Lactams
Medchemexpress LLC Thalidomide-O-C8-Boc | 2225148-52-5 | 95.1% | 1 ML
Thalidomide-O-C8-Boc is a Thalidomide-based Cereblon ligand utilized for the recruitment of CRBN protein. It can be linked to a target protein ligand via a linker to create PROTACs.
- Cereblon ligand
- Used for recruitment of CRBN protein
- Can be linked to a target protein ligand via a linker to create PROTACs
- For research use only
Chemscene ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
ChemScene | Thalidomide-O-PEG2-propargyl | 100MG | CS-0104609 | 0.98 | 2098487-52-4| MFCD32063462 | 400.38
Medchemexpress LLC Thalidomide-pyrrolidine hydrochloride | 2616553-35-4 | 98.0% | 335.74 g·mol⁻¹ | C15H14ClN3O4 | 100 MG
Thalidomide-pyrrolidine hydrochloride is an E3 ligase ligand (compound 18) used as a building block in the synthesis of PROTACs. Provided as the hydrochloride salt at research-grade purity, it is supplied in milligram-scale packages and includes storage recommendations for long-term stability.
- E3 ligase ligand suitable for PROTAC assembly.
- Hydrochloride salt form for improved handling.
- High purity: 98.0%.
- Molecular weight: 335.74 g·mol⁻¹.
- CAS number: 2616553-35-4.
- Available in multiple package sizes including 100 mg.
- Storage recommendations: in solvent -80°C for 2 years, -20°C for 1 year.
Medchemexpress LLC Thalidomide-O-C6-COOH | 2169266-69-5 | 99.3% | 1 ML
Thalidomide-O-C6-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand and a linker used in PROTAC technology. This product targets cereblon.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide-based cereblon ligand
- Designed for PROTAC technology
- Targets cereblon
- Appearance: off-white to light yellow solid
- Solubility: ≥ 100 mg/mL in DMSO
Medchemexpress LLC Thalidomide-5-O-CH2-COOH | 2467425-53-0 | 95.0% | 332.26 g/mol | C15H12N2O7 | 25 MG
Thalidomide-5-O-CH2-COOH is a thalidomide-derived E3 ligase ligand-linker conjugate used as a cereblon ligand in chemical biology and targeted protein degradation research. It is supplied as a solid reagent intended for in vitro studies and synthetic applications.
- Acts as a cereblon (CRBN) ligand for targeted protein degradation studies.
- Designed as a ligand-linker conjugate to enable attachment to target-binding warheads.
- High solubility in DMSO (125 mg/mL) facilitates preparation of concentrated stocks.
- Supplied with typical purity of 95.0% suitable for research use.
- Molecular weight 332.26 g/mol and formula C15H12N2O7 for accurate dosing.
- Stable as a powder when stored frozen for long-term retention.
- Accompanied by datasheet, certificate of analysis, and safety data for handling guidance.
Apexbio Technology LLC Thalidomide 50-35-1 10mM (in 1mL DMSO)
Thalidomide (CAS 50-35-1) is a small-molecule inhibitor targeting the CRBN-DDB1-Cul4A E3 ubiquitin ligase complex It is designed to modulate ubiquitination pathways thereby regulating protein degradation cellular proliferation and immune signaling Thalidomide exerts its biological activity primarily through inhibition of the CRBN-DDB1-Cul4A complex In cell-based studies thalidomide demonstrates inhibitory activity with reported IC50 values ranging from approximately 1 M to 100 M depending on the assay and cell line Based on these pharmacological properties thalidomide holds research potential in the fields of immune regulation angiogenesis inhibition and cancer biology particularly in studies of hematological malignancies such as multiple myeloma
Cayman Chemical AzIdo-ThalIdomIde 25mg
A PROTAC building block; contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry; has been used in the synthesis of a SirReal-based PROTAC for the degradation of Sirt2 in cells
Medchemexpress LLC Thalidomide-5-O-C13-NH2 hydrochloride | 99.9% | 508.05 g/mol | C26H38ClN3O5 | 10 MG
Thalidomide-5-O-C13-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for research use in targeted protein degradation. It is intended for conjugation to target-binding ligands via linkers for PROTAC design and other bifunctional degrader constructs.
- High purity suitable for research assays (approximately 99.9%).
- Hydrochloride salt form for improved stability and handling.
- Compatible with linker conjugation for PROTAC synthesis.
- Recommended storage at -20°C; protect from light and oxygen.
- Supplied in small milligram quantities for exploratory studies.
Medchemexpress LLC Thalidomide-5-O-C12-NH2 hydrochloride | 99.9% | 494.02 g/mol | C25H36ClN3O5 | 10 MG
Thalidomide-5-O-C12-NH2 hydrochloride is a thalidomide-derived cereblon ligand supplied as the hydrochloride salt for research applications. It is intended for use as an E3 ligase recruiter in PROTAC design and biochemical assays that engage CRBN. For research use only.
- High purity 99.9%.
- Molecular formula C25H36ClN3O5.
- Molecular weight 494.02 g/mol.
- Supplied in small milligram quantities, including 10 mg.
- Suitable for ligand conjugation and targeted protein degradation studies.
- Store protected from light; short-term at -20°C, long-term at -80°C in solvent.
Medchemexpress LLC Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride | 2983037-00-7 | 98.0% | 586.03 | C25H36ClN5O9 | 5 MG
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a PEG4-C2 spacer. Supplied as the hydrochloride salt in solid form and reported at high purity, the compound is intended as a building block for PROTAC design and other CRBN-recruiting chemical biology applications.
- E3 ligase ligand-linker conjugate for PROTAC construction.
- Includes a thalidomide-based cereblon ligand to recruit CRBN proteins.
- PEG4-C2 linker with terminal amine for facile conjugation.
- Hydrochloride salt form to aid handling and solubility.
- High purity suitable for synthetic and research workflows.
Medchemexpress LLC Thalidomide-O-C2-acid | 2369068-42-6 | 95.0% | 346.29 g/mol | C16H14N2O7 | 5 MG
Thalidomide-O-C2-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates a thalidomide-based cereblon ligand with a two-carbon linker. It is intended as a research-grade building block for PROTAC synthesis and related chemical biology applications, and is supplied with reported analytical data suitable for experimental use.
- E3 ligase ligand-linker conjugate for PROTAC design.
- Molecular formula C16H14N2O7.
- Molecular weight 346.29 g/mol.
- CAS number 2369068-42-6.
- Reported purity 95.0%.
- Available in small milligram pack sizes for research use.
Medchemexpress LLC Tert-butyl (4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)carbamate | 2093388-52-2 | MFCD32671351 | 99.6% | C22H28N4O6 | 10MG
Thalidomide-NH-C4-NH-Boc is a thalidomide-derived E3 ligase ligand-linker conjugate that combines a cereblon-binding thalidomide core with a Boc-protected C4 amine linker for use in PROTAC synthesis and related chemical biology applications requiring targeted E3 ligase recruitment.
- Boc-protected C4 amine linker enables selective deprotection and conjugation.
- Cereblon-binding thalidomide core suitable for E3 ligase recruitment.
- High purity (99.6%) for reliable synthetic and analytical results.
- Available in multiple sizes for small-scale and larger syntheses.
- Solid, yellow to green appearance; stable when stored protected from light.
Medchemexpress LLC Thalidomide-4-Br | 2093536-12-8 | MFCD31730866 | 99.7% | 337.13 g·mol⁻¹ | C13H9BrN2O4 | 10 MG
Thalidomide-4-Br is a brominated derivative of thalidomide that acts as a small-molecule bromodomain probe. It is provided as a high-purity solid for in vitro and preclinical research in inflammation, oncology, and neurology.
- Bromodomain-containing small molecule probe.
- Suitable for inflammation, tumor, and neurology research.
- High purity: 99.7%.
- Molecular formula C13H9BrN2O4; molecular weight 337.13 g·mol⁻¹.
- Available in multiple pack sizes including 10 mg.
- Powder storage: -20°C (3 years) or 4°C (2 years).