p-Coumaric acid, an isomer of cinnamic acid, demonstrates diverse biological activities including antibacterial, anti-inflammatory, antioxidant, and anti-tumor effects. It has been shown to inhibit cell proliferation and promote apoptosis, making it a subject of interest in various research applications.
- Inhibits proliferation of A375 and B16 cells.
- Promotes cell apoptosis in human and mouse melanoma cells.
- Exhibits antibacterial activity against gram-negative and gram-positive bacteria.
- Reduces polyp incidence and precancerous lesions in animal models.
- Alleviates doxorubicin-induced nephrotoxicity by inhibiting oxidative stress, inflammation, and apoptosis.
- Modulates cell cycle progression and protein expression in A375 and B16 cells.