Pyrazines
TARGETMOL CHEMICALS INC NAE-IN-M22 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. NAE-IN-M22 (NEDD8 inhibitor M22) is a selective potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo. purity: 98%
TARGETMOL CHEMICALS INC CB2R/FAAHMODULATOR-2 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-2 acts as a CB2R agonist and FAAH inhibitor the Ki values are 10.8 and 152.9 nM for CB2R and CB1R respectively and the IC50 value for FAAH is 6.2 uM. CB2R/FAAH modulator-2 has studies research value related to cancer deleterious inflammatory cascades occurring in neurodegenerative diseases and COVID-19 infection. purity: 99%
TARGETMOL CHEMICALS INC A-366 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP respectively.It is more than 1000-fold selective for G9a and GLP over the other 21 methyltransferases. It is an inhibitor of the Spindlin1-H3K4me3 interaction with an IC50 of 182.6 nM.It exhibits high affinity for human H3R with a Ki value of 17 nM and shows subtype selectivity between subgroups of the histaminergic and dopaminergic receptor families. purity: 99%
TARGETMOL CHEMICALS INC JAK1-IN-8 5MG
Also available in 10 mg 25 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. JAK1-IN-8 a specific inhibitor of Janus kinase 1 (JAK1 IC50<500 nM). purity: 98%
TARGETMOL CHEMICALS INC ML221 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ML221 is a potent apelin /APJ functional antagonist inhibiting apelin-13-mediated activation of APJ with IC50s of 0.70 uM in the cAMP assay and 1.75 uM in the (beta)-arrestin assay and EC80 of 10 nM in both assays. purity: 97%
TARGETMOL CHEMICALS INC AHN 1-055 HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. AHN 1-055 hydrochloride (3(alpha)-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM). purity: 99%
TARGETMOL CHEMICALS INC EVIXAPODLIN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50 0.213).Evixapodlin has anticancer and antiviral activities. purity: 99%
TARGETMOL CHEMICALS INC --BLEBBISTATIN 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. (-)-Blebbistatin ((S)-(-)-Blebbistatin) is an S enantiomer of blebbistatin. It is a potent and selective myosin II inhibitor with IC50 ranging from 0.5 to 5 uM. purity: 99%
eMolecules 113305-94-5 | 5-Aminopyrazine-2-carbonitrile | MFCD08234954 | 1g
Ambeed | 34-Dimethoxybenzaldehyde | 500g | 525103631 | A186120 | 120-14-9 | MFCD00003363 | 166.176 | C9H10O3
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TARGETMOL CHEMICALS INC BREVILIN A 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Brevilin A is a sesquiterpene lactone isolated from Centipeda minima inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 uM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumourpurity: 99%
TARGETMOL CHEMICALS INC LFM-A13 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LFM-A13（IC50=2.5 uM） a specific Bruton's tyrosine kinase (BTK) is more than 100-fold specificity than other protein kinases such as JAK1 JAK2 HCK EGFR and IRK. purity: 99%
TARGETMOL CHEMICALS INC TROPIFEXOR 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM. purity: 99%
TARGETMOL CHEMICALS INC CILOMILAST 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM has anti-inflammatory activity and low central nervous system activity. Phase 3. purity: 99%
TARGETMOL CHEMICALS INC CCT129202 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A Aurora B and Aurora C with IC50 of 0.042 uM 0.198 uM and 0.227 uM respectively. It is less potent to FGFR3 GSK3(beta) PDGFR(beta) etc. purity: 98%
TARGETMOL CHEMICALS INC GINSENOSIDE F1 25MG
Also available in 5 mg 10 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Ginsenoside F1 (20(S)-Ginsenoside F1) is an enzymatically modified derivative of ginsenoside Rg1 showing competitive inhibition of the activity of CYP3A4 and a weaker inhibition of the activity of CYP2D6. purity: 99%