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Filtered Search Results
Medchemexpress LLC BI-6015 | 93987-29-2 | 99.9% | 331.35 | 25 MG
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BI-6015 is an antagonist of hepatocyte nuclear factor 4α (HNF4α) that can inhibit the expression of known HNF4α target genes. It represses insulin promoter activity through HNF4α antagonism. BI-6015 can be used for the research of cancer and diabetes.
- HNF4α antagonist
- Inhibits expression of HNF4α target genes
- Represses insulin promoter activity
- Applicable for cancer research
- Applicable for diabetes research
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Tinoridine hydrochloride | 25913-34-2 | 99.95% | 352.88 | 50 MG
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Tinoridine hydrochloride is a nonsteroidal anti-inflammatory agent that also has potent radical scavenger and antiperoxidative activity. It is intended for research use only.
- Reduces stable free radicals and inhibits lipid peroxidation.
- Oxidized during lipid peroxidation.
- Does not affect the reduction of cytochrome c caused by superoxide radical.
- Substantially reduces CCl4-induced alterations in liver microsomal cytochrome P-450 and G6Pase concentrations.
- Promotes rapid recovery to normal values in hepatic endoplasmic reticulum function after CCl4 administration.
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Medchemexpress LLC Acebutolol hydrochloride | 34381-68-5 | 99.70% | 372.89 | 25 MG
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Acebutolol hydrochloride is an orally active β1 adrenergic receptor (β1AR) antagonist. It is used in the treatment of hypertension, angina pectoris, and cardiac arrhythmias.
- Orally active β1 adrenergic receptor (β1AR) antagonist
- Used in the treatment of hypertension
- Used in the treatment of angina pectoris
- Used in the treatment of cardiac arrhythmias
- Launched for clinical use
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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![eMolecules (4-Cyano-3,5-difluorophenyl)zinc bromide, 0.5 M in THF | Synthonix |283.380 | C7H2BrF2NZn | 0.000 | [Br-].Fc1cc([Zn+])cc(F)c1C#N | 50ml | 812584957](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502694436.jpg-250.jpg)
eMolecules (4-Cyano-3,5-difluorophenyl)zinc bromide, 0.5 M in THF | Synthonix |283.380 | C7H2BrF2NZn | 0.000 | [Br-].Fc1cc([Zn+])cc(F)c1C#N | 50ml | 812584957
(4-Cyano-3,5-difluorophenyl)zinc bromide, 0.5 M in THF | Synthonix |283.380 | C7H2BrF2NZn | 0.000 | [Br-].Fc1cc([Zn+])cc(F)c1C#N | 50ml | 812584957
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![eMolecules 89980-68-7 | 3,4-Dimethylphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | MFCD01311496 | 209.369 | C8H9BrMg | 0.000 | [Br-].Cc1ccc([Mg+])cc1C | 100ml | 437237095](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502697714.jpg-250.jpg)
eMolecules 89980-68-7 | 3,4-Dimethylphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | MFCD01311496 | 209.369 | C8H9BrMg | 0.000 | [Br-].Cc1ccc([Mg+])cc1C | 100ml | 437237095
3,4-Dimethylphenylmagnesium bromide, 0.5 M in THF | Synthonix - Stock | 89980-68-7 | MFCD01311496 | 209.369 | C8H9BrMg | 0.000 | [Br-].Cc1ccc([Mg+])cc1C | 100ml | 437237095
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Medchemexpress LLC Jnj28871063 hydrochloride | 944342-90-9 | 98.4% | 519.42 | C24H28Cl2N6O3 | 100 MG
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JNJ28871063 hydrochloride is an ATP-competitive pan-ErbB (EGFR/ErbB) kinase inhibitor used for research. It is orally active, shows potent inhibition of ErbB family kinases, crosses the blood-brain barrier, and has demonstrated antitumor activity in xenograft models.
- Orally active, ATP-competitive pan-ErbB kinase inhibitor.
- Potent inhibition of EGFR (ErbB1), ErbB2, and ErbB4 (IC50 ≈ 21-38 nM).
- Crosses the blood-brain barrier.
- Demonstrated antitumor activity in EGFR/ErbB2-overexpressing xenograft models.
- Supplied as the hydrochloride salt.
- Intended for in vitro and in vivo research use only.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC 1H-Benzimidazole, 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]- | 93987-29-2 | 99.9% | 331.35 | 100 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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BI-6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that inhibits the expression of known HNF4α target genes. It represses insulin promoter activity through HNF4α antagonism and can be used for the research of cancer and diabetes.
- HNF4α antagonist
- Inhibits expression of known HNF4α target genes
- Represses insulin promoter activity through HNF4α antagonism
- Can be used for research of cancer and diabetes
- Cytotoxic to human hepatocellular carcinoma
- Induces hepatic steatosis in primary murine hepatocytes
- Induces loss of HNF4α expression and hepatic steatosis in mice
- Induces apoptosis in a human hepatocellular carcinoma mouse model
- Inhibits HNF4α gene expression in HepG2 cells
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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![eMolecules 265330-98-1 | 5-Ethoxy-5-oxopentylzinc bromide, 0.50 M in THF | Synthonix | MFCD00671978 | 274.460 | C7H13BrO2Zn | 0.000 | [Br-].CCOC(=O)CCCC[Zn+] | 50ml | 532652823](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502696167.jpg-250.jpg)
eMolecules 265330-98-1 | 5-Ethoxy-5-oxopentylzinc bromide, 0.50 M in THF | Synthonix | MFCD00671978 | 274.460 | C7H13BrO2Zn | 0.000 | [Br-].CCOC(=O)CCCC[Zn+] | 50ml | 532652823
5-Ethoxy-5-oxopentylzinc bromide, 0.50 M in THF | Synthonix | 265330-98-1 | MFCD00671978 | 274.460 | C7H13BrO2Zn | 0.000 | [Br-].CCOC(=O)CCCC[Zn+] | 50ml | 532652823
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![eMolecules 497923-83-8 | 2-Chloro-4-fluorophenylzinc iodide, 0.50 M in THF | Synthonix | MFCD02260160 | 321.820 | C6H3ClFIZn | 0.000 | [I-].Fc1ccc([Zn+])c(Cl)c1 | 50ml | 532652662](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502696321.jpg-250.jpg)
eMolecules 497923-83-8 | 2-Chloro-4-fluorophenylzinc iodide, 0.50 M in THF | Synthonix | MFCD02260160 | 321.820 | C6H3ClFIZn | 0.000 | [I-].Fc1ccc([Zn+])c(Cl)c1 | 50ml | 532652662
2-Chloro-4-fluorophenylzinc iodide, 0.50 M in THF | Synthonix | 497923-83-8 | MFCD02260160 | 321.820 | C6H3ClFIZn | 0.000 | [I-].Fc1ccc([Zn+])c(Cl)c1 | 50ml | 532652662
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![eMolecules 92206-73-0 | n-Octadecylmagnesium bromide, 0.50 M in THF | Synthonix357.703 | C18H37BrMg | 97.000 | [Br-].CCCCCCCCCCCCCCCCCC[Mg+] | 25ml | 702446007](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502694899.jpg-250.jpg)
eMolecules 92206-73-0 | n-Octadecylmagnesium bromide, 0.50 M in THF | Synthonix357.703 | C18H37BrMg | 97.000 | [Br-].CCCCCCCCCCCCCCCCCC[Mg+] | 25ml | 702446007
n-Octadecylmagnesium bromide, 0.50 M in THF | Synthonix | 92206-73-0357.703 | C18H37BrMg | 97.000 | [Br-].CCCCCCCCCCCCCCCCCC[Mg+] | 25ml | 702446007
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eMolecules Combi-Blocks Inc. 3-(Bromomethyl)pyridazine hydrobromide 1g 603144237 QB-3920 97.000 1452483-94-1 MFCD20526346 253.925 C5H6Br2N2
Combi-Blocks Inc. 3-(Bromomethyl)pyridazine hydrobromide 1g 603144237 QB-3920 97.000 1452483-94-1 MFCD20526346 253.925 C5H6Br2N2
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AdipoGen Naphthol AS phosphate
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Chemical. CAS 13989-98-5. Formula C17H14NO5P. MW BD9837. Naphthol AS phosphate is a fluorogenic substrate for acid and alkaline phosphatases. Naphthol AS phosphate is converted to naphthol AS displaying excitation/emission spectra of 388/516nm. The fluorescence is a quantitative marker of acid and alkaline phosphatase activity. Acid and alkaline phosphatases are often used as clinical markers of disease, since the concentration of human acid and alkaline phosphatases undergo pronounced changes in particular diseases, resulting in unusually high or low concentrations. It is a histochemical substrate commonly used in conjunction with diazonium salts to form a specific azo dye for immunohistology, immunoblotting, dot blot applications and in situ PCR.
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Medchemexpress LLC Raseglurant hydrochloride | 757949-98-7 | 99.7% | 240.27 g·mol⁻1 | C15H13FN2 | 1 ML
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Raseglurant hydrochloride is the hydrochloride salt of raseglurant (ADX-10059), a negative allosteric modulator of the metabotropic glutamate receptor mGluR5. It is provided as a 10 mM solution in DMSO for research use in pharmacology and in vitro studies; not for human use.
- Hydrochloride salt of raseglurant, a selective mGluR5 negative allosteric modulator.
- Supplied as a 10 mM solution in DMSO.
- Quantity: 1 mL per vial.
- High purity (~99.7%) suitable for research applications.
- Molecular formula C15H13FN2; molecular weight ~240.27 g·mol⁻1.
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Medchemexpress LLC Acoramidis hydrochloride | 2242751-53-5 | 98.5% | 328.77 | 25 MG
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Acoramidis hydrochloride is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). It is used in the study for transthyretin amyloidosis.
- Solid appearance
- Color white to light yellow
- Soluble in DMSO (62.5 mg/mL), insoluble in H2O
- Stabilizes V122I- and WT-TTR
- Stimulates mitochondrial QO2
- Shows minimal inhibition of hERG and cytochrome P450 isozymes
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Medchemexpress LLC (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide | 1005450-55-4 | MFCD18207041 | 99.05% | C22H20F3NO | 25 G
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This compound is a drug intermediate useful for the synthesis of various active compounds. It appears as a white to off-white solid. It is intended for research use only and is not sold to patients.
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