Phenylpropanoids and polyketides
Medchemexpress LLC Psoralen | 66-97-7 | 99.9% | 186.16 | 100 MG
Psoralen, also known as Ficusin, is a naturally occurring coumarin compound isolated from the seeds of Fructus Psoraleae. It is intended for research use only.
- Exhibits anti-cancer activity.
- Acts as an antioxidant.
- Demonstrates antidepressant properties.
- Possesses antibacterial effects.
- Shows antiviral activity.
Matrix Scientific 2-(3,4-DIHYDROXYPHENYL)-5,7--1
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4h-chromen-4-one Mf C15h10o6 Mw 286.24 Cas 491-70-3 Mdl MFCD00017309
Medchemexpress LLC Seratrodast (Standard) | 112665-43-7 | 98.2% | 50 MG
Seratrodast (Standard) is the analytical standard for Seratrodast, designed for research and analytical applications. It functions as a thromboxane A2 receptor (TP) antagonist and a ferroptosis inhibitor, demonstrating anti-asthmatic and anti-epileptic properties.
- Analytical standard for Seratrodast
- Thromboxane A2 receptor (TP) antagonist
- Ferroptosis inhibitor
- Decreases lipid reactive oxygen species (ROS) production
- Regulates the systemic xc-/GSH/GPX4 axis
- Suppresses JNK phosphorylation and p53 expression
- Exhibits anti-asthmatic and anti-epileptic activity
- Commonly utilized in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Cayman Chemical Seratrodast 50mg
A potent antagonist of the TXA2 receptor, blocking specific binding of U-46619 to platelets with an IC50 value of 7.4 nM and platelet aggregation induced by U-44069 with an IC50 value of 350 nM; commonly used to study the roles of the TP receptor in animal airways and in tissue samples
Medchemexpress LLC Seratrodast | 112665-43-7 | 99.6% | 5 MG
Seratrodast (AA 2414) is an orally active antiasthmatic agent that functions as a thromboxane A2 receptor (TP) antagonist and a ferroptosis inhibitor. It operates by reducing lipid reactive oxygen species (ROS) production, modulating the systemic xc-/GSH/GPX4 axis, and inhibiting JNK phosphorylation and p53 expression. This compound exhibits both anti-asthmatic and anti-epileptic activities.
- Inhibits ferroptosis induced by RSL3 or Erastin in HT22 cells.
- Down-regulates the phosphorylation level of JNK.
- Inhibits ROS generation and lipid peroxidation induced by Erastin in HT22 cells.
- Shows no significant cytotoxicity at concentrations below 10 μM in HT22 cells.
- Prevents cell death in HT22 cells induced by ferroptosis inducers.
- Inhibits neuronal ferroptosis in a pentylenetetrazole-induced mouse epilepsy model.
- Reduces epileptic seizures in vivo.
Medchemexpress LLC 3-Nitrocoumarin | 28448-04-6 | 100.0% | 191.14 | 50 MG
3-Nitrocoumarin is an inhibitor for phospholipase C that blocks the generation of inositol triphosphate (IP3), thereby affecting the calcium signaling pathway.
- Purity of 100.0%
- CAS number 28448-04-6
- Molecular weight of 191.14
- Molecular formula C9H5NO4
- Appears as a solid
- Color is light yellow to yellow
- Targets phospholipase and fungal pathways
- Affects metabolic enzyme/protease and anti-infection pathways
- Inhibits glucose-induced increase of intracellular calcium ions in yeast strain WPY260
- Inhibits PLC in Neurospora crassa with an IC50 of 10 μg/mL
- Inhibits the growth of N. crassa and causes morphological changes of apical hyperbranching in hyphae
- Soluble in DMSO at ≥ 100 mg/mL