Custom Peptides
Genelink Random Hexamers, 100 μg, 6 bases, 5'-d(NNNNNN)-3', Equimolar 25% A, C, G, T, ~54 nmol/molecule, HPLC purified
Random Hexamers (100 μg) from GENELINK are a versatile mixture of oligonucleotides, six bases in length, designed for a range of molecular biology applications. These primers are crucial for processes like DNA probe labeling, first-strand cDNA synthesis, and the detection of genetic variations. The random nature of the sequence allows for extensive coverage of target DNA or RNA templates, making them ideal for numerous genomic studies.
- Facilitates DNA probe labeling, cDNA synthesis, and RAPD analysis.
- Enables production of high specific activity labeled DNA probes for sensitive detection.
- Provides random initiation sites across varied RNA templates.
- Supports identification of genetic variations for genetic mapping.
Cayman Chemical GardenosIde 10mg
An iridoid glycoside with anti-inflammatory and antinociceptive activities; decreases free fatty acid-induced accumulation of lipid droplets and increases in TNF-α, IL-6, and IL-1β levels in HepG2 cells at 10 and 20 µM; reduces increases in the expression of purinergic P2X3 and P2X7 receptors, as well as reverses decreases in mechanical withdrawal thresholds in a rat model of chronic constriction injury-induced neuropathic pain
Cayman Chemical Ilorasertib 10MG
A multi-kinase inhibitor; inhibits Aurora C, VEGFR1, VEGFR2, FLT3, CSF-1R, and Aurora B (IC50s = 1, 1, 2, 1, 3, and 7 nM, respectively); inhibits PDGFRα, PDGFRβ, c-Kit, VEGFR3, and Aurora A (IC50s = 11, 13, 20, 43, and 120 nM, respectively); inhibits autophosphorylation of Aurora A, -B, and -C in HeLa cells (IC50s = 189, 13, and 13 nM, respectively); inhibits proliferation of a variety of cancer cells, including MV4-11, SUP-B15, and H1299 cells (IC50s = 0.3, 4, and 2 nM, respectively); decreases histone H3 phosphorylation in blood-borne tumor cells in an engrafted mouse model of leukemia at 25 mg/kg and reduces tumor growth in a variety of mouse xenograft models
Cayman Chemical 6-hydroxy Etodolac 10mg
A metabolite of etodolac; induces false-positive reactions in diazo diagnostic tests for bilirubin in urine
Cayman Chemical ENTRECTINIB 10MG
An inhibitor of TrkA (IC50 = 1.7 nM), TrkB (IC50 = 0.1 nM), and TrkC (IC50 = 0.1 nM), as well as ROS1 (IC50 = 0.2 nM) and ALK (IC50 = 1.6 nM); blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance mutations; induces tumor regression in mice bearing various Trk, ROS1, or ALK-driven xenografts
Cayman Chemical Juglns regIa L. JuglaIn 10mg
A flavonol with diverse biological activities; reduces OSS-induced increases in ROS in HAECs at 2.5 and 5 µM; inhibits the proliferation of, as well as induces JNK activation, autophagosome formation, apoptosis, and cell cycle arrest at the G2/M phase in, MCF-7 human breast cancer cells at 2.5, 5, and 10 µM; reduces tumor growth in an MCF-7 mouse xenograft model at 10 and 20 mg/kg; reduces body weight, renal fibrosis, and blood glucose levels, as well as serum and renal levels of Tnf-α, Il-1β, Il-6, and Ccl2, and improves glucose tolerance in a mouse model of high-fat diet- and obesity-induced kidney disease at 15 and 30 mg/kg
Cayman Chemical SaroglItazar MagnsIum 10mg
A PPARα and PPARγ dual agonist (EC50s = 0.65 and 3,000 pM, respectively); decreases serum triglyceride, free fatty acid, and glucose levels in a db/db mouse model of diabetes at 0.01-3 mg/kg; increases insulin sensitivity in an oral glucose challenge at 1 mg/kg; reverses palmitic acid-induced decreases in the expression of mRNA encoding SOD1, SOD2, GPX, and catalase and increases in the expression of mRNA encoding TNF-α, IL-1β, and IL-6 in HepG2 cells at 10 µM; decreases hepatic inflammation and steatosis in a mouse model of NASH induced by a choline-deficient high-fat diet at 3 mg/kg
Cayman Chemical TaspoglutIdeacetate 10mg
An agonist of GLP-1R (Ki = 1.1 nM for the human receptor); induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM); decreases blood levels of glucose and increases blood levels of insulin in an oral glucose tolerance test in Zucker diabetic obese rats at 1 mg/animal per week; reduces blood levels of GIP, plasma levels of triglycerides, and body weight in the same model
Cayman Chemical SAIKOSAPONIN B2 10MG
A triterpenoid saponin with diverse biological activities; an antagonist of TRPA1; inhibits calcium flux induced by polygodial or allyl isothiocyanate in HEK293 cells expressing human TRPA1 at 0.5 to 1.5 µM; inhibits HCV viral entry into, but not replication in, Huh7.5 cells (EC50 = 16.13 µM;) (CC50 = 740.4 µM); protects SH-SY5Y cells from hydrogen peroxide-induced cell death at 50 UG/ml
Cayman Chemical 3-IsomngostIn 10mg
A xanthone with diverse biological activities; an inhibitor of MTH1 (IC50 = 52 nM); inhibits aldose reductase (IC50 = 3.48 µM), AChE (IC50 = 2.36 UG/ml), and BChE (IC50 = 5.32 UG/ml); inhibits the growth of P. falciparum strains D6 and W2 in isolated and infected red blood cells (IC50s = 3.23 and 2.52 UG/ml, respectively); inhibits cyclin D2/Cdk4 and cyclin E1/Cdk2 (EC50s = 15.6 and 34.92 µM, respectively) and reduces viability of HCC1937 and HCT116 cells (IC50s = 59.9 and 47.4 µM, respectively)
Cayman Chemical ArnIcolIde D 10mg
A sesquiterpene lactone with anticancer activity; inhibits the proliferation of MDA-MB-231, MDA-MB-468, and MCF-7 human breast cancer cells (IC50s = 5.211, 3.405, and 9.083 µM, respectively, after 48 hours); inhibits migration of MDA-MB-231 cells at 2.5, 5, and 10 µM; reduces tumor volume in an MDA-MB-231 orthotopic mouse xenograft model at 25 and 50 mg/kg
Cayman Chemical CInamoylglycIn 10mg
A metabolite of trans-cinnamic acid; urinary levels are decreased in a mouse model of piperacillin- and tazobactam-induced gut microbiota colonization resistance; serum levels are increased in patients with CKD
Cayman Chemical MartInostat 10mg
An HDAC inhibitor (IC50s = 0.3, 2, 0.6, and 4.1 nM for HDAC1, -2, -3, and -6, respectively); selective for these HDACs over HDAC4, -5, -7, -8, and -9 (IC50s = 1,970, 352, >20,000, >15,000, and >15,000 nM, respectively); reduces H3K9ac and H4K12ac in primary mouse neuronal cells (EC50s = 100 nM for both)
