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Filtered Search Results
Apexbio Technology LLC Tozadenant 870070-55-6 250mg
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Tozadenant is a small-molecule antagonist targeting the adenosine A2A receptor It is designed to selectively inhibit A2A receptors thereby modulating the indirect basal ganglia pathway and influencing neuronal activity involved in motor control Tozadenant exerts its biological activity primarily through selective A2A receptor blockade In animal models tozadenant demonstrates enhancement of motor neuron function Human studies using perfusion MRI indicate that administration of tozadenant decreases regional cerebral blood flow particularly in bilateral thalamic areas Based on these pharmacological properties tozadenant holds research potential in investigating Parkinson s disease and movement disorders associated with basal ganglia dysfunction
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eMolecules Combi-Blocks Inc Ethyl 3-ethoxyprop-2-enoate 1kg 848837071 HC-6543 95 000 1001-26-9 144 170 C7H12O3
Combi-Blocks Inc Ethyl 3-ethoxyprop-2-enoate 1kg 848837071 HC-6543 95 000 1001-26-9 144 170 C7H12O3
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Medchemexpress LLC Clofencet 250mg | 129025-54-3 | 278.69 g·mol⁻¹ | C13H11ClN2O3 | 250 MG
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Clofencet is a wheat hybridizing agent used in agricultural research to produce hybrid wheat seeds by inhibiting pollen development without affecting female fertility. It is supplied for research use only.
- Used to induce wheat hybridization by inhibiting pollen development.
- High purity: 98.62%.
- Molecular formula C13H11ClN2O3; molecular weight 278.69 g·mol⁻¹.
- Light yellow to brown solid; soluble in DMSO (5.83 mg/mL), insoluble in water (<0.1 mg/mL).
- Available in multiple package sizes including 250 mg.
- Storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (6 months) or -20°C (1 month).
- For research use only.
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Medchemexpress LLC Methyl α-D-mannopyranoside | 617-04-9 | MFCD00063262 | 98.0% | 194.18 g/mol | C7H14O6 | 1 ML
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Methyl α-D-mannopyranoside is a methylated mannose derivative used as a research reagent in glycobiology and microbiology for lectin-binding studies and as a competitive inhibitor of mannose-binding proteins. It is supplied as a white to off-white solid with high purity and defined storage recommendations.
- Cas number 617-04-9.
- Molecular formula C7H14O6.
- Molecular weight 194.18 g/mol.
- Purity 98.0% (NMR).
- Appearance white to off-white solid.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Typical applications include glycobiology, lectin inhibition, and microbiology research.
- For research use only; not for human therapeutic use.
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Medchemexpress LLC Parecoxib sodium impurity 10 | 198471-06-6 | 97.0% | 356.40 | C18H16N2O4S | 250 MG
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Parecoxib sodium impurity 10 is a characterized impurity of parecoxib sodium supplied as a research reference standard for analytical, synthetic, and impurity-identification work. It is provided for research use only and not for human or clinical applications.
- Used as an analytical reference for impurity profiling and method development.
- Intended for use as a drug intermediate or impurity characterization standard.
- Purity: 97.0% (as listed by supplier).
- Molecular formula C18H16N2O4S; molecular weight 356.40.
- Available in multiple sizes, including 250 mg, to support R&D and analytical needs.
- Store under conditions specified in the certificate of analysis to ensure stability.
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Medchemexpress LLC 10-camphorsulfonic acid ethyl ester | 108481-13-6 | >95.0% | 260.35 g/mol | C12H20O4S | 250 MG
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10-Camphorsulfonic acid ethyl ester is the ethyl ester derivative of camphorsulfonic acid and is reported as an impurity of the antifungal voriconazole. It is provided for research and analytical use; molecular formula C12H20O4S and molecular weight 260.35 g/mol. Users should consult the certificate of analysis for detailed purity, storage, and handling information.
- Ethyl ester derivative of camphorsulfonic acid.
- Used as an impurity or analytical reference standard in pharmaceutical analysis.
- Identified by CAS number 108481-13-6.
- Molecular formula C12H20O4S and molecular weight 260.35 g/mol.
- Storage and purity information provided in the certificate of analysis.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000378589 CERDULATINIB HYDROC 50MG
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Medchemexpress LLC Copanlisib dihydrochloride | 1402152-13-9 | C23H30Cl2N8O4 | 50 MG
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Copanlisib dihydrochloride is a potent, selective, and ATP-competitive pan-class I PI3K inhibitor. It exhibits IC50 values of 0.5 nM for PI3Kα, 0.7 nM for PI3Kδ, 3.7 nM for PI3Kβ, and 6.4 nM for PI3Kγ. This compound demonstrates superior antitumor activity and shows over 2,000-fold selectivity against other lipid and protein kinases, with the exception of mTOR.
- Induces apoptosis in a subset of tumor cell lines resistant to certain treatments.
- Shows complete inhibition of PI3K-mediated AKT phosphorylation in ELT3 cells at 5 nM.
- Potently inhibits cell proliferation in various human tumor cell lines, particularly those with PIK3CA-activating mutations or HER2-positive.
- Significantly increases caspase-9 activities and levels of phosphorylated p53 at Ser15 and cleaved PARP in BT20 breast cancer cells.
- Demonstrates robust antitumor activity in rat KPL4 tumor xenograft models, with high tumor growth inhibition rates.
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Medchemexpress LLC PROTAC BET Degrader-10 | 1957234-97-7 | 99.4% | 783.29 | 50 MG
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PROTAC BET Degrader-10 (dBET37) is a potent BET protein BRD4 degrader. It is connected by ligands for Cereblon and BRD4, and has a DC50 of 49 nM. This product is for research use only and not sold to patients. PROTACs use two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase and the other targets the protein of interest. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Potent BET protein BRD4 degrader
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Connected by ligands for Cereblon and BRD4
- DC50 of 49 nM
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eMolecules GSK3326595 | 1616392-22-3 | MFCD29991177 | 100mg
Ambeed | GSK3326595 | 100mg | 552727478 | A416840 | | 1616392-22-3 | MFCD29991177 | 452.559 | C24H32N6O3
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Medchemexpress LLC HY-18252 100mg Medchemexpress, Avanafil TA1790 CAS:330784-47-9 Purity:98%
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Medchemexpress,HY-18252 100mg Avanafil TA1790 CAS:330784-47-9 Formula:C23H26ClN7O3 Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Gusacitinib | 1425381-60-7 | MFCD31692335 | 99.4% | 460.5 g/mol | C24H28N8O2 | 100 MG
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Gusacitinib is an orally active dual spleen tyrosine kinase (SYK) and Janus kinase (JAK) inhibitor supplied for research use in biochemical, cellular, and preclinical studies. The material is characterized by analytical data and supplied with documentation to support research applications.
- Dual SYK/JAK inhibitory activity for immune signaling research.
- High purity suitable for biochemical and cellular assays.
- Supplied as a solid for formulation and dosing flexibility.
- Documented characterization with COA and analytical data.
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Medchemexpress LLC HY-19763 5mg Medchemexpress, BEBT-908 CAS:1235449-52-1 Purity:>98%
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Medchemexpress, HY-19763 5mg BEBT-908 CAS:1235449-52-1 BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor extracted from patent US/20120088764A1, Compound 243, has an IC50<0.1 μM, PI3Kα inhibitor 1 also inhibits HDAC (0.1 μM≤IC50≤1 μM) . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Cerdulatinib hydrochloride | 1369761-01-2 | MFCD28348366 | 99.0% | 482.00 g·mol⁻¹ | C20H28ClN7O3S | 10 MG
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Cerdulatinib hydrochloride is a selective, orally active, reversible ATP-competitive inhibitor of spleen tyrosine kinase (SYK) and Janus kinases (JAKs). It is used as a research compound for studies of immune signaling, autoimmune disease models, and B-cell malignancies.
- Selective dual SYK and JAK inhibition suitable for signaling studies.
- High reported purity appropriate for biochemical and cellular assays.
- Available in small solid quantities for preclinical research use.
- Soluble in DMSO, enabling preparation of concentrated assay stocks.
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Medchemexpress LLC HY-13522 50mg Medchemexpress, CUDC-907 fimepinostat CAS:1339928-25-4 Purity:98%
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Medchemexpress,HY-13522 50mg CUDC-907 fimepinostat CAS:1339928-25-4 Formula:C23H24N8O4S CUDC-907 potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively. Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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