Furans
Medchemexpress LLC ATH686 | 853299-52-2 | 99.54% | 515.53 | 5 MG
ATH686 is a potent, selective, and ATP-competitive FLT3 inhibitor that targets mutant FLT3 protein kinase activity. It inhibits the proliferation of cells harboring FLT3 mutants by inducing apoptosis and cell cycle inhibition, also exhibiting antileukemic effects.
- Potently inhibits cell proliferation (IC50 around 0.001 μM) in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells
- Induces apoptosis
- Inhibits autophosphorylation of mutant FLT3
- Exhibits antileukemic effects
Sigma Aldrich Fine Chemicals Biosciences fluorescein diacetate used10G
fluorescein diacetate (fDA) is a non-fluorescent molecule which is hydrolysed to fluorescent fluorescein in live cells. Dead cells cannot accumulate or hydrolyse fDA.
Medchemexpress LLC Trotabresib | 1706738-98-8 | 99.7% | 383.46 | 100 MG
Trotabresib is a reversible and orally active BET inhibitor used in the study of advanced solid tumors. It inhibits the proliferation of diffuse midline glioma (DMG) cells and shows stronger antitumor activity against H3K27M mutant DMG cells than DMG wildtype.
- Reversible and orally active BET inhibitor
- Applied in studies for advanced solid tumors
- Inhibits proliferation of diffuse midline glioma (DMG) cells
- Shows stronger antitumor activity against H3K27M mutant DMG cells than DMG wildtype
Apexbio Technology LLC Menadiol Diacetate 573-20-6 200mg
Menadiol Diacetate (CAS 573-20-6) is a synthetic derivative of vitamin K investigated for its regulatory effects on cellular signaling pathways and enzyme activities In experimental studies Menadiol Diacetate has been shown to induce S phase arrest in the cell cycle leading to apoptotic cell death This compound is utilized in research focused on cancer and related diseases providing a tool for exploring mechanisms of cell proliferation and apoptosis in vitro
Medchemexpress LLC JQKD82 trihydrochloride | 2863676-87-1 | 99.89% | 610.01 | 50 MG
JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. It increases H3K4me3 and can be used for the research of multiple myeloma.
- Increases global H3K4me3 levels in cells.
- Inhibits cell growth in a dose- and time-dependent manner (IC50=0.42 μM).
- Induces G1 cell-cycle arrest.
- Exhibits anti-multiple myeloma activity in vivo.
- Leads to increased H3K4me3 levels and reduced MYC immuno-staining.
- Significantly reduces tumor burden in mouse models.
Medchemexpress LLC ATH686 | 853299-52-2 | 99.5% | 515.53 | 50 MG
ATH686 is a potent, selective, and ATP-competitive FLT3 inhibitor. It targets mutant FLT3 protein kinase activity, inhibiting the proliferation of cells harboring FLT3 mutants by inducing apoptosis and cell cycle inhibition. It has demonstrated antileukemic effects.
- Potent, selective, and ATP-competitive FLT3 inhibitor.
- Targets mutant FLT3 protein kinase activity.
- Induces apoptosis and cell cycle inhibition.
- Inhibits proliferation of cells harboring FLT3 mutants.
- Demonstrates antileukemic effects.
- For research use only.
Medchemexpress LLC WST-1 | 150849-52-8 | 97.3% | 651.34 | 50 MG
WST-1 is a water-soluble tetrazolium salt that induces intracellular mitochondrial dehydrogenase to conduct an NADH-dependent enzyme digestion reaction, releasing a water-soluble methyl benzene product. It can be used for the detection of cell proliferation and cytotoxicity by determining the light absorption value at 450 nm. This product is for research use only.
- Water-soluble tetrazolium salt
- Induces intracellular mitochondrial dehydrogenase activity
- Releases a water-soluble methyl benzene product
- Suitable for detection of cell proliferation
- Suitable for cytotoxicity analysis
- Determines light absorption value at 450 nm
- Used in cell staining analysis
- Relevant for cell function analysis
- Considered a cell viability dye
Medchemexpress LLC JQKD82 trihydrochloride | 2863676-87-1 | MFCD34676876 | 99.9% | 610.01 g/mol | C27H43Cl3N4O5 | 5 MG
JQKD82 trihydrochloride is the trihydrochloride salt of a selective, cell-permeable small-molecule inhibitor of KDM5 histone demethylases. It elevates H3K4me3 levels in cells and is used in cellular and epigenetic studies, including multiple myeloma research. Molecular formula C27H43Cl3N4O5; molecular weight 610.01 g/mol; reported purity 99.89%.
- Selective KDM5 inhibitor suitable for cellular assays.
- Increases H3K4me3 levels in treated cells.
- Cell-permeable small-molecule salt form.
- High reported purity of 99.89%.
- Supplied as solid and as DMSO stock solutions.
- Useful for epigenetic and cancer research applications.
Selleck Chemical LLC Wortmannin S2758-20mg
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay with little selectivity within the PI3K family Wortmannin blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays Wortmannin also inhibits PLK1 activity
Medchemexpress LLC Trotabresib | 1706738-98-8 | 99.7% | 383.46 | 50 MG
Trotabresib (CC-90010) is a reversible and orally active BET inhibitor. It is used in the study of advanced solid tumors and inhibits the proliferation of diffuse midline glioma (DMG) cells.
- Reversible and orally active BET inhibitor
- Applied in the study for advanced solid tumors
- Inhibits proliferation of diffuse midline glioma (DMG) cells
- Exhibits stronger antitumor activity against H3K27M mutant DMG cells than DMG wildtype
Medchemexpress LLC Paederosidic acid | 18842-98-3 | MFCD28124366 | 10 MG
Paederosidic acid, isolated from P. scandens, is a chemical compound exhibiting anticancer and anti-inflammation activities. It primarily acts by inducing mitochondria-mediated apoptosis in lung cancer cells.
- Inhibits lung cancer cells by inducing mitochondria-mediated apoptosis.
- Shows effects on NCI-H1650, HCC827, and A549 cells.
- Up-regulates caspase-3, caspase-8, caspase-9, Bid, Bax.
- Down-regulates Bcl-2.
- Stimulates Cyto-C release from mitochondria.
Medchemexpress LLC TCS PrP Inhibitor 13 25mg | 34320-83-7 | 25MG
TCS PrP Inhibitor 13 an antiprion agent is a cellular prion protein (PrPC) inhibitor TCS PrP Inhibitor 13 as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor shows an IC50 value of 3 nM in both ScN2a and F3 cell lines TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1
Medchemexpress LLC Ath686 | 853299-52-2 | MFCD22665713 | 99.5% | 515.53 | C25H28F3N7O2 | 10 MG
ATH686 is a potent, selective, ATP-competitive FLT3 kinase inhibitor used in research to study FLT3-mutant leukemia. It inhibits mutant FLT3 activity, induces apoptosis, and suppresses proliferation in FLT3-mutant cells.
- Potent, selective ATP-competitive FLT3 inhibition.
- Demonstrated induction of apoptosis and cell-cycle arrest in FLT3-mutant cells.
- High purity suitable for biochemical and cellular assays.
- Available as solid and as 10 mM solution in DMSO for convenience.
- Stable under recommended storage conditions for long-term use.
Medchemexpress LLC Betulin diacetate | 1721-69-3 | MFCD00017378 | 95.0% | 526.79 | 5 MG
Betulin diacetate, a triterpene and derivative of Betulin, is an anti-AID agent and also possesses anti-cancer activity.
- Is a triterpene and derivative of Betulin
- Acts as an anti-AID agent
- Possesses anti-cancer activity
- Shows cytotoxicity against various human cell lines including 518A2, A-375, A2780, A549, HT-29, HeLa, and MCF7
- Induces melanogenesis in mouse B16 2F2 cells
- Inhibits growth in mouse B16 2F2 cells
- Exhibits anti-HIV activity against acutely infected H9 lymphocytes
Medchemexpress LLC JQKD82 trihydrochloride | 2863676-87-1 | 99.9% | C27H43Cl3N4O5 | 10MG
JQKD82 trihydrochloride is a cell-permeable, selective inhibitor of lysine demethylase KDM5 (JARID1) used in epigenetic research. It increases histone H3 lysine 4 trimethylation (H3K4me3) and is applied in studies of multiple myeloma and KDM5-mediated regulation.
- Selective KDM5 inhibitor.
- Cell-permeable small molecule for intracellular studies.
- Increases H3K4me3 levels in treated cells.
- Supplied as the trihydrochloride salt for enhanced stability.
- High purity suitable for research use (99.9%).
- Available in multiple milligram pack sizes for assay flexibility.