Carboximidamides
1-Methyl-3-nitroguanidine (wetted with ca. 25% Water) (unit weight on dry weight basis) 98.0+%, TCI America™
CAS: 4245-76-5 Molecular Formula: C2H6N4O2 Molecular Weight (g/mol): 118.10 MDL Number: MFCD00024167 InChI Key: XCXKNNGWSDYMMS-UHFFFAOYSA-N PubChem CID: 20237 IUPAC Name: N''-methyl-N-nitroguanidine SMILES: CN=C(N)N[N+]([O-])=O
Medchemexpress LLC 1H-1,2,3-triazole-4-carboxamide derivative (BIIB091) | 2247614-80-6 | 99.9% | C28H34N10O2 | 10MG
BIIB091 is a potent, selective, reversible Bruton's tyrosine kinase (BTK) inhibitor supplied as a high-purity small-molecule reagent for research and preclinical studies. It is used to probe BTK signaling and to evaluate therapeutic approaches in autoimmune and B-cell-mediated disease models. Not for human or clinical use.
- Potent, selective reversible BTK inhibitor (IC50 <0.5 nM).
- High purity (99.85% by HPLC).
- Molecular formula C28H34N10O2; molecular weight 542.64.
- Suitable for in vitro and preclinical assays.
- Orally active profile reported in preclinical studies.
- Supplied as a powder; soluble in DMSO.
Medchemexpress LLC 1-tert-butyl N-(5R)-substituted triazole-4-carboxamide (BIIB091) | 2247614-80-6 | 99.9% | 542.64 g/mol | C28H34N10O2 | 5 MG
BIIB091 is a potent, selective, orally active, reversible Bruton tyrosine kinase (BTK) inhibitor supplied for laboratory research. It shows sub-nanomolar enzymatic potency and is provided as solid material or as a DMSO solution for in vitro and preclinical studies; refer to the manufacturer datasheet for safety, handling, and the certificate of analysis.
- Sub-nanomolar BTK potency (IC50 <0.5 nM).
- Reversible and highly selective BTK inhibition.
- Chemical formula C28H34N10O2; molecular weight 542.64 g/mol.
- Available as solid quantities and as a 10 mM solution in DMSO.
- High purity (>99.8% by HPLC) suitable for research applications.
Medchemexpress LLC 1-Methylguanidine monohydrochloride | 21770-81-0 | 109.56 | 1 G
1-Methylguanidine monohydrochloride is an endogenous metabolite. It is for research use only and not sold to patients.
- Endogenous metabolite
- White to off-white solid appearance
- High purity of 98.0%
- Molecular weight: 109.56
- Solid storage: 4°C, sealed, away from moisture
- In solvent storage: -80°C for 6 months; -20°C for 1 month (sealed, away from moisture)
Medchemexpress LLC Guanidine, N-methyl-, hydrochloride (1:1) | 21770-81-0 | 109.56 | 500 MG
1-Methylguanidine monohydrochloride is provided as a white to off-white solid. It has been tested and complies with the given specifications. This product is intended for research use only and has not been fully validated for medical applications.
- White to off-white solid appearance
- Tested and complies with specifications
- Storage at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month, sealed and away from moisture
Medchemexpress LLC Guanidine, N-methyl-, hydrochloride (1:1) | 21770-81-0 | 109.56 | 10 G
1-Methylguanidine monohydrochloride is an endogenous metabolite for research applications. This compound presents as a white to off-white solid with a high purity of 98.0%. It is suitable for various research fields including metabolic disease and as a reference standard.
- Endogenous metabolite
- High purity of 98.0%
- Appears as a white to off-white solid
- Store at 4°C, sealed, away from moisture
- Stock solutions in solvent can be stored at -80°C for 6 months or -20°C for 1 month
- Soluble in water and PBS
![Medchemexpress LLC 7-ethyl-4-[3-(4-ethylsulfonyl-2-methoxyphenyl)-4-fluorophenyl]imidazo[4,5-c]pyridazine | 1614245-70-3 | 99.3% | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230936.png-250.jpg)
Medchemexpress LLC 7-ethyl-4-[3-(4-ethylsulfonyl-2-methoxyphenyl)-4-fluorophenyl]imidazo[4,5-c]pyridazine | 1614245-70-3 | 99.3% | 10 MG
Darigabat is a subtype-selective GABAA positive allosteric modulator used for preclinical research into epilepsy, anxiety, and seizure disorders. It is a small-molecule research compound with confirmed chemical identity and supplier-stated purity.
- CAS number 1614245-70-3.
- Chemical formula C22H21FN4O3S.
- Molecular weight 440.49 g/mol.
- Purity 99.3% (supplier listing).
- Packaging 10 MG; solid storage 4°C, protect from light; in solvent -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or veterinary use.
Medchemexpress LLC Smap-2 (DT-1154) | 1809068-70-9 | 99.5% | 5 MG
SMAP-2 (DT-1154) is a small-molecule, orally active activator of protein phosphatase 2A (PP2A) with demonstrated anti-cancer activity in preclinical studies. It is supplied as a white to off-white solid and includes manufacturer-reported solubility and storage guidance.
- Orally bioavailable PP2A activator with anticancer activity.
- High purity: 99.53% (manufacturer reported).
- Molecular weight 532.57; formula C27H27F3N2O4S.
- Soluble in DMSO (300 mg/mL); in vivo formulation guidance provided.
- Powder storage: -20°C (3 years) or 4°C (2 years); in solvent: -80°C (2 years).
Medchemexpress LLC Nardosinone | 23720-80-1 | 99.5% | 250.33 | C15H22O3 | 10 MG
Nardosinone is a naturally derived small molecule reported to enhance neuritogenic responses to dbcAMP and staurosporine. It is supplied as a high-purity research reagent with documented solubility and storage guidance for experimental use.
- High purity (~99.5%).
- Molecular formula C15H22O3; molecular weight 250.33 g/mol.
- Available as a solid, white to off-white; common package size 10 MG.
- Soluble in DMSO (100 mg/mL); in vivo formulations noted with 10% DMSO plus SBE-β-CD or corn oil.
- Store at 4°C and protect from light; in solution store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Melitracen hydrochloride | 10563-70-9 | MFCD00242905 | 99.8% | 327.89 g/mol | C21H26ClN | 50 MG
Melitracen hydrochloride is the hydrochloride salt of melitracen, supplied as a high-purity research standard for analytical, pharmacological, and formulation studies. It is a white to off-white solid (CAS 10563-70-9) with defined solubility and storage recommendations to support reproducible results.
- High purity suitable for analytical and pharmacological research.
- White to off-white solid with consistent physical properties.
- Soluble in water and DMSO; may require sonication.
- Store solid at 4°C, sealed and protected from moisture; solutions at -80°C (long term) or -20°C (short term).
- Supplied in small pack sizes convenient for assay and preclinical work.
Medchemexpress LLC Nardosinone | 23720-80-1 | 250.33 | 5 MG
Nardosinone, isolated from Nardostachys chinensis, is identified as the first enhancer of the neuritogenic action of dbcAMP and staurosporine. It may serve as a pharmacological tool for studying the mechanism of action of nerve growth factor (NGF) and other neuritogenic substances.
- Purity of 99.81%
- Appearance as a white to off-white solid
- Store at 4°C, protected from light; in solvent, store at -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO at 100 mg/mL
- Initial source from plants, Valerianaceae, Nardostachys jatamansi (D. Don) DC.
- Classified as a terpenoid, sesquiterpene
- Exhibits antiinflammatory activity in RAW264.7 cells with an IC50 of 11.1 μM
Medchemexpress LLC Isosinensetin | 17290-70-9 | MFCD21333406 | 99.9% | 372.37 | C20H20O7 | 10 MG
Isosinensetin is a naturally occurring flavonoid research compound used as an inhibitor of HIV-1 protease and protein tyrosine phosphatase 1B (PTP1B), with reported activity against P-glycoprotein. It is provided as a high-purity reagent for biochemical and cell-based studies.
- High purity (99.9%) suitable for research applications.
- Molecular formula C20H20O7; molecular weight 372.37.
- Reported biological activities include PTP1B and HIV-1 protease inhibition and P-gp modulation.
- Recommended storage: 4°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month).
- Supplied as a 10 mg vial for small-scale laboratory research.
Medchemexpress LLC Parishin C | 174972-80-6 | 5 MG
Parishin C is a parishin derivative isolated from *Gastrodia elata* that may possess antioxidant properties. It is the analytical standard of Parishin C, intended for research and analytical applications.
- Derived from *Gastrodia elata*
- May possess antioxidant properties
- Analytical standard for research and analytical applications
- Purity: 99.24%
- Molecular weight: 728.65
- Molecular formula: C₃₂H₄₀O₁₉
- Appearance: Solid
- Color: White to off-white
- Soluble in DMSO and H₂O
- Store solid at 4°C, protected from light
- Store in solvent at -80°C for 6 months or -20°C for 1 month, protected from light
Medchemexpress LLC Atx inhibitor 1 | 2225892-70-4 | 99.3% | 501.30 g/mol | C21H23Cl2N2O6P | 5 MG
ATX inhibitor 1 is a potent autotaxin (ATX) inhibitor with nanomolar activity (IC50 = 1.23 nM by FS-3 assay; 2.18 nM by bis-pNPP). It is supplied as a solid research compound for in vitro and preclinical research use only.
- Potent autotaxin inhibitor with nanomolar IC50 values (1.23 nM FS-3; 2.18 nM bis-pNPP).
- Molecular formula: C21H23Cl2N2O6P.
- Molecular weight: 501.30 g/mol.
- Purity: 99.3% by HPLC.
- Physical form: solid powder.
- Storage: powder -20°C for 3 years or 4°C for 2 years; in solvent -80°C for 6 months.
- Available sizes: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, or 10 mM in DMSO solutions.
- For research use only; not for human therapeutic use.
Medchemexpress LLC Mitraphylline | 509-80-8 | 10 MG
Mitraphylline is the major pentacyclic oxindolic alkaloid found in Uncaria tomentosa. It inhibits lipopolysaccharide-mediated activation of primary human neutrophils and exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can also inhibit interleukin release in vivo.
- Purity: 99.30%
- Appearance: solid, white to off-white
- Solubility (in vitro): 6.76 mg/mL in DMSO (18.35 mM); requires ultrasonic
- Storage: 4°C, sealed, away from moisture and light
- In solvent storage: -80°C for 6 months; -20°C for 1 month (sealed, away from moisture and light)
- Reduces NO production and downregulates pro-inflammatory cytokines in human LPS-activated neutrophils
- Exhibits antiproliferative activity in GAMG (IC50 = 20.05 μM) and SKN-BE cells
- Impairs TNF-α liberation and inhibits IL-1α/β in mice in vivo
- For research use only