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Filtered Search Results
Medchemexpress LLC 31-Norlanostenol | 16910-39-7 | 1 MG
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31-Norlanostenol is a triterpenic compound isolated from the latex of Euphorbia officinarum. It can act as an efficient insect growth regulator on S. frugiperda and Tenebrio molitor. This product is for research use only.
- Triterpenic compound
- Isolated from the latex of Euphorbia officinarum
- Acts as an efficient insect growth regulator on S. frugiperda and Tenebrio molitor
- Purity: 99.94%
- Molecular Weight: 414.71
- Formula: C29H50O
- Appearance: Solid
- Color: White to off-white
- Structure classification: Terpenoids, Triterpenes
- Initial source: Plants, Euphorbiaceae, Euphorbia boetica
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Medchemexpress LLC Q-Peptide | 1361235-89-3 | 99.46% | 827.80 | 10 MG
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Q-Peptide is a synthetic peptide derived from angiopoietin-1 (QHREDGS) that has demonstrated the ability to enhance keratinocyte migration. This property suggests its potential role in accelerating wound closure, as observed in a diabetic mouse model. The product is intended for research use only.
- Increases keratinocyte migration.
- Improves wound healing in diabetic mouse models.
- Accelerates wound closure.
- High purity (99.46%).
- Available in various quantities for research needs.
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Medchemexpress LLC Quinidine (15% dihydroquinidine) | 56-54-2 | 98.36% | 5 G
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Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. It is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine also acts as a K+ channel blocker with an IC50 of 19.9 μM, and it can induce apoptosis. It can be used for malaria research.
- Antiarrhythmic agent: Helps in the treatment of irregular heartbeats.
- Potent, orally active, selective cytochrome P450db inhibitor: Targets and inhibits specific cytochrome P450 enzymes.
- K+ channel blocker: Blocks potassium channels with an IC50 of 19.9 μM.
- Induces apoptosis: Capable of triggering programmed cell death.
- Used for malaria research: Applicable in studies related to malaria.
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Medchemexpress LLC Chlorcyclizine hydrochloride | 14362-31-3 | 99.8% | 337.29 | 200 MG
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Chlorcyclizine hydrochloride is a histamine H1 antagonist. This product is a solid with a white to off-white appearance.
- Has a purity of 99.77%.
- Soluble in DMSO at 77.5 mg/mL.
- Targets the histamine H1 receptor.
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Medchemexpress LLC Glucagon-like peptide-1 (GLP-1)(7-36), amide acetate | 1119517-19-9 | 99.0% | 3297.64 (free base) | 1 MG
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GLP-1(7-36), amide acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells. It is for research use only.
- Stimulates glucose-induced insulin secretion from β cells.
- Active GLP-1 secretion is stimulated by fatty acids such as palmitic, oleic, linoleic, or linolenic acid.
- Increases active GLP-1 concentrations in vitro.
- Increases active GLP-1(7-36) amide levels in portal blood in vivo.
- Co-administration of glucose and tea oil additively increases peak GLP-1 levels.
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Medchemexpress LLC Chlorprothixene (hydrochloride) | 6469-93-8 | 99.9% | 200 MG
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Chlorprothixene is a dopamine and histamine receptor antagonist known for its antipsychotic activity. It exhibits high affinity for various human dopamine and histamine receptors.
- Antagonizes human D1, D2, D3, D5, and H1 receptors with low nanomolar Ki values.
- Inhibits 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 in HEK293 cells.
- Antagonizes H1 receptor activity in human HeLa cells.
- Binds to 5-HT7, 5-HT6, and 5-HT2 receptors with high pKi values.
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Medchemexpress LLC 3,5-Dicaffeoyl-epi-quinic acid | 879305-14-3 | 97.7% | 516.45 | 5 MG
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3,5-Dicaffeoyl-epi-quinic acid is a compound extracted from *Chrysanthemum morifolium*. It demonstrates significant antioxidant activities, effectively scavenging DPPH radical and superoxide anion radical with IC50s of 5.6 and 2.9 μg/mL, respectively.
- Extracted from Chrysanthemum morifolium
- Exhibits antioxidant activities
- Scavenges DPPH radical and superoxide anion radical
- IC50s of 5.6 and 2.9 μg/mL for DPPH and superoxide anion radicals
- Appears as a white to off-white solid
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Medchemexpress LLC Thioridazine | 50-52-2 | MFCD00242875 | 99.5% | 200 MG
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Thioridazine is an antagonist of the dopamine receptor D2 family proteins, exhibiting potent anti-psychotic and anti-anxiety activities. It is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with an anti-angiogenic effect, showing antiproliferative and apoptosis induction effects in various types of cancer cells, with specificity in targeting cancer stem cells (CSCs).
- Reduces cell viability of NCI-N87 and AGS cells
- Reduces cell viability of cervical and endometrial cancer cells
- Induces gastric cancer cell death via the mitochondrial apoptosis pathway
- Modulates cell cycle progression by interfering with the PI3K/Akt pathway and induces G1 cell cycle arrest
- Inhibits the growth of antibiotic-sensitive and multidrug-resistant strains of A. baumannii
- Extends the survival of tumor-bearing mice
- Reduces oral behavior and selectively blocks repetitive head bobbing
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Medchemexpress LLC Tertiapin-Q | 910044-56-3 | 99.8% | 2452.00 | 5 MG
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Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1) potassium channels, intended for research use only. It also potently and selectively blocks Kir3.1-Kir3.4 channels and calcium-activated large conductance potassium channels, blocking somatostatin (SS-14)-activated current. As a muscarinic acetylcholine receptor-operated K+ current (IK,Ach) blocker, Tertiapin-Q significantly prolongs the atrial effective refractory period (AERP).
- Highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir1.1) potassium channels
- Potently and selectively blocks Kir3.1-Kir3.4 and calcium-activated large conductance potassium channels
- Blocks somatostatin (SS-14)-activated current
- Functions as a muscarinic acetylcholine receptor-operated K+ current (IK,Ach) blocker
- Prolongs atrial effective refractory period (AERP)
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Medchemexpress LLC AZ-5104 | 1421373-98-9 | 99.91% | 200 MG
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AZ-5104 is an active, demethylated metabolite of AZD 9291 and functions as an EGFR inhibitor. It demonstrates inhibitory effects on EGFR phosphorylation across various cell lines, targeting both mutant and wild-type EGFR.
- Inhibits EGFR with specific IC50 values across multiple targets
- Effective in tumor shrinkage in C/L858R and C/L+T mice
- Shows minimal off-target activity against non-HER family kinases
- Potentially targets both HER2 and HER4 kinase activity
- Store powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 2 years or -20°C for 1 year
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Medchemexpress LLC Halcinonide | 3093-35-4 | 98.3% | 200 MG
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Halcinonide is a high potency corticosteroid used topically in the treatment of certain skin conditions. This product is for research use only and not sold to patients.
- High potency corticosteroid
- Used topically for skin conditions
- For research use only
- Solid appearance
- Light yellow to yellow color
- Molecular weight: 454.96
- Formula: C24H32ClFO5
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Medchemexpress LLC Dihydroergotamine mesylate | 6190-39-2 | 99.94% | 50 MG
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Dihydroergotamine mesylate is a BBB-permeable ergot alkaloid for the research of migraines. It reduces cell survival in A549 and NCI-H226 cells and inhibits cell survival in Hep3B, PLC/PRF/5, Huh7, and HepG2 cells.
- Reduces cell survival in A549 and NCI-H226 cells
- Inhibits cell survival in Hep3B, PLC/PRF/5, Huh7, and HepG2 cells
- Induces mitochondrial morphologic alterations and dysfunction
- Increases ROS generation and induces apoptosis
- Disturbs ATP production in A549 cells
- Inhibits STAT3 activation and enhances protein stability of Mcl-1
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Medchemexpress LLC Butoconazole nitrate | 64872-77-1 | 99.4% | 200 MG
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Butoconazole nitrate is an imidazole antifungal agent that is active against Candida spp., including *Candida albicans*. It functions by inhibiting steroid synthesis, specifically the conversion of lanosterol to ergosterol, which alters fungal cell membrane lipid composition, leading to changes in cell permeability and ultimately growth inhibition of the fungal cell.
- Active against *Candida* species
- Effective for vaginal infections caused by *Candida albicans*
- Inhibits fungal steroid synthesis
- Alters fungal cell membrane lipid composition
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Medchemexpress LLC Almonertinib (mesylate) | 2134096-06-1 | 99.7% | 621.75 | 1 ML
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Almonertinib mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor. It shows high selectivity for EGFR-sensitizing and T790M resistance mutations, with inhibitory activity against T790M, T790M/L858R, and T790M/Del19. It is used for the research of non-small cell lung cancer (NSCLC). This compound can also inhibit other EGFR sensitive mutations, including G719X, del19, L858R, and L861Q.
- Orally available inhibitor
- Irreversible, third-generation EGFR tyrosine kinase inhibitor
- High selectivity for EGFR-sensitizing and T790M resistance mutations
- Inhibitory activity against T790M, T790M/L858R, and T790M/Del19
- Less effective against wild type EGFR
- Used for non-small cell lung cancer research
- Can inhibit other EGFR sensitive mutations like G719X, del19, L858R, and L861Q
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Medchemexpress LLC Firmonertinib mesylate | 2130958-55-1 | 99.9% | 664.70 | 25 MG
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Firmonertinib mesylate is an orally active, mutant-selective, and blood-brain barrier penetrant EGFR inhibitor. It inhibits EGFR active mutations and the T790M acquired resistant mutation. This compound has potential for research into cancer diseases, particularly advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation.
- Orally active
- Mutant-selective
- Blood-brain barrier penetrant EGFR inhibitor
- Inhibits EGFR active mutations
- Inhibits T790M acquired resistant mutation
- Potential for research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation
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