Biotin and derivatives
Medchemexpress LLC Biotin-sar-oh | 154024-76-7 | 315.39 | C13H21N3O4S | 1 G
Biotin-sar-oh is a cleavable antibody-drug conjugate (ADC) linker bearing a biotin functionality, used in the synthesis of antibody-drug conjugates and probe development.
- Cleavable ADC linker for conjugation and release strategies.
- Biotinylated for affinity capture and detection.
- Molecular formula: C13H21N3O4S; molecular weight: 315.39.
- Available pack sizes: 250 mg and 1 g.
- CAS number: 154024-76-7.
Medchemexpress LLC Biotin-PEG3-acid 1g | 252881-76-8 | 447.55 | C19H33N3O7S | 1 G
Biotin-PEG3-acid is a biotin-labeled, PEG-based PROTAC linker used to introduce a biotin tag with a short PEG3 spacer in PROTAC synthesis and bioconjugation workflows. The material is supplied as a 1 g purified solid (typical purity 98.0%) with molecular weight 447.55 g/mol and chemical formula C19H33N3O7S, and is accompanied by a batch-specific certificate of analysis.
- Provides a biotin handle separated by a PEG3 spacer to reduce steric hindrance
- Designed for incorporation into PROTACs and other bioconjugates
- Improves aqueous solubility compared with direct biotinylation
- Typically supplied with batch certificate showing ~98.0% purity
- Solid form with known molecular weight and formula for formulation planning
![Medchemexpress LLC 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(23-amino-3,6,9,12,15,18,21-heptaoxatricos-1-yl) hexahydro-2-oxo- | 1334172-76-7 | 98.0% | C26H50N4O9S | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(23-amino-3,6,9,12,15,18,21-heptaoxatricos-1-yl) hexahydro-2-oxo- | 1334172-76-7 | 98.0% | C26H50N4O9S | 100 MG
Biotin-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. These molecules contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains ligands for E3 ubiquitin ligase and target proteins
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Biotin-EDA | 111790-37-5 | 97.5% | 50 MG
Biotin-EDA is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs. This product is for research use only and is not sold to patients.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Solid, white to off-white appearance
- Soluble in DMSO (requires ultrasonic)
- Store solid at 4°C, protected from light
- Store in solvent at -80°C for 6 months or -20°C for 1 month, protected from light
Medchemexpress LLC Biotin-PEG3-acid 100mg | 252881-76-8 | 100 MG
Biotin-PEG3-acid is a biotin-labeled polyethylene glycol (PEG3) linker containing a terminal carboxylic acid. It is supplied as a purified research-grade small molecule for use in PROTAC synthesis and biotinylation applications.
- Biotin-labeled PEG3 linker with terminal carboxylic acid.
- Designed for PROTAC synthesis and biotinylation workflows.
- High purity, 98.0%.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Store sealed at 4°C; in solution store at -80°C for long-term stability.
- Available in 100 MG and larger pack sizes for research use.
Medchemexpress LLC (+)-Biotin-SLC | 1864003-57-5 | ≥97.0% | 250 MG
(+)-Biotin-SLC is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two ligands (E3 ubiquitin ligase and target protein) connected by a linker
- Exploits intracellular ubiquitin-proteasome system for target protein degradation
- For research use only
- Appearance: Solid
- Color: White to off-white
- Storage: 4°C under nitrogen; in solvent: -80°C (6 months) or -20°C (1 month) under nitrogen
Medchemexpress LLC AF647-NHS ester | 407627-60-5 | 99.7% | 956.09 | C40H49N3O16S4 | 10 MG
AF647-NHS ester is an N-hydroxysuccinimide ester of a far-red fluorescent dye used to covalently label amine-containing biomolecules for fluorescence imaging and detection. It is supplied as a solid optimized for conjugation to proteins, antibodies, and peptides.
- Far-red excitation at 635 nm (instantaneous 620 nm) suitable for 633-647 nm lasers.
- High purity by HPLC: 99.74%.
- Molecular weight 956.09; formula C40H49N3O16S4.
- Appearance: dark purple to black solid.
- Storage: long-term at 4 °C sealed; in solvent, -80 °C up to 6 months.
- Supplied as 10 MG vials.
Medchemexpress LLC Biotin-C4-amide-C5-NH2 | 151294-96-1 | 97.0% | 314.45 | C14H26N4O2S | 100 MG
Biotin-C4-amide-C5-NH2 is a biotin-based, cleavable linker used to attach cytotoxins to antibodies in the synthesis of antibody-drug conjugates (ADCs). It is supplied as a solid with specified purity and storage instructions for research applications.
- Cleavable ADC linker suitable for ADC construction and biotin labeling.
- Solid, white to off-white appearance.
- Molecular weight 314.45 and formula C14H26N4O2S.
- Purity 97.0%.
- Available in multiple pack sizes, including 100 MG.
- Storage: store at 4°C protected from light; in solution keep at -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC Bis-PEG10-NHS ester | 2221949-02-4 | 95.0% | 752.76 | C32H52N2O18 | 100 MG
Bis-PEG10-NHS ester is a PEG-based linker containing two N-hydroxysuccinimide (NHS) ester groups. It is used as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs) and PROTACs to enable conjugation to primary amines.
- Contains two NHS ester functional groups for amine conjugation.
- Purity typically 95.0%.
- Molecular weight approximately 752.76; formula C32H52N2O18.
- CAS number 2221949-02-4 for unambiguous identification.
- Available in multiple pack sizes, including 100 mg.
- Storage: pure form at -20°C; in solvent store at -80°C for longer-term stability.
![Medchemexpress LLC N-(4-aminobutyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | 151294-96-1 | MFCD28397129 | 97.0% | 314.45 g/mol | C14H26N4O2S | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203872.png-250.jpg)
Medchemexpress LLC N-(4-aminobutyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | 151294-96-1 | MFCD28397129 | 97.0% | 314.45 g/mol | C14H26N4O2S | 50 MG
Biotin-C4-amide-C5-NH2 is a cleavable antibody-drug conjugate (ADC) linker bearing a biotin tag and a primary amine for affinity capture and conjugation during ADC synthesis and analysis. Intended for research use only.
- Cleavable ADC linker with biotin tag for affinity-based capture.
- Primary amine enables conjugation to payloads or linkers.
- High purity: 97.0% (typical).
- Molecular weight 314.45 g/mol; formula C14H26N4O2S.
- Storage: store at 4°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month).
- For research use only; not for human therapeutic use.
Medchemexpress LLC Biotin-SLC | 1864003-57-5 | ≥97.0% | 100 MG
Biotin-SLC is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other for the target protein. They function by utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl chain-based PROTAC linker
- Used for PROTAC synthesis
- Exploits the intracellular ubiquitin-proteasome system for selective protein degradation
- Molecular weight: 427.60
- Molecular formula: C₂₁H₃₇N₃O₄S
- Purity: ≥97.0%
- Appearance: Solid, white to off-white
- Storage at 4°C under nitrogen; in solvent: -80°C for 6 months or -20°C for 1 month under nitrogen
![Medchemexpress LLC (1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl 2,5-dioxopyrrolidin-1-yl carbonate. | 1426827-79-3 | MFCD19705416 | 99.5% | 291.30 g/mol | C15H17NO5 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000299394.png-250.jpg)
Medchemexpress LLC (1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl 2,5-dioxopyrrolidin-1-yl carbonate. | 1426827-79-3 | MFCD19705416 | 99.5% | 291.30 g/mol | C15H17NO5 | 100 MG
Endo-BCN-NHS carbonate is a succinimidyl carbonate reagent that installs bicyclo[6.1.0]non-4-yn (BCN) handles onto primary amines, enabling strain-promoted azide-alkyne cycloaddition (SPAAC) for copper-free click crosslinking. It is used to functionalize proteins and elastin-like polymers for hydrogel formation and cell-encapsulation studies.
- High purity (99.54%).
- Molecular formula C15H17NO5, molecular weight 291.30 g/mol.
- Reacts with primary amines to introduce BCN handles for SPAAC crosslinking.
- Appearance: white to light yellow solid.
- Recommended storage: powder at -20°C; in solvent: -80°C (6 months) or -20°C (1 month).
- Available in multiple package sizes including 100 mg.
Medchemexpress LLC Peptidyl arginine deiminase 4, human (biotinylated, His-tagged) | >95.0% | 20UG
Recombinant full-length human peptidyl arginine deiminase 4 (PADI4), biotinylated and N-terminal His-tagged, supplied as a 20 μg solution formulated in 20 mM Tris, 500 mM NaCl, 0.5 mM TCEP, 1 mM EDTA, 10% glycerol, pH 7.6. Intended for biochemical assays, affinity capture, and binding studies using biotin-streptavidin or His-tag detection.
- Full-length sequence (M1-P663)
- Biotinylated for streptavidin-based capture and detection
- N-terminal His tag for purification and detection
- Greater than 95.0% purity by reducing SDS-PAGE
- Molecular weight approximately 76.6 kDa
- Expressed in Escherichia coli
- Formulated in stabilizing buffer (Tris, NaCl, TCEP, EDTA, glycerol)
- Supplied as 20 μg aliquot, recommended storage at -80 °C
Medchemexpress LLC Bz-(Me)Tz-NHS | 1454558-58-7 | 95.0% | 412.40 g/mol | C19H20N6O5 | 10 MG
Bz-(Me)Tz-NHS is a methyltetrazine-containing N-hydroxysuccinimide (NHS) ester used as a bioorthogonal linker for copper-free click chemistry. It undergoes rapid inverse electron-demand Diels-Alder (iEDDA) reactions with strained alkenes to enable fast, selective conjugation under mild, biocompatible conditions. The reagent is supplied as a purple solid with high purity and requires sealed, low-temperature storage to maintain stability.
- Methyltetrazine-containing NHS ester enabling copper-free inverse electron-demand Diels-Alder conjugation.
- Rapid reaction kinetics with strained alkenes for efficient labeling.
- NHS ester functional group for covalent coupling to primary amines.
- High purity suitable for bioconjugation workflows.
- Purple solid appearance for easy visual identification.
- Stable when stored sealed at 4°C; in solvent store at -80°C for long-term preservation.
Medchemexpress LLC m-PEG6-NHS ester | 1449390-12-8 | ≥97.0% | 421.44 g·mol⁻¹ | C18H31NO10 | 50 MG
m-PEG6-NHS ester is a non-cleavable 6-unit polyethylene glycol (PEG) linker terminating in an activated N-hydroxysuccinimide (NHS) ester; it is used for amide coupling to amines in the synthesis of antibody-drug conjugates and PROTACs.
- Purity: ≥97.0%.
- Molecular weight: 421.44 g·mol⁻¹.
- Chemical formula: C18H31NO10.
- CAS number: 1449390-12-8.
- Form: liquid, colorless to light yellow; density ~1.21 g/cm³.
- Storage: pure form -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
- Applications: non-cleavable PEG6 linker for ADC synthesis; PEG/alkyl/ether-based PROTAC linker.
- Packaging: commonly available in 100 MG, 250 MG, 1 G, and 5 G; larger quantities available by quote; a 50 MG pack is indicated in supplier data but on the manufacturer page.