Phenylpropanoids and polyketides
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 200mg
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression
Medchemexpress LLC N-(1-oxoheptyl)-D-gamma-glutamyl-(6R)-6-carboxy-L-lysyl-D-alanine | 79335-75-4 | 99.9% | 502.56 g/mol | C22H38N4O9 | 10mg
FK-565 is a nucleotide oligomerization domain-1 (NOD1) ligand FK-565 induces murine model with arteritis[1]
Medchemexpress LLC Tacrolimus (Standard) | 104987-11-3 | 99.6% | 804.02 | 100 MG
Tacrolimus (Standard) is an analytical standard intended for research and analytical applications. This macrocyclic lactone binds to FK506 binding protein (FKBP) to form a complex. It inhibits calcineurin phosphatase, which in turn inhibits T-lymphocyte signal transduction and IL-2 transcription, possessing immunosuppressive properties.
- Analytical standard for research and analytical applications
- Used in qualitative research experiments
- Used in quantitative research experiments
- Used in methodological research experiments
- Suitable for HPLC, GC, and MS applications
- Inhibits calcineurin phosphatase
- Inhibits T-lymphocyte signal transduction and IL-2 transcription
- Possesses immunosuppressive properties
![Alkali Scientific FK 506 [Tacrolimus] [Fujimycin], 100 Mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000659710.jpg-250.jpg)
Alkali Scientific FK 506 [Tacrolimus] [Fujimycin], 100 Mg
Tacrolimus (FK 506, also known as Fujimycin) is a highly effective immunosuppressant used in laboratory and clinical research. This 100mg laboratory-grade quantity is commonly used in studies related to immune suppression, particularly in transplant immunology and autoimmune diseases. Tacrolimus inhibits T-cell activation by binding to the FKBP-12 protein and blocking the action of calcineurin, an enzyme critical to T-cell signaling. The result is a profound suppression of immune responses, making tacrolimus essential for investigating immune-related disorders and testing the efficacy of immunosuppressive therapies. It is a key tool in advancing research in immunology and transplantation science.
![Medchemexpress LLC (E)-1-[(2R)-2-(2-hydroxyethyl)piperidin-1-yl]-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop-2-en-1-one | 121524-18-3 | 99.2% | 375.46 g/mol | C23H25N3O2 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243688.png-250.jpg)
Medchemexpress LLC (E)-1-[(2R)-2-(2-hydroxyethyl)piperidin-1-yl]-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)prop-2-en-1-one | 121524-18-3 | 99.2% | 375.46 g/mol | C23H25N3O2 | 1 MG
FK 453 is a research-grade small molecule adenosine A1 receptor antagonist with low-nanomolar potency (IC50 = 17.2 nM). It is supplied as a high-purity powder intended for in vitro pharmacology, receptor profiling, and other laboratory research applications.
- Potent and selective adenosine A1 receptor antagonist.
- Low-nanomolar potency (IC50 17.2 nM).
- High purity (99.2%).
- Molecular formula C23H25N3O2; molecular weight 375.46 g/mol.
- Supplied as a powder with DMSO solubility for assay preparation.
- Available in small-scale quantities suitable for research use.
Medchemexpress LLC FK 3311 (COX-2 inhibitor V) | 116686-15-8 | MFCD00876455 | 98.7% | 341.33 g·mol⁻1 | C15H13F2NO4S | 5 MG
FK 3311 is a selective cyclooxygenase-2 (COX-2) inhibitor supplied as a powdered research reagent for studies of inflammation and COX-2-mediated pathways. Analytical characterization and stability data are provided to support assay and in vivo use.
- Selective COX-2 inhibition for inflammation research.
- High reported purity (≈98.7%) suitable for biochemical assays.
- Characterized by NMR and LC-MS with available COA and datasheet.
- Powder form with defined storage conditions to maintain stability.
- Suitable for in vitro and in vivo pharmacology studies.
Medchemexpress LLC Tacrolimus 8-epimer | 129212-35-7 | MFCD27967171 | 5mg
Tacrolimus anhydrous 8-epimer (Tacrolimus EP impurity D) is a l-pipecolic acid macrolide lactone an important immunosuppressive agent that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines especially IL-2[1]
![Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387556-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML
AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. It potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473. In vivo, it causes significant tumor growth inhibition in breast adenocarcinoma xenograft models.
- Allosteric AKT inhibitor.
- Potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473, with IC50s of 0.422 and 0.322 μM respectively.
- Inhibits the phosphorylation of ribosomal protein S6, a downstream effector of the PI3K-AKT pathway.
- Potently inhibits the phosphorylation of PRAS40.
- In vivo, potently inhibits the phosphorylation of its downstream substrate GSK3β as well as the phosphorylation of AKT (Ser473).
- Causes significant tumor growth inhibition in BT474c breast adenocarcinoma xenograft models when dosed at 200 mg/kg daily.
TARGETMOL CHEMICALS INC 4 4 -Dimethoxychalcone 50MG
Also available in 1 mL, 25 mg, 100 mg and bulk. Please contact Fisher for quotes.4,4'-Dimethoxychalcone (4,4-Dimethoxychalcone) is a natural product. Purity 99.35%
Medchemexpress LLC (±)-Naringenin (Standard) | 67604-48-2 | 98.8% | 272.25 | 25 MG
(±)-Naringenin (Standard) is the analytical standard of (±)-Naringenin. It is a naturally-occurring flavonoid intended for research and analytical applications. It displays a vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
- Used as a reference standard in qualitative, quantitative, and methodological research experiments.
- Commonly applied in techniques such as HPLC, GC, and MS.
- Appearance is a solid, white to light yellow.
- Chemical formula is C₁₅H₁₂O₅.
- Classified under flavonoids and phenols.
- Initial source is from other plant families.
![eMolecules 480-41-1 | (S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one | AA Blocks LLC | MFCD00870553 | 272.256 | C15H12O5 | 0.000 | Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 | 5g | 489792953](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3966901.jpg-250.jpg)
eMolecules 480-41-1 | (S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one | AA Blocks LLC | MFCD00870553 | 272.256 | C15H12O5 | 0.000 | Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 | 5g | 489792953
(S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one | AA Blocks LLC | 480-41-1 | MFCD00870553 | 272.256 | C15H12O5 | 0.000 | Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 | 5g | 489792953
Medchemexpress LLC Trans-chalcone | 614-47-1 | MFCD00003082 | 98.8% | 208.26 g/mol | C15H12O | 5g
trans-Chalcone isolated from Aronia melanocarpa skin is a biphenolic core structure of flavonoids precursor trans-Chalcone is a potent fatty acid synthase (FAS) and -amylase inhibitor trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7 trans-Chalcone has antifungal and anticancer activity[1][2][3]
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 10 G
4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity. This product is for research use only.
- Regulates adipocyte differentiation through PPARγ activation.
- Modulates the expression and secretion of various adipokines.
- Increases mRNA expression of adipogenic genes during differentiation.
- Reduces upregulated mRNA expression of inflammatory cytokines.
- Suitable for research use.
Apexbio Technology LLC Naringenin 480-41-1 10mM (in 1mL DMSO)
Naringenin (CAS 480-41-1) is a small-molecule inhibitor designed to modulate inflammatory and antiviral pathways thereby regulating cellular inflammatory responses and viral replication Naringenin exerts its biological activity primarily through inhibition of the NF- B pathway resulting in reduced inflammatory cytokine production Additionally it demonstrates antioxidative properties by scavenging reactive oxygen species (ROS) In in vitro studies naringenin exhibits inhibition of dengue virus replication with reported IC50 values ranging from approximately 52 64 M to 143 M depending on experimental conditions and viral strains Based on these pharmacological properties naringenin holds research potential in inflammation oxidative stress-related cellular models and dengue virus infection studies
Apexbio Technology LLC AKT inhibitor VIII(Synonyms: AKTi-1/2, Akt Inhibitor VIII, AKTi VIII, Akt kinase inhibitor VIII, Isozyme-selective AKT inhibitor VIII), 10mM (in 1mL DMSO), CAS: 612847-09-3.
AKT inhibitor VIII (CAS 612847-09-3) is a cell-permeable reversible inhibitor targeting Akt isoforms Akt1 Akt2 and Akt3 exhibiting IC50 values of 58 nM 210 nM and 2119 nM respectively It acts by suppressing Akt signaling as demonstrated by its ability to inhibit IGF-1-stimulated Akt phosphorylation and to reduce PRAS40 phosphorylation in PC12 cells In MCF-7 breast cancer cells AKT inhibitor VIII enhances the antiproliferative activity of furanodiene augmenting its effects on Akt/p-Akt downregulation and promoting PARP cleavage This compound is valuable for exploring Akt-dependent signaling pathways in oncology research and neuronal cell biology studies