Custom Peptides
Cayman Chemical MecamylamInhydrochlorIde 10mg
A noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50s range from 1-7 μM)
Cayman Chemical CalycosIn 7-OD-GlucosIde 10mg
An isoflavone glycoside; scavenges 34.5% of generated DPPH radicals compared to a vehicle control in a cell-free assay at 100 μg/ml; inhibits LPS-induced cytotoxicity, ROS production, and cytoskeletal defects in HUVECs at 10 μg/ml; reduces brain infarct volume in a rat model of ischemia-reperfusion injury induced by MCAO at 26.8 mg/kg
Cayman Chemical PhosphoramIdonsodIum salt 10mg
A natural and potent inhibitor of NEP and NEP2, with Ki values of 2 nM for both enzymes; also a weak inhibitor of the related zinc metalloprotease ECE (Ki = 3.5 µM); has little or no effect on a variety of other proteases
Cayman Chemical 1 2DIoleoylsnglycero3PA 10mg
A phospholipid; has been used in the generation of micelles, liposomes, and other artificial membranes
Cayman Chemical 4Hydroxy1 2phenylethylpI 10mg
A building block; has been used in the synthesis of ligands of the mAChR or σ1 receptor; a metabolite of furanyl fentanyl and FIBF
Cayman Chemical CytarabIn 5-monphosphate 10mg
An active metabolite of cytarabine; is incorporated into DNA by DNA polymerase α, which slows the rate of DNA synthesis by approximately 2000-fold in a cell-free assay; inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM; improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg
Cayman Chemical DIhydronarwedIn 10mg
An alkaloid and GSK3β inhibitor; inhibits recombinant human GSK3β at 10 µM
Cayman Chemical SEL120-34AhydrochlorIde 10mg
A dual inhibitor of Cdk8 and Cdk19 (IC50s = 4.4 and 10.4 nM, respectively); selective for Cdk8 and Cdk19 over a panel of CDK/cyclin complexes at 1 µM; inhibits IFN-γ-induced phosphorylation of STAT1 in HCT116 colon cancer cells at 0.1-5 µM; inhibits proliferation of MOLM-16, MV4-11, and KG-1 cells (GI50s = <1 µM); reduces tumor growth in a KG-1 mouse xenograft model at 60 mg/kg
Cayman Chemical LabetalolhydrochlorIde 10mg
An analytical reference standard categorized as a β-adrenergic receptor antagonist; has been used as a doping agent in sports; intended for use in analytical forensic applications
Cayman Chemical 3-HydroxygenkwnIn 10mg
A flavonoid with antioxidant and anticancer activities; scavenges superoxide anions in a cell-free assay at 100 µM; decreases EGFR and phosphorylated EGFR levels in, and reduces viability of, PC-9 and H1975 NSCLC cells at 25 and 50 µM; decreases intratumoral levels of EGFR and phosphorylated EGFR and reduces tumor growth in an H1975 mouse xenograft model at 1 mg/kg
Cayman Chemical PIrtobrutInIb 10mg
A BTK inhibitor (IC50s = 10-100 and C481S, respectively); selective for BTK over EGFR (IC50 = 1-10 µM); decreases the number of Ki67-positive cells in MEC-1 CLL mouse xenograft models using MEC-1 cells that express either wild-type BTK or BTKC481S
Cayman Chemical HGlyArgpNAhydrochLRIde 10mg
A colorimetric thrombin substrate; cleavage of the GR peptide sequence releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity
Cayman Chemical 3MethylquInoxalIn2carboxy 10mg
A major metabolite of olaquindox; induces cell cycle arrest at the S phase and is toxic to Chang liver cells in a concentration- and time-dependent manner; has been used as a marker of olaquindox use in livestock applications