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Filtered Search Results
Medchemexpress LLC Cycloguanil hydrochloride | 152-53-4 | 99.9% | 1 ML
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Cycloguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor. It blocks the folate metabolic pathway, affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil inhibits DHFR in *Plasmodium*, making it useful in malaria research. It also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, demonstrating anticancer activity.
- Inhibits dihydrofolate reductase (DHFR)
- Blocks folate metabolic pathway
- Interferes with DNA replication
- Useful in malaria research
- Exhibits anticancer activity
- Potently inhibits transcriptional activity of STAT3
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Medchemexpress LLC Saxagliptin hydrochloride | 709031-78-7 | 99.7% | 351.87 | 50 MG
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Saxagliptin hydrochloride is a potent, selective, reversible, competitive, and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with a Ki of 0.6-1.3 nM. It has potential for research into type 2 diabetes mellitus. It has been shown to induce β-cell proliferation, increase p-AKT and active β-catenin protein levels, and increase insulin secretion.
- Potent, selective, reversible, competitive, and orally active
- Inhibits dipeptidyl peptidase-4 (DPP-4) with a Ki of 0.6-1.3 nM
- Potential for type 2 diabetes mellitus research
- Induces β-cell proliferation
- Increases p-AKT and active β-catenin protein levels
- Increases insulin secretion and decreases glucagon secretion
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Medchemexpress LLC L-methioninamide hydrochloride | 16120-92-6 | MFCD00039084 | 99.2% | 184.69 g/mol | C5H13ClN2OS | 10 G
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L-methioninamide hydrochloride is the hydrochloride salt of L-methioninamide, a methionine analogue reported to inhibit methionyl-tRNA synthetase. It is supplied for research use and is available as solid material or as ready-to-use DMSO solutions for biochemical and biological studies.
- Acts as a methionyl-tRNA synthetase inhibitor.
- Available as solid and as 10 mM DMSO solution formats.
- High purity suitable for analytical and biological research.
- Molecular weight 184.69 g/mol; formula C5H13ClN2OS.
- For research use only; not for human or clinical use.
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Medchemexpress LLC Cilobradine hydrochloride | 186097-54-1 | 99.7% | 519.07 | 25 MG
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Cilobradine hydrochloride is an HCN channel blocker that induces cardiac pacemaker currents and produces antidepressant effects. It works by blocking HCN channel currents in cells and can reverse depressive-like behavior in vivo, with effects lasting for about two weeks.
- Induces cardiac pacemaker currents
- Produces antidepressant effects
- Blocks HCN channel currents in HEK293 cells
- Not isoform-specific in steady-state inhibition of different HCN isoforms
- Can prolong the latency of the a-wave or b-wave of the rat electroretinogram (ERG)
- Can reverse depressive-like behavior
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Medchemexpress LLC Tracazolate hydrochloride | 1135210-68-2 | 99.2% | 25 MG
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Tracazolate hydrochloride | 1135210-68-2 | 99.2% | 25 MG
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Medchemexpress LLC Pevonedistat hydrochloride | 1160295-21-5 | 98.6% | 479.98 | 10 MG
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Pevonedistat hydrochloride | 1160295-21-5 | 98.6% | 479.98 | 10 MG
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Medchemexpress LLC Valnivudine hydrochloride | 956483-03-7 | 99.0% | 534.04 | 5 MG
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FV-100 is a potent, selective, and orally active anti-varicella zoster virus agent. It is a proagent of CF-1743 and demonstrates very low toxicity in vivo.
- Potent and selective anti-varicella zoster virus (VZV) agent.
- Orally active.
- Exhibits very low toxicity in vivo.
- Intensely fluorescent when illuminated by wavelengths of 340-380 nm.
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Medchemexpress LLC Asimadoline hydrochloride | 185951-07-9 | 99.6% | 451.00 | 5 MG
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Asimadoline hydrochloride is an orally active, selective, and peripherally active κ-opioid agonist. It demonstrates low permeability across the blood-brain barrier and exhibits peripheral anti-inflammatory actions. Research indicates its potential for treating irritable bowel syndrome (IBS) and ameliorating allodynia in diabetic rats.
- Orally active and selective κ-opioid agonist
- Low permeability across the blood-brain barrier
- Exhibits peripheral anti-inflammatory actions
- Potential for irritable bowel syndrome treatment
- Ameliorates allodynia in diabetic rats
- Rapid metabolism across species
- Highly selective for κ-opioid receptors
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Medchemexpress LLC 3-methoxyphenylacetic acid | 1798-09-0 | MFCD00004334 | 99.6% | 166.17 g/mol | C9H10O3 | 50 G
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3-methoxyphenylacetic acid is an organic reagent and reference standard supplied as a solid for laboratory research use. It is commonly used in organic synthesis and biochemical assays where a high-purity m-anisylacetic acid derivative is required.
- High purity: 99.6% suitable for analytical and synthetic applications.
- Molecular formula: C9H10O3.
- Molecular weight: 166.17 g/mol.
- Appearance: solid/powder for easy handling and weighing.
- Storage stability: powder stable at -20°C (up to 3 years) or 4°C (up to 2 years); in solvent store at -80°C (6 months) or -20°C (1 month).
- Available in multiple solid pack sizes to support varying scale of experiments.
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Selleck Chemical LLC Thiazolidinedione-E1775-100G
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2 4-Thiazolidinedione (Thiazolidinedione) an insulin sensitizer is a specific agonist of peroxisome proliferator-activated receptor (PPAR) Thiazolidinedione treatment corrects impaired muscle insulin action in vivo
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Medchemexpress LLC Cyclobenzaprine (hydrochloride) | 6202-23-9 | 99.9% | 25 MG
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Cyclobenzaprine hydrochloride is an orally active 5-HT2 receptor antagonist that centrally provides skeletal muscle relaxation, alleviates muscle spasms, and reduces pain. It also possesses antiparasitic activity, showing promise for research in acute, painful skeletal muscle disorders and infectious diseases.
- Orally active 5-HT2 receptor antagonist
- Provides skeletal muscle relaxation and alleviates muscle spasms
- Reduces pain
- Exhibits antiparasitic activity
- Active against Leishmania infantum promastigotes and intracellular amastigotes
- Induces oxidative stress in Leishmania infantum
- Suppresses quadriceps activity in ischemic spinal cord rigidity models
- Prevents tonic-extensor seizures
- Reduces parasite load in Leishmania infantum-infected mice
- Blocks α-motoneuronal excitation
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Medchemexpress LLC Ractopamine hydrochloride | 90274-24-1 | 99.2% | 50 MG
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Ractopamine hydrochloride, also known as LY031537, is a potent β-adrenergic receptor (βAR) agonist with a Kd value of approximately 25 nM for pig β1AR and β2AR. It is associated with protein metabolism and is used in research to promote lean tissue growth and enhance production efficiency in pigs.
- Potent β-adrenergic receptor (βAR) agonist
- Impacts protein metabolism
- Research application in lean tissue growth
- Improved production efficiency in pigs
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Medchemexpress LLC (R)-viloxazine hydrochloride | 56287-63-9 | MFCD18379655 | 99.1% | 273.76 | C13H20ClNO3 | 5MG
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(R)-Viloxazine hydrochloride is the R-enantiomer of viloxazine hydrochloride supplied as a high-purity research chemical for laboratory pharmacology and biochemical studies. It is described as a less active enantiomer of viloxazine and is characterized by a defined molecular composition, physical form, and recommended storage conditions.
- R-enantiomer of viloxazine hydrochloride.
- Cas 56287-63-9.
- Purity 99.1%.
- Molecular formula C13H20ClNO3.
- Molecular weight 273.76.
- Appearance solid powder.
- Recommended storage: powder at -20°C (3 years) or 4°C (2 years); in solvent at -80°C (6 months) or -20°C (1 month).
- For research use only; not intended for human consumption.
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Medchemexpress LLC Milnacipran hydrochloride | 101152-94-7 | 99.7% | 25 MG
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Milnacipran hydrochloride is an orally active Serotonin and Norepinephrine reuptake inhibitor. It inhibits monoamine transporters, specifically the norepinephrine transporter and the serotonin transporter, with Ki values of 31 and 8.5 nM, respectively. It also inhibits pERK1/2 activation. Milnacipran hydrochloride exhibits antidepressant, anxiolytic, and analgesic properties and can inhibit biting behavior in mice. It is used in the study of major depressive disorder, anxiety disorders, and neuropathic pain, such as fibromyalgia.
- Orally active serotonin and norepinephrine reuptake inhibitor
- Inhibits monoamine transporters with Ki values of 31 and 8.5 nM
- Inhibits pERK1/2 activation
- Exhibits antidepressant, anxiolytic, and analgesic properties
- Can inhibit biting behavior in mice
- Used in studies for major depressive disorder, anxiety disorders, and neuropathic pain
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Medchemexpress LLC Norverapamil hydrochloride | 67812-42-4 | MFCD00078605 | 99.8% | 477.04 g/mol | C26H37ClN2O4 | 100 MG
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Norverapamil hydrochloride is the N-demethylated metabolite of verapamil. It functions as an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor and is supplied for research use in solid form or as a DMSO solution.
- High purity: 99.8% for reliable experimental results.
- White to off-white solid for easy handling.
- Soluble in water (≥50 mg/mL) and DMSO (≥31 mg/mL) for formulation flexibility.
- Stable when stored sealed at 4°C; in solvent store -80°C (6 months) or -20°C (1 month).
- Suitable as a research reagent for studies of calcium channel modulation and P-gp function.
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