Dimethyl Sulfoxide
Apexbio Technology LLC Floxuridine 50-91-9 10mM (in 1mL DMSO)
Floxuridine is an antineoplastic antimetabolite compound functioning through inhibition of thymidylate synthase leading to interference with thymidine nucleotide biosynthesis This interruption induces DNA replication stress characterized by formation of double-strand DNA breaks Floxuridine exposure activates cellular DNA damage response pathways specifically ATR and ATM kinase signaling cascades and leads to the phosphorylation of checkpoint kinase 1 (Chk1) This compound has been widely utilized in oncology research to analyze DNA damage mechanisms cellular proliferation inhibition and apoptosis induction in human tumor cell lines Floxuridine demonstrates antiproliferative activity in cell-based assays with reported IC50 values typically ranging between 50 nM and 500 nM depending on cell line and experimental conditions
Apexbio Technology LLC Riociguat 625115-55-1 10mM (in 1mL DMSO)
Riociguat (CAS 625115-55-1) chemically known as BAY 63-2521 is a small-molecule stimulator of soluble guanylate cyclase (sGC) It directly activates sGC independently and also enhances the enzyme s sensitivity to nitric oxide (NO) leading to elevated cyclic guanosine monophosphate (cGMP) levels Elevated cGMP induces smooth muscle relaxation and vasodilation Riociguat has been examined clinically for potential therapeutic roles in chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH)
Apexbio Technology LLC Prednisolone 50-24-8 10mM (in 1mL DMSO)
Prednisolone is a synthetic glucocorticoid structurally derived from cortisol characterized by anti-inflammatory and immunosuppressive properties Through binding to intracellular glucocorticoid receptors prednisolone modulates gene expression leading to inhibition of pro-inflammatory cytokine production suppression of immune cell proliferation and attenuation of inflammatory mediators In biomedical research prednisolone is commonly employed to investigate inflammatory pathways autoimmune responses and immune regulation mechanisms Additionally it serves as a reference compound in the screening and evaluation of novel anti-inflammatory and immunomodulatory therapeutics
Apexbio Technology LLC Parthenolide 20554-84-1 10mM (in 1mL DMSO)
Parthenolide (CAS 20554-84-1) is a sesquiterpene lactone naturally derived from feverfew (Chrysanthemum parthenium) It exerts biological activity primarily via inhibition of the NF- B signaling pathway suppression of STAT3 activation and modulation of oxidative stress pathways leading to anti-inflammatory and anticancer effects In biomedical research parthenolide is commonly utilized to investigate molecular mechanisms governing inflammation cellular apoptosis and tumor growth suppression as well as in studies targeting leukemia and solid tumors
Apexbio Technology LLC Phenacetin 62-44-2 10mM (in 1mL DMSO)
Phenacetin (CAS 62-44-2) is a synthetic non-opioid analgesic historically utilized for alleviating pain and reducing fever lacking intrinsic anti-inflammatory effects Its analgesic mechanism primarily involves inhibition of cyclooxygenase (COX) enzyme activity in the central nervous system leading to decreased prostaglandin synthesis Previously studied for its pharmacological action on pain modulation pathways phenacetin serves currently as an experimental reference compound in evaluating nephrotoxic effects in biomedical research following its market withdrawal due to nephropathy concerns
Apexbio Technology LLC LY2835219 1231930-82-7 10mM (in 1mL DMSO)
LY2835219 (CAS 1231930-82-7) is a selective orally bioavailable inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) It targets CDK4 and CDK6 with reported IC50 values of 2 nM and 10 nM respectively thereby reducing phosphorylation of the retinoblastoma protein (Rb) This mechanism leads to cell-cycle arrest during the G1 phase and subsequent inhibition of tumor cell proliferation LY2835219 demonstrates the capacity to cross the blood-brain barrier indicating its potential utility in research involving primary or metastatic intracranial tumors
Apexbio Technology LLC Carprofen 53716-49-7 10mM (in 1mL DMSO)
Carprofen (CAS 53716-49-7) is a non-steroidal anti-inflammatory drug (NSAID) primarily characterized by selective inhibition of cyclooxygenase-2 (COX-2) This selective targeting leads to decreased prostaglandin synthesis mitigating inflammation and pain responses In assays involving canine COX-2 enzyme carprofen exhibits inhibitory activity with an IC50 value of approximately 0 03 mM Due to its targeted COX-2 inhibition carprofen serves as a useful research compound in veterinary and biomedical studies investigating inflammatory pathways and analgesic mechanisms
Apexbio Technology LLC Dofetilide 115256-11-6 10mM (in 1mL DMSO)
Dofetilide (CAS 115256-11-6) chemically designated as UK 68789 is a class III antiarrhythmic small molecule that selectively inhibits the rapid delayed rectifier potassium channel (IKr) This inhibition leads to prolonged ventricular action potential duration and extended effective refractory periods in cardiac cells Noted for favorable oral bioavailability Dofetilide is extensively utilized in cardiac electrophysiological research including studies aimed at elucidating arrhythmogenic mechanisms linked to IKr channel function assessing novel antiarrhythmic candidates and exploring physiological and pathological aspects of cardiac rhythm regulation
Apexbio Technology LLC Vorapaxar 618385-01-6 10mM (in 1mL DMSO)
Vorapaxar (CAS 618385-01-6) is a selective inhibitor of protease-activated receptor 1 (PAR1) a G-protein coupled receptor activated by thrombin-mediated cleavage on platelet surfaces leading to platelet activation Derived from the natural product himbacine vorapaxar directly binds PAR1 inhibiting platelet aggregation induced by thrombin receptor-activating peptides (IC 25 nM) and thrombin itself (IC 47 nM) In phase III clinical trials in patients daily oral administration reduced the incidence of cardiovascular death or ischemic events highlighting its relevance as an antithrombotic research agent
Apexbio Technology LLC Tinidazole 19387-91-8 10mM (in 1mL DMSO)
Tinidazole is a synthetic nitroimidazole derivative with antiparasitic and antibacterial activity used to study protozoal infections and anaerobic bacterial conditions After cellular uptake it is activated by nitroreductase enzymes forming cytotoxic metabolites that induce DNA strand breaks and inhibit nucleic acid synthesis leading to cell death Tinidazole is commonly used in vitro to evaluate its efficacy against pathogens like Giardia lamblia Trichomonas vaginalis and Entamoeba histolytica IC50 values against Giardia lamblia trophozoites typically range from 0 5 to 5 M making it a useful tool for antiparasitic drug screening and antimicrobial studies
Apexbio Technology LLC N6022(Synonyms: N6022, GSNOR inhibitor N6022, N-6022, N 6022, GSNOR Inhibitor N-6022, CAS 1208315-24-5, GSNORi N6022), 10mM (in 1mL DMSO), CAS: 1208315-24-5.
N6022 (CAS 1208315-24-5) is a selective reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) an enzyme involved in regulating the levels of S-nitrosoglutathione (GSNO) Inhibition of GSNOR leads to elevated GSNO concentrations promoting vasodilatory and anti-inflammatory effects In biochemical assays N6022 exhibits IC50 values of 8 nM (GSNO reduction assay) and 32 nM (HMGSH oxidation assay) with corresponding Ki values of 2 5 nM and 3 1 nM respectively Due to its selectivity profile and potency N6022 has entered clinical evaluation for inflammatory pulmonary conditions
Apexbio Technology LLC Corticosterone(Synonyms: 17-Deoxycortisol, 11β,21-Dihydroxyprogesterone, Reichstein's Substance B, Kendall's Compound B), 10mM (in 1mL DMSO), CAS: 50-22-6.
Corticosterone (CAS 50-22-6) is an endogenous steroid hormone secreted by the adrenal cortex which exhibits affinity toward both glucocorticoid and mineralocorticoid receptors Its mechanism of action involves serum- and glucocorticoid-inducible kinase (SGK)-mediated phosphorylation of GDP dissociation inhibitor (GDI) at Ser-213 thereby promoting GDI-Rab4 complex assembly This activity enhances Rab4-dependent recycling of AMPA receptors to cortical neuron synapses leading to elevated synaptic excitatory responses Corticosterone thus serves as a useful biochemical tool for investigating stress-related modulation of synaptic transmission and plasticity
Apexbio Technology LLC GSK2636771 1372540-25-4 10mM (in 1mL DMSO)
GSK2636771 (CAS 1372540-25-4) is a selective inhibitor targeting the p110 isoform of class I phosphoinositide 3-kinase (PI3K) PI3Ks comprise catalytic subunits p110 and which mediate signaling cascades critical for cellular proliferation and survival Specifically GSK2636771 reduces AKT phosphorylation in breast cancer cell lines leading to diminished cellular viability In PTEN-deficient endometrioid endometrial cancer (EEC) cell lines combination with the p110 inhibitor A66 enhances inhibition of cell growth This compound serves as a research tool for investigating PI3K signaling and potential cancer therapeutic strategies
Apexbio Technology LLC (-)-MK 801 121917-57-5 10mM (in 1mL DMSO)
(-)-MK 801 (CAS 121917-57-5) is a small molecule serving as a non-competitive antagonist at the N-methyl-D-aspartate (NMDA) receptor It crosses the blood-brain barrier binding reversibly and with high affinity to cortical membranes in a saturable regionally specific manner notably within the hippocampus (-)-MK 801 selectively inhibits depolarization responses to NMDA receptor activation leading to suppression of seizure-like neuronal activity induced by neurotoxins such as tetrodotoxin Due to these properties it has widespread use as a research tool in neuroscience particularly in investigating excitotoxicity epilepsy and neurological disorders associated with NMDA receptor dysfunction
Apexbio Technology LLC Trametinib DMSO solvate 1187431-43-1 10mM (in 1mL DMSO)
Trametinib DMSO solvate (CAS 1187431-43-1) is a potent allosteric inhibitor of MEK1 and MEK2 that acts through an ATP-noncompetitive mechanism In preclinical models it has demonstrated broad antitumor activity notably in colorectal cancer cell lines such as HT-29 and COLO205 Trametinib induces the expression of p15 and p27 suppresses cyclin D1 promotes RB dephosphorylation and G1 cell cycle arrest and reduces thymidylate synthase expression Furthermore it inhibits ERK1/2 phosphorylation leading to growth suppression in B-RAF mutant tumor cells Trametinib serves as a valuable tool for studying MAPK pathway signaling and targeted cancer therapeutics