Lactams
Medchemexpress LLC Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc | 1799711-31-1 | 98.4% | C30H42N4O11 | 10MG
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate supplied as a solid for research use. The compound features a PEG3 linker and a Boc-protected terminal amine, offered with high reported purity and characterized molecular data, suitable as a synthetic intermediate in chemical biology and PROTAC development.
- High reported purity suitable for synthesis and analysis.
- Characterized molecular formula and molecular weight for experimental planning.
- Boc-protected terminal amine enables selective deprotection and conjugation.
- PEG3 linker provides flexibility and improved solubility in conjugates.
- Available in small milligram quantities for research workflows.
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | MFCD32701934 | 95.1% | C26H34N2O7 | 10MG
Thalidomide-O-C8-Boc is a thalidomide-derived Cereblon (CRBN) ligand intended for use as the E3 ligase-recruiting moiety in PROTAC design. It features an O-linked eight-carbon spacer with a Boc-protected terminus to enable linker attachment. Manufacturer data report molecular formula C26H34N2O7, molecular weight 486.56, and typical purity ~95%.
- Provides an O-linked C8 spacer with a Boc-protected terminus for linker attachment.
- Suitable for recruiting Cereblon (CRBN) as the E3 ligase in degrader strategies.
- Reported purity approximately 95.1%.
- High solubility in DMSO (100 mg/mL); manufacturer lists example in vivo formulations.
- Recommended storage: solid at -20°C under nitrogen; in solution -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Thalidomide-O-amido-PEG2-C2-NH2 (TFA) | 1957235-75-4 | 576.48 | 500 MG
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate. It incorporates the Thalidomide based cereblon ligand and a 2-unit PEG linker used in PROTAC technology. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Thalidomide based cereblon ligand
- Uses a 2-unit PEG linker
- Utilized in PROTAC technology
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Tetrazine-tagged thalidomide | 2087490-42-2 | 98.6% | 571.58 g/mol | C29H29N7O6 | 100 MG
Tz-Thalidomide is a tetrazine-tagged derivative of thalidomide used in bioorthogonal click-chemistry and as an E3 ligase ligand for biochemical research. It contains a reactive tetrazine group for rapid conjugation via inverse electron demand Diels-Alder reactions and has been characterized for binding to BRD4.
- Tetrazine moiety enables rapid inverse electron demand Diels-Alder (iEDDA) click reactions.
- Functions as an E3 ligase ligand for targeted protein interaction studies.
- Documented binding affinity to BRD4 in biochemical assays.
- High purity suitable for research applications.
- Available as a solid and as a 10 mM solution in DMSO for experimental flexibility.
Medchemexpress LLC Thalidomide-O-amido-C4-NH2 (trifluoroacetate) | 1799711-25-3 | MFCD31560484 | 99.9% | 516.42 g/mol | C21H23F3N4O8 | 50 MG
Thalidomide-O-amido-C4-NH2 (trifluoroacetate) is a thalidomide-derived cereblon ligand supplied as the TFA salt for use as an E3 ligase ligand/linker building block in PROTAC and chemical biology research.
- Provided as the trifluoroacetate salt.
- High purity (99.9%, LCMS).
- Molecular weight 516.42 g/mol.
- CAS number 1799711-25-3.
- Appearance: solid, white to off-white.
- Packaged as a 50 MG quantity.
Medchemexpress LLC Sulbactam pivoxil | 69388-79-0 | MFCD00867003 | 98.0% | 347.38 | C14H21NO7S | 100 MG
Sulbactam pivoxil is the pivoxil ester prodrug of sulbactam, a β-lactamase inhibitor supplied as a research/analytical standard. The material is provided as a white to off-white solid with reported purity of 98.0% and a molecular weight of 347.38, and is used to support studies of oral bioavailability, pharmacokinetics, and β-lactamase inhibition.
- Prodrug form improves oral absorption compared with sulbactam.
- Useful as a reference standard for pharmacokinetic and microbiology studies.
- High reported purity supports analytical and formulation work.
- Available in solid and ready-to-use solution formats for flexibility.
- Recommended storage conditions provided to preserve stability.
Medchemexpress LLC Tetrazine-tagged thalidomide | 2087490-42-2 | MFCD34706062 | 98.6% | 571.58 g/mol | C29H29N7O6 | 5 MG
Tz-Thalidomide is a tetrazine-tagged derivative of thalidomide developed as an E3 ligase ligand and click-chemistry reagent. It is designed to undergo inverse electron-demand Diels-Alder (iEDDA) reactions with strained alkenes and has demonstrated binding activity to BRD4 in biochemical assays.
- Tetrazine functional group for rapid iEDDA click reactions with TCO-modified partners.
- Reported BRD4 binding (IC50: 46.25 μM for BRD4-1; 62.55 μM for BRD4-2).
- High purity suitable for research applications (98.6%).
- Solid, pink to red appearance for easy handling.
- Soluble in DMSO (~50 mg/mL), facilitating stock solution preparation.
- Storage conditions provided to support stability in powder and solution.
Medchemexpress LLC Thalidomide O-amido C3-COOH | 2308035-51-8 | 98.4% | 417.37 g/mol | C19H19N3O8 | 50 MG
Thalidomide O-amido C3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon-binding moiety with a short linker terminating in a carboxylic acid. It is provided as a research-grade chemical for use in PROTAC design and related chemical biology applications.
- Contains thalidomide-based cereblon ligand
- Three-carbon (C3) linker with terminal carboxylic acid
- Molecular formula C19H19N3O8; molecular weight 417.37 g/mol
- Purity 98.4% (research grade)
- Supplied as a white solid suitable for chemical synthesis
- Intended for research use only, not for human or clinical use
Medchemexpress LLC Thalidomide-O-COOH | 1061605-21-7 | MFCD31560477 | >98.0% | 332.27 | C15H12N2O7 | 10 G
Thalidomide-O-COOH is a thalidomide-derived cereblon (CRBN) ligand used as an E3 ligase recruiting moiety in PROTAC and targeted protein degradation design. The compound is supplied as a solid with molecular formula C15H12N2O7 and molecular weight 332.27 g/mol (CAS 1061605-21-7).
- Serves as a cereblon (CRBN) binding ligand for PROTAC construction.
- Suitable for medicinal chemistry and chemical biology research.
- Provided in multiple laboratory-scale pack sizes for synthesis and screening.
- Characterized by manufacturer datasheet and SDS for handling and storage guidance.
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | 416.38 g/mol | C19H20N4O7 | 5 MG
Thalidomide-C2-amido-C2-COOH is an E3 ligase ligand-linker conjugate that incorporates a cereblon-binding thalidomide-derived moiety and a carboxylic acid linker. It is intended for use as a research reagent in PROTAC design and related chemical biology studies; not for human or clinical use.
- CAS number: 2353496-84-9.
- Molecular formula: C19H20N4O7.
- Molecular weight: 416.38 g/mol.
- Purity: 98.45% (typical by supplier).
- Solubility: DMSO up to 100 mg/mL (may require sonication).
- Storage: powder at -20°C; stock solutions at -80°C for long term.
- Intended use: CRBN ligand for PROTAC design and E3 ligase studies.
- Available in small mg quantities for research use.
Medchemexpress LLC Thalidomide-4-O-C6-NH2 hydrochloride | 2245697-88-3 | 98.5% | C19H24ClN3O5 | 10MG
Thalidomide-4-O-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate used in PROTAC research, notably as a component of the degrader dTAG-13 that directs FKBP12F36V and BET proteins for degradation. It is intended for laboratory research into E3 ligase recruitment, targeted protein degradation, apoptosis, and autophagy.
- High purity suitable for research (98.5%).
- Soluble in DMSO at 83.33 mg/mL (203.31 mM); ultrasonic assistance may be needed.
- Engages cereblon for E3 ligase-mediated protein degradation.
- Useful for PROTAC assembly and linker conjugation workflows.
- Available in small research quantities to support assay development.
- Recommended storage: 4°C sealed, away from moisture and light; in solvent, store at -80°C for long term.
Medchemexpress LLC Thalidomide-NH-PEG3-COOH | 2375283-62-6 | 98.9% | C22H27N3O9 | 10MG
Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that links a thalidomide-derived cereblon (CRBN) ligand to a three-unit polyethylene glycol (PEG3) spacer terminated with a carboxylic acid. It is designed as a building block for PROTAC synthesis to recruit the CRBN E3 ligase and enable conjugation to target-binding ligands.
- High reported purity (98.9%).
- Includes a thalidomide-derived cereblon ligand for CRBN recruitment.
- PEG3 spacer provides flexible, hydrophilic linkage.
- Terminal carboxylic acid enables standard coupling chemistries.
- Soluble in DMSO for common assay and synthesis workflows.
- Supplied as a solid suitable for storage and handling in research labs.
Medchemexpress LLC Biotin-thalidomide | 2230857-87-9 | MFCD32851674 | 99.7% | C44H64N8O13S | 10MG
Biotin-thalidomide is a biotin-conjugated thalidomide derivative that binds the cereblon (CRBN) E3 ligase and is supplied as a high-purity reagent for use in PROTAC synthesis and biochemical assays.
- Binds cereblon (CRBN) E3 ligase
- Suitable for PROTAC synthesis and biochemical binding studies
- Facilitates affinity capture and pull-down assays via biotin tag
- Provided as a high-purity reagent for research use
- Characterized by molecular formula and SMILES for cheminformatics
![eMolecules Broadpharm / Thalidomide-O-acetamido-C4-amine HCl salt / 100mg / 686681011 / BP-27849 / 98.000 / 1799711-24-2 / [null] / 402.407 / C19H22N4O6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475321.JPG-250.jpg)
eMolecules Broadpharm / Thalidomide-O-acetamido-C4-amine HCl salt / 100mg / 686681011 / BP-27849 / 98.000 / 1799711-24-2 / [null] / 402.407 / C19H22N4O6
Broadpharm / Thalidomide-O-acetamido-C4-amine HCl salt / 100mg / 686681011 / BP-27849 / 98.000 / 1799711-24-2 / [null] / 402.407 / C19H22N4O6