Lactams
eMolecules 28562-53-0 | 4-Acetoxy-2-azetidinone | Synthonix | MFCD00010593 | 129.115 | C5H7NO3 | 95.000 | CC(=O)OC1CC(=O)N1 | 25g | 831793453
4-Acetoxy-2-azetidinone | Synthonix | 28562-53-0 | MFCD00010593 | 129.115 | C5H7NO3 | 95.000 | CC(=O)OC1CC(=O)N1 | 25g | 831793453
Medchemexpress LLC (S)-thalidomide-4-oh | 2357105-36-1 | 98.0% | 274.23 g/mol | C13H10N2O5 | 50 MG
(S)-Thalidomide-4-OH is the S-enantiomer of thalidomide-4-OH, a thalidomide-derived cereblon ligand used in chemical biology and medicinal chemistry. Supplied as a solid research reagent, it is commonly used to recruit CRBN in PROTAC design and as a building block for medicinal chemistry.
- S-enantiomer of thalidomide-4-OH for stereospecific studies.
- Cereblon (CRBN) ligand for E3 ligase recruitment.
- Suitable building block for PROTAC synthesis and linker chemistry.
- Off-white to light yellow solid; typical pack size 50 mg.
- Reported purity 98.0% and molecular weight 274.23 g/mol.
Abcam (R,S)-Lenalidomide, Thalidomide analog, TNF alpha inhibitor, 25MG
MW 259.26 Da, Purity >98%. Thalidomide (ab120032) analog and TNF-α inhibitor. Potent antitumor and anti-inflammatory effects. Modulates and potentiates host immune responses against multiple myeloma. Active in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Thalidomide-propargyl | 2098487-39-7 | 99.97% | 312.28 | 25 MG
Thalidomide-propargyl is a Thalidomide-based Cereblon ligand used for the recruitment of CRBN protein. It can be linked to a protein ligand via a linker to form IMiD-containing PROTACs. This compound is also a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Cereblon ligand
- Recruits CRBN protein
- Forms IMiD-containing PROTACs
- Click chemistry reagent
- Features an Alkyne group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | 99.3% | 388.37 | 50 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide, serving as the final intermediate in the synthesis of Thalidomide-4-OH. It functions as a Cereblon ligand, recruiting CRBN proteins. The t-Bu protecting group can be removed under acidic conditions to facilitate the synthesis of PROTAC molecules. This compound is a crucial intermediate for synthesizing CRBN-based designed PROTAC molecules.
- Functions as a Cereblon ligand
- Recruits CRBN proteins
- t-Bu protecting group can be removed under acidic conditions
- Key intermediate for synthesizing CRBN-based designed PROTAC molecules
Medchemexpress LLC Sulbactam sodium | 69388-84-7 | 99.4% | 5 MG
Sulbactam sodium is the analytical standard of Sulbactam (sodium) and is intended for research and analytical applications. It is a competitive, irreversible beta-lactamase inhibitor, demonstrating antimicrobial activity against multidrug-resistant (MDR) Acinetobacter calcoaceticus-Acinetobacter baumannii (Acb) complex. This compound is of analytical standard grade and is commonly used as a reference standard in research experiments.
- Intended for research and analytical applications
- Competitive, irreversible beta-lactamase inhibitor
- Exhibits antimicrobial activity against multidrug-resistant (MDR) Acinetobacter calcoaceticus-Acinetobacter baumannii (Acb) complex
- Used as a reference standard in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS
Medchemexpress LLC Thalidomide-NH-C9-NH2 hydrochloride | 2305936-77-8 | 99.9% | 450.96 g/mol | C22H31ClN4O4 | 10 MG
Thalidomide-NH-C9-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt for use in proteolysis-targeting chimera (PROTAC) construction and related chemical biology research. Provided as a light yellow solid with high purity and defined storage stability, it is intended for laboratory research use only.
- High purity (99.85%) suitable for research applications.
- Hydrochloride salt form to aid handling and solubility considerations.
- Available in small research pack sizes, including 10 mg, for synthesis workflows.
- Designed to act as a CRBN-binding E3 ligase ligand in PROTAC constructs.
- Recommended storage: -20°C sealed; in solvent: -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC Thalidomide-4-O-CH2-COO(t-Bu) | 1950635-36-5 | 99.3% | 388.37 | 25 MG
Thalidomide-4-O-CH2-COO(t-Bu) is a t-Bu modified thalidomide that functions as a Cereblon ligand, recruiting CRBN proteins. This compound serves as a final intermediate in the synthesis of Thalidomide-4-OH. Its t-Bu protecting group can be removed under acidic conditions, making it suitable for participation in PROTAC molecule synthesis and a key intermediate for CRBN-based designed PROTAC molecules.
- t-Bu modified thalidomide
- Intermediate in Thalidomide-4-OH synthesis
- Functions as a Cereblon ligand
- Recruits CRBN proteins
- t-Bu protecting group is removable under acidic conditions
- Key intermediate for CRBN-based PROTAC molecule synthesis
Medchemexpress LLC Thalidomide-NH-CBP/p300 ligand 2 | 2484739-21-9 | 98.6% | 922.03 | 25 MG
Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based CBP and p300 degrader, as extracted from patent WO2020173440. This compound is intended for research use only.
- Protac-based CBP and p300 degrader
- Extracted from patent WO2020173440
- For research use only
Medchemexpress LLC Thalidomide-4-O-C14-NH2 hydrochloride | 99.9% | 522.08 | C27H40ClN3O5 | 10 MG
Thalidomide-4-O-C14-NH2 hydrochloride is a carbon-14 radiolabeled thalidomide derivative used as a cereblon (CRBN) ligand in research applications, including PROTAC assembly. The product is supplied as the hydrochloride salt with high purity and characterized molecular properties for use in biochemical and pharmacokinetic studies.
Medchemexpress LLC Thalidomide-piperazine 5-fluoride hydrochloride | 2222114-23-8 | MFCD32203462 | 98.9% | 396.80 g/mol | C17H18ClFN4O4 | 5 G
Thalidomide-piperazine 5-fluoride hydrochloride is a thalidomide-derived cereblon (CRBN) E3 ubiquitin ligase ligand supplied as the hydrochloride salt for research use. It is a light-yellow solid with high reported purity and is intended for use in PROTAC synthesis and related chemical biology applications.
- Used as a ligand for cereblon (CRBN) in PROTAC synthesis.
- High purity (98.9%) suitable for research applications.
- Provided as a hydrochloride salt for improved handling.
- Light yellow solid form for easy weighing and storage.
- Storage: room temperature; in solvent, -80°C (2 years) or -20°C (1 year).
- Available in multiple package sizes including gram-scale quantities.
eMolecules 17557-84-5 | 3-Azetidinone hydrochloride | Synthonix - Stock | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 10g | 525905205
3-Azetidinone hydrochloride | Synthonix - Stock | 17557-84-5 | MFCD01861742 | 107.540 | C3H6ClNO | 97.000 | Cl.O=C1CNC1 | 10g | 525905205
Medchemexpress LLC Sulbactam | 68373-14-8 | 100.0% | 1 ML
Sulbactam is a competitive, irreversible beta-lactamase inhibitor that demonstrates antimicrobial activity against multidrug-resistant (MDR) Acinetobacter calcoaceticus-Acinetobacter baumannii (Acb) complex. It exhibits a wide range of antibacterial activity against both Gram-positive and Gram-negative aerobic and anaerobic bacteria.
- Competitive, irreversible beta-lactamase inhibitor
- Antimicrobial against multidrug-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii (Acb) complex
- Wide range of antibacterial activity
- Active against Gram-positive and Gram-negative aerobic and anaerobic bacteria
- For research use only