Lactams
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 (TFA) | 1950635-14-9 | 99.8% | 544.48 | 50 MG
Thalidomide-O-amido-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the cereblon ligand and a linker. This compound is suitable for use in the synthesis of PROTACs, which function by exploiting the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- E3 ligase ligand-linker conjugate
- Incorporates cereblon ligand and a linker
- Used in the synthesis of PROTACs
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC 5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | 2230957-36-3 | >98.0% | 290.25 | C14H11FN2O4 | 1 G
Thalidomide-1-Me,5-F is a fluorinated thalidomide derivative (5-fluoro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione) described as an E3 ligase activator. It is provided as a research chemical for use as a biochemical probe, synthetic building block, or starting material for further derivatization.
- Acts as an E3 ligase activator useful in targeted protein degradation studies.
- Contains a fluorine atom enabling SNAr reactions and further derivatization.
- Supplied in small-quantity packages suitable for research and synthesis.
- Well-defined chemical identity with CAS 2230957-36-3.
- Chemical formula C14H11FN2O4 and molecular weight 290.25.
Medchemexpress LLC Thalidomide-5-PEG3-NH2 hydrochloride | 2761385-81-1 | 97.9% | 441.86 g·mol⁻1 | C19H24ClN3O7 | 5 MG
Thalidomide-5-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-based cereblon ligand with a PEG3 linker terminating in a primary amine. Supplied as the hydrochloride salt, it is intended as a building block for PROTAC design and bioconjugation chemistry.
- Contains a PEG3 linker with a terminal primary amine for conjugation.
- Supplied as hydrochloride salt to aid handling and stability.
- Intended for use as an E3 ligase recruiting ligand in PROTAC synthesis.
- High reported purity suitable for research applications.
- Available in small research sizes for medicinal chemistry workflows.
Medchemexpress LLC Thalidomide-pinacolborane | 2229725-98-6 | 95.0% | 384.19 g·mol⁻¹ | C19H21BN2O6 | 10 MG
Thalidomide-pinacolborane is a thalidomide-derived small molecule bearing a pinacol boronic ester (Bpin). It serves as an E3 ligase (cereblon) ligand useful in targeted protein degradation (PROTAC) research and as a synthetic intermediate for cross-coupling chemistries.
Medchemexpress LLC Thalidomide-5-O-C6-NH2 hydrochloride | 2761398-05-2 | 409.86 | 5 MG
Thalidomide-5-O-C6-NH2 hydrochloride is a cereblon ligand based on Thalidomide. It is utilized in the recruitment of CRBN protein and can be linked to a ligand for protein via a linker to form PROTACs. It is a solid with a white to off-white appearance.
- Cereblon ligand
- Utilized in CRBN protein recruitment
- Can form PROTACs when linked to a protein ligand
- Available as a white to off-white solid
- Shipped at room temperature
- Stored at -20°C, protected from light and under nitrogen
Medchemexpress LLC Thalidomide-4-Br | 2093536-12-8 | MFCD31730866 | 99.6% | 337.13 g·mol⁻¹ | C13H9BrN2O4 | 200 MG
Thalidomide-4-Br is a brominated thalidomide derivative used as a research compound that engages bromodomains and cereblon-related E3 ligase biology. It is applied in studies of inflammation, tumor biology, and neurology and is supplied as a high-purity solid with recommended cold storage for powder and solutions.
- Engages bromodomains and E3 ligase pathways.
- Used in inflammation, tumor, and neurology research.
- Reported purity approximately 99.6% (COA/product listings).
- Solid, off-white to gray physical form.
- Storage: powder at -20°C (long term) or 4°C (short term); solutions at -80°C or -20°C.
- Available in small-scale amounts and DMSO solution formats.
Medchemexpress LLC Thalidomide-o-amido-c3-cooh | 2308035-51-8 | MFCD31560483 | >95.0% | 417.4 g/mol | C19H19N3O8 | 500 MG
Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon (CRBN) ligand with a three-carbon linker terminating in a carboxylic acid. It is intended for use in PROTAC synthesis and related chemical biology research, enabling conjugation to target-binding ligands for targeted protein degradation studies.
- Synthesized E3 ligase ligand-linker conjugate suitable for PROTAC design.
- Contains a thalidomide-derived cereblon ligand for CRBN recruitment.
- Features a C3 linker terminating in a carboxylic acid for conjugation.
- Available as a solid research-grade reagent in multiple package sizes.
- Recommended storage: 4°C under inert gas; in solvent store at -80°C for long term.
- Hazard: handle with appropriate personal protective equipment; may cause skin and eye irritation and is harmful if swallowed.
Medchemexpress LLC Thalidomide-NH-C5-NH2 hydrochloride | 2375194-03-7 | 99.86% | 394.85 | 25 MG
Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. This product is for research use only.
- Purity of 99.86%
- Inhibits Cereblon
- Utilizes PROTAC technology for targeted protein degradation
Medchemexpress LLC Thalidomide 4-fluoride | 835616-60-9 | 99.9 % | 276.22 | 50 G
Thalidomide 4-fluoride is a Thalidomide-based Cereblon ligand designed for the recruitment of CRBN protein. It can be linked to other ligands by a linker to form PROTAC degraders. In vitro, Thalidomide targets cereblon (CRBN), a ubiquitously expressed protein that is part of the cullin-4 E3 ubiquitin ligase complex. Cereblon mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
- Thalidomide-based cereblon ligand
- Used in the recruitment of CRBN protein
- Can be connected to other ligands to form PROTAC degraders
- Targets cereblon (CRBN), a protein involved in the cullin-4 E3 ubiquitin ligase complex
- Mediates ubiquitination and proteasomal degradation of target proteins
- High purity for reliable research
- Solid appearance, off-white to gray color
- Stable under recommended storage conditions
- Soluble in DMSO (200 mg/mL)
Medchemexpress LLC Thalidomide-5-COOH | 1216805-11-6 | 99.9% | 302.24 | 500 MG
Thalidomide-5-COOH is a Thalidomide-based cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a protein ligand via a linker to form PROTACs.
- Utilized for the recruitment of CRBN protein
- Can be linked to a protein ligand via a linker
- Forms PROTACs
- PROTACs use the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Thalidomide-5-O-C4-NH2 hydrochloride | 2694727-93-8 | 100.0% | 381.81 g/mol | C17H20ClN3O5 | 10 MG
Thalidomide-5-O-C4-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand intended for chemical biology research and PROTAC design. Supplied as a white to off-white solid in small milligram quantities, the compound functions as an E3 ligase recruiting moiety that can be connected to target ligands via linkers for targeted protein degradation studies.
- High purity suitable for research applications (reported ~99.98%).
- Acts as a cereblon-binding ligand for E3 ligase recruitment.
- Designed for PROTAC synthesis and linker conjugation.
- Available in small milligram pack sizes for screening and synthesis.
- Solid form, white to off-white, stable under recommended storage.
- Includes CAS number 2694727-93-8 for unambiguous identification.
Medchemexpress LLC Thalidomide-nh-c6-nh-boc | 2093536-13-9 | 96.1% | 100 MG
Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used for MI-389 (compound 22) synthesis. MI-389 is a potent phthalimide PROTAC degrader based on the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A).
- Decreases cell growth with an EC50 value of 21.3 nM (comparable to sunitinib)
- Leads to GSPT1 destabilization in a dose-dependent manner, showing complete GSPT1 depletion at 100 nM.
Medchemexpress LLC Thalidomide-O-amido-C6-NH2 TFA | 1950635-14-9 | 99.8% | 544.48 | 1 G
Thalidomide-O-amido-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, and can be used in the synthesis of PROTACs.
- Can be used in the synthesis of PROTACs.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Incorporates the Thalidomide based cereblon ligand.
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | MFCD31560482 | 99.6% | 660.67 g/mol | C23H30F3N5O9 | 25 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a trifluoroacetate salt E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a three-unit polyethylene glycol (PEG3) linker for use in PROTAC synthesis and related chemical biology research. It is supplied as a high-purity solid and is intended for research use only.
- Contains a thalidomide-based cereblon ligand for cereblon-mediated degradation studies.
- PEG3 linker provides flexibility and solubility for linker optimization in PROTAC design.
- Offered as a solid TFA salt for convenient handling and storage.
- High purity suitable for synthetic chemistry and biological probe development.
- Recommended storage: powder at -20°C; in solution, store at -80°C for long-term preservation.
Medchemexpress LLC Thalidomide-O-amido-PEG3-C2-NH2 TFA | 1957236-21-3 | MFCD31560482 | >98.0% | 572.5 g/mol | C24H27F3N4O9 | 5 MG
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a thalidomide-based cereblon E3 ligase ligand-linker conjugate provided as the trifluoroacetic acid (TFA) salt. It is intended as a building block for PROTAC synthesis, combining a thalidomide-derived CRBN-binding moiety with a three-unit polyethylene glycol (PEG3) spacer and a short C2 amine handle for conjugation.
- Provides a cereblon-binding thalidomide ligand for PROTAC design.
- Includes a PEG3 linker to improve solubility and flexibility.
- Features a C2 amine handle for facile coupling to warheads.
- Offered as the TFA salt to aid handling and stability.
- Supplied at high purity (>98%) suitable for synthetic use.
- Available in small research-scale quantities for method development.