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Filtered Search Results
Medchemexpress LLC GPR30 agonist-1 | 415919-74-3 | MFCD02316399 | 98.6% | 374.25 g/mol | C19H17BrFNO | 5 MG
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GPR30 agonist-1 is a small-molecule agonist of G protein-coupled receptor 30 (GPR30/GPER) used in biochemical and pharmacological research. It has reported vasorelaxant activity and is supplied as a purified powder for in vitro and in vivo studies. The compound is soluble in DMSO and is provided in multiple vial sizes for research use.
- Selective agonist of GPR30, suitable for receptor signaling studies.
- Reported to exert vasorelaxant effects in vascular tissue.
- High purity (≈98.6%) suitable for research applications.
- Molecular formula C19H17BrFNO; molecular weight 374.25 g/mol.
- Soluble in DMSO at 50 mg/mL with ultrasonic warming.
- Recommended storage: powder at -20°C for long-term stability.
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Medchemexpress LLC AST5902 trimesylate | 2929417-90-1 | 98.8% | 842.88 g/mol | C30H41F3N8O11S3 | 5 MG
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AST5902 trimesylate is the primary metabolite of the EGFR inhibitor alflutinib and exhibits antineoplastic activity. Supplied as a research standard (CAS 2929417-90-1), it is intended for in vitro and in vivo research use such as metabolite profiling, pharmacology, and analytical reference studies.
- High purity suitable for analytical and biological research.
- Molecular weight 842.88 g/mol and formula C30H41F3N8O11S3.
- Available as a solid and as ready-to-use DMSO solutions.
- Intended for in vitro and in vivo research applications only.
- Appropriate as a reference standard for metabolite and pharmacokinetic studies.
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Medchemexpress LLC 2-(1-phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester | 1598426-03-9 | MFCD28347705 | 98.1% | 283.33 g·mol⁻¹ | C16H17N3O2 | 5 MG
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CG347B is a selective histone deacetylase 6 (HDAC6) inhibitor used as a research tool in oncology, immunology, and neurology studies and as an intermediate in the synthesis of metalloenzyme inhibitors. It is supplied as a white to off-white solid (C16H17N3O2, 283.33 g·mol⁻¹) with reported high purity and well-characterized solubility properties for in vitro and in vivo formulations.
- Selective HDAC6 inhibition for epigenetics research
- High reported purity (~98.1%) for reliable experimental results
- Solid, white to off-white form for straightforward handling and storage
- High DMSO solubility (250 mg/mL) suitable for in vitro assays
- Soluble in in vivo vehicle at ≥6.25 mg/mL for formulation studies
- Available in small research quantities for screening and pilot studies
- Manufacturer-provided datasheet, SDS, and COA available for quality assurance
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Medchemexpress LLC Evixapodlin (GS-4224) | 2374856-75-2 | 98.1% | 691.61 g·mol⁻¹ | C34H36Cl2N8O4 | 5 MG
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Evixapodlin (GS-4224) is a potent small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction, reported with an IC50 of 0.213 nM and demonstrated anticancer and antiviral activity. It is supplied as a research-grade chemical for in vitro and preclinical studies.
- High potency PD-1/PD-L1 PPI inhibition (IC50 ~0.213 nM).
- Reported purity 98.1% by manufacturer.
- Soluble in DMSO at 50 mg/mL for in vitro use.
- Available in small milligram quantities and as DMSO solution for assay setup.
- Recommended storage conditions to preserve stability of powder and solutions.
- Suitable for biochemical and cellular immune checkpoint assays.
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Medchemexpress LLC 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole | 872726-44-8 | MFCD12024619 | 99.8% | 289.32 g/mol | C15H12FNO2S | 10 MG
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GW 610 (2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole) is an antitumor benzothiazole small molecule and a potent aryl hydrocarbon receptor (AhR) ligand. Supplied for research use only, the compound is provided as a 10 mg solid suitable for in vitro and preclinical studies.
- High purity: 99.8% (manufacturer reported).
- Molecular weight: 289.32 g/mol, useful for dosing calculations.
- Chemical formula: C15H12FNO2S.
- Shown in literature to have selective antiproliferative activity against cancer cell lines.
- Suitable for mechanistic studies involving AhR signaling.
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Medchemexpress LLC BCATc Inhibitor 2 50mg | 406191-34-2 | 418.77 g/mol | C16H10ClF3N2O4S | 50 MG
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BCATc Inhibitor 2 is a selective small-molecule inhibitor of the cytosolic branched-chain aminotransferase (BCATc/BCAT1), used in laboratory research to probe branched-chain amino acid metabolism and neurodegenerative disease mechanisms. The compound is supplied as a solid and reported to have high purity.
- Selective BCATc inhibitor with reported IC50s of 0.2 μM (rat rBCATc) and 0.8 μM (human hBCATc)
- Shows lower potency on mitochondrial BCATm (reported ~3.0 μM)
- High reported purity (99.28%) suitable for research applications
- Solid, white to off-white physical form for standard laboratory handling
- Molecular weight 418.77 g/mol and formula C16H10ClF3N2O4S
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Medchemexpress LLC AC 187 TFA, 10mg | Purity: 99.43% | Formula: C129H206F3N37O42
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AC 187 TFA is a potent and orally active amylin receptor antagonist with an IC50 of 0.48 nM and a Ki of 0.275 nM. AC 187 TFA shows more selective for amylin receptor than calcitonin and CGRP receptors. AC 187 TFA has neuroprotective effects.
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Medchemexpress LLC 2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine | 2748337-86-0 | 99.8% | 5MG
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2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine | 2748337-86-0 | 99.8% | 5MG
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Medchemexpress LLC HSMG-1 inhibitor 11e | 1402452-10-1 | 99.9% | 517.60 g/mol | C26H27N7O3S | 25MG
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hSMG-1 inhibitor 11e is a potent, selective small-molecule inhibitor of human SMG-1 kinase with sub-nanomolar activity (IC50 <0.05 nM). It demonstrates strong selectivity versus related kinases, is supplied as a solid (white to light yellow), and is intended for research use. The compound is soluble in DMSO and has defined storage recommendations for both solid and solution forms.
- Sub-nanomolar potency (hSMG-1 IC50 <0.05 nM).
- High selectivity over several off-target kinases (mTOR, PI3Kα/γ, CDK1/2).
- High purity (99.94%).
- Good DMSO solubility (50 mg/mL) for in vitro applications.
- Recommended storage: solid at 4°C; in solvent at -80°C for long-term stability.
- White to light yellow solid appearance.
- Molecular weight 517.60 g/mol; formula C26H27N7O3S.
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Medchemexpress LLC 1-(2,6-dichlorophenyl)-3-(5-nitrothiophen-3-yl)urea | 672286-03-2 | MFCD00121277 | 99.5% | 332.16 | C11H7Cl2N3O3S | 100MG
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DFP00173 is a potent, selective inhibitor of aquaporin-3 (AQP3) developed for laboratory research. It inhibits mouse and human AQP3 with an IC50 of approximately 0.1-0.4 μM and reduces glycerol permeability in human erythrocytes with an IC50 of ~0.2 μM. The compound is supplied as a solid with multiple size options and as a DMSO stock solution for in vitro studies; it is for research use only.
- potent, selective aquaporin-3 inhibitor.
- activity: IC50 approximately 0.1-0.4 μM against AQP3.
- inhibits glycerol permeability in human erythrocytes with IC50 ≈ 0.2 μM.
- high purity (about 99.5%).
- molecular weight 332.16 g/mol.
- available as solid and as 10 mM solution in DMSO.
- storage: powder at -20 °C long term; stock solutions at -80 °C recommended.
- intended for laboratory research use only.
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Medchemexpress LLC N,N,2-trimethyl-5-((4-(2-(4-(3-methylureido)phenyl)pyridin-4-yl)pyrimidin-2-yl)amino)benzenesulfonam | 1402452-10-1 | 99.9% | 517.60 | C26H27N7O3S | 50MG
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hSMG-1 inhibitor 11e is a selective small-molecule inhibitor of the human SMG-1 kinase provided as a solid research reagent. It is intended for use in biochemical and cellular assays that probe PI3K-related protein kinase activity. The compound has a high reported purity and established solubility in DMSO, with recommended sealed storage away from moisture and light.
- Molecular formula: C26H27N7O3S and molecular weight approximately 517.60.
- High reported purity suitable for research applications.
- Physical form: solid; appearance white to light yellow.
- Solubility: readily soluble in DMSO (about 50 mg/mL); ultrasonic agitation may be required.
- Storage: keep sealed, away from moisture and light; in solvent store at -80°C for long term.
- Intended use: in vitro kinase inhibition and mechanistic studies.
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Medchemexpress LLC N-(2,6-dichlorophenyl)-N'-(5-nitro-3-thienyl)urea | 672286-03-2 | 99.5% | 332.16 g/mol | C11H7Cl2N3O3S | 10MG
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DFP00173 is a potent, selective small-molecule inhibitor of aquaporin-3 (AQP3) intended for research use. It inhibits mouse and human AQP3 with an IC50 of approximately 0.1-0.4 μM and reduces erythrocyte glycerol permeability (IC50 ≈ 0.2 μM). The compound is supplied as a high-purity solid with documented solubility and storage guidelines for in vitro and in vivo studies.
- Potent AQP3 inhibition at submicromolar concentrations.
- Selective for AQP3 over related AQP isoforms.
- High purity suitable for biochemical and cellular assays.
- Readily soluble in DMSO for in vitro dosing.
- Validated in vivo formulation protocols available.
- Stable under recommended powder storage conditions.
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Medchemexpress LLC hSMG-1 inhibitor 11e | 1402452-10-1 | 99.9% | 517.60 | C26H27N7O3S | 100MG
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hSMG-1 inhibitor 11e is a research-grade, potent and selective inhibitor of the human SMG-1 kinase. It exhibits sub-nanomolar potency (hSMG-1 IC50 <0.05 nM) and pronounced selectivity versus related kinases, and is supplied as a solid or as a 10 mM solution in DMSO for biochemical and cellular studies.
- Potent hSMG-1 inhibition (IC50 <0.05 nM).
- High selectivity (>900-fold) over mTOR, with reported IC50s for mTOR 45 nM, PI3Kα 61 nM, PI3Kγ 92 nM.
- Molecular formula C26H27N7O3S; molecular weight 517.60.
- Purity 99.9% (manufacturer listed 99.94%, rounded to tenths).
- Available as solid (including 100 mg) and 10 mM solution in DMSO.
- Suitable for biochemical kinase assays and cellular pathway studies.
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Medchemexpress LLC N-[(1R)-1-(3-cyclopentyloxyphenyl)ethyl]-3-[(2,4-dioxopyrimidin-1-yl)methoxy]propane-1-sulfonamide | 1198221-21-4 | 99.8% | 451.5 g/mol | C21H29N3O6S | 1MG
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TAS-114 is an orally active small-molecule inhibitor that dual-targets deoxyuridine triphosphatase (dUTPase) and dihydropyrimidine dehydrogenase (DPD). It has been investigated as an adjunct to fluoropyrimidine chemotherapy to enhance efficacy by modulating nucleotide metabolism and reducing catabolism of 5-fluorouracil (CAS 1198221-21-4).
- Dual inhibition of dUTPase and DPD enhances fluoropyrimidine efficacy.
- Oral bioavailability suitable for systemic administration.
- Defined molecular formula and molecular weight support reproducible characterization.
- High reported chemical purity enables reliable experimental results.
- Appropriate for preclinical research on combination chemotherapy strategies.
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Medchemexpress LLC 4-chloro-2-[[(E)-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid | 99754-06-0 | 99.3% | 371.86 | C21H22ClNO3 | 10MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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ONO-RS-082 is a reversible inhibitor of phospholipase A2 (PLA2) used in biochemical and cell-based research to probe PLA2-dependent signaling. It inhibits PLA2 with an IC50 of 1.0 μM and does not inhibit phospholipase C at concentrations up to 100 μM. The compound is supplied as a high-purity small molecule with documented solubility and storage recommendations for experimental use.
- Reversible PLA2 inhibition (IC50 = 1.0 μM)
- No PLC inhibition up to 100 μM
- High purity suitable for research applications
- Soluble in DMSO; in vivo formulation protocols available
- Stable as powder at -20°C for long-term storage
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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