Pyrrolidines

Organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that form a cyclic secondary amine.

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3,286 – 3,300 of 6,328 results

3,286

Medchemexpress LLC BAY-298 | 2471978-97-7 | 100.0% | 100 MG

BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist. It has IC50s of 96 nM for human LH (hLH), 23 nM for rat LH (rLH), and 78 nM for cynomolgus monkey LH (cLH). This compound is capable of reducing sex hormone levels and is intended for research use only.

Orally active and selective luteinizing hormone receptor (LH-R) antagonist
Capable of reducing sex hormone levels
IC50 of 96 nM for human LH, 23 nM for rat LH, and 78 nM for cynomolgus monkey LH
Solid appearance
Off-white to light yellow color

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3,287

Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.8% | 1088.21 | 50 MG

AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), binding to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis and is for research use only.

Binds to BIR3 domains of cIAP1, cIAP2, and XIAP
Induces apoptosis
Inhibits cell viability in H1975 NSCLC cells
Downregulates cIAP-1 and activates RIPK1
Triggers extrinsic and intrinsic apoptosis pathways
Causes degradation of cIAP1 and caspase 3 cleavage in tumor cells in vivo
Leads to substantial tumor regressions in xenograft models

Pricing & Availability

3,288

Medchemexpress LLC (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride | 2376990-26-8 | 99.0% | 632.64 g/mol | C28H43Cl2N5O5S | 5 MG

(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride is a von Hippel-Lindau (VHL) ligand building block used in PROTAC and E3 ligase chemistry. Supplied as a high-purity, research-scale solid, it is suitable for synthetic chemistry and ligand design workflows.

VHL ligand used to recruit the von Hippel-Lindau protein.
High reported purity (99.01%).
White to off-white solid physical form.
Available in small research-scale quantities, including 5 MG.
Datasheet, certificate of analysis, and safety data sheet available for characterization and handling.

Pricing & Availability

3,289

Medchemexpress LLC Protac IDO1 degrader-1 | 2488851-89-2 | 99.0% | 966.80 g·mol⁻¹ | C40H53BrFN9O13 | 5 MG

PROTAC IDO1 Degrader-1 is a research-grade proteolysis targeting chimera (PROTAC) that selectively induces degradation of indoleamine 2,3-dioxygenase 1 (IDO1) by recruiting cereblon E3 ligase, leading to ubiquitination and proteasomal degradation. Cellular studies demonstrate dose-dependent IDO1 degradation and functional enhancement of tumor-killing activity in CAR-T assays.

Induces selective IDO1 degradation in cells (DC50 = 2.84 μM).
Displays IDO1 inhibitory potency (IC50 = 1.07 μM).
Produces up to 93% maximum degradation in HeLa cells.
Soluble in DMSO at 100 mg/mL; in vivo co-solvent formulations reported with ≥2.5 mg/mL solubility.
Store sealed at -20°C; in solution: -80°C up to 6 months, -20°C up to 1 month.
For research use in cellular and in vivo studies.

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3,290

Medchemexpress LLC Mal-C6-α-amanitin | 1578249-76-9 | 98.5% | 1211.34 | C55H78N12O17S | 5 MG

Mal-C6-α-amanitin is an agent-linker conjugate for antibody-drug conjugates that delivers the RNA polymerase II inhibitor α-amanitin via a Mal-C6 linker. It is supplied as a solid for research use and shows potent antitumor activity in preclinical studies.

Agent-linker conjugate for antibody-drug conjugates
Molecular action: RNA polymerase II inhibitor
Form: solid; color white to light yellow
Purity: 98.5%
Pack size: 5 mg
Storage: -20°C, protect from light; in solvent -80°C for 6 months, -20°C for 1 month

Pricing & Availability

3,291

Medchemexpress LLC PROTAC IRAK4 degrader-1 | 2360533-90-8 | 99.8% | 100 MG

PROTAC IRAK4 degrader-1 is a Cereblon-based IRAK4 PROTAC. It is composed of an IRAK4 ligand, an E3 ligase ligand (Pomalidomide), and a PROTAC linker. This compound is for research use only, not for sale to patients.

Cereblon-based IRAK4 PROTAC
Results in significant degradation of IRAK4 protein in OCI-LY-10 cells at varying concentrations
Molecular weight: 904.85
Formula: C44H39F3N12O7
Appearance: White to yellow solid

Pricing & Availability

3,292

Medchemexpress LLC Taltirelin acetate | 1549593-23-8 | 99.4% | 100 MG

Taltirelin acetate is an acetate form of Taltirelin (TA-0910), an orally effective analogue of thyrotropin releasing hormone (TRH). It acts as a TRH receptor superagonist and can cross the blood-brain barrier. Taltirelin acetate stimulates an increase in cytosolic Ca2+ concentration and exhibits neuroprotective effects in cellular and animal models of Parkinson's disease, also alleviating fatigue-like behavior in mouse models of cancer-related fatigue.

Orally effective analogue of thyrotropin releasing hormone (TRH)
TRH receptor superagonist
Crosses the blood-brain barrier
Stimulates increase in cytosolic Ca2+ concentration
Neuroprotective effects in Parkinson's disease models
Alleviates fatigue-like behavior in cancer-related fatigue models
Increases cell viability and reduces apoptosis in SH-SY5Y cells

Pricing & Availability

3,293

Medchemexpress LLC Pasireotide acetate | 396091-76-2 | 99.3% | 1107.26 | C60H70N10O11 | 10 MG

Pasireotide acetate is a somatostatin receptor agonist peptide supplied as the acetate salt for research and preclinical studies. It is commonly used to study hormone secretion and endocrine disease models, and is provided with supporting analytical data such as COA, HNMR, and LCMS.

Somatostatin receptor agonist peptide for research use
Acetate salt form, suitable for aqueous preparations
High purity (~99.3%) as reported by manufacturer
Available in multiple pack sizes, including 10 MG
Used in studies of GH, IGF-I, and ACTH secretion and endocrine disease models

Pricing & Availability

3,294

Medchemexpress LLC OT-82 | 1800487-55-1 | 99.9% | 424.47 | 100 MG

OT-82 is a potent, selective, and orally active inhibitor of NAMPT. It is selectively toxic to cells of hematopoietic origin and induces cell death in a NAD+ dependent manner, making it a promising antineoplastic agent for the study of hematological malignancies. This product is for research use only.

Potent, selective, and orally active NAMPT inhibitor.
Selectively toxic to cells of hematopoietic origin.
Induces cell death in a NAD+ dependent manner.
Promising antineoplastic agent for hematological malignancies.
Exhibits hallmarks of apoptotic cell death.
Inhibits recombinant NAMPT activity and reduces cellular NAD and ATP concentrations.
Potently inhibited tumor growth in a multiple myeloma mouse model.

Pricing & Availability

3,295

Medchemexpress LLC (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH | 2086301-47-3 | 99.3% | C39H58N6O7S | 10MG

(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is a Boc-protected VH032-derived VHL ligand-linker conjugate supplied as a high-purity research reagent for PROTAC and E3 ligase recruitment studies. It is intended for biochemical and cellular experiments and includes solubility and formulation guidance for in vitro and in vivo use.

Boc-protected VHL ligand-linker conjugate suitable for PROTAC research.
High purity (99.31%).
Molecular weight 754.98 g/mol; formula C39H58N6O7S.
Soluble in DMSO at up to 100 mg/mL with ultrasonic assistance.
In vivo formulation examples provided for common vehicles.
Available in multiple small-mass package sizes for research use.

Pricing & Availability

3,296

Selleck Chemical LLC ACT-1016-0707-E1941-1G

ACT-1016-0707 (LPA1 receptor antagonist 2) is an orally active and selective antagonist of LPA1 Receptor with IC50 of 3 1 nM for hLPAR1 in tango assay It has the potential to treat fibrotic diseases

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3,297

Medchemexpress LLC Tert-butyl 6-anilino pyrrolo[3,2-c]pyridine-1-carboxylate (chloro, imidazolyl, pyrazolyl substituted) | 1400284-80-1 | 99.1% | 503.98 g·mol⁻¹ | C26H26ClN7O2 | 50MG

CCT251455 is a potent and selective inhibitor of the mitotic kinase monopolar spindle 1 (MPS1), used in biochemical and cell-based research to probe mitotic checkpoint function and cell-cycle regulation. Supplied as a purified solid with accompanying documentation, it is intended for laboratory research use only and is available in multiple pack sizes and solution formats for convenience.

Potent, selective MPS1 kinase inhibitor (IC50 3 nM).
High purity suitable for research applications (99.1%).
Molecular weight 503.98 g·mol⁻¹ and formula C26H26ClN7O2.
Available as solid packs and as a 10 mM solution in DMSO.
Documentation provided: product data sheet, COA, SDS.
Intended for research use only; not for human or clinical use.

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3,298

Innovative Research Inc Rat PAI1 Rcmb WT Act HIS lbl

Rat PAI-1 Recombinant Wild Type Active HIS Labeled 1 mg - Rat PAI-1 Recombinant Wild Type Active HIS Labeled from Innovative Research has been recombinantly produced in E. coli and purified by a propritetary process that combines multiple conventional chromatographic methods. This is a Frozen liquid buffered in 0.05M Sodium Acetate; 0.1M NaCl; 1mM EDTA; pH 5.0 and a purity of >95% as determined by SDS-PAGE. N-terminus of (wild type) rat PAI-1 tagged with 6x-HIS, allowing immobilization of functionally active PAI-1 onto surfaces such as metal chelate microtiter plates or Ni+2 resins. This is an active fraction that is more than 99% pure and 98% active (determined by SDS-PAGE). This product can be used as a control in applications like ELISA and Western Blot, as well as blocking/inhibition, fibrinolysis, plasminogen activation, receptor binding, in hypertension studies, and for protein-protein interactions

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3,299

Medchemexpress LLC HY-14806 10mg Medchemexpress, Teneligliptin CAS:760937-92-6 Purity:>98%

Medchemexpress, HY-14806 10mg Teneligliptin CAS:760937-92-6 Teneligliptin (MP-513) is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor. Teneligliptin competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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3,300

Medchemexpress LLC PROTAC CRBN Degrader-1 | 2358775-70-7 | 98.8% | 10 MG

PROTAC CRBN Degrader-1 (Compound 14a) is a VHL-CRBN heterodimerization PROTAC degrader that achieves a selective degradation of CRBN by binding two E3 ubiquitin ligases (VHL and CRBN) to each other.

VHL ligand (S,R,S)-AHPC
CRBN ligand Pomalidomide-C2-NH2
Linker

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Pyrrolidines

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Medchemexpress LLC BAY-298 | 2471978-97-7 | 100.0% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.8% | 1088.21 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride | 2376990-26-8 | 99.0% | 632.64 g/mol | C28H43Cl2N5O5S | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Protac IDO1 degrader-1 | 2488851-89-2 | 99.0% | 966.80 g·mol⁻¹ | C40H53BrFN9O13 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Mal-C6-α-amanitin | 1578249-76-9 | 98.5% | 1211.34 | C55H78N12O17S | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PROTAC IRAK4 degrader-1 | 2360533-90-8 | 99.8% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Taltirelin acetate | 1549593-23-8 | 99.4% | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Pasireotide acetate | 396091-76-2 | 99.3% | 1107.26 | C60H70N10O11 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC OT-82 | 1800487-55-1 | 99.9% | 424.47 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH | 2086301-47-3 | 99.3% | C39H58N6O7S | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Selleck Chemical LLC ACT-1016-0707-E1941-1G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-14806 10mg Medchemexpress, Teneligliptin CAS:760937-92-6 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PROTAC CRBN Degrader-1 | 2358775-70-7 | 98.8% | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More