Fluorobenzenes
Medchemexpress LLC Abemaciclib metabolite M20 | 2138499-06-4 | 98.2% | 100 MG
Abemaciclib metabolite M20 (LSN3106726) is the active metabolite of Abemaciclib and a selective CDK4/6 inhibitor for the treatment of cancer. It induces senescence in breast cancer cells at concentrations of 200 nM and 500 nM over 6-8 days.
- Induces senescence in breast cancer cells.
- Inhibits the growth and cell cycle progression of non-small cell lung cancer (NSCLC) cells, colorectal cancer (CRC) cells, and breast cancer cells.
- IC50 value for CDK4 and CDK6 is in the range of 1-3 nM.
Medchemexpress LLC CMPD1 | 41179-33-3 | 99.86% | 349.40 | 50 MG
CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with an apparent Ki (Kiapp) of 330 nM. It is for research use only and not sold to patients. This compound does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2. It induces mitotic arrest and apoptosis in U87 cells, and inhibits tubulin polymerisation in glioblastoma cells.
- Antiproliferative activity against human A-172 cells assessed as cell growth inhibition (EC50 0.6 μM).
- Antiproliferative activity against human U-251 cells assessed as cell growth inhibition (EC50 0.6 μM).
- Antiproliferative activity against human U-87MG ATCC cells assessed as cell growth inhibition (EC50 0.6 μM).
- Inhibition of tubulin polymerization in human U87 cells assessed as decrease in cell viability after 72 hrs by Alamar blue assay (EC50 < 1 μM).
![Medchemexpress LLC 4-(benzo[d]thiazol-2-ylthio)-3-chloroaniline | 300809-71-6 | MFCD00227023 | 99.9% | C13H9ClN2S2 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259075.png-250.jpg)
Medchemexpress LLC 4-(benzo[d]thiazol-2-ylthio)-3-chloroaniline | 300809-71-6 | MFCD00227023 | 99.9% | C13H9ClN2S2 | 10MG
KRAS inhibitor-9 is a small-molecule research compound that blocks formation of GTP-bound KRAS and downstream KRAS signaling, inducing G2/M cell cycle arrest and apoptosis in responsive cells. It selectively reduces proliferation of KRAS-mutant non-small cell lung cancer cells and is supplied as a high-purity solid or as a DMSO solution for biochemical and cellular assays.
- Potent KRAS inhibition with measurable binding affinity.
- Selectively inhibits proliferation of KRAS-mutant non-small cell lung cancer cells.
- Induces G2/M cell cycle arrest and apoptosis in responsive cell lines.
- High purity and suitable for in vitro biochemical and cell-based assays.
- Available in multiple pack sizes and solution form for experimental convenience.
Medchemexpress LLC Abemaciclib metabolite M20 | 2138499-06-4 | 95.9% | 10 MG
Abemaciclib metabolite M20 (LSN3106726) is the active metabolite of Abemaciclib and functions as a selective CDK4/6 inhibitor for cancer treatment. This product is intended for research use only.
- Induces senescence in breast cancer cells
- Inhibits growth and cell cycle progression in non-small cell lung cancer (NSCLC) cells, colorectal cancer (CRC) cells, and breast cancer cells
- Effective as a CDK4 and CDK6 inhibitor with an IC50 value in the range of 1-3 nM
Medchemexpress LLC WEE1-IN-3 | 2272976-28-8 | 98.6% | 497.59 | 50 MG
WEE1-IN-3 is a potent Wee1 kinase inhibitor, demonstrating an IC50 of less than 10 nM. This compound has shown anticancer activities by inhibiting cancer cell growth, with IC50 values ranging from 100-1000 nM for SW480 cells and under 100 nM for H23 cells. It targets Wee1 kinase, which is crucial for the G2-M cell-cycle checkpoint, a mechanism often exploited by cancer cells that have compromised G1-S checkpoints, and is frequently overexpressed in various cancer types.
- Potent inhibition of Wee1 kinase.
- Exhibits anticancer activities.
- Inhibits the growth of cancer cells.
- Targets the G2-M cell-cycle checkpoint.
- Effective against cells with compromised G1-S checkpoints.
Medchemexpress LLC WEE1-IN-3 | 2272976-28-8 | 98.6% | 497.59 | 100 MG
WEE1-IN-3 is a potent inhibitor of Wee1 kinase with an IC50 of less than 10 nM. It demonstrates anticancer activities. WEE1 kinase is crucial for the G2-M cell-cycle checkpoint, which is involved in DNA repair before mitotic entry. While normal cells repair damaged DNA during G1 arrest, cancer cells often have a deficient G1-S checkpoint and rely on a functional G2-M checkpoint for DNA repair. WEE1 is found to be overexpressed in various cancer types. WEE1-IN-3 inhibits cancer cell growth with IC50 values of 100-1000 nM for SW480 cells and less than 100 nM for H23 cells.
- Potent Wee1 kinase inhibitor with an IC50 of <10 nM.
- Exhibits anticancer activities.
- Inhibits cancer cell growth in SW480 and H23 cells.
- Available as solid or solution in DMSO.
Selleck Chemical LLC CompK-E1161-5MG
CompK (compound K) a potent and selective hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) small molecule inhibitor significantly improves human T-cell functions with enhanced T-cell receptor avidity to recognize tumor-associated antigens and tumor cytolytic activity by CD8 T cells
Medchemexpress LLC KRAS inhibitor-9 | 300809-71-6 | 99.9% | 292.81 | 50 MG
KRAS inhibitor-9 is a potent inhibitor that blocks the formation of GTP-KRAS and downstream activation of KRAS. It causes G2/M cell cycle arrest and induces apoptosis. This inhibitor selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells.
- Binds to KRAS G12D, KRAS G12C, and KRAS Q61H protein
- Induces G2/M cell cycle arrest
- Promotes apoptosis
- Selectively inhibits NSCLC cells with KRAS mutation
![Medchemexpress LLC Acetamide, N-[2-[[4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-1,3,5-triazin-2-yl)amino]ethyl] | 2767424-13-3 | 98.0% | C21H23N5O2 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000258601.png-250.jpg)
Medchemexpress LLC Acetamide, N-[2-[[4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-1,3,5-triazin-2-yl)amino]ethyl] | 2767424-13-3 | 98.0% | C21H23N5O2 | 10MG
PD-L1-IN-1 is a small-molecule inhibitor of the PD-1/PD-L1 immune checkpoint intended for research use. It binds PD-L1, shows an IC50 of 115 nM, enhances IFN-γ release and peripheral blood mononuclear cell-mediated killing of PD-L1-expressing cancer cells, and induces apoptosis while showing low cytotoxicity in healthy cells.
- Potent PD-L1 inhibition (IC50 115 nM).
- Enhances IFN-γ release and immune cell-mediated tumor cell killing.
- Induces apoptosis in PD-L1-expressing cancer cell lines.
- Low cytotoxicity in noncancerous cells.
- High solubility in DMSO for assay preparation.
- Defined storage recommendations for powder and solutions.
Biotium FLUBIDA-2
Flubida-2 has been used to detect pH at a specific site in a cell such as cell organelles by directing the probe to where avidin fusion proteins are located. The probe is a conjugate of biotin and fluorescein diacetate, which is nonfluorescent until the probe has entered the cells and hydrolyzed by endoesterases. Flubida-2 is membrane-permeable and thus can be delivered into cells via simple incubation with the probe in a buffer. Properties: Off-white solid soluble in DMSO; Store at 4°C; C43H48N4O9S; MW: 812.93
Medchemexpress LLC A1874 | 50MG
A1874 is a nutlin-based (MDM2 ligand) and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells) Effective in inhibiting many cancer cell lines proliferation[1]
Medchemexpress LLC Tas-119 | 1453099-83-6 | 98.0% | 506.36 | 50 MG
TAS-119 is a potent, selective, and orally active Aurora A inhibitor with an IC50 of 1.0 nM. It demonstrates high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). This compound exhibits potent antitumor activities.
- Enhances the antiproliferative effect of Paclitaxel in various human cancer cell lines, including Paclitaxel-resistant cells.
- Increases cell growth inhibition by taxanes (Paclitaxel, Docetaxel, and Cabazitaxel) in HeLa cells.
- Induces mitotic accumulation predominantly in tumor cells compared to normal diploid fibroblasts.
- Induces phosphorylated histone H3 (pHH3) in nude rats with HeLa-luc xenografts.
Medchemexpress LLC A1874 | 100MG
A1874 is a nutlin-based (MDM2 ligand) and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells) Effective in inhibiting many cancer cell lines proliferation[1]
Selleck Chemical LLC IQ-1
IQ-1 enables Wnt/ -catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction
Medchemexpress LLC Deoxyelephantopin | 29307-03-7 | 5 MG
Deoxyelephantopin is a natural bioactive sesquiterpene lactone derived from Elephantopus scaber. It has demonstrated promising anticancer effects across a wide range of cancers by inhibiting NF-κB, MAPK, PI3K/Akt, and β-catenin signaling pathways.
- Inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines.
- Increases the expression of p53, p-JNK, and p-p38 in cancer cells.
- Decreases the expression of p-STAT3 and p-mTOR in cancer cells.
- Downregulates MMP-2, MMP-9, uPA, and uPAR mRNA levels in cancer cells.