Lactams
Medchemexpress LLC Thalidomide-1-Me,4-OH | 2244568-06-5 | >98.0% | 288.26 | C14H12N2O5 | 25 MG
Thalidomide-1-Me,4-OH is a thalidomide analogue with a 1-methyl and 4-hydroxyl substitution that functions as an E3 ubiquitin ligase ligand. It is used in biochemical research to recruit E3 ligases (Cereblon-related activity) for targeted protein degradation studies.
- Acts as an E3 ligase ligand suitable for cereblon-mediated recruitment.
- Contains 1-methyl and 4-hydroxyl substitutions on the thalidomide scaffold.
- Molecular formula C14H12N2O5, molecular weight 288.26.
- Purity greater than 98%.
- Recommended storage: powder at -20°C (long-term) or 4°C (short-term); in solvent at -80°C for extended storage.
- Supplied in small research quantities, e.g., 25 MG, for biochemical assays.
Medchemexpress LLC Thalidomide-4-OH | 5054-59-1 | MFCD03699892 | 99.9% | 274.23 g·mol⁻¹ | C13H10N2O5 | 10 G
Thalidomide-4-OH is a 4-hydroxylated metabolite of thalidomide used as a Cereblon (CRBN) ligand in chemical biology and PROTAC research. It is supplied as a high-purity solid for synthetic and biochemical applications, with recommended storage under inert atmosphere.
- High purity suitable for synthesis and assays.
- Molecular formula C13H10N2O5; molecular weight 274.23 g·mol⁻¹.
- Used as a CRBN ligand for recruitment of cereblon in PROTACs.
- Available in gram-scale quantities for research workflows.
- Solid with melting point 273-275 °C.
- Recommended storage: 4 °C under nitrogen; in solvent: -80 °C (6 months) or -20 °C (1 month).
Medchemexpress LLC Thalidomide-4-O-C9-NH2 (hydrochloride) | 99.3% | 451.94 | 5 MG
Thalidomide-4-O-C9-NH2 (hydrochloride) is a solid laboratory chemical with a molecular weight of 451.94 and the chemical formula C22H30ClN3O5. It is stable under recommended storage conditions.
- Solid appearance, light yellow to yellow
- Purity of 99.3%
- Stable under recommended storage conditions
- Long-term storage at -20°C (solid) or -80°C (in solvent)
Medchemexpress LLC Thalidomide 4-chloro | 244057-36-1 | MFCD30188071 | 96.0% | 292.68 g·mol⁻¹ | C13H9ClN2O4 | 1 G
Thalidomide 4-chloro is a chlorinated thalidomide derivative that functions as a cereblon (E3 ligase) ligand and E3 ligase activator. It is used in PROTAC development and as a synthetic building block for further derivatization via substitution at the 4-chloro position. The compound is supplied as a solid and is characterized for research applications.
- Molecular formula: C13H9ClN2O4.
- Molecular weight: 292.68 g·mol⁻¹.
- CAS number: 244057-36-1.
- Appearance: solid (powder).
- Purity: 96.0%.
- Intended use: E3 ligase (cereblon) ligand for PROTAC design and derivatization.
- Storage: powder -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
Medchemexpress LLC Thalidomide-4-O-C9-NH2 (hydrochloride) | 99.3% | 451.94 | 25 MG
Thalidomide-4-O-C9-NH2 hydrochloride is a chemical compound for laboratory research and the manufacture of substances. This compound is stable under recommended storage conditions, which include sealed storage at -20°C, away from moisture and light. If in solvent, it can be stored at -80°C for 6 months or -20°C for 1 month.
- Intended for laboratory research and substance manufacturing
- Molecular weight of 451.94
- Purity of 99.26%
- Stable under recommended storage conditions
- Store at -20°C, sealed, away from moisture and light
- In solvent, store at -80°C for 6 months or -20°C for 1 month
- Can be shipped at room temperature if transit is less than 2 weeks
Medchemexpress LLC Thalidomide-4-O-C4-NH2 hydrochloride | 2376990-29-1 | MFCD32705123 | 99.4% | C17H20ClN3O5 | 10MG
Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that combines a thalidomide-derived cereblon-binding moiety with a C4 amine-containing linker for use in PROTAC development and targeted protein degradation research. Supplied as a hydrochloride salt and intended for research use only.
- Hydrochloride salt form for improved handling and solubility.
- High purity suitable for biochemical and cell-based assays.
- Molecular formula C17H20ClN3O5; molecular weight 381.81 g·mol⁻¹.
- Available in small milligram quantities for discovery research.
- Storage: sealed at 4°C; in solution, -80°C for long-term storage.
Medchemexpress LLC Thalidomide-piperazine-PEG1-NH2 (diTFA) | 2984178-51-8 | 99.4% | 657.52 | 25 MG
Thalidomide-Piperazine-PEG1-NH2 (diTFA) is a chemical compound suitable for laboratory research. It is stable under recommended storage conditions and is not classified as a hazardous substance.
- Molecular formula: C25H29F6N5O9
- Molecular weight: 657.52
- Purity: 99.4%
- Appearance: White to yellow solid
- Storage conditions: 4°C sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month
- For research use only
Medchemexpress LLC Thalidomide 4-fluoride (Cereblon ligand 4) | 835616-60-9 | 99.83% | 276.22 | 25 G
Thalidomide 4-fluoride (Cereblon ligand 4) is a Thalidomide-based Cereblon ligand that is utilized in the recruitment of the CRBN protein. It can be linked to the ligand for IRAK4 protein via a linker to form PROTAC IRAK4 degrader-1. It is for research use only and not sold to patients.
- Purity: 99.83%
- Molecular weight: 276.22
- Formula: C13H9FN2O4
- CAS No.: 835616-60-9
- Appearance: Solid
- Color: Off-white to gray
- Solubility (in vitro): DMSO : 200 mg/mL (724.05 mM; requires ultrasonic; hygroscopic DMSO impacts solubility, use newly opened DMSO)
- Storage (powder): -20°C for 3 years, 4°C for 2 years
- Storage (in solvent): -80°C for 2 years, -20°C for 1 year
Medchemexpress LLC Thalidomide-CH2NH2 hydrochloride | 444287-40-5 | 98.1% | 323.73 | 100 MG
Thalidomide-CH2NH2 hydrochloride is a Thalidomide analogue featuring a primary amine, a versatile functional group that can participate in various reactions. It is intended for research use only.
- Features a primary amine group
- Provided as a solid, white to off-white in color
- Ships at room temperature in continental US
- Powder storage at -20°C for 3 years, 4°C for 2 years
- Storage in solvent at -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Thalidomide-4-Br | 2093536-12-8 | MFCD31730866 | 99.6% | 337.13 | C13H9BrN2O4 | 50 MG
Thalidomide-4-Br is a brominated thalidomide derivative used as a cereblon/bromodomain ligand in preclinical research on inflammation, oncology, and neurology. It is supplied as a solid, off-white to gray powder with characterized identity and stability data.
- High purity (reported ≈99.6%).
- Well characterized: CAS 2093536-12-8; formula C13H9BrN2O4; molecular weight 337.13.
- Available in multiple package sizes, including small (50 mg) and larger quantities.
- Defined storage and stability: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Suitable for cereblon-targeting studies and use as a ligand in PROTAC development.
Medchemexpress LLC Thalidomide-4-Br | 2093536-12-8 | MFCD31730866 | 99.6% | 337.13 g·mol⁻¹ | C13H9BrN2O4 | 200 MG
Thalidomide-4-Br is a brominated thalidomide derivative used as a research compound that engages bromodomains and cereblon-related E3 ligase biology. It is applied in studies of inflammation, tumor biology, and neurology and is supplied as a high-purity solid with recommended cold storage for powder and solutions.
- Engages bromodomains and E3 ligase pathways.
- Used in inflammation, tumor, and neurology research.
- Reported purity approximately 99.6% (COA/product listings).
- Solid, off-white to gray physical form.
- Storage: powder at -20°C (long term) or 4°C (short term); solutions at -80°C or -20°C.
- Available in small-scale amounts and DMSO solution formats.
![Medchemexpress LLC 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)amino]-, 1,1-dimethylethyl ester | 2204246-03-5 | 97.2% | 548.59 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000403850-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)amino]-, 1,1-dimethylethyl ester | 2204246-03-5 | 97.2% | 548.59 | 5 MG
Thalidomide-NH-PEG3-NH-Boc is a chemical compound that appears as a light yellow to yellow oil. This product has been thoroughly tested and complies with the given specifications, ensuring its quality and suitability for research purposes.
- Molecular formula: C26H36N4O9
- Molecular weight: 548.59
- Purity (LCMS): 97.20%
- Storage for pure form: -20°C for 3 years; 4°C for 2 years
- Storage in solvent: -80°C for 6 months; -20°C for 1 month
![Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.3% | 440.95 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387076-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 6H-Thieno[3,2-f]triazolo[4,3-a]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, cyclopropyl ester, (6S)- | 3077900-08-1 | 98.3% | 440.95 | 5 MG
DDL-357 is a potent enhancer of secreted clusterin. It has been shown to reduce phospho-tau levels in the brain and improve memory in the murine 3xTg-AD model. It is intended for research use only and not for sale to patients.
- Purity: 98.31%
- Appearance: Solid
- Color: White to off-white
- Shipping: Room temperature in continental US; may vary elsewhere.
- Storage (powder): -20°C for 3 years, 4°C for 2 years.
- Storage (in solvent): -80°C for 6 months, -20°C for 1 month.
- Solubility (in vitro): 100 mg/mL in DMSO (226.78 mM; requires ultrasonic, hygroscopic DMSO affects solubility).
- Solubility (in vivo - protocol 1): ≥ 5 mg/mL (11.34 mM) in a mixture of 10% DMSO, 40% PEG300, 5% Tween-80, and 45% Saline, yielding a clear solution.
Medchemexpress LLC Thalidomide-NH-PEG3-NH-Boc | 2204246-03-5 | 97.2% | 548.59 | 100 MG
Thalidomide-NH-PEG3-NH-Boc is a chemical compound with a molecular weight of 548.59. It appears as a light yellow to yellow oil and its structure is consistent with LCMS analysis. This product has been tested and complies with the given specifications.
- Molecular formula: C26H36N4O9
- Storage in pure form: -20°C for 3 years; 4°C for 2 years
- Storage in solvent: -80°C for 6 months; -20°C for 1 month
- Purity: 97.20%
- Appearance: Light yellow to yellow (oil)
Medchemexpress LLC Thalidomide 5-fluoride | 835616-61-0 | MFCD30188075 | 100.0% | 276.22 g/mol | C13H9FN2O4 | 10 G
Thalidomide 5-fluoride is a thalidomide-derived cereblon ligand used as a building block in PROTAC degraders and other bifunctional molecules. It is supplied as a high-purity solid reagent intended for research and chemical biology applications.
- High purity solid (99.96%).
- Molecular weight 276.22 g/mol.
- Molecular formula C13H9FN2O4.
- Available in laboratory pack sizes, including 10 G.
- Storage: powder at -20°C for long-term, 4°C for shorter term; in solvent store at -80°C.