Pyridines and derivatives
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- (520)
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- (12)
- (1)
- (1)
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- (1)
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- (11)
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- (2)
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- (1)
- (1)
- (1)
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Filtered Search Results
![Alkali Scientific 5 Azacytosine [4 Amino 1,3.5 triazine 2 one], 100 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660200.jpg-250.jpg)
Alkali Scientific 5 Azacytosine [4 Amino 1,3.5 triazine 2 one], 100 G
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5 Azacytosine (100g) is a potent research compound used to study DNA methylation, gene silencing, and epigenetic regulation. It serves as a cytidine analog, incorporating into DNA and blocking methylation processes by inhibiting DNA methyltransferase activity. This inhibition is essential for studying the genetic and biochemical mechanisms of diseases like cancer, where altered methylation patterns are prevalent. The 100g package is ideal for large-scale experiments, particularly in genomics, pharmaceutical development, and biotechnology research. Azacytosine is integral in studying the dynamic regulation of gene expression, making it a critical tool in genetic and epigenetic studies.
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Medchemexpress LLC DC-U4106 | 2410534-62-0 | C29H27N5O5 | 1 MG
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DC-U4106 is a USP8 targeting inhibitor with a Kd value of 4.7 μM and an IC50 value of 1.2 μM. It targets the ubiquitin pathway, facilitating the degradation of Erα. This compound inhibits tumor growth with minimal toxicity and shows potential for breast cancer research.
- Targets the ubiquitin pathway
- Facilitates degradation of Erα
- Inhibits tumor growth with minimal toxicity
- Reduces mRNA levels of ERα and PR
- Regulates RTK pathway related proteins and ERα and PR protein expression
- Induces apoptosis and inhibits cell proliferation
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Medchemexpress LLC Antibacterial agent 125 | 1274611-43-6 | C15H11ClN2O | 50 MG
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Antibacterial agent 125 is an antibacterial agent with potent antimicrobial activity against clinically relevant Gram-positive pathogens, showing MIC50 values ranging from 0.25 - 8 μM. It can be utilized for research into antimicrobial resistance.
- Demonstrates inhibitory activity against methicillin-resistant Staphylococcus aureus strains without inducing cytotoxicity in human cells.
- Possesses high metabolic stability and an excellent safety profile.
- Does not induce resistance after ten passages.
- Has a moderate ability to inhibit biofilm formation.
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Medchemexpress LLC HEX3 | 688805-40-5 | 99.74% | 1035.21 | 5 MG
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HEX3 is a fragment of the adenoviral hexon, which is the major capsid protein of adenovirion and is comprised of three identical polypeptide chains.
- Solid, white to off-white appearance.
- Soluble in water at ≥ 100 mg/mL (96.60 mM).
- Sequence: Lys-Tyr-Ser-Pro-Ser-Asn-Val-Lys-Ile.
- Suitable for research applications.
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Medchemexpress LLC LSECtin/CLEC4G Huma 5ug | 5ug
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The LSECtin/CLEC4G protein displays unique carbohydrate binding characteristics that favor mannose N-acetylglucosamine (GlcNAc) and fucose in a Ca(2 )-dependent manner as shown in vitro Notably it serves as a receptor for Japanese encephalitis virus during microbial infection highlighting its role in viral recognition and host-pathogen interactions LSECtin/CLEC4G Protein Human (Fc) is the recombinant human-derived LSECtin/CLEC4G protein expressed by E coli with N-hFc labeled tag
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Medchemexpress LLC SRX3177 | 2241237-51-2 | C31H32N6O4S | 1 ML
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SRX3177 is a triple inhibitor of CDK4/6, PI3K, and BRD4. This compound blocks the interaction between the SARS-CoV-2 E protein and the BRD2/4 BD1 domain, which helps restore E protein-attenuated NF-κB activity. SRX3177 shows broad cytotoxic activity against cancer cells and can be used for the study of anti-SARS-CoV-2 and cancer.
- Inhibits CDK4/6, PI3K, and BRD4
- Blocks interaction between SARS-CoV-2 E protein and BRD2/4 BD1 domain
- Restores E protein-attenuated NF-κB activity
- Exhibits broad cytotoxic activity against cancer cells
- Useful for anti-SARS-CoV-2 research
- Useful for cancer research
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Medchemexpress LLC Levonadifloxacin | 154357-42-3 | 99.8% | 360.38 | 5 MG
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Levonadifloxacin, also known as (S)-(-)-Nadifloxacin or WCK 771, is an antibiotic and a broad-spectrum anti-staphylococcal agent. It demonstrates antibacterial activity against both Methicillin-susceptible *Staphylococcus aureus* (MSSA) and Methicillin-resistant *S. aureus* (MRSA) strains, leading to a reduction of those phagocytized in THP-1 monocytes.
- Broad-spectrum anti-staphylococcal agent
- Active against MSSA and MRSA strains
- Reduces phagocytized *S. aureus* in THP-1 monocytes
- Efficacious in vivo against *Staphylococcus aureus* in a Neutropenic Murine Lung Infection Model
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Medchemexpress LLC Clk1-in-3 | 2922550-28-3 | 98.5% | 430.48 | 50 MG
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CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A. It also shows a relatively potent inhibition against Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. This compound potently induces autophagy in vitro and can be used for acute liver injury (ALI) research.
- Potent and selective Clk1 inhibitor
- Induces autophagy in vitro
- Can be used for acute liver injury (ALI) research
- Shows potential in anti-tumor applications
- Stimulates degradation of SQSTM1/p62
- Elevates expression level of LC3II protein
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Medchemexpress LLC Apilimod | 541550-19-0 | 99.8% | 418.49 | 100 MG
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Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. It is a potent and highly selective PIKfyve inhibitor.
- Potent IL-12/IL-23 inhibitor
- Highly selective PIKfyve inhibitor
- Inhibits IL-12 with low IC50 values
- Used in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs
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Apexbio Technology LLC IDO-IN-2 1668565-74-9 5mg
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IDO-IN-2 (CAS 1668565-74-9) is a small-molecule inhibitor of indoleamine 2 3-dioxygenase (IDO) an enzyme involved in the catabolism of tryptophan In vitro studies indicate that IDO-IN-2 efficiently attenuates IDO activity in HeLa cells as evidenced by low IC50 values Preclinical investigations suggest that the compound can modulate synaptic plasticity within regions such as the anterior cingulate cortex and amygdala contributing to the alleviation of neuropathic pain and related symptoms IDO-IN-2 serves as a valuable tool for research in neuropharmacology and cancer immunotherapy facilitating the study of IDO pathway modulation
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Medchemexpress LLC Endoxifen | 110025-28-0 | 99.5% | 373.49 | 5 MG
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Endoxifen | 110025-28-0 | 99.5% | 373.49 | 5 MG
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Medchemexpress LLC NSC 694623 | 907957-34-0 | 99.5% | 284.38 | 5 MG
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NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor, specifically targeting recombinant HAT p300/CBP-associated factor (PCAF) with an IC50 value of 15.9 μM. It demonstrates antiproliferative activity against certain cancer cells, making it suitable for anticancer research. This compound exhibits an IC50 of 8.93 μM against SK-N-SH cells and inhibits 21% of HCT116 cells at 25 μM.
- Potent inhibitor of histone acetyltransferase (HAT) PCAF.
- Exhibits antiproliferative activity against specific cancer cells.
- Useful for research applications in anticancer studies.
- Shows growth inhibition against human SK-N-SH cells.
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Apexbio Technology LLC Lercanidipine 100mg
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Lercanidipine (CAS 100427-26-7) is a synthetic dihydropyridine derivative that functions as a selective inhibitor of voltage-gated L-type calcium channels By blocking calcium influx into vascular smooth muscle cells it induces vasodilation and reduces peripheral vascular resistance Lercanidipine is widely utilized in research investigating calcium-mediated signal transduction vascular reactivity and hypertension-related pathophysiology Its well-characterized pharmacological properties make it a valuable tool for elucidating mechanisms underlying cardiovascular regulation and for evaluating novel interventions targeting calcium channel dynamics
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Cayman Chemical Capsazepine Other Receptor Mod
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A competitive antagonist of TRPV1 which blocks the capsaicin-induced uptake of Ca2+ in neonatal rat dorsal root ganglia (IC50 = 0.42 µM) and Chinese hamster ovary cells (IC50 = 17 nM); does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1
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Apexbio Technology LLC NVP-AEW541 475489-16-8 25mg
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NVP-AEW541 (CAS 475489-16-8) is a selective small-molecule inhibitor targeting the insulin-like growth factor-I receptor (IGF-IR) kinase activity Structurally classified as a pyrrolo[2 3-d]pyrimidine derivative NVP-AEW541 effectively inhibits IGF-IR autophosphorylation disrupting downstream IGF-IR mediated signaling cascades It exhibits an IC50 of approximately 0 086 M against IGF-IR kinase In vitro research has demonstrated that treatment of ECC-1 and USPC-1 endometrial cancer cell lines with NVP-AEW541 leads to altered cell cycle progression induction of apoptosis and suppression of proliferation Furthermore NVP-AEW541 has been shown to enhance radiosensitivity specifically in PTEN wild-type cancer cell lines indicating its potential utility as an adjunctive therapeutic agent in oncology research
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