Custom Peptides
Cayman Chemical PKG InhIbItrtrIfluoroACTA 10mg
A specific cGMP-dependent PKG inhibitor (Ki = 86 µM); a nonphosphorylatable synthetic peptide analogous to a substrate corresponding to the serine-32 phosphorylation site in histone H2B
Cayman Chemical KN-93 (hydrochloride), Purity: ≥98%, CAS: 1956426-56-4, 10 mg
A selective inhibitor of CaMKII, competitively blocking CaM binding to the kinase (Ki = 370 nM); inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM)
Cayman Chemical Pirinixic Acid Aminothiazole, Purity: ≥98%, CAS: 1492060-44-2, 10 mg
A dual inhibitor of mPGES-1 and 5-LO (IC50s = 0.4 and 0.2 µM, respectively); reduces the synthesis of PGE2 and LTC4 during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response
Cayman Chemical DL-Sulforaphane N-acetyl-L-cysteine, Purity: ≥95%, CAS: 334829-66-2, 10 mg
A major metabolite of sulforaphane that has been shown induce ARE-driven gene expression with roughly 8-fold less potency than sulforaphane
Cayman Chemical Hydroxy DImetrIdazole 10mg
A metabolite of dimetridazole, the nitroimidazole-based antibacterial and anticoccidial agent suspected to be carcinogenic and mutagenic to humans
Cayman Chemical 4'-Aminomethyl-4,5',8-trimethylpsoralen, Purity: ≥98%, CAS: 64358-50-5, 10 mg
A bifunctional photoreactive agent for crosslinking nucleic acids; intercalates into double-stranded regions in DNA or RNA and, upon UV irradiation, forms covalent adducts with pyrimidine bases; used to study different types of RNA from diverse organisms, including viruses
Cayman Chemical 4-tert-Octylphenol diethoxylate, Purity: ≥98%, CAS: 2315-61-9, 10 mg
A degradation product of the surfactant, Triton X that produces weak estrogenic effects in animal and human research studies
Cayman Chemical Ulixertinib (hydrochloride), Purity: ≥98%, CAS: 1956366-10-1, 10 mg
A reversible ERK1/2 inhibitor (IC50 50 value of 180 nM
Cayman Chemical GBR 12935 (hydrochloride), Purity: ≥98%, CAS: 67469-81-2, 10 mg
An inhibitor of dopamine uptake; binds to the dopamine transporter (Kd = 27.2 nM); selective for the dopamine transporter over the serotonin and norepinephrine transporters (Kds = 940 and 310 nM, respectively); it increases locomotor activity in mice at 10 mg/kg; induces gnawing in mice (ED50 = 17.1 mg/kg)
Cayman Chemical 3,4-dihydro Naratriptan, Purity: ≥95%, CAS: 121679-20-7, 10 mg
A process impurity formed during the preparation of naratriptan
Cayman Chemical 5-(Hydroxymethyl)-2’-deoxycytidine, Purity: ≥95%, CAS: 7226-77-9, 10 mg
A modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA; used to quantify DNA hydroxymethylation levels in biological samples
Cayman Chemical 15-keto Fluprostenol isopropyl ester, Purity: ≥98%, CAS: 404830-45-1, 10 mg
An ester derivative of fluprostenol; a potential inactive metabolite of fluprostenol isopropyl ester (travoprost); a potential impurity found in commercial preparations of fluprostenol isopropyl ester
Cayman Chemical (R)-Lansoprazole, Purity: ≥98%, CAS: 138530-94-6, 10 mg
A pure enantiomer of lansoprazole that inhibits acid formation in isolated canine parietal cells with an IC50 value of 59 nM and inhibits the H+/K+-ATPase with an IC50 value of 4.2 µM
Cayman Chemical Necrox-5 (methanesulfonate), Purity: ≥85%, CAS: 1383718-29-3, 10 mg
A cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity; localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibited ~50% cell death in H9C2 cells exposed to 400 μM t-BHP)
Cayman Chemical p-nitro-Pifithrin-α, Purity: ≥95%, CAS: 389850-21-9, 10 mg
A cell-permeable analog of pifithrin-α that blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-α; suppresses p53-mediated TGF-β1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet