport channels and carbonic anhydrase enzymes In biomedical research Chlorothiazide serves as a pharmacological tool to investigate ion transport pathways renal physiologic processes and mechanisms underlying fluid balance regulation Additionally it is utilized in experimental models studying electrolyte homeostasis and disorders associated with abnormal sodium or chloride retention
Apexbio Technology LLC SEA0400 223104-29-8 10mM (in 1mL DMSO)
SEA0400 (CAS 223104-29-8) is a selective inhibitor of the sodium-calcium exchanger (NCX) an antiporter responsible for cellular calcium homeostasis by facilitating sodium-calcium ion exchange across membranes SEA0400 inhibits NCX activity at nanomolar concentrations (IC50 between 5-33 nM in neuronal and glial cell cultures) with substantially higher potency than KB-R7943 By blocking reverse-mode NCX function during reperfusion scenarios SEA0400 reduces pathological intracellular calcium influx and downstream pro-inflammatory mediator production It has demonstrated neuroprotective effects by reducing infarction volumes in rodent cerebral ischemia models as well as anti-arrhythmic properties in myocardial infarction models
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