Pyridines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing one nitrogen atom and five carbon atoms; includes compounds derived from pyridines.

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Cell Signaling Technology Tox (E5J8A) Rabbit mAb 20 ul

Tox (E5J8A) Rabbit mAb 20 ul

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Sigma Aldrich Fine Chemicals Biosciences Agarose for molecular biol100G

Agarose is a polymer extracted from agar or agar-bearing marine algae. This purified linear galactan hydrocolloid comprises alternating co-polymers D-galactose and 3 6-anhydro-L-galactose units connected by (1A†3) and -(1A†4) glycosidic bonds. Agarose is highly biocompatible and possesses variable mechanical and diffusion properties. Agarose can be used as a gelling agent to separate nucleic acids electrophoretically.

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Medchemexpress LLC Ki-tox-a3 | 1351116-34-1 | 98.9% | 10 MG

KI-TOX-A3 is a selective protein-protein interaction inhibitor that targets the TOX protein. It disrupts the TOX-KAT7 interaction (IC50 = 0.51 μM), promotes proteasomal degradation of TOX, and restores KAT7-mediated H3K14 acetylation. These actions reverse CD8+ T cell exhaustion and inhibit proliferation of T-cell acute lymphoblastic leukemia cells. Supplied as a solid powder for research use.

Selective PPI inhibitor that targets TOX protein.
Potent disruption of TOX-KAT7 interaction (IC50 0.51 μM).
Induces proteasomal degradation of TOX to restore histone acetylation.
Reverses CD8+ T cell exhaustion in preclinical studies.
Inhibits proliferation of T-ALL cells.
High purity (98.9%) and supplied as solid powder.
Storage: powder -20°C; solutions -80°C (6 months) or -20°C (1 month).

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Medchemexpress LLC Ki-tox-a3 | 1351116-34-1 | >99.15% | 319.31 | 25 MG

KI-TOX-A3 is a selective protein-protein interaction (PPI) inhibitor targeting the TOX protein, with an IC50 value of 0.51 μM for TOX-KAT7 interaction. It induces proteasomal degradation of TOX, which restores KAT7-mediated H3K14 acetylation. This action reverses CD8+ T cell exhaustion and inhibits the proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells. KI-TOX-A3 shows promise for research in hematological tumors such as T-ALL.

Selective PPI inhibitor targeting TOX protein
Induces proteasomal degradation of TOX
Restores KAT7-mediated H3K14 acetylation
Reverses CD8+ T cell exhaustion
Inhibits T-cell acute lymphoblastic leukemia (T-ALL) cell proliferation
Promising for research of hematological tumors

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Medchemexpress LLC KI-TOX-A3 | 1351116-34-1 | 99.15% | 319.31 | 5 MG

KI-TOX-A3 is a selective protein-protein interaction (PPI) inhibitor that targets the TOX protein. It has an IC50 value of 0.51 μM for the TOX-KAT7 interaction. This compound induces proteasomal degradation of TOX, which restores KAT7-mediated H3K14 acetylation, thereby reversing CD8+ T cell exhaustion and inhibiting the proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells. KI-TOX-A3 shows promise for research into hematological tumors like T-ALL. It is intended for research use only and not for sale to patients.

Selective protein-protein interaction (PPI) inhibitor targeting TOX protein.
Induces proteasomal degradation of TOX.
Restores KAT7-mediated H3K14 acetylation.
Reverses CD8+ T cell exhaustion.
Inhibits T-cell acute lymphoblastic leukemia (T-ALL) cell proliferation.
Promising for research of hematological tumors (e.g., T-ALL).

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Medchemexpress LLC Low molecular weight protamine | 121052-30-0 | 98.1% | 1880.18 | 10 MG

Low molecular weight protamine (LMWP) is a cell-penetrating peptide that demonstrates vascular endothelial growth factor (VEGF) inhibitory activity. It is utilized in cancer research due to its ability to inhibit tumor growth.

Cell-penetrating peptide
Exhibits vascular endothelial growth factor (VEGF) inhibitory activity
Can inhibit tumor growth
Used in cancer research
Appears as a white to off-white solid
Soluble in H2O: ≥ 100 mg/mL (53.19 mM)

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Medchemexpress LLC LC-04-045 NEK7 molecular glue degrader | 99.6% | 566.05 | 100 MG

LC-04-045 is a selective NIMA-related kinase 7 (NEK7) molecular glue degrader. It induces NEK7 degradation via the CRBN-based ubiquitin-proteasome system, dependent on the glycine 57-containing degron motif. This product inhibits the secretion of downstream cytokines IL-1β and IL-18 and can be used for research on lymphoblastic leukemia.

Selective NEK7 molecular glue degrader
Induces NEK7 degradation via CRBN-based ubiquitin-proteasome system
Inhibits secretion of IL-1β and IL-18
Suitable for lymphoblastic leukemia research
Purity of 99.56%

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Medchemexpress LLC Low molecular weight protamine (LMWP) | 121052-30-0 | 98.07% | 1880.18 | 5 MG

Low molecular weight protamine is a cell-penetrating peptide with vascular endothelial growth factor (VEGF) inhibitory activity. It can inhibit tumor growth and is used in cancer research.

Inhibits tumor growth
Cell-penetrating peptide
Vascular endothelial growth factor inhibitory activity
Used in cancer research

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Medchemexpress LLC SJ3149 CK1α Molecular Glue Degrader | 3026986-17-1 | 99.48% | 376.37 | 1 ML

SJ3149 is a selective and potent molecular glue degrader of CK1α protein with broad antiproliferative activity, intended for use in cancer research. It effectively degrades CK1α protein in MOLM-13 cells at low nanomolar concentrations and inhibits cell growth. In vivo studies also show significant degradation of CK1α protein levels in mice.

Selective and potent molecular glue degrader of CK1α protein.
Broad antiproliferative activity against cancer cells.
Degrades CK1α protein in MOLM-13 cells at 4 nM.
Inhibits MOLM-13 cell growth with an IC50 of 14 nM.
Significantly degrades CK1α protein levels in NSG mice at 50 mg/kg.

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Medchemexpress LLC Low molecular weight protein tyrosine phosphatase (LMW-PTP/ACP1), human | >95.0% | 5UG

Recombinant human low molecular weight protein tyrosine phosphatase (LMW-PTP/ACP1), supplied as a C-terminal His-tagged protein expressed in E. coli and provided lyophilized. The product is supplied with >95% purity by reducing SDS-PAGE, an approximate molecular weight of 18.0 kDa, and is formulated from 50 mM Tris-HCl, 300 mM NaCl, pH 7.4. Intended for research use; recommended reconstitution concentration ≥100 μg/mL.

Recombinant human sequence suitable for biochemical assays.
C-terminal His tag for affinity purification and detection.
High purity for reliable experimental results.
Expressed in E. coli for consistent production.
Lyophilized formulation for extended shelf life.
Provided with certificate of analysis (COA) and safety data sheet (SDS).
Recommended reconstitution at concentrations ≥100 μg/mL.

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Medchemexpress LLC Carbomer 940 | 9007-20-9 | 95.0% | Not specified (crosslinked polymer; no defined molecular weight) | (C3H4O2)n | 100 MG

Carbomer 940 is a crosslinked polyacrylic acid polymer used as a high-efficiency thickening and gelling agent for pharmaceutical, cosmetic, and biochemical applications. It appears as a white to off-white powder and forms stable gels that control viscosity and enable topical and local drug delivery, suspension stabilization, and controlled-release formulations.

Provides high viscosity and gel-forming properties.
Forms a stable gel matrix for controlled drug release.
Resistant to heat, light, and microbial contamination.
Suitable for topical and local formulations.
Purity typically 95.0% for research-grade material.

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Medchemexpress LLC Surfactin | 252023-70-4 | 99.0% | 1025.04 g/mol | No single molecular formula (mixture of isomeric surfactins) | 5 MG

Surfactin is a cyclic lipopeptide biosurfactant (mixture of isomeric forms) used in research on antimicrobial, antifungal, and antiviral activity. Supplied as a high-purity research reagent, it includes documented solubility and storage recommendations for in vitro and in vivo studies.

High purity: 98.96%.
Average molecular weight: 1025.04 g/mol.
Soluble in water and DMSO with ultrasonic assistance.
Powder storage: stable at -20°C for long term.
Commonly used in antimicrobial, antiviral, and surfactant research.
Available in small research pack sizes from 5 mg to larger quoted quantities.

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Medchemexpress LLC Cholestyramine resin | 11041-12-6 | MFCD00130784 | 16.1% | Polymeric anion-exchange resin; no defined molecular formula | 5 G

Cholestyramine (colestyramine) is a crosslinked chloride-form anion-exchange resin supplied as a powder. It binds bile acids in the intestine, reducing enterohepatic bile acid recycling and promoting increased bile acid synthesis from cholesterol. It is used in biochemical research, formulation studies, and assays that require bile acid sequestration.

Binds bile acids in the intestine, reducing enterohepatic recycling.
Promotes increased bile acid synthesis from cholesterol.
Supplied as a powdered, polymeric anion-exchange resin suitable for research and formulation.
Typical chloride assay 13-17% (example 16.1% reported on COA).
No single defined molecular weight because the product is a crosslinked polymer.

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Medchemexpress LLC Cadherin-17 protein, cynomolgus (biotinylated, HEK293, His-Avi) | ≥ 90% | Predicted molecular mass is 88.1 kDa | 200 UG

The biological activity of this Cadherin-17 protein is measured by its binding ability in a functional ELISA. When immobilized at 1 μg/mL on a streptavidin precoated plate, the Biotinylated Cynomolgus Cadherin-17 Protein, His, Avitag can bind Anti-CDH17 antibody (300-350) with a linear range of 2.924-38.1 ng/mL.

The protein is expressed in HEK293 cells.
It is biotinylated with a C-Avi and C-His tag.
The product is supplied as a lyophilized powder.
It is formulated from a 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH 8.0, with trehalose as a protectant.
It can be stored at -20°C for 2 years from the date of receipt.
After reconstitution, it remains stable at 4°C for 1 week or at -20°C for longer with a carrier protein.
Suitable for use in functional ELISA to assess binding capabilities.
Provides a standardized method for evaluating binding affinity to antibodies.

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Medchemexpress LLC Iota-carrageenan | 9062-07-1 | MFCD00151512 | 98.0% | No defined molecular weight (polymeric) | No single defined chemical formula (polymeric) | 5 G

Iota-carrageenan is an iota-type sulfated polysaccharide supplied as a powder for laboratory research. It is used as a biochemical assay reagent and as a gelling or proinflammatory agent in life-science studies. The material is intended for research use only and is provided with supporting documentation for safe handling and quality control.

Is an iota-type sulfated polysaccharide extracted from red seaweed.
Functions as a biochemical assay reagent and proinflammatory agent in research.
Forms thermoreversible gels and can modify viscosity in formulations.
Supplied as a powder with listed purity of 98.0%.
Available in small pack sizes suitable for laboratory use (e.g., 5 G).
Storage: powder stable at -20°C (3 years) or 4°C (2 years); in solvent stability is shorter.
COA, SDS, and datasheet are available for handling and quality information.

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Pyridines and derivatives

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Cell Signaling Technology Tox (E5J8A) Rabbit mAb 20 ul Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ki-tox-a3 | 1351116-34-1 | 98.9% | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ki-tox-a3 | 1351116-34-1 | >99.15% | 319.31 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC KI-TOX-A3 | 1351116-34-1 | 99.15% | 319.31 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Low molecular weight protamine | 121052-30-0 | 98.1% | 1880.18 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC LC-04-045 NEK7 molecular glue degrader | 99.6% | 566.05 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Low molecular weight protamine (LMWP) | 121052-30-0 | 98.07% | 1880.18 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SJ3149 CK1α Molecular Glue Degrader | 3026986-17-1 | 99.48% | 376.37 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Low molecular weight protein tyrosine phosphatase (LMW-PTP/ACP1), human | >95.0% | 5UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Carbomer 940 | 9007-20-9 | 95.0% | Not specified (crosslinked polymer; no defined molecular weight) | (C3H4O2)n | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Surfactin | 252023-70-4 | 99.0% | 1025.04 g/mol | No single molecular formula (mixture of isomeric surfactins) | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cholestyramine resin | 11041-12-6 | MFCD00130784 | 16.1% | Polymeric anion-exchange resin; no defined molecular formula | 5 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Cadherin-17 protein, cynomolgus (biotinylated, HEK293, His-Avi) | ≥ 90% | Predicted molecular mass is 88.1 kDa | 200 UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Iota-carrageenan | 9062-07-1 | MFCD00151512 | 98.0% | No defined molecular weight (polymeric) | No single defined chemical formula (polymeric) | 5 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More