Lactams
Medchemexpress LLC Thalidomide-5-br | 26166-92-7 | MFCD30188073 | 98.4% | 337.13 | C13H9BrN2O4 | 5 MG
Thalidomide-5-Br is a brominated derivative of thalidomide provided for research use. It is described as a compound with a bromodomain and is used in preclinical studies of inflammation, tumor biology, and neurology.
- Used in research related to inflammation, tumor biology, and neurology.
- High purity suitable for biochemical assays and medicinal chemistry.
- Available in small milligram quantities for discovery studies.
- Stable at room temperature for extended storage under recommended conditions.
- Contains a bromodomain-containing structure for target engagement studies.
Medchemexpress LLC Thalidomide-NH-C10-NH2 hydrochloride | 2460022-53-9 | 464.99 | C23H33ClN4O4 | 10 MG
Thalidomide-NH-C10-NH2 hydrochloride is a thalidomide-derived cereblon (CRBN) ligand supplied as a hydrochloride salt in solid form for research use. It is intended for incorporation into PROTACs and other E3 ligase recruiting conjugates for chemical biology and medicinal chemistry studies.
- Thalidomide-derived cereblon ligand for E3 ligase recruitment.
- Suitable for PROTAC construction and linker conjugation.
- Provided as a solid hydrochloride salt for stability and handling.
- Available in small milligram packages appropriate for synthesis and assays.
- Store sealed, away from moisture and light; follow supplier storage guidance.
Medchemexpress LLC (R)-(+)-thalidomide | 260939 | MFCD00210220 | 99.8% | C13H10N2O4 | 10MG
(R)-Thalidomide is the R-enantiomer of thalidomide supplied for research use. It is reported to have psychomotor stabilizing properties and is used as a ligand in studies of cereblon-mediated E3 ligase interactions and related cellular pathways. Provided as a high-purity research chemical for biochemical and cellular assays.
- R-enantiomer of thalidomide for stereospecific studies.
- High purity 99.8% suitable for analytical and biological assays.
- Useful for research on cereblon and E3 ligase interactions.
- Available in milligram scales for laboratory research.
- For research use only; not for human or clinical use.
Medchemexpress LLC Thalidomide-4-Br | 2093536-12-8 | MFCD31730866 | 99.6% | 337.13 | C13H9BrN2O4 | 50 MG
Thalidomide-4-Br is a brominated thalidomide derivative used as a cereblon/bromodomain ligand in preclinical research on inflammation, oncology, and neurology. It is supplied as a solid, off-white to gray powder with characterized identity and stability data.
- High purity (reported ≈99.6%).
- Well characterized: CAS 2093536-12-8; formula C13H9BrN2O4; molecular weight 337.13.
- Available in multiple package sizes, including small (50 mg) and larger quantities.
- Defined storage and stability: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Suitable for cereblon-targeting studies and use as a ligand in PROTAC development.
Medchemexpress LLC Thalidomide-C2-amido-C2-COOH | 2353496-84-9 | 98.5% | C19H20N4O7 | 10MG
Thalidomide-C2-amido-C2-COOH is a thalidomide-derived cereblon (CRBN) ligand-linker conjugate for research use. Supplied as a powder, it is intended as a building block for design and synthesis of PROTAC degraders and other molecules that recruit the CRBN E3 ubiquitin ligase.
- Incorporates a cereblon-binding thalidomide moiety for E3 ligase recruitment.
- Contains a short C2-amido-C2-COOH linker for conjugation to target ligands.
- High purity (98.5%) suitable for synthetic and analytical work.
- Molecular formula and weight provided to support design calculations.
- Soluble in DMSO for preparation of concentrated stock solutions.
- Powder form allows long-term frozen storage for stability.
Medchemexpress LLC Thalidomide-o-amido-c3-peg3-c1-nh2 trifluoroacetate | 1799711-29-7 | MFCD32878273 | 99.1% | C27H35F3N4O11 | 10MG
Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that couples a thalidomide-derived cereblon ligand to a three-unit polyethylene glycol linker, designed for PROTAC synthesis and related chemical biology research. The compound is supplied as an off-white to light yellow oil, with molecular formula C27H35F3N4O11, molecular weight 648.58 g·mol⁻¹, and high purity suitable for research.
- Contains a thalidomide-derived cereblon ligand for E3 ligase recruitment.
- Includes a three-unit polyethylene glycol linker to enhance flexibility and solubility.
- Designed for PROTAC design and targeted protein degradation studies.
- High purity (99.1%) for consistent experimental results.
- Characterized molecular properties facilitate reproducible use in research.
- Available in small packaging sizes suitable for laboratory studies.
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl] oxy] | 2682112-08-7 | MFCD00869897 | 97.0% | C20H22N2O9 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000262032.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl] oxy] | 2682112-08-7 | MFCD00869897 | 97.0% | C20H22N2O9 | 10MG
Thalidomide-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon ligand with a PEG3 spacer terminating in a carboxylic acid. It is designed as a building block for PROTAC and targeted protein degradation research, supplied as a solid with high reported purity and DMSO solubility.
- Incorporates cereblon-binding thalidomide scaffold for E3 recruitment.
- PEG3 linker provides a flexible spacer for target engagement.
- Terminal carboxylic acid enables amide coupling and conjugation chemistry.
- High reported purity (96.95%) suitable for synthesis and analytical work.
- Soluble in DMSO for straightforward stock solution preparation.
- Available in small laboratory pack sizes for research use.