Naphthalenes
Biotium Reactive Dyes Biotin Cell Viability and Apoptosis Cellular Stains ViaTag 550 575 1/EA
ViaTag 550/575 Haloalkane Ligand is a bright fluorescent ligand for the HaloTag self-labeling protein tag Red fluorescent ViaTag 550/575 is cell impermeant and has an excitation/emission of 551/577 nm 30 uL of 1000X
ILEX LIFE SCIENCES LLC PAN Biotech MCDB 131 Cell Culture Medium with L Glutamine with NaHCO3 500 ML 1/EA
PAN-Biotech MCDB 131 Cell Culture Medium w L-Glutamine w 1 176 g/L NaHCO3 500 ml INTRO MCDB 131 was developed for cultivation of HMVEC under reduced serum content For this purpose it is often supplemented with serum EGF and hydrocortisone MCDB 131 is also suitable for other cell types (ex human omental microvascular cells hepatocytes myocytes smooth muscle cells hPSCs and MSCs) MCDB131 includes several components not found in traditional basal media such as trace elements putrescine adenine thymidine and higher levels of some amino acids and vitamins this allows it to be supplemented with very low levels of serum or defined components BICARBONATE With 1 176 g/L Sodium Bicarbonate GLUCOSE With glucose GLUTAMINE With L-Glutamine HEPES Without HEPES FORM Liquid PHENOL RED With Phenol Red SODIUM PYRUVATE With Sodium Pyruvate STERILE Yes STORAGE 2-8 C MANUFACTURER PAN-Biotech GmbH ORIGIN Germany USAGE Laboratory Research Use Only
Medchemexpress LLC G4RGDSP, integrin-binding peptide | 774577-43-4 | 99.6% | 758.74 | 5 MG
G4RGDSP, Integrin-binding peptide, is a cell integrin-binding peptide designed to target integrin receptors. It is used in research and can be coupled to alginate to enhance cell viability in scaffolds. This peptide is also utilized as an extrudable carrier for chondrocyte delivery, particularly in studies involving 3D printing technology.
- Cell integrin-binding peptide
- Targets integrin receptors
- Can be coupled to alginate to increase cell viability in scaffolds
- Used as an extrudable carrier for chondrocyte delivery
- Increases expression of aggregin, collagen type II, and sox9 genes in HAC cells
Medchemexpress LLC Zelavespib hydrochloride | 2095432-24-7 | 99.25% | 548.83 | 25 MG
Zelavespib hydrochloride is a potent Hsp90 inhibitor primarily used for research. It demonstrates significant activity against various tumor cells, inducing apoptosis and inhibiting growth.
- Potent Hsp90 inhibitor with an IC50 of 51 nM in MDA-MB-468 cells.
- Inhibits growth of multiple tumor cell lines.
- Induces significant apoptosis in triple-negative breast cancers (TNBCs).
- Downregulates oncoproteins involved in the invasive potential of TNBCs.
- Cytotoxic to CLL cells with minimal effects on PBMC or resting B cells.
- Reduces CLL viability by inducing mitochondrial apoptosis.
Medchemexpress LLC G4RGDSP, integrin-binding peptide | 774577-43-4 | 99.6% | 758.74 | 50 MG
G4RGDSP, integrin-binding peptide, is a cell integrin-binding peptide that specifically targets integrin receptors. It is designed to be coupled with alginate to enhance the viability of cells within a scaffold. This peptide can also be utilized as an extrudable carrier for chondrocyte delivery, facilitating studies involving 3D printing technology.
- Targets integrin receptors as a cell integrin-binding peptide.
- Can be coupled to alginate to increase cell viability in scaffolds.
- Applicable as an extrudable carrier for chondrocyte delivery in 3D printing technology research.
- Increases the expression of aggregin, collagen type II, and sox9 genes in HAC cells in vitro.
Medchemexpress LLC BI-7273 | 1883429-21-7 | 99.8% | 353.41 | 5 MG
BI-7273 is a selective and cell-permeable BRD9 inhibitor, exhibiting an IC50 of 19 nM and a Kd of 0.75 nM. It also demonstrates significant activity against BRD7, with an IC50 of 117 nM and a Kd of 0.3 nM. Originally designed by Boehringer Ingelheim, this compound is suitable for various laboratory applications.
- Selective BRD9 inhibitor
- Cell-permeable compound
- High effect on BRD7
- Active in U2OS cell lines at 1 μM
- Blocks EOL-1 cell proliferation
Medchemexpress LLC BI-0474 | 2750570-55-7 | 99.8% | 587.74 | 25 MG
BI-0474 is a potent KRASG12C inhibitor demonstrating significant activity against NCI-H358 cells with G12C mutations and anti-tumor effects in non-small cell lung cancer xenograft models.
- Potent KRASG12C inhibitor
- IC50 of 7.0 nM for GDP-KRAS::SOS1 protein-protein interaction
- Exhibits anti-proliferative activity against NCI-H358 cells with G12C mutation
- Demonstrates anti-tumor activity in non-small cell lung cancer xenograft models
Medchemexpress LLC Siramesine (hydrochloride) | 224177-60-0 | 99.7% | C30H32ClFN2O | 1 ML
Siramesine hydrochloride is a potent sigma-2 receptor agonist with subnanomolar affinity (IC50=0.12 nM), showing significant selectivity over sigma-1 receptors. This compound triggers cell death by destabilizing mitochondria and demonstrates anti-cancer activity.
- Potent sigma-2 receptor agonist
- Subnanomolar affinity for sigma-2 receptors
- High selectivity over sigma-1 receptors
- Triggers cell death through mitochondrial destabilization
- Exhibits anti-cancer activity
- Induces cell death in various cell lines
- Activates caspases in HaCaT and U-87MG cells
Medchemexpress LLC Fluoxetine hydrochloride | 56296-78-7 | 99.97% | 1 ML
Fluoxetine hydrochloride is an antidepressant and a selective serotonin reuptake inhibitor.
- Cellular effects (in vitro): Fluoxetine hydrochloride blocks downregulation of cell proliferation induced by inescapable shock in hippocampal cells, increases newborn cells and proliferating cells in the prelimbic cortex, accelerates maturation of immature neurons, and enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. It also increases norepinephrine and dopamine extracellular levels in the prefrontal cortex.
- Animal studies (in vivo): Treatment with fluoxetine hydrochloride reverses deficits in escape latency. Fluoxetine promotes cell proliferation in the dentate gyrus, and coadministration with olanzapine enhances this effect. The combination also leads to substantial increases in extracellular dopamine and norepinephrine levels.
TARGETMOL CHEMICALS INC BI-6015 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BI 6015 is an antagonist of HNF4(alpha). HNF4(alpha) is a nuclear receptor that regulates gene expression in the intestine cells liver cells and pancreas-(beta) cells. purity: 99%
Medchemexpress LLC G4RGDSP, integrin-binding peptide | 774577-43-4 | 99.61% | 758.74 | 100 MG
G4RGDSP, integrin-binding peptide is a cell integrin-binding peptide that targets integrin receptors. It is coupled to alginate to increase the viability of cells in the scaffold and can be used as an extrudable carrier for chondrocyte delivery for the study of 3D printing technology.
- Targets integrin receptors
- Increases viability of cells in scaffold
- Suitable for chondrocyte delivery studies
- Used in 3D printing technology research
- Increases expression of aggregin, collagen type II, and sox9 genes in HAC cells
Medchemexpress LLC G4RGDSP, integrin-binding peptide | 774577-43-4 | 99.6% | 758.74 | 25 MG
G4RGDSP, Integrin-binding peptide is a cell integrin-binding peptide that targets integrin receptors. It is coupled to alginate to increase the viability of cells in the scaffold. It can be used as an extrudable carrier for chondrocyte delivery for the study of 3D printing technology.
- Targets integrin receptors.
- Can be coupled to alginate to increase cell viability in scaffolds.
- Usable as an extrudable carrier for chondrocyte delivery for 3D printing technology.
- Can increase the expression of aggregin, collagen type II, and sox9 genes in HAC cells.
Medchemexpress LLC Fluoxetine hydrochloride | 56296-78-7 | 100.0% | C17H19ClF3NO | 100 MG
Fluoxetine hydrochloride (LY 110140) is an antidepressant and a selective serotonin reuptake inhibitor. It exhibits potent inhibitory activity against human SERT (serotonin reuptake transporter) in HEK293 cells with an IC50 of 150 nM. This product is for research use only.
- Selective serotonin reuptake inhibitor
- Potent inhibitory activity against human SERT in HEK293 cells (IC50: 150 nM)
- Blocks downregulation of cell proliferation in hippocampal cells
- Increases newborn cells in the dentate gyrus of adult rat hippocampus
- Enhances neurogenesis-dependent long-term potentiation (LTP)
- Increases extracellular norepinephrine and dopamine levels in the prefrontal cortex
- Reverses escape latency deficits in rat models of inescapable shock
Medchemexpress LLC 2-Butene-1,4-diamine, N1, N4-bis[3-(ethylamino)propyl]-, hydrochloride (1:4), (2Z)- | 206991-64-2 | 95.0% | 402.27 | 25 MG
PG-11047 (CGC-11047) is a polyamine analogue used for the research of breast cancer. It offers the following features and benefits:
- Inhibits the growth of breast cell lines, with basal-like cell lines being inhibited at lower concentrations than luminal cell lines.
- Causes a significant decrease in S phase fraction at doses that produce little apoptosis.
Medchemexpress LLC BI-0474 | 2750570-55-7 | 99.8% | 587.74 | 100 MG
BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. It demonstrates significant anti-proliferative activity against NCI-H358 cells carrying the G12C mutation and shows favorable anti-tumor activity in non-small cell lung cancer xenograft models.
- Potent KRASG12C inhibitor
- Inhibits GDP-KRAS::SOS1 protein-protein interaction with an IC50 of 7.0 nM
- Exhibits anti-proliferative activity against NCI-H358 cells with G12C mutation
- Shows anti-tumor activity in non-small cell lung cancer xenograft models
- Induces programmed cell death in xenograft models